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A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis

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Bioactive Materials 2023年第8期26卷 264-278页

作者： Ye Yuan Zhaowenbin zhang Fandi Mo Chen Yang Yiren Jiao Enci Wang yuchong zhang Peng Lin Chengkai Hu Weiguo Fu Jiang Chang Lixin Wang Department of Vascular Surgery Zhongshan HospitalFudan University180 Fenglin RoadShanghai200032China Department of Vascular Surgery Zhongshan Xiamen HospitalFudan University668 JinhuRoadXiamen361015China Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou325000China Shanghai Institute of Ceramics Chinese Academy of Sciences1295 Dingxi RoadShanghai200050China

Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic *** this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity in enhancing angiogenesis,regulating inflammation,and inhibiting muscle necrosis was designed to treat lower-limb ischemic *** particular,sodium alginate,calcium silicate and strontium carbonate were used to prepare injectable hydrogels,which was gelled within 10 *** importantly,this composite hydrogel sustainedly releases bioactive Sr^(2+)and SiO_(3)^(2-) ions within 28 *** biological activity of the bioactive ions released from the hydrogels was verified on HUVECs,SMCs,C2C12 and Raw 264.7 cells in vitro,and the therapeutic effect of the hydrogel was confirmed using C57BL/6 mouse model of femoral artery ligation in *** results showed that the composite hydrogel stimulated angiogenesis,developed new collateral capillaries,and re-established the blood *** addition,the bioactive hydrogel directly promoted the expression of muscle-regulating factors(MyoG and MyoD)to protect skeletal muscle from necrosis,inhibited M1 polarization,and promoted M2 polarization of macrophages to reduce inflammation,thereby protecting skeletal muscle cells and indirectly promoting *** results indicate that these bioceramic/alginate composite bioactive hydrogels are effective biomaterials for treating hindlimb ischemia and suggest that biomaterial-based approaches may have remarkable potential in treating ischemic diseases.

关键词： Hindlimb ischemic diseases Strontium carbonate and calcium silicate bioceramic Bioactive hydrogel Muscle necrosis Angiogenesis

Antifreezing and Stretchable Organohydrogels as Soft Actuators

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Research 2019年第1期2019卷 14-24页

作者： Yukun Jian Baoyi Wu Xiaoxia Le Yun Liang yuchong zhang Dachuan zhang Ling zhang Wei Lu Jiawei zhang Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

Inspired by the freezing tolerance performances found in living creatures, an effect approach is presented to develop novelantifreezing polymeric organohydrogel actuators. Through construction of a bilayer hydrogel including a nonresponsivepolyacrylamide (PAAm) layer and a pH-responsive polyacrylic acid (PAA) layer in the presence of a mixed solvent of water andglycerol, organohydrogel actuators that could produce various shape deformations at subzero temperatures have been achieved,and the actuating speed could be tuned by adjusting the temperature and the ratio between glycerol and water. Moreover, aseries of application demonstrations including a weightlifting robot, artificial valve, and robotic arm have been displayed. Inaddition, by introducing the ionic compound KI into the glycerol-based organogel, flexible conductors that could perform stablesensing performance over a wide range of temperatures from -30℃ to 60℃ have been developed.

关键词： freezing hydrogel organo

木瓜蛋白酶联合左侧肾动脉狭窄构建腹主动脉瘤模型

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中华实验外科杂志 2024年第5期41卷 921-924页

作者：胡诚凯张宇翀吴忱烨李哲昀王恩慈莫凡迪林朋邱首继赖颢王利新复旦大学附属中山医院血管外科上海200032 复旦大学附属中山医院心外科上海200032 复旦大学附属中山医院厦门医院血管外科厦门361015

目的:建立一种更加符合腹主动脉瘤(AAA)演变过程的动脉瘤模型。方法:选择体重为2 kg的16只新西兰兔,对其进行编号,并采取随机数字表法将16只兔分为实验组和对照组,每组各8只。实验组采用"左侧肾动脉狭窄"联合木瓜蛋白酶局部湿敷的方法建... 详细信息

