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Numerical Analysis of Doublet Wells for Cold Energy Storage on Heat Damage Treatment in Deep Mines

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Journal of China University of Mining and Technology 2006年第3期16卷 278-282页

作者： HE Man-chao zhang Yi GUO Dong-ming qian Zeng-zhen School of Mechanic and Civil Engineering China University ofMining ＆ Technology Beijing 100083 China School of Engineering and Technology China University of Geology Beijing 100083 China

Deep mining is an inevitable tendency in the development of coal industry. There are many heat damage problems with the increase of mining depth. The technology of using doublet wells, together with Heat Exchange Machine Systems （HEMSs）, to store cold energy is a key to solve the heat damage problems in deep mines. Based on the geological conditions, thermodynamic and hydraulic parameters of Jiahe Mine, the isotherms in the period of cold energy storage and refrigeration and the volumes of cold water within different temperature ranges of the cold energy storage well were numerically analyzed. The results show that 1） with the same pumped and injected water volumes, the lower the temperature of injected water is, the larger the *** cold water in the cold energy storage well is. With the larger volume, the effect of cold energy storage is better. 2） the larger the volumes of pumped and reinjected water frigeration is better. And 3） without disturbance, the volume and temperature of cold water in the cold energy storage well can keep unchanged or have only a little change for a long time. Therefore the technology of doublet wells for cold energy storage is feasible and the cold energy storage aquifers can meet the requirement of the technology.

关键词： deep mine heat damage treatment numerical simulation aquifer cold energy storage

Establishing a model to measure and predict the quality of gastrointestinal endoscopy

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World Journal of Gastroenterology 2019年第8期25卷 1024-1030页

作者： Luo-Wei Wang Han Lin Lei Xin Wei qian Tian-Jiao Wang Jian-Zhong zhang qian-qian Meng Bo Tian Xu-Dong Ma Zhao-Shen Li Digestive Endoscopy Center Department of GastroenterologyChanghai HospitalNaval Medical UniversityShanghai 200433China Unimed Scientific Inc. Wuxi 214000Jiangsu ProvinceChina Department of Intensive Care Unit Shanghai East HospitalTongji UniversityShanghai 200120China Department of Medical Quality Medical and Health AdministrationNational Health Commission of ChinaBeijing 100044China

BACKGROUND Tens of millions of gastrointestinal endoscopic procedures are performed every year in China,but the quality varies significantly and related factors are *** endoscopist-and endoscopy division-related factors may be useful to establish a model to measure and predict the quality of *** To establish a model to measure and predict the quality of gastrointestinal endoscopic procedures in China's *** Selected data on endoscopy experience,equipment,facility,qualification of endoscopists,and other relevant variables were collected from the National Database of Digestive Endoscopy of *** multivariable logistic regression analysis was used to identify the potential predictive variables for occurrence of medical malpractice and patient *** and nonlinear regressions were used to establish models to predict incidence of endoscopic *** In 2012,gastroscopy/colonoscopy-related complications in China's Mainland included bleeding in 4,359 cases(0.02%)and perforation in 914(0.003%).Endoscopic-retrograde-cholangiopancreatography-related complications included severe acute pancreatitis in 593 cases(0.3%),bleeding in 2,151(1.10%),perforation in 257(0.13%)and biliary infection in 4,125(2.11%).Moreover,1,313(5.0%)endoscopists encountered with medical malpractice,and 5,243(20.0%)encountered with the disturbance from *** length of endoscopy experience,weekly working hours,weekly night shifts,annual vacation days and job satisfaction were predictors for the occurrence of medical malpractice and patient ***,the length of endoscopy experience and the ratio of endoscopists to nurses were not adequate to establish an effective predictive model for endoscopy *** The workload and job satisfaction of endoscopists are valuable predictors for medical malpractice or patient *** comprehensive data are needed to establish quality-predictive models for endosco

关键词： Endoscopy Gastroscopy Colonoscopy Endoscopic retrograde cholangiopancreatography Quality control Predictive model Performance predictor

Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 805-811页

作者： qian zhang Hong-Song Li Rong Li Jun-Hui Du Cong Jiao Center of Clinical Aerospace Medicine School of Aerospace MedicineKey Laboratory of Aerospace Medicine of Ministry of EducationAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi'an Medical UniversityXi'an 710077Shaanxi ProvinceChina Department of Ophthalmology Xi’an Ninth Hospital Affiliated to Medical College of Xi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

aiM:To observe the role and mechanism of autophagy in retinal pigment epithelial cell(RPE)damaged by high glucose,so as to offer a new idea for the treatment of diabetic retinopathy(DR).METHODS:ARPE-19,a human RPE cell line cultured in vitro was divided into the normal control(NC),autophagy inhibitor 3-methyladenine(3-MA),high-glucose(HG),and HG+3-MA *** viability was detected by CCK-8 assay and the apoptosis rate was measured by flow *** protein expressions of apoptosis markers,including Bax,Bcl-2,and Caspase-3,as well as autophagy marker including microtubule-related protein 1 light chain 3(LC3),p62,and mechanistic target of rapamycin(m TOR)were detected by Western *** flux was detected by transfection with Ad-m Cherry-GFP-LC3 ***:Under high glucose conditions,the viability of ARPE-19 was decreased,and the apoptosis rate increased,the protein expressions of Bax,Caspase-3,and LC3-II/LC3-I were all increased and the expressions of Bcl-2,p62 and p-m TOR decreased,and autophagic flux was increased compared with that of the *** with 3-MA reversed all these changes caused by high ***:The current study demonstrates the mechanisms of cell damage of ARPE-19 through high glucose/m TOR/autophagy/apoptosis pathway,and new strategies for DR may be developed based on autophagy regulation to manage cell death of RPE cells.

关键词： diabetic retinopathy retinal pigment epithelial cell apoptosis autophagy the mechanistic target of rapamycin(mTOR)

Raman scattering in In/InOx core-shell structured nanoparticles

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Chinese Physics B 2014年第8期23卷 117-120页

作者： Wang Meng Tian Ye zhang Jian-Ming Guo Chuan-Fei zhang Xin-Zheng Liu qian The MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Applied Physics School and School of Physics Nankai University Tianjin 300457 China National Center for Nanoscience and Technology Belting 100190 China University of the Chinese Academy of Sciences Beijing 100190 China Department of Physics and TcSUH University of Houston Houston TX 77204 USA

The properties of Raman phonons are very important due to the fact that they can availably reflect some important physical information. An abnormal Raman peak is observed at about 558 cm-1 in In film composed of In/InOx core-shell structured nanoparticles, and the phonon mode stays very stable when the temperature changes. Our results indicate that this Raman scattering is attributed to the existence of incomplete indium oxide in the oxide shell.

关键词： Raman scattering core-shell structure indium nanoparticles

QTL editing confers opposing yield performance in different rice varieties

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Journal of Integrative Plant Biology 2018年第2期60卷 89-93页

作者： Lan Shen Chun Wang Yaping Fu Junjie Wang Qing Liu Xiaoming zhang Changjie Yan qian qian Kejian Wang Key Laboratory of Plant Functional Genomics Ministry of Education Yangzhou University State Key Laboratory of Rice Biology China National Rice Research Institute Chinese Academy of Agricultural Sciences State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural Sciences

Grain yield is one of the most important and complex trait for genetic improvement in crops; it is known to be controlled by a number of genes known as quantitative trait loci（QTLs）. In the past decade, many yield-contributing QTLs have been identified in ***, it remains unclear whether those QTLs confer the same yield performance in different genetic backgrounds. Here, we performed CRISPR/Cas_9-mediated QTL editing in five widely-cultivated rice varieties and revealed that the same QTL can have diverse, even opposing, effects on grain yield in different genetic backgrounds.

