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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： zhang shao-yan QIU Lei zhang Shun-xian XIAO He-ping CHU Nai-hui zhang Xia zhang Hui-qiang ZHENG Pei-yong zhang Hui-yong LU Zhen-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in China from December 2012 to December 2016. A total of 312 MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12 Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 216 cases completed the trial, 111 in the BFJD Granules group and 105 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5 months vs. 11 months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1%, 26/81;P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P<0.01). Overall, the death rates in the two groups were not significantly different;5.1%(8/156) in the BFJD Granules group and 2.6%(4/156) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial

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Altered miR-143 and miR-150 expressions in peripheral blood mononuclear cells for diagnosis of non-small cell lung cancer

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Chinese Medical Journal 2013年第23期126卷 4510-4516页

作者： ZENG Xiao-li zhang shao-yan ZHENG Jun-fang YUAN Hui WANG yan Department of Clinical Laboratory Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Thoracic Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Biochemistry and Molecular Biology Capital Medical University Beijing 100069 China

Background Sensitive and specific biomarkers for identifying early stage of non-small cell lung cancer （NSCLC） are urgently needed to improve the therapeutic outcome and reduce the *** non-coding microRNAs （miRNAs） are key components of cancer development and are considered as potential biomarkers for cancer diagnosis and for monitoring *** aim of this study was to determine whether aberrant miRNA expression can be used as a marker in peripheral blood mononuclear cells （PBMC） for the diagnosis of *** The levels of two mature miRNAs （miR-143 and miR-150） were detected by probe-based stem-loop quantitative reverse-transcriptase PCR （RT-qPCR） in PBMC of 64 patients with NSCLC and 26 healthy individuals,and the relationship between miR-143 and miR-150 levels and clinical and pathological factors was *** All endogenous miRNAs were present in peripheral blood in a remarkably stable form and detected by ***-143 expression in the PBMC specimens was significantly lower in NSCLC patients than in healthy individuals （P ＜0.0001）.MiR-150 expression in the PBMC specimens was not significantly different between NSCLC patients and healthy individuals （P=0.260）.MiR-150 expression was significantly higher in lung adenocarcinoma patients than in healthy individuals （P=0.001）.There was a very strong difference in the expression level of miR-150 between lung adenocarcinoma patients and lung squamous cell caminoma patients （P ＜0.0001）.In receiver operating characteristic curve （ROC） analysis,low expression of miR-143 showed the area under the ROC （AUC） of 0.885 for distinguishing cancer patients from healthy *** expression of miR-150 had an AUC of 0.834 for distinguishing lung adenocarcinoma patients from healthy *** expression of miR-150 had an AUC of 0.951 for distinguishing lung adenocarcinoma from lung squamous cell *** miR-150 level was significantly associated with distant metastasis （P=0.014）.Conclu

关键词： microRNA carcinoma,non-small cell lung diagnosis

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Alcohol Drinking, Dyslipidemia, and Diabetes： A Population-based Prospective Cohort Study among Inner Mongolians in China

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Biomedical and Environmental Sciences 2016年第8期29卷 555-562页

作者： LIANG Zhu QIU Qiao yan WU Jia Hui ZHOU Jing Wen XU Tian zhang Ming Zhi zhang Yong Hong zhang shao yan Department of Epidemiology School of Public Health Medical College of Soochow University Suzhou 215123 Jiangsu China Jiangsu Key Laboratoty of Preventive and Translational Medicine for Geriatric Diseases School of Public Health Soochow University Suzhou 215123 Jiangsu China KunShan Center for Disease Control And Prevention KunShan 215300 Jiangsu China

Objective No previous studies have evaluated the association between dyslipidemia, alcohol drinking, and diabetes in an Inner Mongolian population. We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population. Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China. Participants were classified into four subgroups according to their drinking status and dyslipidemia. Multivariate logistic regression analysis and receiver operating characteristic （ROC） curves were used to evaluate the association between alcohol drinking, dyslipidemia, and diabetes. Results During the follow-up period, 203 participants were found to have developed diabetes. The multiva riable-adjusted odds ratios （95% confidence interval） for the incidence of non-dyslipidemia/drinkers, dyslipidemia/non-drinkers, and dyslipidemia/drinkers in diabetic patients were 1.40 （0.82-2.37）, 1.73 （1.17-2.55）, and 2.31 （1.38-3.87）, respectively, when compared with non-dyslipidemia/non-drinkers. The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors （AUC=0.746） was significantly （P=O.003） larger than the one containing only conventional factors （AUC=0.711）. Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes, and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population. These findings suggest that dyslipidemia and drinkin8 status may be valuable in predicting diabetes incidence.

