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抢抓机遇深化改革努力促进高校快速和谐发展

河北科技大学学报（社会科学版） 2005年第4期5卷 17-22页

作者：陆长福张卫东孙贺郭春东河北科技大学河北石家庄050018

本文结合河北科技大学实际,重点分析了高校快速和谐发展面临的主要机遇和主要挑战,并提出了高校快速和谐发展的思路和对策。

关键词：高校和谐发展

Bacterial persisters: molecular mechanisms and therapeutic development

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3305-3336页

作者： Hongxia Niu Jiaying Gu Ying zhang School of Basic Medical Science and Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053 ZhejiangChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003 ZhejiangChina Jinan Microecological Biomedicine Shandong Laboratory Jinan 250022 ShandongChina

Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation *** cells can regrow after stress removal and remain susceptible to the same *** are underlying the problems of treating chronic and persistent infections and relapse infections after treatment,drug resistance development,and biofilm infections,and pose significant challenges for effective *** the characteristics and the exact mechanisms of persister formation,especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent ***,genes related to persister formation and survival are being discovered and confirmed,but the mechanisms by which bacteria form persisters are very complex,and there are still many unanswered *** article comprehensively summarizes the historical background of bacterial persisters,details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria,systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells,as well as consolidates the diverse anti-persister compounds and *** hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatmentofpersistent infections.

关键词： mechanisms treatment persist

SCAB1 coordinates sequential Ca^(2+) and ABA signals during osmotic stress induced stomatal closure in Arabidopsis

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Science China(Life Sciences) 2024年第1期67卷 1-18页

作者： Tianren zhang Li Bai Yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Hyperosmotic stress caused by drought is a detrimental threat to plant growth and agricultural productivity due to limited water *** are gateways of transpiration and gas exchange,the swift adjustment of stomatal aperture has a strong influence on plant drought *** intensive investigations of stomatal closure during drought stress in past decades,little is known about how sequential signals are integrated during complete ***,we discovered that the rapid Ca^(2+) signaling and subsequent abscisic acid(ABA)signaling contribute to the kinetics of both F-actin reorganizations and stomatal closure in Arabidopsis thaliana,while STOMATAL CLOSURE-RELATED ACTIN BINDING PROTEIN1(SCAB1)is the molecular switch for this entire *** the early stage of osmotic shock responses,swift elevated calcium signaling promotes SCAB1 phosphorylation through calcium sensors CALCIUM DEPENDENT PROTEIN KINASE3(CPK3)and *** phosphorylation restrained the microfilament binding affinity of SCAB1,which bring about the Factin disassembly and stomatal closure *** the osmotic stress signal continued,both the kinase activity of CPK3 and the phosphorylation level of SCAB1 attenuated *** further found that ABA signaling is indispensable for these attenuations,which presumably contributed to the actin filament reassembly process as well as completion of stomatal ***,the dynamic changes of SCAB1 phosphorylation status are crucial for the kinetics of stomatal *** together,our results support a model in which SCAB1 works as a molecular switch,and directs the microfilament rearrangement through integrating the sequentially generated Ca^(2+) and ABA signals during osmotic stress induced stomatal closure.

关键词： calcium signal ABA stomatal movement microfilaments kinase

爆炸荷载下背爆面柔性聚脲防护混凝土靶板的反直观行为

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含能材料 2024年第9期32卷 887-898页

作者：徐昊张锐黄微波董奇胡俊华梁龙强中国工程物理研究院化工材料研究所四川绵阳621999 青岛理工大学土木工程学院山东青岛266520 青岛沙木新材料有限公司山东青岛266108

金属结构在冲击载荷作用下,最终的变形方向与加载的方向相反,这一现象被称为反直观行为,试验发现背爆面柔性聚脲防护混凝土靶板在75 g TNT爆炸荷载下也发生了反直观行为。为了研究背爆面柔性聚脲防护混凝土靶板在爆炸荷载下的反直观行为... 详细信息

金属结构在冲击载荷作用下,最终的变形方向与加载的方向相反,这一现象被称为反直观行为,试验发现背爆面柔性聚脲防护混凝土靶板在75 g TNT爆炸荷载下也发生了反直观行为。为了研究背爆面柔性聚脲防护混凝土靶板在爆炸荷载下的反直观行为,采用ANSYS/LSDYNA有限元软件,建立了背爆面柔性聚脲防护混凝土靶板在爆炸荷载作用下的有限元模型。利用有限元模型分析背爆面柔性聚脲防护混凝土靶板的动态响应规律,从能量的角度研究靶板反直观行为的发生机理。以靶板的中心点位移和挠度为指标,参数化分析了炸药药量和聚脲涂层厚度对靶板反直观行为的影响规律。结果表明:靶板的反直观行为是由聚脲涂层的应变能释放、混凝土损伤破坏的能量耗散及两种材料间能量的相互转化这三种因素共同作用导致的;炸药药量是反直观行为能否发生的关键因素,当药量较低或较高时,靶板都无法发生反直观行为;涂层厚度在2~8 mm范围内,靶板均出现了反直观行为,其弯曲程度随着涂层厚度的增加先增大后减小。

