检索结果-南通市图书馆

High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

在线全文

学校读者我要写书评

暂无评论

Tungsten 2025年第1期7卷 50-70页

作者： Yi Li Bei-Qi Wang Xin-Yin zhang Shi-Jie Wang Cong-Yi Li hui-Long Yang Ran-Ran Su Tong Liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

MoS2 synaptic transistor with one-step manufacture

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO Yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe zhang hui YAN Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

同方期刊数据库

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei zhang Jian Wu hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

基于Omp1基因的泌尿生殖道感染沙眼衣原体多样性及分布特征分析

在线全文

学校读者我要写书评

暂无评论

中国皮肤性病学杂志 2017年第4期31卷 393-397页

作者：常月立王威张存辉孙克张彦霞张玉妥河北北方学院病原生物学研究所河北张家口075000 保定市第一中心医院检验科河北保定071000 中国人民解放军第二五二医院检验科河北保定071000

目的基于主要外膜蛋白基因(Omp1)研究泌尿生殖道感染患者沙眼衣原体多态性及分布特征,为该疾病的诊治及疫苗研究奠定基础。方法对泌尿生殖道感染临床标本常规处理后,使用沙眼衣原体核酸检测试剂盒筛选阳性标本,然后以巢式PCR扩增Omp1基... 详细信息

目的基于主要外膜蛋白基因(Omp1)研究泌尿生殖道感染患者沙眼衣原体多态性及分布特征,为该疾病的诊治及疫苗研究奠定基础。方法对泌尿生殖道感染临床标本常规处理后,使用沙眼衣原体核酸检测试剂盒筛选阳性标本,然后以巢式PCR扩增Omp1基因,选择4个限制性内切酶进行RFLP分析确定其基因型,选择代表菌株测定Omp1的DNA序列并与参比菌株比较确定其血清型,最后将基因型及血清型与患者的性别、科室及年龄进行对比分析,研究其分布特征。结果 2013-2014年2年间共筛选得到178份阳性标本,61份标本扩增获得Omp1基因,Omp1-PFLP分析将61份标本分为6个基因型,占比分别为24.59%,24.59%,4.92%,9.84%,3.28%和32.79%,血清型分析表明61份标本属于F,H,J,G,Da,D和E 7种血清型,E型及F型占比最多。结论本地区引起泌尿生殖道感染的沙眼衣原体主要属于F,H,J,G,Da,D和E 7种血清型,E型及F型占比最多,基因型及血清型与患者性别具有相关性,与科室、年龄无相关性。

关键词：沙眼衣原体泌尿生殖道主要外膜蛋白 Omp1基因 RFLP 多样性血清型分布特征

在线全文

学校读者我要写书评

暂无评论

儿童呼吸道感染流感嗜血菌的耐药性变迁

中华医院感染学杂志 2015年第16期25卷 3802-3804页

作者：乔海霞张彦霞张存辉常月立张玉妥河北北方学院医学检验学院微生物教研室河北张家口075000

目的了解儿童呼吸道感染流感嗜血菌(HIN)的耐药性变迁,为合理使用抗菌药物提供依据。方法对2008年1月-2012年4月呼吸道感染及健康儿童咽拭子标本中分离的261株HIN,采用K-B法测定其对12种抗菌药物的敏感性,并用cefinase纸片检测菌株的β... 详细信息

目的了解儿童呼吸道感染流感嗜血菌(HIN)的耐药性变迁,为合理使用抗菌药物提供依据。方法对2008年1月-2012年4月呼吸道感染及健康儿童咽拭子标本中分离的261株HIN,采用K-B法测定其对12种抗菌药物的敏感性,并用cefinase纸片检测菌株的β-内酰胺酶的产酶率,采用SAS 9.2进行统计分析。结果 2008-2012年共送检717份标本,检出261株HIN,分离率为36.40%;3年呼吸道感染儿童HIN分离率呈下降趋势;健康儿童HIN携带率呈上升趋势;儿童呼吸道感染HIN对亚胺培南、头孢克洛100.00%敏感,健康儿童携带的HIN对亚胺培南、头孢唑林、头孢克洛、环丙沙星、氯霉素等多种抗菌药物敏感,敏感率均为100.00%。结论儿童HIN的分离率较高,对氨苄西林耐药率呈上升趋势,治疗HIN感染应根据药敏试验结果合理选用抗菌药物,无法获得药敏结果可首选亚胺培南、头孢克洛进行治疗。

关键词：流感嗜血菌抗菌药物耐药性变迁

Nonlinear dynamic analysis of the Three Gorge Project powerhouse excited by pressure fluctuation

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1231-1240页

作者： cun-hui zhang Yun-liang zhang School of Civil and Hydraulic Engineering Dalian University of Technology Dalian 116024 China

This study established a 3D finite element model for 15# hydropower house of the Three Gorges Project (TGP) and performed a nonlinear dynamic analysis under pressure fluctuation. In this numerical model, the stiffness degradation in tension for concrete was considered on the basis of the continuum isotropic damage theory. Natural vibration frequencies of the damaged and undamaged structures were compared after static water pressure was applied. Then a study was further conducted on forced vibration of the powerhouse with pre-existing damages under pressure fluctuation that acts on the flow passage; displacement, velocity and acceleration of the important structural members were afterwards presented and checked. Numerical results show that tensile damages in concrete surrounding the spiral case only exert significant impact upon the dynamic characteristics of substructure but show little effect on the superstructure. Nevertheless vibrations of the powerhouse are still under the recommended vibration limits.

