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Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine:A Clinical Trial

Congenital Heart Disease 2023年第3期18卷 373-385页

作者： Xingbang Li Xuan Zheng Bowen Jin Yunyan Li Yongyu Shao Xiaoxian Deng Dingyang Li Shanshan Li Hongmei Zhou Jie zhang Xianya zhang Qunshan Shen Gangcheng zhang Congenital Heart Disease Center Wuhan Asia Heart HospitalWuhan University of Science and TechnologyWuhan430022China Structural Heart Disease Center Zhongnan HospitalWuhan UniversityWuhan430071China Department of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background:Transcatheter closure of patent foramen ovale(PFO)has been widely accepted as a highly effective way to treat high-risk PFO-related ***,traditional non-degradable occluders made of metal alloys will permanently exist in the body,resulting in thrombosis,valve damage,hemolysis,arrhythmia,or other *** biodegradable PFO occluder developed by Shanghai Mallow Medical Instrument Co.,Ltd.,China can be fully absorbed and degrade into nontoxic ingredients,reducing postoperative ***:To study the safety and efficacy of biodegradable PFO occluders in treating ***:This single-center clinical trial collected 30 patients treated with a biodegradable PFO *** follow-up period lasted 12 months to analyze the echocardiographic characteristics and headache relief through HIT-6 ***:The immediate success rate was 100%,with no intraoperative severe occlusion-related *** contrast transcranial Doppler(cTCD)at 12 months showed that all patients’right-to-left shunts(RLS)were grade I or 0 with no serious postoperative complications,indicating the overall success rate was 100%.The biodegradable PFO occluder mostly degraded six months after the ***:PFO closure with a Mallow biodegradable occluder is safe and effective and has no severe complications.

关键词： Patent foramen ovale biodegradable occluder transcatheter closure migraine complications

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Geochemical signatures and human health risk evaluation of rare earth elements in soils and plants of the northeastern Qinghai-Tibet Plateau,China

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Journal of Arid Land 2022年第11期14卷 1258-1273页

作者： LI Leiming WU Jun LU Jian zhang Xiying XU Juan Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China Yantai Research Institute Harbin Engineering UniversityYantai 264006China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China Qinghai Provincial Key Laboratory of Geology and Environment of Salt Lakes Xining 810008China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China

Information on rare earth elements(REEs)in soils and plants of the Qinghai-Tibet Plateau is very ***,in this study,we performed field sampling to explore the geochemical signatures and human health risk of REEs in soils and plants of the northeastern Qinghai-Tibet Plateau,China.A total of 127 soil samples and 127 plant samples were collected from the northeastern Qinghai-Tibet Plateau to acquire the geochemical signatures and related human health risks of *** mean total concentrations of REEs in soils and plants of the study area reached 178.55 and 10.06 mg/kg,*** light REEs in soils and plants accounted for 76%and 77%of the total REEs,*** showed significantly homogenous distribution in soils but inhomogeneous distribution in plants of the study *** parameters indicated that light REEs were enriched and fractionated significantly,while heavy REEs were moderately fractionated in soils and *** in soils and plants showed significantly negative Europium *** showed slightly positive anomaly in plants and slight anomaly in *** normalized distribution patterns of REEs were generally similar in the analyzed soils and the corresponding plants of the study *** average bio-concentration factor of REEs ranged from 0.0478(Scandium)to 0.0604(Europium),confirming a small accumulation of REEs by *** risks caused by REEs in soils and plants were negligible,while risks for adults were lower than those for *** study provides important information on REEs in soils and plants of the northeastern Qinghai-Tibet Plateau.

关键词： rare earth elements geochemical signatures human health risk carcinogenic risk bio-concentration factor Qinghai-Tibet Plateau

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长链非编码RNAKCNK15-AS1靶向微RNA-140-5p对骨关节炎软骨细胞增殖、凋亡及炎症因子表达的影响

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中华骨与关节外科杂志 2024年第5期17卷 459-466页

