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我国江河演变新格局与系统保护治理

中国水利 2024年第7期 1-8,16页

作者：胡春宏张晓明中国水利水电科学研究院流域水循环模拟与调控国家重点实验室北京100038

系统治理是我国新时期治水实践的根本遵循。近几十年来,受自然气候演变与强人类活动影响,我国江河“量-质-域-流-生”过程,特别是水沙通量及其过程发生了显著变化,导致河流水沙来源变化、河道冲淤转换、河床与河势形态演变、江湖关系变... 详细信息

系统治理是我国新时期治水实践的根本遵循。近几十年来,受自然气候演变与强人类活动影响,我国江河“量-质-域-流-生”过程,特别是水沙通量及其过程发生了显著变化,导致河流水沙来源变化、河道冲淤转换、河床与河势形态演变、江湖关系变化及河口三角洲造陆减缓与蚀退等。我国江河演变呈现新的格局,给江河湖库防洪安全、生态安全和沿岸经济发展带来新的挑战。面对治水新形势,提出需从生态系统整体性和流域系统性出发,科学认知江河水沙情势变化规律与发展趋势,统筹确定流域适宜治理度与水沙调控临界阈值体系,系统推进流域“量-质-域-流-生”协同修复,优化布局水土流失治理格局,持续提升水沙调控及优化配置利用体系整体合力,保护河口生境系统,保障江河长久安澜,筑牢国家水安全防线。

关键词：水沙情势江河演变流域治理度系统治理泥沙资源化利用

Numerical Robust Stability Estimation in Milling Process

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 953-959页

作者： zhang xiaoming ZHU Limin DING Han XIONG Youlun State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai 200240 China

The conventional prediction of milling stability has been extensively studied based on the assumptions that the milling process dynamics is time invariant. However, nominal cutting parameters cannot guarantee the stability of milling process at the shop floor level since there exists many uncertain factors in a practical manufacturing environment. This paper proposes a novel numerical method to estimate the upper and lower bounds of Lobe diagram, which is used to predict the milling stability in a robust way by taking into account the uncertain parameters of milling system. Time finite element method, a milling stability theory is adopted as the conventional deterministic model. The uncertain dynamics parameters are dealt with by the non-probabilistic model in which the parameters with uncertainties are assumed to be bounded and there is no need for probabilistic distribution densities functions. By doing so, interval instead of deterministic stability Lobe is obtained, which guarantees the stability of milling process in an uncertain milling environment, In the simulations, the upper and lower bounds of Lobe diagram obtained by the changes of modal parameters of spindle-tool system and cutting coefficients are given, respectively. The simulation results show that the proposed method is effective and can obtain satisfying bounds of Lobe diagrams. The proposed method is helpful for researchers at shop floor to making decision on machining parameters selection.

关键词： robust stability estimation sensitivity analysis interval arithmetic decision making

A Combinatorial Condition and Boolean Functions with Optimal Algebraic Immunity

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Journal of Systems Science & Complexity 2015年第3期28卷 725-742页

作者： JIN Qingfang LIU Zhuojun WU Baofeng zhang xiaoming Key Laboratory of System and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems Science Chinese Academy of Sciences State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences

This paper first proposes an infinite class of 2k-variable Boolean functions with high nonlinearity and high algebraic degree. Then an infinite class of balanced Boolean functions are proposed by modifying the above Boolean functions. This class of balanced Boolean functions have optimal algebraic degree and high nonlinearity. Both classes have optimal algebraic immunity based on a general combinatorial conjecture.

关键词： Algebraic degree algebraic immunity balancedness Bent function Boolean function nonlinearity.

Decoding the complexity of metastasis

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Cancer Biology & Medicine 2022年第3期19卷 284-288页

作者： Yingcheng Wu Tiancheng zhang xiaoming zhang Qiang Gao Department of Liver Surgery and Transplantation Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyInstitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Genetic Engineering Fudan UniversityShanghai 200433China

Cancer metastasis remains one of the most confounding questions in oncology1,*** current cutting-edge techniques enable very early detection of tumors,profiling whether a tumor has already begun to spread and where it has attempted to colonize remains a major ***,metastatic seeding events exhibit remarkable temporal and spatial heterogeneity,wherein the origin(primary site)and destination(metastatic site)are highly *** example,liver metastasis is particularly common and remains a leading cause of mortality3.

关键词： metastasis mortality founding

A NOTE ON TWO CLASSES OF BOOLEAN FUNCTIONS WITH OPTIMAL ALGEBRAIC IMMUNITY

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Journal of Systems Science & Complexity 2014年第4期27卷 785-794页

作者： WU Baofeng LIU Zhuojun JIN Qingfang zhang xiaoming State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of Sciences Key Laboratory of Mathematics Mechanization.Academy of Mathematics and Systems Science Chinese Academy of Sciences Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems ScienceChinese Academy of Sciences

Tu and Deng proposed a class of bent functions which are of optimal algebraic immunity under the assumption of a combinatorial *** this paper,the authors compute the dual of the Tu-Deng functions and then show that they are still of optimal algebraic immunity under the assumption of the same *** another class of Boolean functions constructed by Tang,et *** are of optimal algebraic immunity with similar forms to Tu-Deng functions,the authors show that they are not bent functions by using some basic properties of binary complete Kloosterman sums.

关键词： Algebraic immunity bent function Boolean function Kloosterman sums Walsh trans-form.