目的:建立一种更加符合腹主动脉瘤(AAA)演变过程的动脉瘤模型。方法:选择体重为2 kg的16只新西兰兔,对其进行编号,并采取随机数字表法将16只兔分为实验组和对照组,每组各8只。实验组采用"左侧肾动脉狭窄"联合木瓜蛋白酶局部湿敷的方法建模,对照组采用局部生理盐水湿敷。术后分别在第2周和第4周对两组新西兰兔进行彩色多普勒超声检查,测量湿敷段主动脉直径的变化。处死新西兰兔后,对第2周和第4周的主动脉标本进行苏木精-伊红(HE)、Verhoeff’s Van Gieson(EVG)染色、Masson、转位蛋白(TSPO)和波形蛋白(Vimentin)染色,以及TSPO、Vimentin、α-平滑肌动蛋白(α-SMA)/成纤维细胞活化蛋白(FAP)的免疫荧光染色。利用SPSS和Image J软件对所得数据进行统计学分析。计数资料以频数(%)表示,计量资料以均数±标准差表示,以P<0.05为差异有统计学意义。结果:超声检查显示,实验组的腹主动脉直径随造模进程持续增加,与对照组比较,差异有统计学意义[(0.54±0.05)cm比(0.28±0.02)cm,Z=-2.6,P<0.01]。此外,第4周实验组的动脉直径明显高于第2周实验组[(0.54±0.05)cm比(0.41±0.03)cm,Z=-2.9,P<0.01]。免疫组织化学结果显示,实验组的动脉瘤壁比较对照组,具有弹力纤维断裂、中膜增厚及外膜胶原纤维沉积等表型。第4周实验组的动脉壁与第2周实验组比较,病变程度加重,相反动脉壁活化巨噬细胞浸润程度下降,且FAP^(+)/α-SMA^(+)的肌成纤维细胞表达明显增高,反映了在动脉瘤进展过程中血管平滑肌细胞的表型转化现象。结论:采用"左侧肾动脉狭窄"联合木瓜蛋白酶局部湿敷的方法可以成功构建更符合人AAA演变的模型。

关键词：腹主动脉瘤肾动脉狭窄木瓜蛋白酶肌成纤维细胞

基于“PETTICOAT”技术的支架系统在B型主动脉夹层远端主动脉重构中的有效性分析——一项多中心“匹配”比较研究

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中华普通外科杂志 2024年第5期39卷 350-356页

作者：胡诚凯杨珏王伟戴向晨陆信武戚悠飞张宏鹏张宇翀邱首继曹根茂王恩慈林朋莫凡迪李仕毅李哲昀左梓昂司逸符伟国王利新复旦大学附属中山医院血管外科复旦大学血管外科研究所上海200032 复旦大学附属中山医院(厦门)血管外科厦门361015 中南大学湘雅医院血管外科长沙410008 天津医科大学总医院血管外科天津300052 上海交通大学医学院附属第九人民医院血管外科上海200011 海南省人民医院血管外科海口570311 中国人民解放军总医院血管外科北京100853

目的比较采用Fabulous支架系统修复和标准胸主动脉腔内修复(TEVAR)对B型主动脉夹层(TBAD)远端主动脉的重塑效果。方法收集2017年12月至2019年10月经Fabulous支架治疗的134例TBAD患者以及对应的多中心进行标准TEVAR治疗的159例TBAD患者... 详细信息