作者：孙鹏张国华陈超斌刘彬陈美周一林杨翾武汉市普仁医院骨关节外科武汉430081

目的:探讨长链非编码RNA(lncRNA)KCNK15-AS1是否通过靶向微RNA-140-5p(miR-140-5p)影响骨关节炎(OA)软骨细胞增殖、凋亡,炎症因子表达及细胞外基质(ECM)合成。方法:实时荧光定量PCR(qRT-PCR)检测KCNK15-AS1和miR-140-5p在OA软骨组织中的表达。在OA软骨细胞中转染si-KCNK15-AS1,噻唑蓝(MTT)和流式细胞术分别检测细胞增殖与凋亡,蛋白质印迹法(WB)检测细胞周期蛋白D1(Cyclin D1)、p21、Bcl-2相关X蛋白(Bax)、B细胞淋巴瘤/白血病-2(Bcl-2)、白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)、蛋白聚糖(Aggrecan)、Ⅱ型胶原(Collagen typeⅡ)、基质金属蛋白酶-3(MMP-3)、MMP-9、MMP-13的表达。双荧光素酶活性检测分析KCNK15-AS1与miR-140-5p的靶向关系。si-KCNK15-AS1和anti-miR-140-5p共转染,观察干扰miR-140-5p表达对抑制KCNK15-AS1表达诱导的OA软骨细胞增殖、凋亡,炎症因子表达及ECM合成的影响。结果:与正常软骨组织比较,OA软骨组织中KCNK15-AS1表达量明显增加(P<0.05),miR-140-5p表达量显著减少(P<0.05)。抑制KCNK15-AS1表达明显提高OA软骨细胞24 h、48 h、72 h的吸光度(OD)值和CyclinD1、Bcl-2蛋白表达量、Aggrecan、Collagen typeⅡ水平(P<0.05),显著降低细胞凋亡率、p21、Bax蛋白水平、IL-6、TNF-α、IL-8、MMP-3、MMP-9、MMP-13水平(P<0.05)。KCNK15-AS1靶向miR-140-5p抑制miR-140-5p的表达。干扰miR-140-5p表达逆转了抑制KCNK15-AS1表达对OA软骨细胞增殖、ECM合成的促进作用,对细胞凋亡、炎症因子表达的抑制作用。结论:LncRNA KCNK15-AS1通过靶向调控miR-140-5p表达影响OA软骨细胞增殖、凋亡、炎症因子表达及ECM合成。

关键词：长链非编码RNA KCNK15-AS1 微RNA-140-5p 软骨细胞增殖炎症细胞外基质

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基于分子对接和分子动态模拟探讨葛根素缓解大鼠心肌缺血再灌注损伤的作用机制

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华中科技大学学报（医学版） 2024年第1期53卷 26-32页

作者：张春艳曹晓璐刘嵩黄瑞松李姝雅王江友武汉科技大学医学院制药工艺研究所职业危害识别与控制湖北省重点实验室武汉430065 武汉科技大学附属武汉亚洲心脏病医院心内科武汉430022 武汉科技大学附属武汉亚心总医院心内科武汉430058

目的基于分子对接和动态模拟,联合整体动物水平研究,揭示葛根素缓解心肌缺血再灌注损伤的具体作用机制。方法采用分子对接联合分子动态模拟技术预测葛根素与细胞沉默调节蛋白1(SIRT1)的结合潜力;结扎SD大鼠左冠状动脉前降支构建心肌... 详细信息

目的基于分子对接和动态模拟,联合整体动物水平研究,揭示葛根素缓解心肌缺血再灌注损伤的具体作用机制。方法采用分子对接联合分子动态模拟技术预测葛根素与细胞沉默调节蛋白1(SIRT1)的结合潜力;结扎SD大鼠左冠状动脉前降支构建心肌缺血再灌注模型,观察给予葛根素对心肌损伤的保护作用,观察抑制SIRT1表达后葛根素对心肌损伤的保护作用变化。2,3,5-氯化三苯基四氮唑(TTC)染色评估梗死面积;TUNEL联合免疫荧光检测心肌细胞凋亡率和SIRT1表达;透射电镜观察心肌超微结构;Western blot检测铁死亡相关蛋白表达。结果分子对接结果表明葛根素和SIRT1能够形成稳定的复合物发挥药效;在构建心肌缺血再灌注模型的大鼠体内给予葛根素处理,能明显改善心肌损伤,上调SIRT1、溶质载体家族成员11(SLC7A11)、谷胱甘肽过氧化物酶4(GPX4),并下调铁反应元件结合蛋白2(IREB2)表达;一旦抑制SIRT1蛋白表达后,则葛根素的心肌保护作用被抑制。结论分子对接和分子动态模拟技术能较好地预测葛根素与主要靶点SIRT1的作用潜力,葛根素通过激活SIRT1通路抑制铁死亡从而缓解心肌缺血再灌注损伤。

