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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 690-697页

作者： Yun zhang lulu zhang Yunze Cai the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China

This paper presents a novel cooperative value iteration(VI)-based adaptive dynamic programming method for multi-player differential game models with a convergence *** players are divided into two groups in the learning process and adapt their policies *** method removes the dependence of admissible initial policies,which is one of the main drawbacks of the PI-based ***,this algorithm enables the players to adapt their control policies without full knowledge of others’ system parameters or control *** efficacy of our method is illustrated by three examples.

关键词： Adaptive dynamic programming incomplete information multi-player differential game value iteration

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

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Neural Regeneration Research 2024年第9期19卷 2041-2049页

作者： Zhihua Wang Wu Zhou Zhixiong zhang lulu zhang Meihua Li Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Postdoctoral Innovation Practice Base The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Nephrology Nanchang People’s Hospital Affiliated to Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury *** oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox *** is a classic drug used to treat type 2 diabetes that can inhibit *** studies have shown that,when used to treat cardiovascular and digestive system diseases,metformin can also upregulate heme oxygenase-1 ***,we hypothesized that heme oxygenase-1 plays a significant role in mediating the beneficial effects of metformin on neuronal ferroptosis after spinal cord *** test this,we first performed a bioinformatics analysis based on the GEO database and found that heme oxygenase-1 was upregulated in the lesion of rats with spinal cord ***,we confirmed this finding in a rat model of T9 spinal cord compression injury that exhibited spinal cord nerve cell *** intraperitoneal injection of metformin for 14 days was found to both upregulate heme oxygenase-1 expression and reduce neuronal ferroptosis in rats with spinal cord ***,we used a lentivirus vector to knock down heme oxygenase-1 expression in the spinal cord,and found that this significantly reduced the effect of metformin on ferroptosis after spinal cord *** together,these findings suggest that metformin inhibits neuronal ferroptosis after spinal cord injury,and that this effect is partially dependent on upregulation of heme oxygenase-1.

关键词： acyl-CoA synthetase long-chain family member 4 ferroptosis glutathione peroxidase 4 heme oxygenase-1 inflammation iron lipid peroxidation metformin neuroprotection spinal cord injury

Multi-Objective Loosely Synchronized Search for Multi-Objective Multi-Agent Path Finding with Asynchronous Actions

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 667-677页

作者： DU Haikuo GUO Zhengyu zhang lulu CAI Yunze Department of Automation Shanghai Jiao Tong UniversityShanghai200240China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai200240China China Airborne Missile Academy LuoyangHenan471000China National Key Laboratory of Air-based Information Perception and Fusion LuoyangHenan471000China

In recent years,the path planning for multi-agent technology has gradually matured,and has made breakthrough *** main difficulties in path planning for multi-agent are large state space,long algorithm running time,multiple optimization objectives,and asynchronous action of multiple *** solve the above problems,this paper first introduces the main problem of the research:multi-objective multi-agent path finding with asynchronous action,and proposes the algorithm framework of multi-objective loose synchronous(MO-LS)*** combining A*and M*,MO-LS-A*and MO-LS-M*algorithms are respectively *** completeness and optimality of the algorithm are proved,and a series of comparative experiments are designed to analyze the factors affecting the performance of the algorithm,verifying that the proposed MO-LS-M*algorithm has certain advantages.

关键词： multi-agent path finding multi-objective path planning asynchronous action loosely synchronous search

Path Planning Based on A-Star and Dynamic Window Approach Algorithm for Wild Environment

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 725-736页

作者： DONG Dejin DONG Shiyin zhang lulu CAI Yunze Department of Automation Shanghai Jiao Tong UniversityShanghai200240China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai200240China Shanghai Electro-Mechanical Engineering Institute Shanghai201109China

The path planning problem of complex wild environment with multiple elements still poses *** paper designs an algorithm that integrates global and local planning to apply to the wild environmental path *** modeling process of wild environment map is *** optimization strategies are designed to improve the A-Star in overcoming the problems of touching the edge of obstacles,redundant nodes and twisting paths.A new weighted cost function is designed to achieve different planning ***,the improved dynamic window approach(DWA)is designed to avoid local optimality and improve time efficiency compared to traditional *** the necessary path re-planning of wild environment,the improved A-Star is integrated with the improved DWA to solve re-planning problem of unknown and moving obstacles in wild environment with multiple *** improved fusion algorithm effectively solves problems and consumes less time,and the simulation results verify the effectiveness of improved algorithms above.

