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The next decade of SET:from an oncoprotein to beyond

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Journal of Molecular Cell Biology 2024年第1期16卷 1-14页

作者： han Yao meng zhang Donglai Wang State Key Laboratory of Common Mechanism Research for Major Diseases&Department of Medical Genetics Institute of Basic Medical Sciences&School of Basic MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

This year marks the fourth decade of research into the protein SET,which was discovered in *** was initially identified as an oncoprotein but later shown to be a multifaceted protein involved in regulating numerous biological processes under both physiological and pathophysiological *** dysfunction is closely associated with diseases,such as cancer and Alzheimer's *** the increasing understanding of how SET works and how it is regulated in cells,targeting aberrant SET has emerged as a potential strategy for disease *** this review,we present a comprehensive overview of the advancements in SET studies,encompassing its biological functions,regulatory networks,clinical implications,and pharmacological ***,we provide insights into the future prospects of SET research,with a particular emphasis on its promising potential in the realm of immune modulation.

关键词： SET biological process regulatory mechanism disease therapy

The influence of inter-band rock on rib spalling in longwall panel with large mining height

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International Journal of Mining Science and Technology 2024年第4期34卷 427-442页

作者： Jiachen Wang meng Li Zhaohui Wang Zheng Li han zhang Shixiong Song School of Energy and Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China Coal Industry Engineering Research Center of Top-coal Caving Mining Beijing 100083China Faculty of Engineering Hokkaido UniversitySapporo 060-8628Japan

In order to improve rib stability,failure criteria and instability mode of a thick coal seam with inter-band rock layer are analysed in this study.A three-dimensional mechanical model is established for the rib by considering the rock layer.A safety factor is defined foy the rib,and it is observed that the safety factor exhibits a positive correlation with the thickness and strength of the inter-band rock.A calculation method for determining critical parameters of the rock layer is presented to ensure the rib *** is revealed that incomplete propagation of the fracture at the hard rock constitutes a fundamental prerequisite for ensuring the rib *** influence of the position of the inter-band rock in the coal seam on failure mechanism of the rib was thoroughly investigated by developing a series of physical models for the rib at the face *** best position for the inter-band rock in the coal seam is at a height of 1.5 m away from the roof line,which tends to provide a good stability state for the *** different inter-band rock positions,two ways of controlling rib by increasing supports stiffness and flexible grouting reinforcement are proposed.

关键词： Rib spalling Inter-band rock Large mining height Limit analysis Physical model experiment Numerical simulation

A New Method to Identify the Maximum Time Interval between Individual Events in Compound Rainstorm and Heatwave Events

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International Journal of Disaster Risk Science 2024年第3期15卷 453-466页

作者： Junlin zhang Wei Xu Yu Qiao Xinli Liao Chenna meng Qinmei han Key Laboratory of Environmental Change and Natural Disaster of Ministry of Education Faculty of Geographical Science Beijing Normal University Academy of Disaster Reduction and Emergency Management Ministry of Emergency Management and Ministry of Education Beijing Normal University State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University National Climate Center China Meteorological Administration

Growing evidence indicates that extreme heat and rain may occur in succession within short time periods and cause greater impacts than individual events separated in time and space. Therefore, many studies have examined the impacts of compound hazard events on the social-ecological system at various scales. The definition of compound events is fundamental for such research. However, there are no existing studies that support the determination of time interval between individual events of a compound rainstorm and heatwave(CRH) event, which consists of two or more potentially qualifying component heatwave and rainstorm events. To address the deficiency in defining what individual events can constitute a CRH event, this study proposed a novel method to determine the maximum time interval for CRH events through the change in CRH event frequency with increasing time interval between individual events, using southern China as a case study. The results show that the threshold identified by the proposed method is reasonable. For more than 90% of the meteorological stations, the frequency of CRH events has reached a maximum when the time interval is less than or equal to the threshold. This study can aid in time interval selection, which is an important step for subsequent study of CRH events.

关键词： Compound extreme weather event Rainstorm and heatwave Southern China Threshold Time interval

Research on casing deformation prevention technology based on cementing slurry system optimization

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Petroleum Science 2024年第2期21卷 1231-1240页

作者： Yan Yan meng Cai Wen-Hai Ma Xiao-Chuan zhang Li-Hong han Yong-Hong Liu State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment Materials CNPC Tubular Goods Research InstituteXi©an710077ShaanxiChina College of Mechanical and Electrical Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Gas Evaluation and Exploitation Key Laboratory of Sichuan Province Chengdu610095SichuanChina CNPC Daqing Oilfield Company Daqing163453HeilongjiangChina

The casing deformation prevention technology based on the optimization of cement slurry is proposed to reduce the casing deformation of shale oil and gas wells during hydraulic fracturing. In this paper, the fracture mechanism of hollow particles in cement sheath was firstly analyzed by discrete element method, and the effect of hollow particles in cement on casing deformation was investigated by laboratory experiment method. Finally, field test was carried out to verify the improvement effect of the casing deformation based on cement slurry modification. The results show that the formation displacement can be absorbed effectively by hollow particles inside the cement transferring the excessive deformation away from casing. The particles in the uncemented state provide deformation space during formation slipping. The casing with diameter of 139.7 mm could be passed through by bridge plug with the diameter of 99 mm when the mass ratio of particle/cement reaches 1:4. According to the field test feedback, the method based on optimization of cement slurry can effectively reduce the risk of casing deformation, and the recommended range of hollow microbeads content in the cement slurry is between 15% and 25%.

关键词： Cement slurry Hollow ceramsite Casing deformation Formation slip Field test

The pathogenic mechanism of syndactyly type V identified in aHoxd13Q50R knock-in mice

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Bone Research 2024年第2期12卷 349-360页

作者： han Wang Xiumin Chen Xiaolu meng Yixuan Cao Shirui han Keqiang Liu Ximeng Zhao Xiuli Zhao Xue zhang McKusick-zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13Q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13Q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD13Q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

Thermal stability improvement and microstructure optimization of high cobalt content Nd-Fe-B magnets via terbium grain boundary diffusion

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Journal of Rare Earths 2024年第8期42卷 1531-1538,I0004页

作者： Jiyuan Xu Ruiyang meng Jing Liu Jiateng zhang Rui han Yikun Fang Shengzhi Dong Wei Li Division of Functional Materials Research Central Iron and Steel Research InstituteBeijing100081China

The substitution of Fe by Co in the 2:14:1 phase is an effective method to increase the Curie temperature and enhance the thermal stability of the Nd-Fe-B ***,the accumulation of Co ele ment at the grain boundaries(GBs) changes the GBs from nonmagnetic to ferromagnetic and causes the thinlayer GBs to become rare,In this paper,the method of diffusing Tb element was chosen to improve the microstructure and temperature stability of high-Co *** original sintered Nd_(28.5)Dy_(3)-CO_(x)e_(bal)M_(0.6)B_(i)(x=0,6 wt%,12 wt%;M = Cu,Al,Zr) magnets with different Co contents were diffused with Tb by grain boundary diffusion(GBD).After GBD,high-Co magnets exhibit more continuously distributed thin-layer GBs,and their thermal stability is significantly *** high-Co magnets(x=6 wt%),the absolute value of the temperature coefficient of coercivity decreases from 0.603%/K to0.508%/K in the temperature range of 293-413 K,that of remanence decreases from 0.099%/K to 0.091%/K,and the coercivity increases from 18.44 to 25.04 *** electron microscopy(TEM)characterization reveals that there are both the 1:2 phase and the amorphous phase in the high-Co magnet before and after GBD,EDS elemental analysis shows that Tb element is more likely to preferentially replace the rare earth elements in the 2:14:1 main phase than in the 1:2 phase and the amorphous *** concentration of Tb at the edge of the main phase is much higher than that in the 1:2phase and amorphous phase,which is beneficial to the improvement of the *** preferential replacement of Tb elements at the edge of the 2:14:1 phase and thin-layer GBs with a more continuous distribution are synergistically responsible for improving the thermal stability of high-Co *** study indicates that GBD is an effective method to improve the microstructure and thermal stability of high-Co magnets.

