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热处理工艺对中碳中合金钢显微组织的影响

兵器材料科学与工程 2024年第1期47卷 53-57页

作者：张玲玉满达孙德冰段飞鹏李玮金自力宋文钟内蒙古科技大学材料与冶金学院内蒙古包头014010 内蒙古科技大学分析测试中心内蒙古包头014010 白云鄂博共伴生矿资源高效综合利用省部共建协同创新中心内蒙古包头014010 内蒙古包钢稀土钢板材有限责任公司内蒙古包头014010

以国内某厂锻后退火态40CrNiMoV钢为研究对象,在实验室箱式热处理炉进行910℃正火+880℃淬火热处理,探究不同正火及淬火奥氏体化时间的中合金元素固溶与析出对40CrNiMoV钢显微组织的影响。结果表明:在910℃×1 h正火+880℃×1 h淬火工艺... 详细信息

以国内某厂锻后退火态40CrNiMoV钢为研究对象,在实验室箱式热处理炉进行910℃正火+880℃淬火热处理,探究不同正火及淬火奥氏体化时间的中合金元素固溶与析出对40CrNiMoV钢显微组织的影响。结果表明:在910℃×1 h正火+880℃×1 h淬火工艺下,存在较多细小的VC钉扎在原奥氏体晶界,使奥氏体晶粒尺寸约为8μm。随正火及淬火奥氏体化时间的延长,VC逐渐长大,当大于80 nmVC约占15%时失去钉扎效应。当910℃×4 h正火+880℃×4 h淬火时,原奥氏体局部晶粒尺寸可达40μm,因此,奥氏体化时间不宜过长,910℃×2 h正火+880℃×2 h淬火为最佳热处理工艺,可保证合金元素充分回溶,同时利用细小第二相达到细化组织的目的。

关键词：奥氏体化时间 VC 原奥氏体晶粒热处理工艺

Glutamate synthase 1 is involved in iron-deficiency response and long-distance transportation in Arabidopsis

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Journal of Integrative Plant Biology 2020年第12期62卷 1925-1941页

作者： man Cui Mengjun Gu Yaru Lu Yue zhang Chunlin Chen Hong‐Qing Ling Huilan Wu The State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China

Iron is an essential microelement for plant *** uptake from the soil,iron is chelated by ligands and translocated from roots to shoots for sub-sequent ***,the number of ligands in-volved in iron chelation is *** this study,we identified and demonstrated that GLU1,which encodes a ferredoxin-dependent glutamate synthase,was involved in iron ***,the expression of GLU1 was strongly induced by iron deficiency ***,lesion of GLU1 results in reduced transcription of many iron-deficiency-responsive genes in roots and *** mutant plants revealed a decreased iron concentration in the shoots,and displayed severe leaf chlorosis under the condition of Fe limitation,compared to ***,the product of GLU1,glutamate,could chelate iron in vivo and promote iron ***,we also found that supplementation of glutamate in the medium can alleviate cadmium toxicity in ***,our results provide evidence that GLU1 is involved in iron homeo-stasis through affecting glutamate synthesis under iron deficiency conditions in Arabidopsis.

关键词： chelate roots synthesis

Geomechanics model test and numerical simulation of 2G-NPR bolt support effect in an active fault tunnel

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Journal of Mountain Science 2022年第9期19卷 2729-2741页

作者： REN Shu-lin HE man-chao LIN Wei-jun zhang Teng-wu TAO Zhi-gang State Key Laboratory for Geomechanics&Deep Underground Engineering Beijing 100083China School of Mechanics and Civil Engineering China University of Mining&Technology Beijing 100083China 3 Department of Civil and Environmental EngineeringUniversity of AlbertaEdmonton T6G 1H9Canada

Active faults are a common adverse geological phenomenon that can occur during tunnel excavation and has a very negative impact on the construction and operation of the *** this paper,the grade IV rock surrounding the cross-fault tunnel with poor geological conditions has been chosen for the *** support capacity of 2^(nd) Generation-Negative Poisson’s Ratio(2G-NPR)bolt in an active fault tunnel has been carried out on the basis of relevant results obtained from the geomechanical model test and numerical investigations of failure model for existing unsupported fault *** investigation shows that surrounding rock of the tunnel is prone to shear deformation and crack formation along the fault,as a result,the rock mass on the upper part of the fault slips as a ***,small-scale deformation and loss of blocks are observed around the tunnel;however,the 2G-NPR bolt support is found to be helpful in keeping the overall tunnel intact without any damage and *** to the blocking effect of fault,the stress of the surrounding rock on the upper and lower parts of the fault is significantly different,and the stress at the left shoulder of the tunnel is greater than that at the right *** asymmetrical arrangement of 2G-NPR bolts can effectively control the asymmetric deformation and instability of the surrounding *** present numerical scheme is in good agreement with the model test results,and can reasonably reflect the stress and displacement characteristics of the surrounding rock of the *** comparison to unsupported and ordinary PR(Poisson’s Ratio)bolt support,2G-NPR bolt can effectively limit the fault slip and control the stability of the surrounding rock of the fault *** research findings may serve as a guideline for the use of 2G-NPR bolts in fault tunnel support engineering.