关键词：分子对接分子动态葛根素心肌缺血再灌注 SIRT1

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Implications of stalagmite density for past climate change:An example from stalagmite growth during the last deglaciation from Wanxiang Cave,western Loess Plateau

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Chinese Science Bulletin 2010年第34期55卷 3936-3943页

作者： zhang DeZhong zhang PingZhong SANG WenCui CHENG Hai WU XiuPing YUAN Ye BAI YiJun WANG JiangLin JIA JiHong Key Laboratory of Western China's Environmental System of Ministry of Education College of Earth and Environmental Sciences Lanzhou University Lanzhou 730000 China Institute of Global Environmental Change Xi'an Jiaotong University Xi'an 710049 China Department of Geology and Geophysics University of Minnesota Minneapolis MN 55455 USA

The density of a stalagmite(wx42A)from Wanxiang Cave,Wudu County,Gansu Province,China,in the western margin of the Asian summer monsoon region,presents regular fluctuations in different deposition periods during the last *** long timescales,high-precision 230Th dating and high-resolution stalagmite density data indicate that the density-time series between 17644 a BP and 12758 a BP is quite similar to the stalagmite δ18O record which reflects Asian monsoon ***/weakening(lighter/heavier stalagmite δ18O values)of the Asian monsoon is accompanied by increase/decrease in stalagmite *** short timescales,decrease in stalagmite density correlates to monsoon-retreat events such as the Inter-AllerФd Cold Period(IACP),Older Dryas(OD)and Inter-BФlling Cold Period(IBCP).Generally,this kind of decrease in stalagmite density reflects precipitation decrease with weakening of the Asian monsoon,which in turn slows cave dripwater rate and decreases crystal nuclei,leading to enlargement of calcite crystals,weakened biological activity and decreased soil pCO2 which increases the abundance of impure detrital materials in ***,during the period of large amplitude reduction of precipitation and biological activity which resulted from extreme monsoon-retreat events,temperature variation would dominate fluctuation of stalagmite *** example,stalagmite density increased suddenly when temperature dropped suddenly in the north Atlantic during Heinrich event 1(H-1).This may be caused by low seepage water temperature,more dissolved calcium carbonate,compact regular crystals forming under higher supersaturation,leading to the stalagmite increased *** density fluctuation sensitively recorded stalagmite growth history and environment,demonstrating that stalagmite density can be used as a proxy for paleoclimatic research.

关键词：石笋记录记录密度黄土高原西部末次冰消期 Heinrich事件气候变化笋生长方解石晶体

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Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients

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World Journal of Clinical Cases 2021年第10期9卷 2238-2246页

作者： Hu zhang Jing Liu Song-Lin Ma Man-Lin Huang Yan Fan Min Song Jing Yang Xiao-Xia zhang Qi-Long Song Jing Gong Ping-Xiao Huang Heng zhang Department of Gastroenterology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Department of Gastroenterology The Eighth Hospital of WuhanWuhan 430014Hubei ProvinceChina

BACKGROUND Four-liter polyethylene glycol(PEG)solutions are effective for bowel cleansing,but their large volume might hinder patient *** to the unique features of Asians,4 L PEG might be a suboptimal bowel preparation in predominantly ethnically Asian *** view of this,a balance should be achieved between the volume and *** ideal bowel cleansing regimen for a colonoscopy has yet to be determined in a Chinese *** To compare the cleansing efficacy of 3 L PEG plus simethicone with 4 L *** A total of 291 patients were randomly allocated to two groups:Group 1(n=145)received 4 L split-dose PEG(4-P);group 2(n=146)received 3 L split-dose PEG plus simethicone(3-PS).Bowel-cleansing efficacy was evaluated by endoscopists using the Boston bowel preparation scale(BBPS)and the bubbles *** Although there were no significant differences in the total BBPS score or the adequate rate of bowel preparation between the two groups,the BBPS score of the right-side colon was significantly higher in the 3-SP group(2.37±0.54 vs 2.21±0.78;P=0.04).Moreover,the use of simethicone significantly reduced bubbles in all colon segments(P<0.001).The mean withdrawal time was significantly shorter in the 3-PS group(8.8±3.4 vs 9.6±2.3;P=0.02).Furthermore,significantly more proximal adenomas were detected in the 3-PS group(53.6%vs 45.7%;P=0.03).In addition,the proportions of patients with nausea and bloating were significantly lower in the 3-SP group(P<0.01 for both).More patients in the 3-PS group expressed willingness to repeat the bowel preparation(87.7%vs 76.6%,P=0.01).CONCLUSION Three-liter PEG shows satisfactory bowel cleansing despite the decrease in dosage,and addition of simethicone with better bubble elimination and enhanced patient acceptance offers excellent potential impact on the detection of proximal adenomas in Chinese patients.