关键词：反直观行为柔性聚脲混凝土靶板爆炸荷载

Application of magnetotactic bacteria as engineering microrobots:Higher delivery efficiency of antitumor medicine

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Chinese Chemical Letters 2024年第10期35卷 139-146页

作者： Jing zhang Charles Wang Yaoyao zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and lon Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China University of California San DiegoLa JollaCA 92093United States International Magnetobiology Frontier Research Center Hefei 230031China

For a significant duration,enhancing the efficacy of cancer therapy has remained a critical *** bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery ***,classified as anaerobic,aquatic,and gram-negative microorganisms,exhibit remarkable motility and precise control over their internal biomineralization *** unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion,enclosed within a *** bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex *** harnessing these biochemical attributes,MTB could potentially offer substantial advantages in the realm of cancer *** article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent *** objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.

关键词： Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery Bioconjugation

Adaptive Graph Convolutional Adjacency Matrix Network for Video Summarization

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Computers, Materials & Continua 2024年第8期80卷 1947-1965页

作者： Jing zhang Guangli Wu Shanshan Song School of Cyberspace Security Gansu University of Political Science and LawLanzhou730000China

Video summarization aims to select key frames or key shots to create summaries for fast retrieval,compression,and efficient browsing of *** neural networks efficiently capture information about graph nodes and their neighbors,but ignore the dynamic dependencies between *** address this challenge,we propose an innovative Adaptive Graph Convolutional Adjacency Matrix Network(TAMGCN),leveraging the attention mechanism to dynamically adjust dependencies between graph ***,we first segment shots and extract features of each frame,then compute the representative features of each ***,we utilize the attention mechanism to dynamically adjust the adjacency matrix of the graph convolutional network to better capture the dynamic dependencies between graph ***,we fuse temporal features extracted by Bi-directional Long Short-Term Memory network with structural features extracted by the graph convolutional network to generate high-quality *** experiments are conducted on two benchmark datasets,TVSum and SumMe,yielding F1-scores of 60.8%and 53.2%,*** results demonstrate that our method outperforms most state-of-the-art video summarization techniques.

关键词： Attention mechanism deep learning graph neural network key-shot video summarization

Improved dynamic regret of distributed online multiple Frank-Wolfe convex optimization

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Science China(Information Sciences) 2024年第11期67卷 164-179页

作者： Wentao zhang Yang SHI Baoyong zhang Deming YUAN School of Automation Nanjing University of Science and Technology Department of Mechanical Engineering University of Victoria

In this paper, we explore a distributed online convex optimization problem over a time-varying multi-agent network. The network aims to minimize a global loss function through local computation and communication with neighboring agents. To effectively handle the optimization problem which involves highdimensional and structural constraint sets, we develop a distributed online multiple Frank-Wolfe algorithm that circumvents the expensive computational cost associated with projection operations. The dynamic regret bounds are established as O(T1-γ+ HT) with the linear oracle number O(T1+γ), which depends on the horizon（total iteration number） T, the function variation HT, and the tuning parameter 0 < γ < *** particular, when the prior knowledge of HTand T is available, the bound can be enhanced to O（1 +HT）. Moreover, we explore the significant advantages provided by the multiple iteration technique and reveal a trade-off between dynamic regret bound, computational cost, and communication cost. Finally,the performance of our algorithm is validated and compared through the distributed online ridge regression problems with two constraint sets.

关键词： distributed online convex optimization multiple iterations Frank-Wolfe algorithm dynamic regret gradient tracking method

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Insights into dammarane-type triterpenoid saponin biosynthesis from the telomere-totelomere genome of Gynostemma pentaphyllum

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Plant Communications 2024年第8期5卷 100-103页

作者： Lingling Yun Chuyi zhang Tongtong Liang Yu Tian Guoxu Ma Vincent Courdavault Sijie Sun Baiping Ma Ziqin Li Rucan Li Feng Cao Xiaofeng Shen Jianhe wei Ying Li Baolin Guo Chao Sun Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Biomole cules et Biotechnologies Ve ge tales EA2106Universite de Tours37200 ToursFrance Beijing Institute of Radiation Medicine Beijing 100850China Present address:National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Dear Editor,Gynostemma pentaphyllum(Thunb.)Makino,a perennial climbing vine in the Cucurbitaceae family,has been widely used in traditional medicine for over 600 years(Blumert and Liu,1999).It serves as a valuable natural source of over 200 dammaranetype saponins with notable bioactive properties,including anti-cancer,cardioprotective,hepatoprotective,neuroprotective,and anti-diabetic activities(Li et al.,2016;Nguyen et al.,2021).

关键词： protective Gynostemma saponins

Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong Liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang Jin-E Lu Yan Liu Xi Chen Meng-Meng Qu Yang zhang wei-Guo Hong Yong-Gang Li Junliang Fu Fu-Sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses