检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

痔疮合并单纯性肛瘘同期手术的可行性分析

安徽医专学报 2024年第4期23卷 34-36页

作者：谢永俊张明金段同华中国人民解放军联勤保障部队第九〇一医院安徽合肥230031

目的:探讨痔疮合并单纯性肛瘘同期手术治疗的临床可行性,并分析手术操作注意事项。方法:回顾性分析医院收治的90例痔疮合并单纯性肛瘘患者的临床资料,按照治疗方法的不同分为对照组和实验组,比较两组手术时间、术中出血量、住院时间,术... 详细信息

目的:探讨痔疮合并单纯性肛瘘同期手术治疗的临床可行性,并分析手术操作注意事项。方法:回顾性分析医院收治的90例痔疮合并单纯性肛瘘患者的临床资料,按照治疗方法的不同分为对照组和实验组,比较两组手术时间、术中出血量、住院时间,术后随访并记录有效率、术后伤口疼痛及肛门功能评分。结果:两组患者在术中出血、住院天数、肛门功能评分等方面,差异无统计学意义(P>0.05)。实验组手术时间高于对照组,对照组VAS评分高于实验组,差异均具有统计学意义(P0.05)。结论:在遵循个体化治疗的前提下,痔疮合并单纯性肛瘘同期手术治疗是可行的,可以减轻患者经济负担,且并未增加术后复发及肛门狭窄或肛门失禁风险。

关键词：痔疮单纯性肛瘘同期手术分期手术

Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-Meng Huang ming-jin zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

基于Transformer与改进记忆机制的用电量预测研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

信息技术 2024年第6期48卷 67-74,79页

作者：蔡岳张津铭郭晶徐玉华孙知信南京邮电大学现代邮政学院江苏省邮政大数据技术与应用工程研究中心国家邮政局邮政行业技术研发中心(物联网技术)宽带无线通信与传感网技术教育部重点实验室南京210000 国网信息通信产业集团北京102211 四川中电启明星信息技术有限公司成都610041

近年来我国经济的高速发展对电力配置提出了更高要求,实现电力资源的高效配置需要更加精准的用电量预测。随着人工智能、机器学习等技术的发展,高效精准的用电量预测成为可能。目前该领域普遍使用Long Short-Term Memory (LSTM)及其变... 详细信息

近年来我国经济的高速发展对电力配置提出了更高要求,实现电力资源的高效配置需要更加精准的用电量预测。随着人工智能、机器学习等技术的发展,高效精准的用电量预测成为可能。目前该领域普遍使用Long Short-Term Memory (LSTM)及其变种模型,但准确度相对较低。文中提出了一种基于改进记忆机制与Transformer的用电量预测模型,使用Transformer编码输入,提出了一种新型记忆机制来执行预测。实验表明该方法相较随机森林回归和LSTM及其变种模型,一周内平均误差分别下降9.05%与5.32%,模型收敛速度更快且具有较好的泛化性能。

关键词：记忆网络 Transformer 时序预测机器学习长短期记忆

Lobelia chinensis: chemical constituents and anticancer activity perspective

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第2期12卷 103-107页

作者： CHEN Mei-Wan CHEN Wen-Rong zhang jin-ming LONG Xiao-Ying WANG Yi-Tao State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao School of Traditional Chinese Medicine Guangdong Pharmaceutical University

Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities(e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer). This paper focuses on the properties, chemical constituents, and anticancer activity of L. chinensis to clarify the connection among them, and identify the active anticancer compounds. This work serves as the foundation for further research and development of L. chinensis.

关键词： Lobelia chinensis Chemical constituents Anticancer activity

Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第39期12卷 6376-6381页

作者： Xiao-Lan zhang jin-ming Liu Chang-Chun Yang Yi-Lin Zheng Li Liu Zhan-Kui Wang Hui-Qing Jiang Department of Gastroenterology the Second Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China