关键词： Tunnel engineering Fault 2G-NPR bolt Geomechanics model test Numerical simulation

艾草R2R3-MYB转录因子家族成员的鉴定及表达分析

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中国中药杂志 2024年第16期49卷 4407-4419页

作者：崔占虎李淑娇满永宏李明杰古力张重义李孟芝黄显章王宇卿南阳医学高等专科学校、河南省中药效应物质与质量控制研究中医药重点实验室、南阳道地药材(艾草)研究院河南南阳473061 福建农林大学福建福州350002 南阳理工学院、河南省张仲景方药与免疫调节重点实验室河南南阳473004

MYB(v-myb avian myeloblastosis viral oncogene homolog)家族转录因子是高等植物转录因子中数目最多的一类基因家族成员,可分为4个亚家族,其中R2R3-MYB是最常见的亚家族类型。R2R3-MYB类转录因子广泛参与植物的器官发育和次生代谢产... 详细信息

MYB(v-myb avian myeloblastosis viral oncogene homolog)家族转录因子是高等植物转录因子中数目最多的一类基因家族成员,可分为4个亚家族,其中R2R3-MYB是最常见的亚家族类型。R2R3-MYB类转录因子广泛参与植物的器官发育和次生代谢产物生物合成的调控。为研究R2R3-MYB家族转录因子在艾叶黄酮合成和腺毛发育中发挥的作用,该研究基于艾的全基因组数据筛选、鉴定出92个R2R3-MYB转录因子,并利用生物信息学预测其潜在功能。结果表明,92个转录因子的氨基酸长度为168~547 aa,相对分子质量为19.6~60.5 kDa,均为亲水性蛋白。亚细胞定位分析表明,89个AaMYB蛋白定位结果为细胞核,3个蛋白同时定位于细胞核和细胞质中。依据拟南芥R2R3-MYB家族分类,92个艾R2R3-MYB蛋白分为26个亚家族,同一亚族基因结构基本类似。顺式作用元件预测结果表明光响应元件、茉莉酸甲酯元件和脱落酸元件在R2R3-MYB基因启动子区域分布广泛。转录组表达分析结果显示,AaMYB60、AaMYB63和AaMYB86在叶片中的表达均高于茎和根中的表达,说明这3个转录因子主要在叶片中发挥作用。此外,利用系统进化分析筛选出5个参与艾叶黄酮生物合成或腺毛发育的候选R2R3-MYB转录因子。该研究可为后期艾的优良品种选育和种质创新等提供重要的基因资源。

关键词：艾 R2R3-MYB转录因子基因组生物信息学系统进化

亲属活体单段供肝移植治疗极低体重婴儿胆道闭锁一例

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中华器官移植杂志 2010年第2期31卷 93-96页

作者：张明满严律南郭春宝蒲从伦李英存康权戴小科任志美邓玉华重庆医科大学附属儿童医院 400014 四川大学华西医院

目的总结亲属活体单段供肝移植治疗极低体重婴儿胆道闭锁的临床经验。方法受者为出生仅145d的男婴，身高66cm，体量3．08kg，被确诊为胆道闭锁伴肝硬化。供者为患儿母亲，年龄36岁，身高145cm，体重47kg。采用改良背驮式原位肝移植术，... 详细信息

目的总结亲属活体单段供肝移植治疗极低体重婴儿胆道闭锁的临床经验。方法受者为出生仅145d的男婴，身高66cm，体量3．08kg，被确诊为胆道闭锁伴肝硬化。供者为患儿母亲，年龄36岁，身高145cm，体重47kg。采用改良背驮式原位肝移植术，切取供者Ⅱ段肝组织作为供肝，移植肝体积与受者标准肝体积比值为92．5％，GRWR为5．19％，供肝动脉与受者肝右动脉用供者左侧股外侧浅隐静脉搭桥行端端吻合，受者三支肝静脉经整合后与供肝静脉行端端吻合，供肝胆管与受者空肠行Rouwen—Y吻合。术后监测供、受者生命体征、肝肾功能及出血和凝血状况等，常规抗感染治疗。受者术后采用环孢索A、吗替麦考酚酯及甲泼尼龙的方案预防排斥反应。结果供肝切取手术历时370min，术巾供者出血150ml均回输，切取供肝重量为160g。肝移植手术历时451min，术中受者失血230ml，输注全血200ml和红细胞悬液50ml，无肝期时间为71min，供肝冷缺血时间为132min。供者恢复顺利，术后8d拆线出院。受者术后5d肝功能基本恢复正常，术后7d各项化验指标均正常。但术后7和15d时，受者分别发生肠道吻合口漏各1次，经修补后痊愈。受者于术后35d出院，出院时体重增加0．3kg，各方面与同龄婴儿相当。结论亲属活体单段供肝移植是治疗极低体重患儿终末期肝病的一种可供选择的治疗方法，经充分的术前评估、精细的手术操作及良好的同手术期管理后，手术能取得良好效果。

关键词：肝移植活体供者婴儿胆道闭锁

微量泵脉冲输注戈那瑞林治疗特发性低促性腺激素性性腺功能减退症

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中华内分泌代谢杂志 2011年第8期27卷 654-658页

作者：孙首悦王卫庆蒋怡然王毅峰叶俊娜张曼娜周伟詹维伟李小英宁光上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病临床医学中心上海市内分泌代谢病研究所200025 瑞金医院超声诊断科

目的观察微量泵脉冲输注戈那瑞林（LHRH）治疗特发性低促性腺激素性性腺功能减退症（IHH）的有效性。方法开放、自身对照前瞻性研究。31例患者人选，分为3组：A组无脉冲型，男性23例；B组脉冲频率不足型，男性2例；C组女性6例。使用微... 详细信息

目的观察微量泵脉冲输注戈那瑞林（LHRH）治疗特发性低促性腺激素性性腺功能减退症（IHH）的有效性。方法开放、自身对照前瞻性研究。31例患者人选，分为3组：A组无脉冲型，男性23例；B组脉冲频率不足型，男性2例；C组女性6例。使用微量输液泵每90min皮下脉冲输注LHRH，治疗24周。比较治疗前后性激素和相关症状变化情况。结果治疗24周LH峰值A组（6．92±5．66）IU／L，B组（9．55±0．98）IU／L，C组（6．93±4．52）IU／L。FSH峰值A组（7．44±3．80）IU／L，B组（12．85±12．80）IU／L，C组（7．38±4．98）IU／L；睾酮A组（3．18±1．81）ng/ml，B组（5．78±4．65）ng/ml；比治疗前明显升高（均．P〈0．01）。A、B两组睾丸体积均比治疗前增大。7例精液产生，6例生精。C组子宫体积增加85．4％。双侧卵巢体积增加。5例在3个月内初潮。约19．4％患者出现注射部位局部轻度不良反应。结论微量泵脉冲输注戈那瑞林治疗IHH是有效的，但给药方法仍有可改进之处。

关键词：性腺功能减退症戈那瑞林输注泵

Association of leukocyte telomere length with non-alcoholic fatty liver disease in patients with type 2 diabetes

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Chinese Medical Journal 2019年第24期132卷 2927-2933页

作者： Min zhang man-Li Hu Jiao-Jiao Huang San-Shan Xia Yan Yang Kun Dong Hubei Medical Evaluation and Continuing Education Office WuhanHubei 430000China Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China Department of Endocrinology Wuhan Fourth HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China

Background:Leukocyte telomere has been shown to be related to insulin resistance-related diseases,such as type 2 diabetes mellitus(T2DM)and non-alcoholic fatty liver disease(NAFLD).This cross-sectional study investigated the association of leukocyte telomere length(LTL)with NAFLD in T2DM ***:Clinical features were collected and LTL was measured by Southern blot-based terminal restriction fragment length analysis in 120 T2DM patients without NAFLD and 120 age-matched T2DM patients with *** was clinically defined by manifestations of *** correlation between LTL and clinical and biochemical parameters were analyzed by Pearson correlation or Spearman correlation *** for NAFLD in T2DM patients were identified using multiple logistic ***:LTL in T2DM patients with NAFLD were significantly longer than those without NAFLD(6400.2±71.8 base pairs[bp]vs.6023.7±49.5 bp,P<0.001),especially when diabetes duration was less than 2 ***,the trend of shorter LTL was associated with the increased diabetes duration in T2DM patient with NAFLD,but not in T2DM patients without ***,LTL(odds ratio[OR]:1.001,95%confidence interval[CI]:1.000–1.002,P=0.001),as well as body mass index(OR:1.314,95%CI:1.169–1.477,P<0.001)and triglycerides(OR:1.984,95%CI:1.432–2.747,P<0.001),had a significant association with NAFLD status in T2DM ***:T2DM patients with NAFLD had a significantly longer LTL than those without *** longer LTL was especially evident in the early stage of T2DM,indicating that longer LTL may be used as a biomarker for NAFLD in T2DM patients.