关键词： QTL editing confers opposing yield performance in different rice varieties Figure

Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype

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Burns & Trauma 2022年第1期10卷 33-47页

作者： Shiyan Li Ping Yang Xiaofeng Ding Hao zhang Youjun Ding qian Tan Department of Burns and Plastic Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNO.321Zhongshan RoadNanjingJiangsuChina Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNO.321Zhongshan RoadNanjingJiangsu 210008China Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical College of Jiangsu UniversityNO.321Zhongshan RoadNanjingJiangsu 210008China Department of Burns and Plastic Surgery Anqing Shihua HospitalNanjing Drum Tower Hospital GroupAnqing 246002China

Background:Skin wound healing depends on the progress of different but overlapping stages of healing,including hemostasis,inflammatory,proliferative and *** of these stages to occur in a timely and gradual manner may result in non-healing pathological *** and neutrophils have been shown to play an essential role in the inflammatory responses of wound tissue,and their active plasticity allows them to modulate tissue damage and repair *** ability of macrophages and neutrophils to regulate the occurrence and resolution of inflammatory processes is essential for the treatment of pathological wound ***:Mice were categorized into negative control,streptozotocin,streptozotocin+puerarin and puerarin *** traditional Chinese medicine extract puerarin was selected to treat different groups of mice with a full-thickness skin defect *** of the RAW264.7 cell line were stimulated under different puerarin ***,real time quantitative polymerase chain reaction(RT-qPCR),western blot,immunofluorescence and other assays were carried out to explore the effect of puerarin on wound healing and its molecular ***:Animal experiments found that the wound healing of diabetic mice treated with puerarin was significantly accelerated,and histological analysis found that puerarin treatment markedly decreased the infiltration of macrophages and neutrophils in wound *** western blot,RT-qPCR and immunofluorescence experiments,it was observed that puerarin treatment remarkably inhibited nuclear factor kinase B(NF-κB)and mitogen-activated protein kinase(MAPK)signaling pathways,downregulated the expression of inflammatory cytokines and induced the M2 polarization of *** the cellular level,we also observed that puerarin improved M2 macrophage polarization and inhibited inflammatory pathway activation in a high-glucose ***:Puerarin has a significant therapeutic effect on wound he

关键词： Macrophage Puerarin Wound healing Diabetes Skin Streptozotocin Traditional Chinese medicine Nuclear factor kinase B Mitogen-activated protein kinase

Twice-split phosphorus application alleviates low-temperature impacts on wheat by improved spikelet development and setting

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Journal of Integrative Agriculture 2023年第12期22卷 3667-3680页

作者： XU Hui HOU Kuo-yang FANG Hao LIU qian-qian WU Qiu LIN Fei-fei DENG Rui zhang Lin-jie CHEN Xiang LI Jin-cai School of Agronomy Anhui Agricultural UniversityHefei 230036P.R.China Jiangsu Collaborative Innovation Centre for Modern Crop Production Nanjing 210095P.R.China

Extreme low-temperature incidents have become more frequent and severe as climate change *** HuangHuai-Hai wheat growing area of China,the late spring coldness occurring at the jointing-booting stage(the anther interval stage)has resulted in significant yield losses of winter *** study attempts to develop an economical,feasible,and efficient cultivation technique for improving the low-temperature(LT)resistance of wheat by exploring the effects of twice-split phosphorus application(TSPA)on wheat antioxidant characteristics and carbon and nitrogen metabolism physiology under LT treatment at the anther interval stage using Yannong 19 as the experimental *** treatments consisted of traditional phosphorus application and TSPA,followed by a-4℃ LT treatment and natural temperature(NT)control at the anther interval *** analyses showed that,compared with the traditional application,the TSPA increased the net photosynthetic rate(P_(n)),stomatal conductance(Gs),and transpiration rate(T_(r))of leaves and reduced the intercellular carbon dioxide concentration(C_(i)).The activity of carbon and nitrogen metabolism enzymes in the young wheat spikes was also increased by the TSPA,which promoted the accumulation of soluble sugar(SS),sucrose(SUC),soluble protein(SP),and proline(Pro)in young wheat spike and reduced the toxicity of malondialdehyde(MDA).Due to the improved organic nutrition for reproductive development,the young wheat spikes exhibited enhanced LT resistance,which reduced the sterile spikelet number(SSN)per spike by 11.8%and increased the spikelet setting rate(SSR)and final yield by 6.0 and 8.4%,respectively,compared to the traditional *** positive effects of split phosphorus application became more pronounced when the LT treatment was prolonged.

