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Scale adaptive fitness evaluation‐based particle swarm optimisation for hyperparameter and architecture optimisation in neural networks and deep learning

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 849-862页

作者： Ye‐Qun Wang Jian‐Yu Li Chun‐Hua Chen Jun zhang zhi‐Hui Zhan School of Computer Science and Engineering South China University of TechnologyGuangzhouChina School of Software Engineering South China University of TechnologyGuangzhouChina Hanyang University AnsanSouth Korea

Research into automatically searching for an optimal neural network(NN)by optimi-sation algorithms is a significant research topic in deep learning and artificial ***,this is still challenging due to two issues:Both the hyperparameter and ar-chitecture should be optimised and the optimisation process is computationally *** tackle these two issues,this paper focusses on solving the hyperparameter and architecture optimization problem for the NN and proposes a novel light‐weight scale‐adaptive fitness evaluation‐based particle swarm optimisation(SAFE‐PSO)***,the SAFE‐PSO algorithm considers the hyperparameters and architectures together in the optimisation problem and therefore can find their optimal combination for the globally best ***,the computational cost can be reduced by using multi‐scale accuracy evaluation methods to evaluate ***,a stagnation‐based switch strategy is proposed to adaptively switch different evaluation methods to better balance the search performance and computational *** SAFE‐PSO algorithm is tested on two widely used datasets:The 10‐category(i.e.,CIFAR10)and the 100−cate-gory(i.e.,CIFAR100).The experimental results show that SAFE‐PSO is very effective and efficient,which can not only find a promising NN automatically but also find a better NN than compared algorithms at the same computational cost.

关键词： deep learning evolutionary computation hyperparameter and architecture optimisation neural networks particle swarm optimisation scale‐adaptive fitness evaluation

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中国铁路工程关键技术标准海外转化应用研究

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标准科学 2024年第9期 62-69页

作者：杨廷志李欢李景孙宇宁张明中车青岛四方机车车辆股份有限公司中国标准化研究院

本文分析了近年来境外铁路建设市场和技术标准应用环境,分析比较了铁路工程建设标准体系差异性,对海外铁路工程建设项目给出了案例分析,并对中国铁路工程关键技术标准在海外转化应用提出了对策建议。

关键词：铁路工程工程建设技术标准海外转化应用

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重庆市首例新型布尼亚病毒感染案例报道

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重庆医科大学学报 2024年第1期49卷 94-96页

作者：邬文燕智深深胡谢飞李丽娟张媛媛姚海李维重庆大学附属中心医院/重庆市急救医疗中心检验科重庆400014 重庆大学附属中心医院/重庆市急救医疗中心骨科重庆400014

发热伴血小板减少综合征(severe fever with thrombocy-topenia syndrome,SFTS)是由新型布尼亚病毒(severe fever with thrombocytopenia syndrome virus,SFTSV)引起的一种传染病,多由蜱虫叮咬所导致,具有较强的传染性。患者病情进展较快,临床症状以发热伴血小板和血细胞减少、伴不同程度的胃肠道症状为主,部分患者可伴有神志不清等神经系统症状[1]。2009年SFTSV首次在中国被发现,是一种新发传染病,临床报道较少。

关键词：发热伴血小板减少综合征新型布尼亚病毒新发传染病血细胞减少胃肠道症状案例报道神经系统症状患者病情进展

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Nash bargaining solution based multi-cell and multi-user interference alignment scheme for cellular networks

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The Journal of China Universities of Posts and Telecommunications 2014年第4期21卷 1-7,14页

作者： NIU Qin ZENG zhi-min zhang Tian-kui GAO Qiu-bin SUN Shao-hui School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and Telecommunications State Key Laboratory of Wireless Mobile Communications China Academy of Telecommunication Technology