关键词： Nd-Fe-B magnets Coercivity Grain boundary diffusion Thermal stability Micro structure Rare earths

A Tri-mode of Mock-Walker Cells

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Advances in Atmospheric Sciences 2024年第4期41卷 671-679页

作者： han QIN Ji NIE Zhiyong meng Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China China Meteorological Administration Tornado Key Laboratory Foshan 528061China

This work uses cloud-resolving simulations to study mock-Walker cells driven by a specified sea surface temperature(SST).The associated precipitation in the mock-Walker cells exhibits three different modes,including a single peak of precipitation over the SST maximum(mode 1),symmetric double peaks of precipitation straddling the SST maximum(mode 2),and a single peak of precipitation on one side of the SST maximum(mode 3).The three modes are caused by three distinct convective activity center migration *** indicate that the virtual effect of water vapor plays an important role in differentiating the three *** the SST gradient is large,the virtual effect may be strong enough to overcome the temperature effect,generating a low-level low-pressure anomaly below the ascending branch of the Walker cell off the *** results here highlight the importance of the virtual effect of water vapor and its interaction with convection and large-scale circulation in the Walker circulation.

关键词： Walker circulation cloud-resolving simulation virtual effect

基于滑模控制法的不确定复杂网络间有限时间组合同步

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控制与决策 2017年第8期32卷 1533-1536页

作者：张檬韩敏大连理工大学电子信息与电气工程学部辽宁大连116023

将组合同步的概念引入到复杂网络,针对4个不确定复杂网络间的有限时间组合同步问题进行研究;将同时受到未知参量及不确定扰动影响的4个复杂网络按照A+B+C-D的形式进行组合;基于滑模控制原理及有限时间稳定性理论,设计网络滑模面及控制输... 详细信息

将组合同步的概念引入到复杂网络,针对4个不确定复杂网络间的有限时间组合同步问题进行研究;将同时受到未知参量及不确定扰动影响的4个复杂网络按照A+B+C-D的形式进行组合;基于滑模控制原理及有限时间稳定性理论,设计网络滑模面及控制输入,得到实现同步的充分条件.最后通过数值仿真验证所提方法的有效性.

关键词：组合同步复杂网络滑模控制有限时间

Novel method for the recognition of Jinnan cattle action using bottleneck attention enhanced two-stream neural network

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 203-210页

作者： Wangli Hao meng han Kai zhang Li zhang Wangbao Hao Fuzhong Li Zhenyu Liu School of Software Shanxi Agricultural UniversityJinzhong 030801ShanxiChina Yuncheng National Jinnan Cattle Genetic Resources and Gene Protection Center Yongji 044500ShanxiChina Yongji Puzhou Old City Beimenwai Cattle Farm Yongji 044500ShanxiChina College of Engineering Shanxi Agricultural UniversityJinzhong 030801ShanxiChina

Effective and accurate action recognition is essential to the intelligent breeding of the Jinnan ***,there are still several challenges in the current Jinnan cattle action *** methods are based on manual characteristics and low recognition *** study is aimed at the efficient and accurate development of Jinnan cattle action recognition methods to overcome existing problems and support intelligent *** acquired data from the previous methods contain a lot of noise,which will cause individual cattle to have excessive behaviors due to *** the high labor costs,low efficiency,and low model accuracy of the above approaches,this study developed a bottleneck attention-enhanced two-stream(BATS)Jinnan cattle action recognition *** primarily comprises a Spatial Stream Subnetwork,a Temporal Stream Subnetwork,and a Bottleneck Attention *** can capture the spatial-channel dependencies in RGB and optical flow two branches respectively,so as to extract richer and more robust ***,the decision of the two branches can be fused to gain improved cattle action recognition *** with the traditional methods,the model proposed in this study has achieved state-of-the-art recognition performance,and the accuracy of motion recognition was 96.53%,which was 4.60%higher than other *** method significantly improves the efficiency and accuracy of behavior recognition and provides an important research foundation and direction for the development of higher-level behavior analysis models in the future development of smart animal husbandry.

关键词： Jinnan cattle action recognition bottleneck attention two-stream neural network