关键词： Diabetes Dyslipidemia, Drinking, Prospective Cohort study

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Clustering of Cardiovascular Risk Factors and Diabetes： A Prospective Cohort Study on the Inner Mongolian Population in China

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Biomedical and Environmental Sciences 2018年第10期31卷 749-756页

作者： WANG Ting Ting LIN Bo CUI Wen Xiu zhang Ming Zhi zhang Yong Hong zhang shao yan Department of Epidemiology School of Public Health andJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Suzhou 215123 Jiangsu China Harbin Center for Disease Control and Prevention Harbin 150000 Heilongjiang China

Objective To evaluate the effect of clustering of cardiovascular risk factors（CVRFs） on type 2 diabetes mellitus（T2 DM） incidence and identify some high predictive clusters in the Inner Mongolian population in China. Methods A total of 1,884 Mongolian individuals aged 20 years or above were followed up from 2002 to 2013 and included in the final analysis. We categorized the participants into two subgroups according to the study outcome event. A Cox proportional hazards model was used to evaluate the effect of clustering of CVRFs on the incidence of T2 DM. Areas under the curve were used to compare the effect of every cluster on T2 DM and identify those having higher predictive value. Results We found 203 persons with T2 DM. Subjects with incident T2 DM tended to be older, had a higher prevalence of drinking, had higher systolic and diastolic pressures; total cholesterol, triglyceride, low-density lipoprotein cholesterol, and C-reactive protein levels; waist circumference; body mass index; and heart rate and lower HDL-C level than did those without T2 DM. The multivariable adjusted hazard ratio（95% confidence interval） of T2 DM was calculated based on comparisons with subjects with 0 CVRFs; in participants with 2 and ≥ 3 factors, the adjusted hazard ratios were 2.257（1.448, 3.518） and 3.316（2.119, 5.188）, respectively. Conclusion The clustering of CVRFs increased the risk of T2 DM. On the basis of fast heart rate, the cluster of abdominal obesity and other CVRFs had higher predictive value for T2 DM than the other three CVRF clusters.

关键词： Type 2 diabetes Cardiovascular risk factors Abdominal obesity Heart rate

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Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China

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Biomedical and Environmental Sciences 2018年第4期31卷 300-305页

作者： QIU Qiao yan zhang Bei Lei zhang Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu zhang Yong Hong zhang shao yan Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Suzhou 215123 Jiangsu China The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310000 Zhejiang China Wujin District Center for Disease Control and Prevention Changzhou 213159 Jiangsu China Nanjing Brain Hospital Nanjing 210029 JiangsuChina Kunshan Center for Disease Control and Prevention Suzhou 215123 Jiangsu China

This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.

关键词： CRP DM Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes A Population-based Prospective Cohort Study of Inner Mongolians in China IR

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Spin asymmetry and dipole moments inτ-pair production with ultraperipheral heavy ion collisions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 15-21页

作者： Dingyu shao Bin yan Shu-Run Yuan Cheng zhang Department of Physics Center for Field Theory and Particle PhysicsFudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China(NSFC)and Fudan UniversityShanghai 200438China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics Peking UniversityBeijing 100871China

The anomalous magnetic(MDM)and electric(EDM)dipole moments of theτlepton serve as crucial indicators of new physics beyond the standard *** azimuthal angular asymmetry as a novel tool in ultraperipheral collisions(UPCs),we attain unparalleled precision in the study of these key *** by the highly linear polarization of coherent photons,this method uniquely enables both the MDM and EDM to contribute to the cos 2φangular distribution in similar ***,our approach substantially narrows the parameter space,excluding more than half of it compared to expected UPC-based measurements reliant solely on the total *** method not only provides improved constraints but also minimizes the need for additional theoretical assumptions,and offers a novel avenue to probe the EDM effects.

关键词： ultraperipheral collisions magnetic and electric dipole moments spin asymmetry

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A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research International 2024年第1期31卷 74-91页

作者： yan yan Guang-hao Shang Li-ping zhang shao-ying Li Han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

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Overexpression of catalytic subunit M2 in patients with ovarian cancer

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Chinese Medical Journal 2012年第12期125卷 2151-2156页

作者： WANG Li-ming LU Fei-fei zhang shao-yan YAO Ru-yong XING Xiao-ming WEI Zhi-min Department of Obstetrics and Gynecology Department of Central Laboratory AffiliatedHospital of Medical College of Qingdao University QingdaoShandong 266003 China Department of Pathology AffiliatedHospital of Medical College of Qingdao University QingdaoShandong 266003 China