关键词： Polyethylene glycol Simethicone Colonoscopy Bowel preparation Cleansing efficacy

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LncRNA TMPO-AS1调节miR-340-5p/RUNX1轴对结直肠癌细胞增殖、迁移和侵袭的影响

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河北医药 2024年第2期46卷 165-170页

作者：许汉兵韩建涛张成鹏湖北省武汉市第三医院(武汉大学同仁医院)普外科 430000

目的探讨长链非编码RNA TMPO反义RNA1(LncRNA TMPO-AS1)调控miR-340-5p/RUNT相关转录因子1(RUNX1)轴对结直肠癌(CRC)细胞增殖、迁移和侵袭的影响。方法qRT-PCR检测人正常结肠上皮细胞HCoEpiC、人CRC细胞SW480、HCT116、LOVO、HT-29中TMPO-AS1、miR-340-5p、RUNX1表达;将HCT116细胞随机分为:si-ctrl组、si-TMPO-AS1组、mimics NC组、miR-340-5p组、si-TMPO-AS1+anti-miR-ctrl组、si-TMPO-AS1+anti-miR-340-5p组;qRT-PCR检测6组HCT116细胞TMPO-AS1、miR-340-5p、RUNX1水平;CCK-8法检测HCT116细胞活力;EDU法检测HCT116细胞增殖;Transwell检测HCT116细胞迁移和侵袭;western blot检测HCT116细胞RUNX1、PCNA、MMP-2表达;双荧光素酶报告基因实验分别验证TMPO-AS1和miR-340-5p、miR-340-5p和RUNX1的关系。结果与HCoEpiC细胞比较,不同CRC细胞中TMPO-AS1、RUNX1表达显著性升高,miR-424-5p表达显著性降低(P<0.05),且HCT116细胞变化结果更显著,后续实验选择HCT116细胞。与si-ctrl组比较,si-TMPO-AS1组HCT116细胞TMPO-AS1、RUNX1 mRNA水平、细胞活力A值、EDU阳性细胞率、迁移与侵袭细胞数、RUNX1、PCNA、MMP-2蛋白水平均显著性降低,miR-340-5p mRNA水平显著性升高(P<0.05);与mimics NC组比较,miR-340-5p组HCT116细胞RUNX1 mRNA水平、细胞活力A值、EDU阳性细胞率、迁移与侵袭细胞数、RUNX1、PCNA、MMP-2蛋白水平均显著性降低,miR-340-5p mRNA水平显著性升高(P<0.05);与si-TMPO-AS1+anti-miR-ctrl组比较,si-TMPO-AS1+anti-miR-340-5p组HCT116细胞RUNX1 mRNA水平、细胞活力A值、EDU阳性细胞率、迁移与侵袭细胞数、RUNX1、PCNA、MMP-2蛋白水平均显著性升高,miR-340-5p mRNA水平显著性降低(P<0.05);TMPO-AS1靶向负调控miR-340-5p表达,miR-340-5p靶向负调控RUNX1表达。结论沉默TMPO-AS1靶向上调miR-340-5p表达,从而下调RUNX1表达,抑制HCT116细胞增殖、迁移和侵袭。

关键词： LncRNA TMPO-AS1 miR-340-5p RUNX1 结直肠癌细胞

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Correlation and interaction between temperature and freeze-thaw in representative regions of Antarctica

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International Journal of Digital Earth 2022年第1期15卷 2296-2318页

作者： Dong Liang Huadong Guo Qing Cheng Lu zhang Lingyi Kong Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China International Research Center of Big Data for Sustainable Development Goals BeijingPeople’s Republic of China School of Computer Science China University of GeoscienceWuhanPeople’s Republic of China