关键词： optimizing phosphorus application low-temperature stress carbon and nitrogen metabolism young spike development wheat

Geochronology and zircon geochemistry of auriferous intrusions in the Bumo deposit,Hainan Province,China

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Acta Geochimica 2022年第2期41卷 208-225页

作者： Yan Hai Bingtao Li Teng Deng Deru Xu Li Wang Youzhong Xiong Xiaowen zhang Zhiling Wang Shaohao Zou Zhengpeng Ding qian qian Shichao Guo School of Earth Sciences East China University of TechnologyNanchang 330013China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Zhaojin Group Co. LtdDongfang 572600HainanChina Jiangxi Engineering Laboratory on Radioactive Geoscience and Big Data Technology East China University of TechnologyNanchang 330013JiangxiChina Resource and Environment Survey Institute of Hainan Province Haikou 570206China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

Intrusion-related gold deposits(IRGS)are a lowgrade,large-tonnage exploration ***,auriferous magmatic rocks were found in the Bumo deposit of the Gezhen shear zone in Hainan Province,***,the geochronology and geochemical characteristics of the intrusions,as well as the mineralization potential,are still *** and petrographic work show that the sulfidebearing intrusions can be divided into diorite porphyrites,quartz monzodiorites and *** LA–ICP–MS U–Pb dating demonstrates that diorite porphyrites,quartz monzodiorites and monzodiorites were formed at104±1,114±1,114±1 Ma,*** addition,sulfides in Yanshanian intrusion-related gold mineralization haveδ;S values of 0.2–4.4%,lower than those in Hercynian-Indosinian(1.9–9.8%)orogenic deposits(ca.219–378 Ma)in the Gezhen shear *** addition,all these intrusions display close correlations between Eu/EuN*with Th/U,consistent with the differentiation of amphibole,apatite and titanite from a hydrous ***,zircon Eu/EuN*in the intrusions are higher than0.4,demonstrating that the magmatic rocks have high water contents and oxygen fugacity values,favorable for gold ***,the Yanshanian magmatic rocks can be a new potential gold exploration target in the Gezhen shear zone.

关键词： Hainan Bumo Intrusion-related mineralization Zircon trace elements Gold mineralization

The Characteristics of vasa Gene from Japanese Sea Bass(Lateolabrax japonicas) and Its Response to the External Hormones

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Journal of Ocean University of China 2015年第4期14卷 717-723页

作者： CHI Meili WEN Haishen NI Meng qian Kun zhang Pei CHai Senhao Fisheries College Ocean University of China

The RNA helicase Vasa is an important regulator of primordial germ cell development. Its function in mature fish, espe- cially the hormone-related differences in maturing male fish has seldom been documented. In this study, a full length cDNA sequence of the vasa gene was cloned from Japanese sea bass, Lateolabraxjaponicas, and it was namedjsb-vasa. Homology analysis showed thatjsb-vasa was closely related to its teleost homologs. The spatial distribution ofjsb-vasa indicated that it was only highly ex- pressed in testis, showing its germ cell-specific expression pattern. During the testicular development cycle, jsb-vasa was highly expressed during early period of spermatogenesis, and reduced when spermatogenesis advanced. In addition, the jsb-vasa gene ex- pression was significantly inhibited at 6 h, 12 h and 24 h after injecting hCG （human ehorionic gonadotropin） and GnRHa （Gonad- otropin-releasing hormone analogue）, indicating thatjsb-vasa gene may play an important role in spermatogenesis of Japanese sea bass, and be under the regulation of external sex hormones.

关键词： vasa gene Japanese sea bass hCG/GnRHa treatment spermatogenesis