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Clinical characteristics and outcomes of bacteremia in Staphylococcus aureus community-onset pneumonia among children

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Clinical characteristics and outcomes of bacteremia in Staph...

胶原酶生物学特征及胶原酶注射治疗椎间盘突出症的临床应用

2015年浙江省医学会儿科学分会学术年会暨儿内科疾病诊治新进展国家级继续教育学习班

作者： Wen SH Wu HJ Lin L zhang wx zhang HL Zhu LL Guo SZ Li CC Department of Pediatric Respiratory Medicine Yuying Children’s Hospital affiliated to Wenzhoumedical University

Objective Early recognition of bacteremia in Staphylococcus aureus community-onset pneumonia(COP)is important for clinical *** aim of our research was to investigate the clinical characteristics and outcomes differences between bacteremia and nonbacteremia in *** COP *** We conducted a retrospective study of younger than 14 years old children admitted to our hospital with ***

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中国组织工程研究与临床康复 2007年第26期11卷 5211-5214页

作者：张文祥倪家骧首都医科大学宣武医院疼痛诊疗科北京市100053

目的:充分认识胶原酶的生物学特征及其注射治疗对椎间盘的影响以及其在椎间盘突出症中的重要作用。资料来源:应用计算机检索CNKI期刊全文数据库医药卫生类2000-01/2007-02期间的文章,检索词:注射用胶原酶。同时检索Pubmed数据库2000-01/... 详细信息

目的:充分认识胶原酶的生物学特征及其注射治疗对椎间盘的影响以及其在椎间盘突出症中的重要作用。资料来源:应用计算机检索CNKI期刊全文数据库医药卫生类2000-01/2007-02期间的文章,检索词:注射用胶原酶。同时检索Pubmed数据库2000-01/2007-02期间的文章,检索词:collaganase AND disk。资料选择:对资料进行初审,选择从基础药理到临床应用密切相关的文献查找原文。然后选择在临床方面病例数较多的文献,特别把具有代表性的观点列举出来。资料提炼:共收集到相关中文文献72条,按上述标准纳入15条。英文文献30条,按上述标准纳入15条。资料综合:篇中有10篇侧重于胶原酶的药理及其对脊髓和神经影响的基础研究。其余20篇侧重于临床应用总结分析及推广。30结论:因胶原酶的生物学特征,胶原酶注射是目前治疗椎间盘突出的最有效方法之一,但其安全性以及对脊髓和神经的远期影响有待于进一步研究。

关键词：胶原酶椎间盘突出症综述文献生物制剂生物疗法

自身免疫性肝炎大鼠模型外周血淋巴细胞体外培养与褪黑素的影响

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中国组织工程研究与临床康复 2007年第28期11卷 5511-5514页

作者：丁体龙马勇袁福华张文学解放军第一二三医院南京军区肝病中心安徽省蚌埠市233015

目的:观察褪黑素对体外培养淋巴细胞增殖及促进细胞因子分泌的作用。方法:实验于2004-10/2006-10在解放军第一二三医院南京军区肝病中心实验室完成。①实验材料:Wistar大鼠,雄性,3月龄,体质量(230±20)g,购自上海斯莱克实验动物有限责... 详细信息

目的:观察褪黑素对体外培养淋巴细胞增殖及促进细胞因子分泌的作用。方法:实验于2004-10/2006-10在解放军第一二三医院南京军区肝病中心实验室完成。①实验材料:Wistar大鼠,雄性,3月龄,体质量(230±20)g,购自上海斯莱克实验动物有限责任公司。褪黑素:美国Sigma公司产品。②实验方法:采用弗氏完全佐剂加肝细胞特异性脂蛋白法建立自身免疫性肝炎大鼠模型。分别抽取正常大鼠及模型大鼠的外周血,实验室常规培养,并将其分为3组:褪黑素组培养基中加褪黑素使终浓度为2mg/L;促肝细胞生长素组培养基中加促肝细胞生长素使终浓度为2mg/L;空白对照组培养基中不加任何细胞分裂刺激剂。③实验评估:培养48h后,对外周血淋巴细胞进行常规计数并采用液体闪烁计数仪记录1min计数结果值。用于观察褪黑素与促肝细胞生长素促进外周血淋巴细胞增殖的效果。并检测培养上清液中的各细胞因子浓度,用于观察褪黑素与促肝细胞生长素促进外周血淋巴细胞分泌细胞因子的作用。结果:①褪黑素对正常大鼠外周血淋巴细胞有促进增殖作用,细胞数与1min计数值较空白对照组明显升高(P0.05),促肝细胞生长素组Th1和Th2细胞因子与空白对照组无明显差异(P>0.05)。④在褪黑素作用下,模型大鼠Th1细胞因子IL-2和IFN-γ水平较空白对照和促肝细胞生长素组明显升高(P0.05)。结论:褪黑素对自身免疫性肝炎大鼠外周血淋巴细胞有较强的刺激分裂作用。