关键词： path planning path re-planning wild environment A-Star algorithm dynamic window approach

Corrosion Behavior of Graphene Nanosheets Reinforced Magnesium Matrix Composites in Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 525-536页

作者： Liwen Chen Jianhui Jing lulu zhang Jing Li Weipeng Chen Limin Li Yuan Zhao Hua Hou Yuhong Zhao School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Shanxi Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringNorth University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Magnesium(Mg)alloy is considered as a promising biodegradable implant material but restricted to rapid ***,the new strategies based on thixomolding process had been explored to utilize the outstanding anti-permeability of graphene nanosheets(GNPs)while inhibit its galvanic corrosion with the matrix,so as to improve the corrosion resistance of *** agglomerate of GNPs with 0.9 wt%content is the main reason for the deterioration of corrosion performance due to the formation of micro-galvanic *** grain refinement of composites with 0.6 wt%content had positive effects on the better corrosion *** process adjusting,the unique distributions of GNPs along grain boundaries play a vital role in improving the corrosion *** can be ascribed to the following mechanisms:(I)The barriers can be established between the Mg matrix and corrosive medium,hence blocking the charge transfer at the interface;(II)The GNPs can effectively promote apatite deposition on the Mg matrix,leading to form dense apatite layers and prevent the further invasion of SBF;(III)The GNPs acting as reinforcements exists in the corrosion layer and apatite layer,impede the apatite layer falling off from the Mg *** findings broaden the horizon for biomedical applications in Mg matrix composites to realize desired performances.

关键词： Magnesium matrix composite Graphene nanosheets Corrosion resistance

Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae

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Science China(Life Sciences) 2024年第2期67卷 421-423页

作者： Chi zhang lulu zhang Feng Wang Yaling Zeng Liying Sun Di Wang Yamei Li Liqin Wang Junping Peng NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100176China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100730China Shenzhen Center for Chronic Disease Control Shenzhen 518020China

Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in *** from clinical samples(zhang et al.,2021).

关键词： gonorrhoeae resistance

Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1677-1692页

作者： Dongsheng Bai Jiawei Zhao Runde Wang Jiaying Du Chen Zhou Chunyang Gu Yuxiang Wang lulu zhang Yue Zhao Na Lu State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal *** identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is *** our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus *** enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory ***,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy ***,*** up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRNA and an increase in mucin synthesis in goblet *** espe-cially significant finding is that *** activates the AhR pathway,thereby promoting the expression of *** summary,our results strongly indicate that *** enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRNA stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

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Genes & Diseases 2024年第2期11卷 1050-1065页

作者： Xiaoxuan Wang Lijuan Luo Jingtao Xu Qiuping Lu Haichao Xia Yanran Huang lulu zhang Liping Xie Habu Jiwa Shiqiong Liang Xiaoji Luo Jinyong Luo Key Laboratory of Diagnostic Medicine Designated By the Chinese Ministry of Education School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Bladder cancer (BC) is one of the most common malignant tumors in the urinary *** to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat *** (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor ***,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular *** found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC ***,Ecn had no notable cytotoxicity towards human normal *** subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC ***,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC *** summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling *** meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.

关键词： Bladder cancer Combination chemotherapy Echinatin p38 Wnt/β-catenin

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联合均值和散度逆高斯回归模型的参数估计

统计与决策 2024年第9期40卷 49-54页

作者：张露露黄希芬云南师范大学数学学院昆明650500

逆高斯回归模型可用于分析正偏态数据,人们通常研究解释变量对其均值参数的影响,但往往忽略了对其散度参数的影响,文章则基于解释变量对均值和散度都有影响的前提,针对联合均值和散度逆高斯回归模型,探讨模型参数的极大似然估计问题。M... 详细信息

逆高斯回归模型可用于分析正偏态数据,人们通常研究解释变量对其均值参数的影响,但往往忽略了对其散度参数的影响,文章则基于解释变量对均值和散度都有影响的前提,针对联合均值和散度逆高斯回归模型,探讨模型参数的极大似然估计问题。MM算法在优化问题上具有分离参数、降低目标函数的维度、简化求解过程等优点,将MM算法应用于联合均值和散度逆高斯回归模型,能将多元似然函数彻底分解为一系列一元函数之和,从而绕开了参数估计中的矩阵求逆问题。模拟研究表明,当数据量达到100时就能得到很好的估计效果;实证分析表明,理论研究在实际应用中具有可行性。

关键词：逆高斯分布 MM算法参数分离 Bootstrap方法

A CRISPR/Cas12a-based platform for rapid on-site bovine viral diarrhea virus diagnostics

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Journal of Integrative Agriculture 2024年第8期23卷 2872-2876页

作者： Meixi Wang Jitao Chang Yuxin Han Chaonan Wang Songkang Qin Jun Wang lulu zhang Yuanmao Zhu Fei Xue Fang Wang Hongliang Chai Yulong Wang Xinjie Wang Xin Yin State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China Institute of Western Agriculture Chinese Academy of Agricultural SciencesChangji 831100China

Bovine viral diarrhea virus(BVDV)is a positive-sense single-stranded RNA virus,belonging to the genus Pestivirus in the Flaviviridae family(Riitho et al.2020).Currently,BVDV is divided into 3 main genotypes,BVDV-1,BVD... 详细信息

关键词： BVDV CRISPR/Cas diarrhea