In wireless cellular networks, the interference alignment （IA） is a promising technique for interference management. A new IA scheme for downlink cellular network with multi-cell and multi-user was proposed, in the proposed scheme, the interference in the networks is divided into inter-cell interference （ICI） among cells and inter-user interference （IUI） in each cell. The ICI is aligned onto a multi-dimensional subspace by multiplying the ICI alignment precoding matrix which is designed by the singular value decomposition （SVD） scheme at the base station （BS） side. The aligned ICI is eliminated by timing the interference suppression matrix which is designed by zero-forcing （ZF） scheme at the user equipment （UE） side. Meanwhile, the IUI is aligned by multiplying the IUI alignment precoding matrix which is designed based on Nash bargaining solution （NBS） in game theory. The NBS is solved by the particle swarm optimization （PSO） method. Simulations show that, compared with the traditional ZF IA scheme, the proposed scheme can obtain higher data rate and guarantee the data rate fairness of UEs with little additional complexity.

关键词： cellular network interference alignment Nash bargaining solution data rate fairness particle swarm optimization

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Synthesis and in vitro cytotoxic activities of sorafenib derivatives

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Chinese Chemical Letters 2014年第5期25卷 702-704页

作者： Ke Wang Yan Li Li-Jing zhang Xiao-Guang Chen zhi-Qiang Feng Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia MedicaChinese Academy of Medical Sciences &Peking Union Medical College State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences &Peking Union Medical College

A series of novel sorafenib derivatives have been designed and *** cytotoxic activities of these compounds were tested in three tumor cell *** of the compounds showed potent antiproliferative activity against the tested cell lines with IC50= 0–20 mmol/*** compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell *** them,compound 5g demonstrated significant inhibitory activity against A549,ACHN and MDAMB-231 cell lines with IC50values of 1.29,1.99,3.11 mmol/L,respectively.

关键词： Sorafenib Antiproliferative activity A549 ACHN MDA-MB-231

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Present Terrestrial Heat Flow Measurements of the Geothermal Fields in the Chagan Sag of the YingenEjinaqi Basin,Inner Mongolia,China

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Acta Geologica Sinica(English Edition) 2019年第2期93卷 283-296页

作者： FENG Renpeng ZUO Yinhui YANG Meihua zhang Jiong LIU zhi ZHOU Yongshui HAO Qingqing State Key Laboratory of Oil and Gas Geology and Exploitation Chengdu University of Technology Shandong Provincial Key Laboratory of Depositional Mineralization & Sedimentary Minerals Shandong University of Science and Technology State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum Geothermal and Environmental Research Institute Institute for Global Environment Change Xi'an Jiaotong University Research Institute of Exploration and Development Zhongyuan Oilfield SINOPEC Institute of Mineral Resources Research China Metallurgical Geology Bureau

Owing to the lack o f terrestrial heat flow data, studying lithospheric thermal structure and geodynamics of the Yingen-Ejinaqi Basin in Inner Mongolia is limited. In this paper, the terrestrial heat flow o f the Chagan sag in the YingenEjinaqi Basin were calculated by 193 system steady-state temperature measurements of 4 wells, and newly measuring 62 rock thermal conductivity and 20 heat production rate data on basis o f the original 107 rock thermal conductivity and 70 heat production data. The results show that the average thermal conductivity and heat production rate are 2.11 ±0.28 W/(m.K) and2.42±0.25 nW/m^3 in the Lower Cretaceous o f the Chagan sag. The average geothermal gradient from the Lower Suhongtu 2 Formation to the Suhongtu 1 Fonnation is 37.6 °C/km, and that o f the Bayingebi 2 Formation is 27.4 °C/km. Meanwhile, the average terrestrial heat flow in the Chagan sag is 70.6 mW/m^2. On the above results, it is clear that there is an obvious negative correlation between the thermal conductivity o f the stratum and its geothermal gradient. Moreover, it reveals that there is a geothermal state between tectonically stable and active areas. This work may provide geothermal parameters for further research o f lithospheric thermal structure and geodynamics in the Chagan sag.