目的比较采用Fabulous支架系统修复和标准胸主动脉腔内修复(TEVAR)对B型主动脉夹层(TBAD)远端主动脉的重塑效果。方法收集2017年12月至2019年10月经Fabulous支架治疗的134例TBAD患者以及对应的多中心进行标准TEVAR治疗的159例TBAD患者的数据。通过倾向性匹配分析,对比两组患者在术后1年的预后和主动脉重塑效果。结果通过倾向性匹配分析,一共62例Fabulous治疗的患者和匹配的62例标准TEVAR治疗的患者纳入分析。两组患者在术前基线情况方面差异无统计学意义。在裸支架区域的主动脉重塑方面,Fabulous组患者在真腔最小直径[10.6(4.4,14.5)mm比4.7(0.9,10.7)mm,P=0.001]和假腔最大直径[-24.2(-30.5,-4.9)mm比0.7(-11.8,2.3)mm,P<0.001]的变化趋势均优于标准TEVAR组患者,且Fabulous组患者的假腔完全血栓化比例明显优于标准TEVAR组患者(62.9%比37.1%,P=0.042)。结论TBAD患者采用Fabulous支架系统有更好的远端主动脉重塑效果。

关键词：主动脉,胸动脉瘤,夹层假腔血栓化主动脉重塑

基于BCC＿CSM模式的破纪录高温事件研究

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气象科学 2018年第4期38卷 531-538页

作者：张羽充况雪源南京大学大气科学学院南京210023

利用国家气候中心发展的海气耦合模式BCC_CSM 1.1模拟的北半球逐日最高气温数据探讨了近年来破纪录高温事件频数变化特征,并预估了其在未来不同情景排放下的可能变化。基于单点逐日最高气温模拟资料呈正态分布及破纪录高温事件符合随机... 详细信息

利用国家气候中心发展的海气耦合模式BCC_CSM 1.1模拟的北半球逐日最高气温数据探讨了近年来破纪录高温事件频数变化特征,并预估了其在未来不同情景排放下的可能变化。基于单点逐日最高气温模拟资料呈正态分布及破纪录高温事件符合随机理论,对北半球近50 a破纪录高温事件频数进行了模拟与理论的对比分析。结果表明:破纪录高温事件频数模拟理论比呈现显著的上升趋势,且这种上升趋势海洋大于陆地,低纬大于高纬;通过与气温相关分析得知破纪录高温事件频数模拟理论比的上升趋势主要是由北半球气温上升导致。在此基础上,比较了RCP4.5与RCP8.5两种不同排放情景下破纪录高温事件频数模拟理论比的变化特征,结果表明在后期(2060—2098)二者差异显著,前者变化较为平稳,而后者具有显著上升趋势,这种差异是对气温不同变化的响应,且低纬海洋的响应比陆地更为敏感。

关键词：全球变暖破纪录事件高温 BCC_CSM模式

Application of "Fabulous" stent system to improve aortic remodeling after TEVAR for type B aortic dissection

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Chinese Medical Journal 2023年第10期136卷 1231-1233页

作者： Chengkai Hu Jue Yang Wei Wang Xiangchen Dai Xinwu Lu Youfei Qi Hongpeng zhang yuchong zhang Ye Yuan Enci Wang Yi Si Weiguo Fu Lixin Wang Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Vascular Surgery Institute of Fudan University Shanghai 200032China Department of Vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China Department of Vascular Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Vascular Surgery Tianjin Medical University General HospitalTianjin 300052China Department of Vascular Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Vascular Surgery Hainan General HospitalHaikouHainan 570311China Department of Vascular Surgery Chinese PLA General HospitalBeijing 100853China

It is known that the Proximal Extension To Induce Complete Attachment(PETTICOAT)technique improves the distal aortic remodeling compared with standard thoracic endovascular aortic repair(TEVAR).[1,2]However,the only available Zenith Dissection Endovascular System(Cook Medical Inc.,Bloomington,Ind,USA)has several limitations,including only two sizes(36 mm and 46 mm)and an one-taper design,which may not be suitable for the complex morphology of dissection at distal aorta,particular for the east Asian ***,our center designed the new“Fabulous”stent system and acheieved better early curative effect.

