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Bioactive hydrogels for bone regeneration

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Bioactive Materials 2018年第4期3卷 401-417页

作者： Xin bai mingzhu Gao Sahla Syed Jerry Zhuang Xiaoyang Xu xue-qing zhang Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong University800 Dongchuan RoadShanghai200240P.R.China Department of Chemical and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

Bone self-healing is limited and generally requires external intervention to augment bone repair and *** traditional methods for repairing bone defects such as autografts,allografts,and xenografts have been widely used,they all have corresponding disadvantages,thus limiting their clinical *** the development of a variety of biomaterials,including metal implants,calcium phosphate cements(CPC),hydroxyapatite,etc.,the desired therapeutic effect is not fully ***,polymeric scaffolds,particularly hydrogels,are of interest and their unique configurations and tunable physicochemical properties have been extensively *** review will focus on the applications of various cutting-edge bioactive hydrogels systems in bone regeneration,as well as their advantages and *** will examine the composition and defects of the bone,discuss the current biomaterials for bone regeneration,and classify recently developed polymeric materials for hydrogel *** will also elaborate on the properties of desirable hydrogels as well as the fabrication techniques and different delivery ***,the existing challenges,considerations,and the future prospective of hydrogels in bone regeneration will be outlined.

关键词： Bone regeneration Hydrogel Biomaterials Tissue engineering

The spatiotemporal evolution of EGFR C797S mutation in EGFR-mutant non-small cell lung cancer:opportunities for third-generation EGFR inhibitors re-challenge

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Science Bulletin 2019年第8期64卷 499-503页

作者： Yi-Chen zhang qing Zhou Zhi-hong Chen ming-Feng zhang Jin-Ji Yang Hai-Yan Tu Xu-Chao zhang Chong-Rui Xu hong-hong Yan Xiao-Xiao Peng Xiao-Yan bai shao-Kun Chuai Jun-Yi Ye Yi-Long Wu The Second School of Clinical Medicine Southern Medical University Guangdong Lung Cancer Institute Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences Burning Rock Biotech

Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated impressive activity in EGFR T790M-positive non-small cell lung cancer (NSCLC) progressed from prior EGFR-TKI... 详细信息

关键词： cis The spatiotemporal evolution of EGFR C797S mutation in EGFR-mutant non-small cell lung cancer:opportunities for third-generation EGFR inhibitors re-challenge

GaSb p-Channel Metal-Oxide-Semiconductor Field-Effect Transistors with Ni/Pt/Au Source/Drain Ohmic Contacts

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Chinese Physics Letters 2012年第12期29卷 188-191页

作者： WU Li-Shu SUN Bing CHANG Hu-Dong ZHAO Wei xue bai-qing zhang Xiong LIU hong-Gang Advanced Photonics Center School of Electronic Science and EngineeringSoutheast UniversityNanjing 210096 Microwave Device and IC Department Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029

GaSb is an attractive candidate for future high-performance Ⅲ-Ⅴ p-channel metal-oxide-semiconductor-field-effect-transistors(pMOSFETs)because of its high hole *** effect of HCl based-chemical cleaning on removing the non-self limiting and instable native oxide layer of GaSb to obtain a clean and smooth surface has been *** is observed that the rms roughness of a GaSb surface is significantly reduced from 2.731 nm to 0.693 nm by using HCl:H_(2)O(1:3)*** Ni/Pt/Au ohmic contact exhibits an optimal specific contact resistivity of about 6.89×10^(-7)Ω·cm^(2) with a 60 s rapid thermal anneal(RTA)at 250℃.Based on the chemical cleaning and ohmic contact experimental results,inversion-channel enhancement GaSb pMOSFETs are *** a 6μm gate length GaSb pMOSFET,a maximum drain current of about 4.0 mA/mm,a drain current on-off(ION/IOFF)ratio of>10^(3),and a subthreshold swing of~250 mV/decade are *** with the split C-V method,a peak hole mobility of about 160 cm^(2)/V·s is obtained for a 24μm gate length GaSb pMOSFET.

关键词： GaSb drain removing

Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer

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Chinese Medical Journal 2007年第6期120卷 496-502页

作者： LI Hai-shan LIU Yong LI Ding-feng zhang Ran-ran TANG Hai-li zhang Yu-wei HUANG Wei LIU Ying PENG hong XU Jian-qing hong Kun-xue shao Yi-ming State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease 100050 China

Background Although DNA vaccine is considered as the next generation of vaccine, most DNA vaccine candidates are still suffering from the relatively weak immunogenicity despite the increased dosage of plasmid DNA administered. In order to enhance the immune responses elicited by a codon-optimized HIV gag DNA vaccine, a modified plasmid vector pDRVI1.0 and a booster immunization with replicating Tiantan vaccinia （RTV） strain expressing the same gene were employed. Methods Vector pDRVI1.0 was constructed through inserting the 72-bp element from the SV40 enhancer, which was reported promoting nuclear transport of plasmid DNA, to the upstream of cytomegalovirus enhancer/promoter region of the plasmid vector pVR1012. Gene expression levels from expression plasmids based on pDRVI1.0 and pVR1012 were tested. Humoral and cellular immune responses induced by DNA vaccine alone or DNA prime-RTV boost regimen were determined in mice. Results It was shown that the 72-bp element significantly enhanced the gene expression level in non-dividing cells. gag-specific humoral and cellular immune responses induced by DNA vaccination were both significantly improved, while the Thl/Th2 balance was not obviously affected by the 72-bp element. RTV boosting further significantly enhanced DNA vaccine-palmed antibody and T cell responses in a Thl-biased manner. Conclusions The 72-bp SV40 enhancer element should be included in the DNA vaccine vector and RTV strain is a very efficient live vector for boosting immunization.