Background The formation and growth of tumors are related to the synthesis of the DNA. The enzyme ribonucleotide reductase （RR） is an enzyme that regulates the total rate of DNA synthesis and thus plays a pivotal role in cell growth. Catalytic subunit M2 （RRM2） is the main unit modulating the ribonucleotide reductase enzymatic activity. This study aimed to investigate the expression of RRM2 mRNA and protein in patients with ovarian cancer and its relevance to diagnosis and clinical outcome of the patients. Methods RRM2 mRNA levels and protein expression were detected in 98 ovarian specimens with immunohistochemistry and real-time quantitative polymerase chain reaction （PCR）. Expression of the RRM2 protein and correlation of the RRM2 gene expression with clinical pathological features were analyzed. The Kaplan-Meier test was used for evaluating RRM2 expression and time to progression and survival. The Cox proportional model was used to analyze the risk factors in prognosis of patients. Results Positive RRM2 immunostaining was found in 43 of 62 （69.4%） patients with epithelial ovarian cancer, 10 of 15 （66.7%） patients with borderline neoplasm, 4 of 15 （26.7%） patients with benign growths, and none of the normal group. The RRM2 mRNA levels were significantly over expressed in epithelial ovarian cancer （1.722＋0.639） and borderline ovarian neoplasms （1.365＋0.615）, compared to the normal group （0.678＋0.446） and benign group （0.828_＋0.545）. Patients with ovarian caner in clinical FIGO-stages Ill-IV presented higher RRM2 gene expression than those in clinical FIGO-stages I-I1. Furthermore, the survival of patients with low RRM2 mRNA level was significantly better than patients with high levels （P 〈0.05）. By Cox proportional risk model analysis, the risk of mortality of patients with high level expression of RRM2 mRNA was 2.553 times greater than those with low expression. Conclusion RRM2 expression closely correlates with the development of ovarian tumor and may serve as a

关键词： ovarian neoplasms ribonucleotide reductase M2 real-time quantitative polymerase chain reaction immunohistochemistry diagnosis prognosis

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73例耐多药肺结核并发肺毁损的临床特征分析

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中国现代医学杂志 2024年第9期34卷 1-7页

作者：樊雅欣张惠勇张少言张顺先李翠吴定中鹿振辉邱磊上海中医药大学附属龙华医院呼吸疾病研究所上海200032

目的分析耐多药肺结核并发肺毁损的临床特征,为结核性毁损肺的诊治及防治提供依据。方法采用回顾性病例系列研究方法,选取从2013年1月—2017年12月来自15个省18家医院确诊的耐多药肺结核患者662例。其中,并发肺毁损患者73例(肺毁损组),... 详细信息

目的分析耐多药肺结核并发肺毁损的临床特征,为结核性毁损肺的诊治及防治提供依据。方法采用回顾性病例系列研究方法,选取从2013年1月—2017年12月来自15个省18家医院确诊的耐多药肺结核患者662例。其中,并发肺毁损患者73例(肺毁损组),未并发肺毁损患者589例(非肺毁损组),分析两组患者的人口学资料、实验室检查、耐药情况、结核病病史、中医证候积分、影像学表现及治疗结局等临床资料。结果肺毁损组患者的平均年龄高于非肺毁损组患者(P0.05)。肺毁损组患者的肺结核初次诊断到耐多药肺结核初次诊断时间、耐多药肺结核初次诊断到耐多药肺结核治疗的时间均长于非肺毁损组患者(P<0.05)。肺毁损组患者咳嗽、咳痰、胸痛、气短及潮热等症状严重于非肺毁损组患者(P<0.05)。肺毁损组患者的病灶平均肺叶受累数量多于非肺毁损组患者(P<0.05)。肺毁损组患者的治愈率低于非肺毁损组患者(P<0.05)。结论关注伴有毁损肺高危因素(农民、中年、诊断治疗延迟、肺叶病变广泛等)的耐多药肺结核患者,加强抗结核全程督导治疗,减少肺毁损的发生,提高治愈率。

关键词：耐多药肺结核毁损肺结核分枝杆菌临床特征

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Fistulectomy as a surgical option for pulmonary arteriovenous malformation

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中华医学杂志(英文版) 2009年第19期122卷 2321-2324页

作者： zhang shao-yan zhang Zhi-tai OU Song-lei HU yan-sheng SONG Fei-qiang LI Xin MA Xu-chen MA Xin-xin LIANG Lin LI Dong GUO Lin SUN Zhen Department of Thoracic Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China）

Background Surgical resection remains the treatment of choice for pulmonary arteriovenous malformation butremoves some normal lung *** study aimed to evaluate the effect and safety of the lung-saving procedureof fistulectomy as an alternative to lung *** From July 2003 to July 2008,6 selected patients with pulmonary arteriovenous malformations *** them,1 patient underwent emergency operation and 2 underwent bilateral *** patientreceived postoperative *** No hospital deaths or postoperative morbidity *** significantly after *** were free of symptoms and hypoxia during a follow-up for 9 months to 5 *** Fistulectomy is a safe and effective procedure for patients with pulmonary arteriovenous malformationand may be an alternative to lung resection.

关键词： fistula benign or congenital lesions lung pulmonary arteries

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