关键词： aortic dissection remodeling

Distributed dynamic event-based finite-time dissipative synchronization control for semi-Markov switched fuzzy cyber-physical systems against random packet losses

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Chinese Physics B 2023年第10期32卷 328-342页

作者：伍锡如张煜翀张畑畑张斌磊 School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin 541004China

This paper is concerned with the finite-time dissipative synchronization control problem of semi-Markov switched cyber-physical systems in the presence of packet losses, which is constructed by the Takagi–Sugeno fuzzy model. To save the network communication burden, a distributed dynamic event-triggered mechanism is developed to restrain the information update. Besides, random packet dropouts following the Bernoulli distribution are assumed to occur in sensor to controller channels, where the triggered control input is analyzed via an equivalent method containing a new stochastic variable. By establishing the mode-dependent Lyapunov–Krasovskii functional with augmented terms, the finite-time boundness of the error system limited to strict dissipativity is studied. As a result of the help of an extended reciprocally convex matrix inequality technique, less conservative criteria in terms of linear matrix inequalities are deduced to calculate the desired control gains. Finally, two examples in regard to practical systems are provided to display the effectiveness of the proposed theory.

关键词： cyber-physical systems finite-time synchronization distributed dynamic event-triggered mechanism random packet losses

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冻土区坡体蠕滑作用下管道应力数值计算

油气储运 2021年第2期40卷 185-191页

作者：张羽翀李龙黄鑫张姝慧国家管网集团西部管道公司兰州输气分公司甘肃省兰州市730070

长输油气管道在一般地段埋地敷设,当经过季节性斜坡冻土区时,由于冻融引起的坡体蠕滑作用导致管道产生附加应力。通过安装管道轴向应变传感器可监测坡体蠕滑作用导致的管道轴向应力变化,但开展管道强度评价时,需要明确管道应变监测初始... 详细信息

长输油气管道在一般地段埋地敷设,当经过季节性斜坡冻土区时,由于冻融引起的坡体蠕滑作用导致管道产生附加应力。通过安装管道轴向应变传感器可监测坡体蠕滑作用导致的管道轴向应力变化,但开展管道强度评价时,需要明确管道应变监测初始应力,由于应力检测技术多在实验室环境下使用,工程上并不成熟,目前行业内一般通过有限元建模计算方法获取管道应变监测初始应力。以涩宁兰一线某穿越斜坡季节性冻土地貌埋地管道为例,介绍了位于季节性冻土区的管道当前面临的主要风险、土体位移分布形式与位移的确定,以及季节性冻土区斜坡体位移作用下管道的受力和变形情况。采用向量式有限元方法,利用空间梁单元和非线性土弹簧模型对灾害点管道进行了数值模拟,并得到管道现状应力分布,为确定管道本体应变监测截面位置、估计管道现状应力分布及管道安全评价提供依据。

关键词：季节性冻土区管道位移模型计算应力分析

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基于双向条纹投影的复杂纹理物体三维测量

光学学报 2024年第9期44卷 93-104页

作者：张巍陈玉翀姚鹏程盖绍彦达飞鹏东南大学自动化学院江苏南京210096 东南大学复杂工程系统测量与控制教育部重点实验室江苏南京210096

针对结构光系统中复杂纹理的反射率不连续会引起测量误差这一问题,分析并构建了其误差模型,指出了相位误差与相位梯度及灰度梯度之间的相关性,并由此提出了一种基于双向条纹投影的高精度复杂纹理物体测量方法。该方法通过投影横、纵光... 详细信息

针对结构光系统中复杂纹理的反射率不连续会引起测量误差这一问题,分析并构建了其误差模型,指出了相位误差与相位梯度及灰度梯度之间的相关性,并由此提出了一种基于双向条纹投影的高精度复杂纹理物体测量方法。该方法通过投影横、纵光栅获取双向相位信息,并利用提出的映射方法将横向相位映射至纵向,与原纵向相位进行线性运算从而得到平均相位。然后,计算提取的物体纹理边缘切线和校正后相位梯度的夹角,采用相应的误差补偿算法对平均相位进行补偿,最终重建得到校正后点云。对比实验的结果表明,在同等测量效率下,所提方法能够以更高的精度重建复杂纹理物体,相较传统方法,其平均绝对误差和均方根误差最高可降低45.4%和50.1%。

关键词：测量三维测量相移技术双向条纹复杂纹理误差校正