As the most sensitive and direct indicator of global climate change,the freezing and thawing of the Antarctic ice sheet is of great significance for research on surface mass and energy *** this study,four representative regions in Antarctica were selected and correlation analysis,Granger causality testing,and cluster analysis were applied to comprehensively analyze the correlation and response of spatiotemporal variation in freeze-thaw and *** conclusions are as follows.(1)In the Antarctic Peninsula,a phenomenon was demonstrated that the summer shifts *** December and colder March temperatures were observed in the Amery Ice Shelf and Queen Maud Land.(2)The Antarctic Peninsula featured the most severe degree of melting among the four regions,with the largest melt area in the past 30 years appearing during the 2015/2016 ***,the number of melt days in most areas of the Antarctic Peninsula was observed to have decreased.(3)There is a strong correlation between the freeze-thaw state of the Antarctic ice sheet and temperature,as well as spatial differences among regions,but the data were clustered at different time scales.

关键词： Antarctic ice sheet Big Earth Data freeze-thaw microwave remote sensing snowmelt temperature

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不同剂量利伐沙班在房颤患者治疗中有效性和安全性的研究

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标记免疫分析与临床 2024年第2期31卷 270-275页

作者：颜新生张李涛刘晓辉张真路闫宝夏凌云王晓苏武汉亚心总医院检验科武汉430056 武汉亚洲心脏病医院检验科武汉430022 武汉亚心总医院心内科武汉430056

目的探讨不同剂量利伐沙班对心房颤动患者栓塞预防效果及安全性。方法选择2018年3月至2021年12月武汉亚洲心脏病医院和武汉亚心总医院口服利伐沙班的房颤患者,按每日处方剂量分为利伐沙班10mg剂量组和15mg剂量组,记录并比较随访期间两... 详细信息

目的探讨不同剂量利伐沙班对心房颤动患者栓塞预防效果及安全性。方法选择2018年3月至2021年12月武汉亚洲心脏病医院和武汉亚心总医院口服利伐沙班的房颤患者,按每日处方剂量分为利伐沙班10mg剂量组和15mg剂量组,记录并比较随访期间两组的血栓、出血和全因死亡不良事件发生率,分析相关的影响因素。结果两组患者血栓、出血和全因死亡发生率比较,10mg剂量组均高于15mg剂量组,差异没有统计学意义(χ^(2)=0.418、3.757、2.084,均P>0.05);两组患者总不良事件发生率比较,10mg剂量组高于15mg剂量组,差异有统计学意义(χ^(2)=5.071,P=0.024);多因素Logistic回归结果显示D二聚体水平[OR(95%CI)=1.07(1.00~1.14)]是房颤患者发生血栓事件的独立危险因素(P=0.035);糖尿病[OR(95%CI)=3.44(1.24~9.51)]是房颤患者全因死亡事件的独立危险因素(P=0.017)。结论临床实践中10mg利伐沙班剂量没有显著的获益,患者的有效性和安全性不优于甚至劣于15mg剂量。D二聚体水平升高、糖尿病史为发生不良事件的危险因素。

关键词：房颤利伐沙班剂量有效性

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A narrative review of organoids for investigating organ aging:opportunities and challenges

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Journal of Bio-X Research 2023年第1期6卷 3-14页

作者： Xiaoyan Sun Fei Sun Yixin zhang Jing Qu Weiqi zhang Guang-Hui Liu CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences China National Center for Bioinformation BeijingChina Department of Cell Biology Duke University Medical CenterDurhamNCUSA State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijingChina

Aging research has shifted from studying phenotypes to studying in-depth mechanisms in recent ***,extrapolating cellular and molecular bases of aging from studying traditional model systems to humans has been *** advent of organoids holds promise for overcoming the limitations of monolayer cell culture and bridging the gap between animal models and ***,we mainly discuss recent paradigms for using organoid models in studying organ *** stem cells-derived organoid provides a promising platform for simulating the pathophysiology of several aging-related diseases,especially neurodegenerative diseases,and adult stem cells organoids derived from different age groups have been applied to detect aging-related functional *** also assess the value of organoid model systems in understanding human aging and aging-related diseases,and identify challenges to be addressed in the future,such as the immaturity of organoids,and effective methods of inducing aging.

关键词： aging disease modeling organoid senescence stem cell

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