关键词：褪黑素自身免疫性肝炎外周血淋巴细胞体外培养

相关信号转导分子在创伤性兔膝骨关节炎发病中的变化

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中国组织工程研究与临床康复 2007年第49期11卷 9886-9889页

作者：张文贤张晓刚李卫平吕江宏杨灵歌甘肃省中医院骨科甘肃省兰州市730050

目的:在创伤性兔膝骨关节炎的发病机制中关节软骨细胞凋亡、诱导型一氧化氮合酶、基质金属蛋白酶组织抑制因子3、尿激酶型纤溶酶原激活物及其受体蛋白均会发生一些变化,观察其相关特征,从而确立骨关节炎"细胞通讯"的病理机制。方法:实验... 详细信息

目的:在创伤性兔膝骨关节炎的发病机制中关节软骨细胞凋亡、诱导型一氧化氮合酶、基质金属蛋白酶组织抑制因子3、尿激酶型纤溶酶原激活物及其受体蛋白均会发生一些变化,观察其相关特征,从而确立骨关节炎"细胞通讯"的病理机制。方法:实验于2004-07/2006-07在兰州大学第一附属医院中心实验室及甘肃中医学院实验室完成。①实验动物:将36只健康青紫蓝家兔(雌雄各半)随机分成正常组、模型组各18只。②实验方法:模型组用硫喷妥钠30mg/kg腹腔麻醉,在无菌条件下取双侧膝关节内侧切口长约3cm,直视下探查关节腔无原发病变后,用眼科剪伸入切断前后交叉韧带、内侧副韧带、完整切除内侧半月板进行造模,正常组不作任何处理。③实验评估:运用流式细胞分析法、免疫组化法分别于6、8周两个时期进行DNA倍体含量、基质金属蛋白酶组织抑制因子3、尿激酶型纤溶酶原激活物及其受体蛋白、诱导型一氧化氮合酶蛋白阳性强度观察。结果:参加实验36只家兔,进入结果分析20只。①诱导型一氧化氮合酶蛋白表达:6周时各组间差异无显著性,8周时模型组损伤胶原化区与各组间差异显著(P<0.05)。②基质金属蛋白酶组织抑制因子3蛋白表达:6周时各组间比较差异有显著性,正常组6周和8周比较差异有显著性(P<0.05)。③细胞凋亡情况:8周时正常组与模型组DNA比率差异有显著性、但细胞凋亡均数差异无显著性。④尿激酶型纤溶酶原激活物及其受体蛋白表达:6,8周时各组间比较差异有显著性;正常组与模型组损伤胶原化区、正常组与模型组增殖肥厚区、正常组与模型组无损伤区;损伤胶原化区与增殖肥厚区、损伤胶原化区与无损伤区间差异有统计学意义(P<0.05);正常组和模型组6周和8周比较差异均有显著性(P<0.05)。结论:骨关节炎病理机制中存在破坏与修复相互拮抗平衡的分子"多轴心机制"。

关键词：骨关节炎细胞凋亡尿激酶型纤溶酶原激活物及其受体蛋白基质金属蛋白酶组织抑制因子3 诱导型一氧化氮合酶

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强直性脊椎炎的发病假说及其病理机制

中国组织工程研究与临床康复 2007年第45期11卷 9176-9181页

作者：李卫平张文贤代长泉王华明甘肃省中医院骨科甘肃省兰州市730050

目的:认识强直性脊椎炎的多种发病假说,以明确和分析其病理机制。资料来源:应用计算机检索Pubmed数据库1994-01/2007-03有关强直性脊柱炎病理机制的文章,检索词"ankylosingspondylitis pathomechanism",限定文章语言种类为English;同时... 详细信息

目的:认识强直性脊椎炎的多种发病假说,以明确和分析其病理机制。资料来源:应用计算机检索Pubmed数据库1994-01/2007-03有关强直性脊柱炎病理机制的文章,检索词"ankylosingspondylitis pathomechanism",限定文章语言种类为English;同时计算机检索中国期刊全文数据库2000-01/2005-04期间的相关文章,检索词"强直性脊柱炎,病理机制",限定文章语言种类为中文。资料选择:对资料进行初审,选取符合研究要求的有关文章找全文。纳入标准:有关强直性脊椎炎病理机制的研究(包括基础研究和临床研究)。排除标准:重复或类似的同一研究、综述文献(或个案报道等)。资料提炼:共收集到65篇有关强直性脊椎炎病理机制的文章,排除重复或类似的同一研究,30篇符合综述要求。资料综合:①国内有关强直性脊椎炎病理机制的研究:就强直性脊椎炎患者外周血液及关节液中的某个因子在遗传、免疫等方面的易感性表达,进行相关分析。②国外有关强直性脊椎炎病理机制研究:在分子生物学及遗传免疫学领域,就某个易感因子提出"基因"的关联假说。③强直性脊椎炎病理机制研究展望:针对强直性脊椎炎病理机制,在细胞通讯与细胞信号转导的分子机制方面进行研究。结论:强直性脊柱炎是环境因素与遗传因素共同作用的结果,环境因素是发病的诱因,遗传的易感性是强直性脊柱炎发病的基础,其中,人类白细胞抗原B27的未折叠蛋白应答是核心。强直性脊椎炎的病理机制存在以"免疫应答为开始、信号转导为过程、基因易感为结果"的轴心系统。

关键词：脊柱炎强直性病理学 HLA-B27抗原综述文献组织构建

Advances in methane emissions from agricultural sources:Part *** and mitigation

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Journal of Environmental Sciences 2024年第6期140卷 279-291页

作者： Xiaokun Wu Ying zhang Yinghui Han Yagang zhang Yuhang zhang Xiaodan Cheng Pei Zhong Xue Yuan Yuanxun zhang Zhengqiang Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071003China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Interdisciplinary Mathematics Institute University of South CarolinaColumbiaSC 29208United States Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China

Methane is one of the major greenhouse gases(GHGs)and agriculture is recognized as its primary *** accounting is a prerequisite for developing effective agriculture mitigation *** this review,methane accounting methods and research status for various agricultural emission source including rice fields,animal enteric fermentation and livestock and poultry manure management were overview,and the influencing factors of each emission source were analyzed and *** the same time,it analyzes the different research efforts involving agricultural methane accounting and makes recommendations based on the actual ***,mitigation strategies based on accounting results and actual situation are *** review aims to provide basic data and reference for agriculture-oriented countries and regions to actively participate in climate action and carry out effective methane emission mitigation.

关键词： Methane emission Agricultural sources Accounting methodology Mitigation Emission influencing factors

Genome-Wide Association Study of Cooked Rice Textural Attributes and Starch Physicochemical Properties in indica Rice

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Rice science 2024年第3期31卷 300-316,I0018-I0041页

作者： DENG Bowen zhang Yanni zhang Fan WANG Wensheng XU Jianlong zhang Yu BAO Jinsong Institute of Nuclear Agricultural Sciences Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang ProvinceCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Hainan Institute Zhejiang UniversitySanya 572025China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Rice cooking and eating qualities(CEQ)are mainly determined by cooked rice textural parameters and starch physicochemical ***,the genetic bases of grain texture and starch properties in rice have not been fully *** conducted a genome-wide association study for apparent amylose content(AAC),starch pasting viscosities,and cooked rice textural parameters using 279 indica rice accessions from the 3000 Rice Genome *** identified 26 QTLs in the whole population and detected single nucleotide polymorphisms(SNPs)with the lowest P-value at the Waxy(wx)locus for all traits except pasting temperature and ***,we detected significant SNPs at the SUBSTANDARD STARCH GRAIN6(SSG6)locus for AAC,setback(SB),hardness,adhesiveness,chewiness(CHEW),gumminess(GUM),and *** subsequently divided the population using a SNP adjacent to the Waxy locus,and identified 23 QTLs and 12 QTLs in two sub-panels,wxT and wxA,*** these sub-panels,SSG6 was also identified to be associated with pasting parameters,including peak viscosity,hot paste viscosity,cold paste viscosity,and consistency ***,a candidate gene encoding monosaccharide transporter 5(OsMST5)was identified to be associated with AAC,breakdown,SB,CHEW,and *** total,39 QTLs were co-localized with known genes or previously reported *** identified genes and QTLs provide valuable information for genetic manipulation to improve rice CEQ.

关键词： cooking and eating quality genome-wide association study rice Waxy gene

Study on flow characteristics and phase holdup in a slurry bubble column coupled with mild agitation Author links open overlay panel

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Particuology 2024年第8期91卷 226-234页

作者： Qingyuan An Jiantao Li Lei zhang Nailiang Wang Pengfei zhang Zhenghong Luo Chunxi Lu State Key Laboratory of High-Efficiency Coal Utilization and Green Chemical Engineering Ningxia UniversityYinchuan750021China State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and EnvironmentChina University of Petroleum BeijingBeijing102249China Department of Chemical&Biological Engineering Monash UniversityVictoria3800Australia

A pilot-scale experimental setup was constructed to investigate the effect of mild agitation on the bubble characteristics and phase holdup in a slurry bubble *** agitation positively impacts the axial uniform distribution of solid holdup,though it shows insignificant influence on the radial *** homogenous regime,mild agitation promotes the coalescence of bubbles,and the effect becomes stronger with increasing agitator *** mild agitation contributes to a decrease in bubble size in heterogeneous flow *** agitation presents a significant effect on the gas holdup by adjusting the bubble size and bubble motion *** modification was introduced to predict the gas holdup considering the effects of mild agitation,a necessary consideration for applications requiring mild *** adapted model predicts gas holdup with a maximum error of 12.9%.

关键词： Slurry bubble column Mild agitation Phase holdup Bubble characteristics

Ecological impacts of the expansion of offshore wind farms on trophic level species of marine food chain

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Journal of Environmental Sciences 2024年第5期139卷 226-244页

作者： Lijing Wang Bangguo Wang Wenxi Cen Rui Xu Yuwei Huang Xin zhang Yinghui Han Yuanxun zhang College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Yanshan Earth Critical Zone and Surface Fluxes Research Station University of Chinese Academy of SciencesBeijing 101408China Chinese Research Academy of Environmental Sciences Beijing 100012China National Joint Research Center for Yangtze River Conservation Beijing 100012China College of Environmental Engineering Beijing University of TechnologyBeijing 100124China Institute of Eco-Environmental Forensics Shandong UniversityQingdao 266237China

The global demand for renewable energy has resulted in a rapid expansion of offshore wind farms(OWFs)and increased attention to the ecological impacts of OWFs on the marine *** reviews mainly focused on the OWFs’impacts on individual species like birds,bats,or *** review collected numerous field-measured data and simulated results to summarize the ecological impacts on phytoplankton,zooplankton,zoobenthos,fishes,and mammals from each trophic level and also analyze their interactions in the marine food *** and zooplankton are positively or adversely affected by the‘wave effect’,‘shading effect’,oxygen depletion and predation pressure,leading to a ±10% fluctuation of primary *** zoobenthos are threatened transiently by habitat destruction with a reduction of around 60% in biomass in the construction stage,their abundance exhibited an over 90% increase,dominated by sessile species,due to the‘reef effect’in the operation *** fishes and mammals are to endure the interferences of noise and electromagnetic,but they are also aggregated around OWFs by the‘reef effect’and‘reserve effect’.Furthermore,the complexity of marine ecosystem would increase with a promotion of the total system biomass by 40% through trophic cascade effects strengthen and resource partitioning alternation triggered by the proliferation of *** suitable site selection,long-term monitoring,and life-cycle-assessment of ecological impacts of OWFs that are lacking in current literature have been described in this review,as well as the carbon emission and deposition.

关键词： Offshore wind farms(OWFs) Ecological impacts Plankton Benthos Fish Mammal