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Acta Pharmaceutica Sinica B 2024年第4期14卷 1592-1604页

作者： Yuanjin zhang Junze Huang Shengbo Huang Jie Liu Luyao Deng Chenmeizi Liang Yuanqing Guo Bingyi yao xin Wang Changning Maternity and Infant Health Hospital and School of Life Sciences Shanghai Key Laboratory of Regulatory BiologyEast China Normal UniversityShanghai 200241China

Organic anion-transporting polypeptides IB1(OATPIB1)plays a crucial role in the transport of ***,there are too few animal models related to OATPIB1,especially humanized animal *** this study,the human SLCOIB1 cDNA was inserted into the second exon of the rat Slcolb2 gene using CRISPR/Cas9 *** characteristics of statins were conducted in wild-type(WT),humanized OATPIB1(hOATPIB1),and OATPIB2 knockout(OATPIB2 KO)rats,*** results showed that human OATPIB1 was successfully expressed in rat liver and exhibited transport ***,the pharmacokinetic results revealed that OATPIB1 exhibited varying uptake levels of pivastatin,rosuvastatin,and fluvastatin,leading to different levels of exposure within the *** results were consistent with those obtained from in vitro experiments using overexpressed cell *** conclusion,we established a novel humanized SLCOIBI transgenic rat model to assess the role of human OATPIB1 in the uptake of different *** different uptake mediated by OATPIB1 may be an important reason for the different efficacy of *** hOATPIB1 rat is a promising model for improving the prediction of human drug transport.

关键词： CRISPR/Cas9 Drug transport Drug disposition Geneediting Humanized rat model OATP1B1 SLCO1B1 Statins

Artificial optical microfingerprints for advanced anticounterfeiting

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Nano Research 2024年第5期17卷 4371-4378页

作者： Xueke Pang Qiang zhang Jingyang Wang xin Jiang Menglin Wu Mingyue Cui Zhixia Feng Wenxin Xu Bin Song yao He Suzhou Key Laboratory of Nanotechnology and Biomedicine Institute of Functional Nano&Soft Materials&Collaborative Innovation Center of Suzhou Nano Science and Technology(NANO-CIC)Soochow UniversitySuzhou 215123China School of Sensing Science and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for ***,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are *** study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML *** approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical ***,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition ***,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks.

关键词： artificial microfingerprints physically unclonable functions deep learning anti-counterfeiting

Hawking-Page transition and the dual relations of anti-de Sitter black holes surrounded by dark energy in general dimensions

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Communications in Theoretical Physics 2024年第7期76卷 94-104页

作者： zhang xin Xu Wei School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Recently,a dual relation T_(0)(n+1)=T_(HP)(n)between the minimum temperature(T_(0)(n+1))black hole phase and the Hawking-Page transition(T_(HP)(n))black hole phase in two successive dimensions was introduced by Wei et al(2020 ***.D10210411);this was reminiscent of the anti-de Sitter/conformal field theory(AdS/CFT)correspondence,as the Hawking-Page transition temperature could be treated as the temperature of the dual physical quantity on the boundary and the latter corresponds to that in the *** this paper,we discuss the Hawking-Page transition and the dual relations in Ads black holes surrounded by dark energy in general *** findings reveal the occurrence of the Hawking-Page transition between the thermal AdS radiation and thermodynamically stable large AdS black holes,in both the spacetime surrounded by phantom dark energy and the spacetime surrounded by quintessence dark *** discuss the effects of the phantom dark energy and quintessence dark energy on the Hawking-Page transition *** the dual relation in particular,it works well for the case of an AdS black holes surrounded by phantom dark *** the case of an Ads black hole surrounded by quintessence dark energy,the dual relation should be modified under an open assumption that the state parameter and the density parameter of the quintessence dark energy depend on the dimensions of the spacetime.

关键词： Hawking-Page transition dark energy black hole thermodynamics

Strong Edge Coloring of Outerplane Graphs with Independent Crossings

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 467-477页

作者： Ke-Jie LI xin zhang School of Mathematics and Statistics Xidian UniversityXi’an 710071China

The strong chromatic index of a graph is the minimum number of colors needed in a proper edge coloring so that no edge is adjacent to two edges of the same *** outerplane graph with independent crossings is a graph embedded in the plane in such a way that all vertices are on the outer face and two pairs of crossing edges share no common end *** is proved that every outerplane graph with independent crossings and maximum degreeΔhas strong chromatic index at most 4Δ-6 if Δ≥4,and at most 8 ifΔ≤*** bounds are sharp.

关键词： outer-1-planar graph IC-planar graph strong edge coloring crossing

Incidence Coloring of Outer-1-planar Graphs

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 840-848页

作者： Meng-ke QI xin zhang School of Mathematics and Statistics Xidian UniversityXi'an 710071China

A graph is outer-1-planar if it can be drawn in the plane so that all vertices lie on the outer-face and each edge crosses at most one another *** is known that every outer-1-planar graph is a planar *** this paper,we conjecture that every planar graph G has a proper incidence(Δ(G)+2)-coloring and confirm it for outer-1-planar graphs with maximum degree at least 8 or with girth at least ***,we prove that every outer-1-planar graph G has an incidence(Δ(G)+3,2)-coloring,and every outer-1-planar graph G with maximum degree at least 8 or with girth at least 4 has an incidence(Δ(G)+2,2)-coloring.