关键词： DNA vaccines SV40 enhancer prime-boost vaccinia Tiantan strain

Fine-Tuning of Structural Distortion and Magnetic Anisotropy by Organosulfonates in Octahedral Cobalt(Ⅱ)Complexes

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Chinese Journal of Chemistry 2022年第18期40卷 2193-2202页

作者： Dong shao Fang-xue Xu Lei Yin hong-qing Li Yu-Chen Sun Zhong-Wen Ouyang Zhen-Xing Wang Yi-Quan zhang Xin-Yi Wang State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210023 China Hubei Key Laboratory of Processing and Application of Catalytic Materials College of Chemistry and Chemical EngineeringHuanggang Normal UniversityHuanggangHubei438000 China Jiangsu Key Laboratory for NSLSCS School of Physical Science and TechnologyNanjing Normal UniversityNanjingJiangsu210097 China Wuhan National High Magnetic Field Centre Huazhong University of Science and TechnologyWuhanHubei430074 China

Precise modulation of the magnetic anisotropy of metal ions remains highly important for the development of high–performance single-molecule magnets(SMMs).We herein reported the synthetic,structural,spectral,magnetic,and computational studies on four mononuclear Co^(Ⅱ) complexes in a distorted octahedral *** change of the organosulfonate anions triggers significant modification of the distorted octahedral CoN6 coordination sphere,which enables us to tackle the influence of the structural distortion on the magnetic anisotropy in these *** measurements revealed that the four complexes possess easy–plane magnetic anisotropy with large and positive zero-field splitting parameters,which decrease with the increasing distortion of the pseudo–octahedral Co^(Ⅱ) coordination *** correlation was further confirmed by high–frequency/–field EPR(HF–EPR)spectra and theoretical *** magnetic susceptibility measurements indicate that these complexes both exhibit slow magnetic relaxation under an external dc field,indicating the field-induced single-ion magnets(SIMs)of the four *** results indicate that structural distortion plays an important role in the magnetic anisotropy of CoⅡcomplexes and should be carefully considered in the design of molecular complexes with high magnetic anisotropy.

关键词： Cobalt Solid-state structures Magnetic properties Single-molecule magnets /Magnetic anisotropy

Sonographic features of umbilical vein recanalization for a Rex shunt on cavernous transformation of portal vein in children

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World Journal of Clinical Cases 2020年第22期8卷 5555-5563页

作者： Yu-qing zhang qing Wang Mei Wu Ya Li Xiu-Liang Wei Fei-xue zhang Yan Li Guang-Rui shao Juan Xiao Department of Ultrasound The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Radiology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Nuclear Medicine The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Radiology The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Center of Evidence-Based Medicine Institute of Medical SciencesThe Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina

BACKGROUND The Rex shunt was widely used as the preferred surgical approach for cavernous transformation of the portal vein(CTPV)in children that creates a bypass between the superior mesenteric vein and the intrahepatic left portal vein(LPV).This procedure can relieve portal hypertension and restore physiological hepatopetal ***,the modified procedure is technically demanding because it is difficult to make an end-to-end anastomosis of a bypass to a hypoplastic *** studies reported using a recanalized umbilical vein as a conduit to resolve this ***,the feasibility of umbilical vein recanalization for a Rex shunt has not been fully *** To investigate the efficacy of a recanalized umbilical vein as a conduit for a Rex shunt on CTPV in children by *** A total of 47 children who were diagnosed with CTPV with prehepatic portal hypertension in the Second Hospital,Cheeloo College of Medicine,Shandong University,were enrolled in this *** children received a recanalized umbilical vein as a conduit for a Rex shunt surgery and were enrolled in group ***-two children received the classic Rex shunt surgery and were enrolled in group *** sonographic features of the two groups related to intraoperative and postoperative variation in terms of bypass vessel and the LPV were *** The patency rate of group I(60.0%,9/15)was significantly lower than that of group II(87.5%,28/32)7 d after(on the 8th d)operation(P0.05).Moreover,3 mo after(at the beginning of the 4th mo)surgery,the inner diameter significantly widened and flow velocity notably increased for the bypass vessels and the sagittal part of the LPV compared to intraoperative values in both shunt groups(P<0.05).However,there was no significant difference between the two surgic

关键词： Cavernous transformation of the portal vein Rex shunt Recanalization Umbilical vein Ultrasonography