关键词： thermophysical parameters geothermal gradient terrestrial heat flow Chagan sag Yingen-Ejinaqi Basin

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Prediction of miRNA Based on miRNA Biogenesis via One-class SVM

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Chemical Research in Chinese Universities 2010年第5期26卷 803-809页

作者： LIU Yuan-ning YAN Wen zhang Hao LI zhi LU Hui-jun LI Xin College of Computer Science and Technology Symbol Computation and Knowledge Engineering of Ministry of Education Jilin University Changehun 130012 P. R. China Institute of Military Veterinary Academy of Military Medical Sciences Changchun 130012 P. R. China Changchun University of Science ＆ Technology Changchun 130022 P. R. China

MicroRNAs are a class of small, single-stranded RNAs which are produced by non-protein-coding RNA genes with a length of 21-29 nt. They regulate the expression of protein-encoding genes at the post-transcriptional level and the degradation ofmRNAs by base pairing to mRNAs. Mature miRNAs are processed from 60-90 nt RNA hairpin structures called pre-miRNAs. At present, most of the machine learning computational methods for pre-miRNAs prediction are based on two-class SVM and use structural information of pre-miRNA hairpins. Those methods share a common feature that all of them need a negative dataset in the training dataset and feature selection in both training and testing dataset. In order to avoid selecting false negative examples of miRNA hairpins in the training dataset which may mislead the classifiers, we presented a microRNA prediction algorithm called MirBio based on miRNAs Biogenesis which is trained only on the information of the positive miRNAs class to predict miRNAs. It can predict both pre-miRNAs and miRNAs and get a relatively satisfying result in this study.

关键词： miRNAs Hairpin One-class classification miRNAs Biogenesis

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Screening of antagonistic Trichoderma strains and their application for controlling stalk rot in maize

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Journal of Integrative Agriculture 2020年第1期19卷 145-152页

作者： LU zhi-xiang TU Guang-ping zhang Ting LI Ya-qian WANG Xin-hua zhang Quan-guo SONG Wei CHEN Jie School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240P.R.China Plant Protection College Shenyang Agricultural UniversityShenyang 110866P.R.China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240P.R.China Key Laboratory of Urban Agriculture Ministry of AgricultureShanghai 200240P.R.China Institute of Cereal and oil Crops Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051P.R.China

Maize is one of the major crops in China, but maize stalk rot occurs nationwide and has become one of the major challenges in maize production in China. In order to find an environment-friendly and feasible technology to control this disease, a Trichoderma-based biocontrol agent was selected. Forty-eight strains with various inhibition activities to Fusarium graminearum, and Fusarium verticillioides were tested. A group of Trichoderma strains(DLY31, SG3403, DLY1303 and GDFS1009) were found to provide an inhibition rate to pathogen growth in vitro of over 70%. These strains also prevented pathogen infection over 65% and promoted the maize seedling growth for the main root in vivo by over 50%. Due to its advantage in antifungal activity against pathogens and promotion activity to maize, Trichoderma asperellum GDSF1009 was selected as the most promising strain of the biocontrol agent in the Trichoderma spectrum. Pot experiments showed that the Trichoderma agent at 2–3 g/pot could achieve the best control of seedling stalk rot and promotion of maize seedling growth. In the field experiments, 8–10 g/hole was able to achieve over 65% control to stalk rot, and yield increased by 2–11%. In the case of natural morbidity, the control efficiency ranged from 27.23 to 48.84%, and the rate of yield increase reached 11.70%, with a dosage of Trichoderma granules at 75 kg ha^-1. Based on these results, we concluded that the Trichoderma agent is a promising biocontrol approach to stalk rot in maize.

关键词： stalk rot in maize biocontrol Trichoderma Fusarium granules

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热处理对316L耐蚀层组织转变及性能的影响

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焊接 2024年第4期 1-7页

作者：王建硕张智韦晨党丽华马青军天津大学天津300350 天津市现代连接技术重点实验室天津300350 天津市特种设备监督检测技术研究院天津300350 国家特种设备焊接材料产品质量检验检测中心天津300350

文中设计了3款不同Cr含量的316L不锈钢药芯焊丝,探究热处理对堆焊耐蚀层组织转变及性能的影响规律。试验结果表明,焊态铁素体数增加,热处理温度升高,保温时间延长都会降低堆焊层中铁素体含量,提高σ相的析出,造成堆焊层强度升高,塑性降... 详细信息