关键词： Three Gorges Project (TGP) Hydropower house Dynamic Nonlinear Damage Pressure fluctuation

姜黄素对肿瘤坏死因子-α诱导后人肝癌细胞核转录因子表达的影响

在线全文

学校读者我要写书评

暂无评论

中国中医药信息杂志 2013年第11期20卷 25-27页

作者：张会存塔娜杨美娟北京市中医研究所北京100010 卫生部卫生发展研究中心北京100191 北京中医药大学北京100029

目的观察姜黄素对经肿瘤坏死因子-α(TNF-α)诱导后人肝癌细胞(Hepg-2)核转录因子(NF-κB)及其抑制蛋白-Bα(Iκ-Bα)表达的影响,探讨其对非酒精性脂肪性肝炎的影响。方法将Hepg-2细胞用含10%胎牛血清的DMEM培养基培养,细胞分为6组,即... 详细信息

目的观察姜黄素对经肿瘤坏死因子-α(TNF-α)诱导后人肝癌细胞(Hepg-2)核转录因子(NF-κB)及其抑制蛋白-Bα(Iκ-Bα)表达的影响,探讨其对非酒精性脂肪性肝炎的影响。方法将Hepg-2细胞用含10%胎牛血清的DMEM培养基培养,细胞分为6组,即正常对照组、TNF-α组、2.5μmol/L姜黄素组、5μmol/L姜黄素组、10μmol/L姜黄素组、20μmol/L姜黄素组。MTT检测姜黄素对Hepg-2细胞增殖活力,Western blotting法检测NF-κB及IκB-Bα蛋白的变化。结果 Hepg-2细胞经TNF-α刺激后,NF-κB表达增强,与正常对照组比较差异有统计学意义(P<0.05),而IκB-α表达虽增加但与正常对照组比较差异无统计学意义;经姜黄素干预后,NF-κB表达明显减弱,而IκB-Bα表达明显增强,与TNF-α组比较差异有统计学意义(P<0.05)。结论姜黄素可拮抗TNF-α诱导的NF-κB炎性信号通路的激活,从而减轻肝细胞的炎性损伤。

关键词：姜黄素肿瘤坏死因子-α 核转录因子-κB 核转录因子抑制蛋白-Bα Hepg-2细胞

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

在线全文

学校读者我要写书评

暂无评论

Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun zhang Wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

张家口市医学生安全与急救素养水平及影响因素分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国健康教育 2018年第3期34卷 268-271页

作者：戴明艳张存辉忻振慧葛丽平亢延飞王剑河北北方学院预防医学教研室河北张家口075000

目的了解张家口市医学生安全与急救素养现状,分析其影响因素,为进一步开展安全与急救教育提供依据。方法采用多阶段分层随机整群抽样的方法抽取张家口市1730名医学生进行问卷调查。运用Epi Data 3.1软件进行问卷录入,SPSS 22.0软件进行... 详细信息

目的了解张家口市医学生安全与急救素养现状,分析其影响因素,为进一步开展安全与急救教育提供依据。方法采用多阶段分层随机整群抽样的方法抽取张家口市1730名医学生进行问卷调查。运用Epi Data 3.1软件进行问卷录入,SPSS 22.0软件进行统计分析。结果张家口市医学生安全与急救素养具备比例为91.92%,对煤气中毒的预防与救护知晓率最高(98.71%),地震逃离知晓率最低(61.18%)。安全与急救素养的主要影响因素为父亲的文化程度(大专及以上OR=10.234,95%CI:2.233～46.890)、母亲的文化程度(初中/高中/中专OR=1.626,95%CI:1.046～2.528)、母亲的职业(农民及农民工OR=6.350,95%CI:3.722～10.835)、家庭月均收入(5000元以上OR=9.043,95%CI:2.873～28.466)、个人月生活费(500～1000元OR=1.621.95%CI:1.063～2.473)。互联网(80.80%)、电视广播(78.92%)、书籍杂志报纸(77.52%)、学校健康教育课程(76.46%)是获取相关知识的主要途径。结论张家口市医学生安全与急救素养整体水平较高,安全与急救素养水平与家庭经济条件、学生月生活费及家长的职业与文化程度有关。

关键词：安全急救健康素养医学生影响因素