Identification of HIV-1 specific T lymphocyte responses in highly exposed persistently seronegative Chinese

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Chinese Medical Journal 2006年第19期119卷 1616-1621页

作者： LIU hong-wei hong Kun-xue MA Jun YUAN Lin LIU Sha CHEN Jian-ping zhang Yuan-zhi RUAN Yu-hua XU Jian-qing shao Yi-ming Division of Virology and Immunology National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Xinjiang Center for Disease Control and Prevention Urumqi 830011 China

Background Studies of highly exposed persistently seronegative （HEPS） individuals may provide valuable information on mechanisms of protection and on vaccine design. Cellular immune responses play a critical role in containing human immunodeficiency virus. However, the cellular immune responses in HEPS individuals have not been thoroughly assessed at the entire viral genome level. Methods Ten HEPS Chinese with a history of frequent penetrative vaginal intercourse （mean frequency, at least once a week）, with some unprotected sexual contact occurring in the weeks or days immediately before enrollment, 25 HIV-1 seropositive individuals, 10 HIV-1-seronegative healthy individuals with low-risk sexual behavior and no history suggestive of exposure to HIV-1 infection were enrolled. HIV-1-specific T cell responses were comprehensively analyzed by an interferon- 7 Elispot assay against 770 overlapping peptides spanning all HIV-1 proteins. Results HIV-1-specific T-cell responses of interferon- 7 secretion were identified in 3 （30%） out of 10 HEPS individuals; the specific cytotoxic T lymphocytes were targeted at Pol （2/10）, Env （2/10）, and Tat （1/10）. HIV-1-specific T-cell responses of interferon- ~ secretion were identified in 20 （80%） out of 25 seropositive intravenous drug users （IDUs）, revealing that all HIV-1 proteins and protein subunits could serve as targets for HIV-1-specific CD8^＋ T cell responses with 85% recognizing Gag, 80% recognizing Nef, 75% recognizing Pol, 60% recognizing Env, 55% recognizing Vpu, 45% recognizing Vpr, 20% recognizing Vif, 20% recognizing Tat and 15% recognizing Rev in these seropositive individuals. None of the seronegative healthy individuals gave the positive T-cell responses. Conclusions About 30% of HEPS Chinese mounted HIV-1 specific T cell immune responses. Cell-mediated immunity against HIV-1 may be developed through non-productive infections.

关键词： HIV seropositivity T-lymphocytes, cytotoxic highly exposed persistently seronegative

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王麟鹏治疗可逆性胼胝体压部综合征头痛1例

北京中医药 2024年第1期43卷 88-89页

作者：张帆王麟鹏袁芳王少松张雪孙敬青首都医科大学附属北京中医医院针灸/康复/神经内科北京100010 北京市第二医院中医科北京100031

可逆性胼胝体压部综合征(reversible splenial lesion syndrome,RESLES)是由多种病因引起的,累及胼胝体压部,且具有可逆性的临床-影像综合征,常见症状有发热、头痛、精神异常、意识状态改变和癫痫发作等。中医学认为,头为诸阳之会、清... 详细信息

可逆性胼胝体压部综合征(reversible splenial lesion syndrome,RESLES)是由多种病因引起的,累及胼胝体压部,且具有可逆性的临床-影像综合征,常见症状有发热、头痛、精神异常、意识状态改变和癫痫发作等。中医学认为,头为诸阳之会、清阳之府、髓海所在。凡五脏精华之血,六腑清阳之气,皆上注于头。外感六淫之邪上犯头部,稽留阻遏清阳,致使脉络拘急、清窍不利。

关键词：可逆性胼胝体压部综合征头痛针灸王麟鹏

Determination of Amino Acids by Ru(bpy)_3^(2+) Cathodic Electrochemiluminescence with High Sensitivity

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Chemical Research in Chinese Universities 2010年第3期26卷 376-379页

作者： ZHOU Xiao-guang YUAN bai-qing zhang Lei LIU Yang HAN Dong-xue YOU Tian-yan Department of Chemistry and Chemical Engineering College of Science Northeast Forestry University Harbin 150040 P. R. China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changehun 130022 P. R. China College of Chemistry Jilin University Changchun 130021 P. R. China

The unique cathodic electrochemiluminescence（ECL） emission of Ru（bpy）3^2＋（bpy=2,2′-bipyridine） was observed via Nation film at Au electrode[Au/Nafion/Ru（bpy）3^2＋] at about 0.20 V（vs. Ag/AgCl） and applied to the determination of several amino acids without prior derivatization with high sensitivity. The cathodic electrochemiluminescence（ECL） exhibits the detection limits and linear ranges of several amino acids comparable to or better than those of capillary electrophoresis with conventional ECL detection method（at 1.10-1.20 V vs. Ag/AgCl） based on precolumn derivatization. The results suggest that the cathodic ECL is promising for the detection of amino acids in bioanalysis.

关键词： Cathodic electrochemiluminescence Ru(bpy)3^2+ Nation Au electrode