关键词： incidence coloring outer--planar graph planar graph

Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress

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World Journal of Gastroenterology 2024年第19期30卷 2564-2574页

作者： Yan-Fei Li Fang-Yuan Zheng xin-Yu Miao Hai-Long Liu yao-yao zhang Nai-Xia Chao Fa-Rong Mo School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Development and Disease Research(Guangxi Medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M *** research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely *** To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC *** Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down ***,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in *** proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,*** expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western ***,apoptosis was investigated using flow cytometry,qRT-PCR,and western *** CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in ***25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC *** The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signali

关键词： Cell division cyclin 25C Hepatocellular carcinoma Endoplasmic reticulum stress Proliferation Apoptosis

Facile and effective synthesis strategy for terbium-doped hydroxyapatite toward photoelectric devices and flexible functional fibers

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Rare Metals 2024年第4期43卷 1713-1723页

作者： Xiao-Dong zhang Kun Nie Zi-yao Hu Ran-Ran Zhou Xiu-Qiang Duan Wu-Bin Dai Song-Song Nie Song-Jun yao Luo-xin Wang Le-Fu Mei Hua Wang Yi-Yi yao Xiao-Xue Ma Hubei Key Laboratory for New Textile Materials and Applications and State Key Laboratory of New Textile Materials and Advanced Processing Technology School of Materials Science and EngineeringWuhan Textile UniversityWuhan430200China Key Laboratory of Testing and Tracing of Rare Earth Products for State Market Regulation Jiangxi University of Science and TechnologyGanzhou341000China Hubei Key Laboratory of Plasma Chemistry and Advanced Materials and Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan Institute of TechnologyWuhan430205China

As a material with good biocompatibility,hydroxyapatite(HAP)can have optical properties after doping with various rare earth *** a biocompatible fluorescent material,doped HAP could have broad applications in biological probes,drug delivery,optoelectronic materials,fluorescence anti-counterfeiting,and other *** this paper,we put forward the preparation of HAP doped with terbium(Ⅲ)ions(Tb^(3+))by hydrothermal *** controlling the Tb^(3+)doping content in reaction and the reaction time,the changes in HAP's structure,morphology,and luminescence properties under different conditions were *** the doping amount of Tb^(3+)reached an optimal value,the dipole-quadrupole would occur and the concentration would be *** control experiment showed that the optimal Tb3+content was 7.5×10^(-5)mol,which showed the best fluorescence ***,a non-luminous material,was rarely used in the field of fluorescent anti-counterfeiting and photoelectric *** proposed to prepare a luminescent aramid/polyphenylene sulfide(ACFs/PPS)fiber paper and a new light-emitting diode(LED)using the Tb-doped HAP *** composite sample exhibited an excellent stability and fluorescence performance,which also demonstrated a possibility of HAP applications in anticounterfeiting and *** introduction of Tb3+dopant HAP was done to give HAP optical properties and broaden the application range of HAP.

关键词： Hydroxyapatite Rare earth luminescence Photoelectric device Aramid Polyphenylene sulfide fiber paper Luminescent fiber

Dissipation-Driven Superradiant Phase Transition of a Two-Dimensional Bose-Einstein Condensate in a Double Cavity

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Chinese Physics Letters 2024年第6期41卷 44-48页

作者： Bo-Hao Wu xin-xin Yang Yu Chen Wei zhang Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Graduate School of China Academy of Engineering Physics Beijing 100193China Beijing Academy of Quantum Information Sciences Beijing 100193China

We study superradiant phase transitions in a hybrid system of a two-dimensional Bose–Einstein condensate of atoms and two cavities arranged with a tilt *** adjusting the loss rate of cavities,we map out the phase diagram of steady states within a mean field *** is found that when the loss rates of the two cavities are different,superradiant transitions may not occur at the same time in the two cavities.A first-order phase transition is observed between the states with only one cavity in superradiance and both in *** the case that both cavities are superradiant,a net photon current is observed flowing from the cavity with small decay rate to the one with large decay *** photon current shows a non-monotonic dependence on the loss rate difference,owing to the competition of photon number difference and cavity field phase *** findings can be realized and detected in experiments.

关键词： Einstein transitions decay

A SCALAR AUXILIARY VARIABLE (SAV) FINITE ELEMENT NUMERICAL SCHEME FOR THE CAHN-HILLIARD-HELE-SHAW SYSTEM WITH DYNAMIC BOUNDARY CONDITIONS

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Journal of Computational Mathematics 2024年第2期42卷 544-569页

作者： Changhui yao Fengdan zhang Cheng Wang School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Department of Mathematics University of MassachusettsNorth DartmouthMA 02747USA

In this paper,we consider the Cahn-Hilliard-Hele-Shaw(CHHS)system with the dynamic boundary conditions,in which both the bulk and surface energy parts play important *** scalar auxiliary variable approach is introduced for the physical system;the mass conservation and energy dissipation is proved for the CHHS ***,a fully discrete SAV finite element scheme is proposed,with the mass conservation and energy dissipation laws established at a theoretical *** addition,the convergence analysis and error estimate is provided for the proposed SAV numerical scheme.

关键词： Cahn-Hilliard-Hele-Shaw system Dynamic boundary conditions Bulk energy and surface energy Scalar auxiliary variable formulation Energy stability Convergence analysis

Double active sites promoting hydrogen evolution activity and stability of CoRuOH/Co_(2)P by rapid hydrolysis

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Chinese Chemical Letters 2024年第7期35卷 206-211页

作者： Bin Dong Ning Yu Qiu-Yue Wang Jing-Ke Ren xin-Yu zhang Zhi-Jie zhang Ruo-yao Fan Da-Peng Liu Yong-Ming Chai State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China

Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a ***,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline ***,the covering of CoRuOH can improve the stability of Co_(2)P for *** drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 *** coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water *** implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.

关键词： CoRuOH/Co_(2)P/CF Enhanced activity and stability Double active site Large current density Hydrogen evolution reaction

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