文中设计了3款不同Cr含量的316L不锈钢药芯焊丝,探究热处理对堆焊耐蚀层组织转变及性能的影响规律。试验结果表明,焊态铁素体数增加,热处理温度升高,保温时间延长都会降低堆焊层中铁素体含量,提高σ相的析出,造成堆焊层强度升高,塑性降低,甚至引发弯曲开裂现象。随着焊态铁素体数的降低,热处理后堆焊层耐蚀性有所提高,但3种不同铁素体数的耐蚀层均能通过晶间腐蚀E法检测。基于优化的耐蚀层力学性能和耐蚀性能结果,提出堆焊耐蚀层用316L不锈钢药芯焊丝合金成分设计原则,通过控制合金元素含量,使焊缝中铁素体数范围保持在5~8之间。

关键词：铁素体数堆焊耐蚀层 σ相力学性能耐蚀性能

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血清TREM-1、TLR4及IL-37水平与变应性鼻炎患者T淋巴细胞亚群的关系研究

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现代生物医学进展 2024年第7期24卷 1301-1305页

作者：刘婷许跃文左华芹张志存张耀庭南京医科大学附属淮安第一医院耳鼻咽喉科江苏淮安223300 江苏省苏北人民医院血液科江苏扬州225001

目的:探讨血清髓系细胞触发受体-1(TREM-1)、Toll样受体4(TLR4)及白细胞介素-37(IL-37)水平与变应性鼻炎(AR)患者T淋巴细胞亚群的关系研究。方法:选取2021年3月~2023年3月南京医科大学附属淮安第一医院和江苏省苏北人民医院收治的AR患者... 详细信息

目的:探讨血清髓系细胞触发受体-1(TREM-1)、Toll样受体4(TLR4)及白细胞介素-37(IL-37)水平与变应性鼻炎(AR)患者T淋巴细胞亚群的关系研究。方法:选取2021年3月~2023年3月南京医科大学附属淮安第一医院和江苏省苏北人民医院收治的AR患者100例纳入AR组,另选取同期体检健康志愿者100名纳入对照组,根据病情程度将AR患者分为中重度AR组63例和轻度AR组37例。采用酶联免疫吸附法与流式细胞术检测血清TREM-1、TLR4、IL-37水平与外周血T淋巴细胞亚群。采用Pearson/Spearman分析AR患者血清TREM-1、TLR4、IL-37水平与外周血T淋巴细胞亚群的相关性。绘制受试者工作特征(ROC)曲线分析血清TREM-1、TLR4、IL-37水平对AR的诊断价值。结果:与对照组比较,AR组血清TREM-1、TLR4和外周血CD8^(+)比例升高,血清IL-37和外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)降低(P<0.05)。与轻度AR组比较,中重度AR组血清TREM-1、TLR4和外周血CD8^(+)比例升高,血清IL-37和外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)降低(P<0.05)。Pearson/Spearman相关性分析显示,AR患者血清TREM-1、TLR4水平与外周血CD3^(+)、CD4^(+)CD4^(+)/CD8^(+)呈负相关,与外周血CD8^(+)比例呈正相关(P<0.05);血清IL-37水平与外周血CD3^(+)CD4^(+)、CD4^(+)/CD8^(+)呈正相关,与外周血CD8^(+)比例呈负相关(P<0.05)。ROC曲线分析显示,血清TREM-1、TLR4、IL-37水平联合诊断AR的曲线下面积为0.960,大于血清TREM-1、TLR4、IL-37水平单独预测的0.851、0.857、0.844。结论:AR患者血清TREM-1、TLR4水平升高,IL-37水平降低,与T淋巴细胞亚群异常密切相关,检测血清TREM-1、TLR4、IL-37水平有助于评估AR发病和病情进展。

关键词：变应性鼻炎 TREM-1 TLR4 IL-37 T淋巴细胞亚群相关性

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