AIM： To investigate whether extracellular signal-regulated kinase 1 （ERK1） is activated and associated with hepatic stellate cell （HSC） proliferation in fibrotic rat liver tissue.METHODS： Rat hepatic fibrosis was induced by bile duct ligation （BDL）. Histopathological changes were evalo uated by hernatoxylin and eosin staining, and Masson＇ s trichrorne method. ERK1 mRNA in rat liver tissue was determined by reverse transcription-polyrnerase chain reaction, while the distribution of ERK1 was assessed by irnrnunohistochernistry. ERK1 protein was detected by Western blotting analysis. The number of activated HSCs was quantified after alpha smooth muscle actin （α-MA） staining.RESULTS： With the development of hepatic fibrosis, the positive staining cells of α-SMA increased obviously, and mainly resided in the portal ducts. Fiber sepia and perisinuses were accompanied with proliferating bile ducts. The positive staining areas of the rat livers in model groups 1-4 wk after ligation of common bile duct （12.88% ± 2.63%, 22.65% ± 2.16%, 27.45% ± 1.86%, 35.25% ± 2.34%, respectively） were significantly larger than those in the control group （5.88% ± 1.46%, P 〈 0.01）. With the development of hepatic fibrosis, the positive cells of ERK1 increased a lot, and were mainly distributed in portal ducts, fiber sepia around the bile ducts, vascular endothelial cells and perisinusoidal cells. Western blotting analysis displayed that the expression of ERK1 and ERK1 protein was up-regulated during the model course, and its level was the highest 4 wk after operation, being 3.9-fold and 7.2-fold higher in fibrotic rat liver than in controls. ERK1 mRNA was expressed in normal rat livers as well, which was up-regulated two days after BDL and reached the highest 4 wk after BDL. The expression of ERK1 was positively correlated with α-MA expression （r = 0.958, P 〈 0.05）.CONCLUSION： The expression of ERK1 protein and mRNA is greatly increased in fibrotic rat liver tissues, which may play a key r

关键词： Extracellular signal-regulated kinase Hepatic fibrosis Hepatic stellate cells Proliferation

Even Search in a Promising Region for Constrained Multi-Objective Optimization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 474-486页

作者： Fei ming Wenyin Gong Yaochu jin School of Computer Science China University of GeosciencesWuhan 430074China IEEE Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia 33619Germany School of Engineering Westlake UniversityHangzhou 310030China

In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However, an overly finetuned strategy or technique might overfit some problem types,resulting in a lack of versatility. In this article, we propose a generic search strategy that performs an even search in a promising region. The promising region, determined by obtained feasible non-dominated solutions, possesses two general ***, the constrained Pareto front(CPF) is included in the promising region. Second, as the number of feasible solutions increases or the convergence performance(i.e., approximation to the CPF) of these solutions improves, the promising region shrinks. Then we develop a new strategy named even search,which utilizes the non-dominated solutions to accelerate convergence and escape from local optima, and the feasible solutions under a constraint relaxation condition to exploit and detect feasible regions. Finally, a diversity measure is adopted to make sure that the individuals in the population evenly cover the valuable areas in the promising region. Experimental results on 45 instances from four benchmark test suites and 14 real-world CMOPs have demonstrated that searching evenly in the promising region can achieve competitive performance and excellent versatility compared to 11 most state-of-the-art methods tailored for CMOPs.

关键词： Constrained multi-objective optimization even search evolutionary algorithms promising region real-world problems

Design of dual-functional protic porous ionic liquids for boosting selective extractive desulfurization

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2817-2829页

作者： jin-Rui zhang Jie Yin jing He Hong-Shun Ran Wei Jiang Hong-Ping Li Wen-Shuai Zhu Hua-ming Li ming zhang School of the Environment and Safety Engineering & Institute for Energy Research Jiangsu University School of Chemistry and Chemical Engineering Jiangsu University

Porous ionic liquids have demonstrated excellent performance in the field of separation, attributed to their high specific surface area and efficient mass transfer. Herein, task-specific protic porous ionic liquids(PPILs) were prepared by employing a novel one-step coupling neutralization reaction strategy for extractive desulfurization. The single-extraction efficiency of PPILs reached 75.0% for ***, adding aromatic hydrocarbon interferents resulted in a slight decrease in the extraction efficiency of PPILs(from 45.2% to 37.3%, 37.9%, and 33.5%), indicating the excellent extraction selectivity of PPILs. The experimental measurements and density functional theory calculations reveal that the surface channels of porous structures can selectively capture dibenzothiophene by the stronger electrophilicity(Eint(HS surface channel/DBT)=-39.8 kcal mol-1), and the multiple extraction sites of ion pairs can effectively enrich and transport dibenzothiophene from the oil phase into PPILs through π...π, C-H...π and hydrogen bonds interactions. Furthermore, this straightforward synthetic strategy can be employed in preparing porous liquids, offering new possibilities for synthesizing PPILs with tailored functionalities.