几丁质脱乙酰酶的生物学功能、三维结构及其抑制剂的研究进展

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农药学学报 2024年第2期26卷 211-223,277页

作者：徐欢何祺崔佳琳靳彬艳路星星张晓鸣凌云张莉中国农业大学理学院应用化学系农药创新中心北京100193

由于农用化学品存在靶标有限性和耐药性等问题,新靶标的开发成为农药研发的重中之重。几丁质是昆虫表皮和真菌细胞壁的主要组成成分,具有重要的生物学功能。几丁质脱乙酰酶(chitin deacetylase,CDA)可将几丁质脱乙酰化为壳聚糖,这一过... 详细信息

由于农用化学品存在靶标有限性和耐药性等问题,新靶标的开发成为农药研发的重中之重。几丁质是昆虫表皮和真菌细胞壁的主要组成成分,具有重要的生物学功能。几丁质脱乙酰酶(chitin deacetylase,CDA)可将几丁质脱乙酰化为壳聚糖,这一过程除了影响昆虫体壁和真菌细胞壁的形成外,还可调控昆虫的生长发育或决定病原菌的致病性。越来越多的研究表明,CDA有望成为新农药创制的候选靶标。本文介绍了CDA作为作物保护潜在靶标的研究进展,主要综述了当前不同来源CDA的生化功能、晶体结构、酶与底物的结合模式和以及近年来已报道的以CDA为靶标的抑制剂的研究进展,可为以几丁质脱乙酰酶为靶标的抑制剂的筛选以及新型农药的开发提供指导。

关键词：几丁质脱乙酰酶生物功能潜在应用价值晶体结构抑制剂研究进展

Promoting wetting of Mg on the SiC surfaces by addition of Al,Zn and Zr elements:A study via first-principle calculations

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Journal of Magnesium and Alloys 2022年第6期10卷 1663-1671页

作者： Weibing Guo Wenshan Bian Haitao Xue xiaoming zhang School of Materials Science and Engineering Hebei University of TechnologyTianjin 300401China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

When preparing SiC/Mg composites,alloy elements play key roles in the nucleation and interfacial *** this paper,effects of Al,Zn and Zr additions on the Mg/SiC interfacial bonding properties were investigated comprehensively via method of first-principle ***(0001)/SiC(0001)interfaces with different terminations and stacking sequences were built and CⅡ-T CⅡtop interface has the largest work of adhesion(W_(ad)).Zn dopants can not improve the W_(ad)for both C-T and Si-T *** atom can only strengthen the C-T *** addition can greatly improve the W_(ad)for both C-T and Si-T interfaces.W_(ad)of C-T interfaces can reach up to 11.55 J/m^(2) and 12.55 J/m^(2) after doping 1 monolayer(ML)of Al and Zr *** W_(ad)can lead to lower contact angles of Mg on SiC surfaces,which can improve wetting and nucleation in SiC/Mg *** of electronic structure shows that Al-C and Zr-C bonds have more covalent composition than the Mg-C bond,which is responsible for the improvement of interfacial bonding *** results in references were also analyzed,which are in well agreement with our calculation results.

关键词： Mg alloy SiC Wetting Electronic structure First-principle calculations

From blood to tissue:take a deeper look at B cells in lupus

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Cellular & Molecular Immunology 2021年第8期18卷 2073-2074页

作者： Qiong Fu xiaoming zhang Department of Rheumatology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghaiChina

A hallmark of systemic lupus erythematosus(SLE)is aberrant B-cell differentiation and function,and the pathogenic roles of B cells are *** addition to producing autoantibodies,lupus B cells actively take part in antigen presentation,costimulation,and immune *** targeting B cells,plasma cells,or their differentiation pathways have been developed.

关键词： lupus stimulation ed.

某三甲综合医院36例儿童药物误服中毒病例分析及药学服务思考

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儿科药学杂志 2024年第2期30卷 25-28页

作者：王鹏徐颖张晓明张少楠安徽省芜湖市第二人民医院安徽芜湖241000

目的:了解安徽省芜湖市第二人民医院儿童药物误服中毒特点和探索药学服务的切入点。方法:回顾性分析我院2020-2021年36例药物误服中毒病例和对同期儿科病区住院的40例儿童家长进行问卷调查,了解我院儿童药物误服中毒一般资料和药物种类... 详细信息

目的:了解安徽省芜湖市第二人民医院儿童药物误服中毒特点和探索药学服务的切入点。方法:回顾性分析我院2020-2021年36例药物误服中毒病例和对同期儿科病区住院的40例儿童家长进行问卷调查,了解我院儿童药物误服中毒一般资料和药物种类分布。对儿童家长进行问卷调查了解药物误服中毒的风险因素和药学服务的价值。结果:我院36例儿童药物误服中毒年龄主要集中在>1~3岁组(33.33%)和>3~6岁组(30.56%)。药品主要集中在降压药(27.03%)、感冒药(10.81%)、灭鼠药(10.81%)、农药(10.81%)、维生素制剂(10.81%)和抗精神病药物(8.11%)。调查显示药品箱配备率及有效使用率低,家庭药品存在乱放现象,院前急救知识匮乏,相关药学服务需求急切。结论:儿童药物误服中毒多为家中常用药品,且均与摆放不当有关,目前急需药师进行安全宣传和院前急救知识的培训。

关键词：儿童家庭药品误服药物中毒