关键词： Non-alcoholic fatty liver disease Telomere Type 2 diabetes mellitus

“互联网+医护一体化”模式在糖尿病肾病行血液透析患者中的应用效果

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护理实践与研究 2024年第9期21卷 1289-1294页

作者：李盼张金凤刘巧梅苏蕊刘嫚商丘市中医院(河南省商丘市 476000)

目的探讨“互联网+医护一体化”模式在糖尿病肾病行血液透析患者中的应用效果。方法选取2021年3月-2022年5月医院收治的糖尿病肾病患者160例作为研究对象,按基本资料具有可比性的原则分为观察组和对照组,每组80例,两组患者均行血液透析... 详细信息

目的探讨“互联网+医护一体化”模式在糖尿病肾病行血液透析患者中的应用效果。方法选取2021年3月-2022年5月医院收治的糖尿病肾病患者160例作为研究对象,按基本资料具有可比性的原则分为观察组和对照组,每组80例,两组患者均行血液透析治疗,对照组采用常规护理干预措施,观察组采用“互联网+医护一体化”模式干预,比较两组患者干预前后肾功能评分、自我管理能力水平评分、生活质量评分,比较两组患者透析相关并发症发生率和对干预措施的满意程度。结果“互联网+医护一体化”模式干预前两组患者肾功能指标、患者自我管理能力评分、患者生活质量评分比较,差异无统计学意义(P>0.05);“互联网+医护一体化”模式干预后观察组患者ET、BUN和Scr水平均低于对照组,差异有统计学意义(P<0.05)。“互联网+医护一体化”模式干预后观察组患者饮食管理、依从性管理、症状管理和日常生活管理评分均高于对照组,差异有统计学意义(P<0.05);“互联网+医护一体化”模式干预后观察组患者心理功能、躯体功能、社会功能和物质生活评分均高于对照组,差异有统计学意义(P<0.05)。实施“互联网+医护一体化”模式的观察组患者透析相关并发症发生率低于对照组,差异有统计学意义(P<0.05)。实施“互联网+医护一体化”模式的观察组患者满意度高于对照组,差异有统计学意义(P<0.05)。结论“互联网+医护一体化”模式可提高糖尿病肾病行血液透析患者肾功能水平,提高自我管理能力,改善患者生活质量,减少透析相关并发症,提高患者满意度。

关键词：互联网医护一体化模式糖尿病肾病血液透析自我管理能力生活质量

Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990-2016:Findings from the Global Burden of Disease Study 2016

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Biomedical and Environmental Sciences 2020年第1期33卷 1-10页

作者： LI man WANG Zhuo Qun zhang Lu ZHENG Hao LIU Dian Wu ZHOU Mai Geng Hebei Key Laboratory of Environment and Human Health Department of Epidemiology and StatisticHebei Medical UniversityShijiazhuang 050017HebeiChina National Center for Chronic and Non-communicable Disease Control and Prevention China CDCBeijing 100050China Hebei Chest Hospital Shijiazhuang 050042HebeiChina

Objective To estimate the burden of cirrhosis and other chronic liver diseases caused by specific etiologies in *** Data from the Global Burden of Disease Study 2016(GBD 2016)were *** evaluated the burden by analyzing age-sex-province-specific prevalence,mortality,and disability-adjusted lifeyears(DALYs)of 33 provinces in *** From 1990 to 2016,prevalence cases in thousands increased by 73.7%from 6833.3(95%UI:6498.0–7180.6)to 11869.6(95%UI:11274.6–12504.7).Age-standardized mortality and DALY rates per100,000 decreased by 51.2%and 53.3%,*** and elderly people(aged≥60 years)preponderance were found for prevalence,mortality,and *** number of prevalence cases,deaths,and DALYs due to hepatitis C virus(HCV)increased by 86.6%,8.7%,and 0.9%,***,age-standardized prevalence rates decreased in 31 provinces,but increased in Yunnan and *** Socio-demographic Index(SDI)values were negatively correlated with age-standardized mortality and DALY rates by provinces in 2016;the correlation coefficients were-0.817 and-0.828,*** Cirrhosis and other chronic liver diseases remain a huge health burden in China,with the increase of population and the aging of *** B virus(HBV)remains the leading cause of the health burden in China.

关键词： Cirrhosis Chronic liver disease China Epidemiology Global burden of disease study