关键词： Protic porous ionic liquids Extractive desulfurization Selectivity Density functional theory

Scalable graphene foam with ultrahigh conductivity for stabilizing Pt towards efficient hydrogen evolution

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 6968-6976页

作者： ming Zhao Meng Huang Huihui jin Dayin He Wei Qian Zixin zhang Daping He State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China School of Information Engineering Wuhan University of TechnologyWuhan 430070China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China

For the carbon-based catalyst to be active and stable,especially in harsh electrochemical environments,the key is to decrease the concentration of defects and raise the degree of graphitization of the carbon ***,we develop a highly graphitized graphene foam with multiplicated structure to fabricate self-supporting Pt-based catalysts for efficient and stable hydrogen evolution reaction(HER)*** foam(GO-2850)is obtained through an ultra-high temperature treatment at 2850℃,with perfect graphene structure and extremely low defect,ensuring high electrical conductivity and corrosion ***,its multiplicated structure provides an inherently favorable environment for the dispersion of Pt nanoparticles(Pt NPs)and offers abundant channels for electrolyte infiltration during the catalytic *** a result,the as-prepared Pt/GO-2850 is far active and stable than the Pt NPs supported on commercial carbon paper(Pt/CP)counterpart toward catalyzing HER,exhibiting an outstanding activity and long-term durability(300 h@10 mA·cm^(−2))in acidic/alkaline/seawater *** can be attributed to the stronger interaction between the lower-defect GO-2850 substrate and Pt,as evidenced by characterization and theoretical *** work extends further insight into the design self-supporting catalysts of high activity and stability with promising prominent application toward green energy devices.

关键词： graphene foam high graphitization Pt nanoparticles hydrogen evolution reaction long-term stability

Selection of reference genes for RT-qPCR analysis of Phenacoccus solenopsis(Hemiptera: Pseudococcidae) sex-dimorphic development

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2019年第4期18卷 854-864页

作者： ZHENG Lu-ying zhang Zhi-jun zhang jin-ming LI Xiao-wei HUANG Jun LIN Wen-cai LI Wei-di LI Chuan-ren LU Yao-bin College of Agriculture Yangtze University Institute of Plant Protection and Microbiology Zhejiang Academy of Agricultural Sciences

Mealybugs, such as Phenacoccus solenopsis, are highly sexually dimorphic. Winged adult males present such remarkable morphological differences from females that, to the untrained eye, conspecific adults of both sexes of P. solenopsis may be considered as two different insect species. A method to investigate sex-dimorphic mechanisms is by evaluating gene expression using RT-qPCR. However, the accuracy and consistency of this technique depend on the reference gene(s) selected. In this study, we analyzed the expression of 10 candidate reference genes in male and female P. solenopsis at different development stages, using common algorithms including the ?Ct method, NormFinder, geNorm, BestKeeper, and a web-based analysis tool, RefFinder. The results showed that EF1-β, RP-L32 and RP-18 S were selected as the most stable genes by both the ?Ct method and NormFinder; TUB-α was the most stable gene identified by BestKeeper; and RP-L40 and RP-L32 were the most stable genes ranked by geNorm. RefFinder, a comprehensive analysis software, ranked the ten genes and determined EF1-β and RP-L32 as the most suitable reference genes for the various developmental stages in male and female P. solenopsis. Furthermore, the two most suitable reference genes were validated by examining expression of the juvenile hormone acid O-methytransferase(JHAMT) gene. Results of the validation portion of the study showed that JHAMT expression was sex-biased towards males and exhibited a dynamic and classic expression pattern among the P. solenopsis developmental stages. The results can help further our knowledge on the molecular mechanisms underlying sexual dimorphic development in P. solenopsis.

关键词： Phenacoccus solenopsis RT-qPCR sexual dimorphic development reference gene gene stability