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Comparison of Ex‑PRESS implantation versus trabeculectomy combined with phacoemulsification in primary open‑angle glaucoma:a retrospective in vivo confocal microscopy study

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Eye and Vision 2024年第2期10卷 1-11页

作者： Yuqiao zhang Beiting He Yulin zhang Jin Zeng Yanlei Chen Yongyi Niu Honghua Yu Yongjie Qin hongyang zhang Department of Ophthalmology Guangdong Eye InstituteGuangdong Academy of Medical SciencesGuangdong Provincial People’s HospitalNo.106 Zhongshan Er RoadGuangzhou 510080China Shantou University Medical College ShantouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Ophthalmology School of MedicineSouth China University of TechnologyGuangzhouChina

Background:To compare the efficacy of Ex-PRESS implantation versus trabeculectomy combined with ***:A retrospective 12-month study on patients with coincident primary open-angle glaucoma(POAG)and *** patients underwent combined phacoemulsification and Ex-PRESS implant(Phaco-ExPRESS,n=35)or phacotrabeculectomy(Phaco-Trab,n=35).The morphological structures of the filtering bleb were examined by slitlamp,anterior segment optical coherence tomography(AS-OCT)and in vivo confocal microscopy(IVCM).Complete success was defined as postoperative intraocular pressure(IOP)<18 mmHg without the use of anti-glaucoma *** success was defined as postoperative IOP<18 mmHg with or without anti-glaucoma *** data were collected preoperatively and postoperatively at 2 weeks,1 month,3 months,6 months,and 12 ***:No significant difference in the variables such as age,IOP and perimetry was found between the groups of Phaco-ExPRESS and *** the one-year postoperative visit for filtering blebs,Phaco-ExPRESS increased the mean area of epithelial microcysts significantly from 0.10±0.05 to 0.20±0.09μm^(2)perμm^(2),while Phaco-Trab decreased the mean area significantly from 0.08±0.04 to 0.04±0.06μm^(2)perμm^(2).Notably,the hyperreflective dots detected by IVCM decreased by 84.9%in Phaco-ExPRESS but increased by 36.3%in *** hyperreflective dots were further identified as neutrophil-and monocyte-like *** number of these cells were negatively correlated with the microcysts area(r=−0.7,P<0.01)but positively associated with the grade of connective tissue(r=0.5,P<0.01).By creating different microstructural changes in the filtering blebs,Phaco-ExPRESS produced a higher complete success rate(84.9%vs.41.2%,P<0.01)and significant decrease in the number of anti-glaucoma medications(P<0.01)when compared with those in ***,the qualified success showed no significant difference between the two groups(

关键词： POAG Ex-PRESS Phacoemulsification Confocal microscopy

Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia

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Genes & Diseases 2024年第5期11卷 374-389页

作者： Zijun Yan Jie Xia Ziyang Cao hongyang zhang Jinxia Wang Tienan Feng Yi Shu Lin Zou Clinical Research Unit Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Institute of Pediatric Infection Immunityand Critical Care MedicineShanghai Jiao Tong University School of MedicineShanghai 200062China Center for Clinical Molecular Laboratory Medicine of Children’s Hospital of Chongqing Medical University Chongqing 400014China Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghai 200025China Bioinformatics and BioMedical Bigdata Mining Laboratory School of Big HealthGuizhou Medical UniversityGuiyangGuizhou 554300China

T-cell acute lymphoblastic leukemia(T-ALL),a heterogeneous hematological malignancy,is caused by the developmental arrest of normal T-cell *** development of targeted therapeutic regimens is impeded by poor knowledge of the stage-specific aberrances in this *** this study,we performed multi-omics integration analysis,which included mRNA expression,chromatin accessibility,and gene-dependency database analyses,to identify potential stage-specific druggable targets and repositioned drugs for this *** multi-omics integration helped identify 29 potential pathological genes for *** genes exhibited tissue-specific expression profiles and were enriched in the cell cycle,hematopoietic stem cell differentiation,and the AMPK signaling *** these,four known druggable targets(CDK6,TUBA1A,TUBB,and TYMS)showed dysregulated and stage-specific expression in malignant T cells and may serve as stage-specific targets in *** TUBA1A expression level was higher in the early T cell precursor(ETP)-ALL cells,while TUBB and TYMS were mainly highly expressed in malignant T cells arrested at the CD4 and CD8 double-positive or single-positive ***6 exhibited a U-shaped expression pattern in malignant T cells along the naıve to maturation ***,mebendazole and gemcitabine,which target TUBA1A and TYMS,respectively,exerted stage-specific inhibitory effects on T-ALL cell lines,indicating their potential stage-specific antileukemic role in ***,our findings might aid in identifying potential stage-specific druggable targets and are promising for achieving more precise therapeutic strategies for T-ALL.

关键词： Multi-omics Stage-specific druggable targets Targeted therapeutic strategies T-cell acute lymphoblastic leukemia Drug repositioning

主体脱嵌及其超越:乡村治理空心化的生成机制与化解路径

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南京社会科学 2024年第9期 70-80页

作者：张红阳中共浙江省委党校浙江省“八八战略”创新发展研究院杭州311121 中共浙江省委党校公共管理教研部杭州311121

乡村治理空心化反映了农民主体作用发挥的不足,是乡村振兴遭遇的现实困难。乡村治理空心化产生于主体脱嵌机制,即农民的三个脱离:脱离农业、脱离农村、脱离公共事务。脱离农业反映乡村治理动力的弱化,脱离农村呈现乡村治理主体的离散,... 详细信息

乡村治理空心化反映了农民主体作用发挥的不足,是乡村振兴遭遇的现实困难。乡村治理空心化产生于主体脱嵌机制,即农民的三个脱离:脱离农业、脱离农村、脱离公共事务。脱离农业反映乡村治理动力的弱化,脱离农村呈现乡村治理主体的离散,脱离公共事务表明乡村治理行动的冷漠。乡村治理空心化这一概念的提出以及主体脱嵌机制的探索,不仅发现了一种被忽视的空心化现象,还诠释了这一现象生成的社会机制。以“共同在场”“双重在场”唤起“主体性回归”,从根本上激发农民的主体意识,为乡村治理空心化问题提供了一条创新且可持续的解决之道。

关键词：农民脱嵌空心化乡村振兴乡村治理

Psychological Impact of the 2022 Round COVID-19 Pandemic on China's College Students

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Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 141-149页

作者：洪冬羊王金霞张虹洋曹紫阳晏紫君邹琳 School of Pediatrics Shanghai Jiao Tong University School of MedicineShanghai 200001China Institute of Pediatric Infection Immunityand Critical Care MedicineShanghai Children's HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China Clinical Research Unit Shanghai Children's HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China

In response to the new round of COVID-19 outbreaks since March 2022,universities with high outbreak rates around the country have taken quarantine measures to contain the *** from previous coronavirus outbreaks has shown that people under quarantine are at risk for mental health *** better understand the impacts of this round of COVID-19 quarantine on domestic college students and their responses,we conducted a systematic survey to assess the stress and anxiety,and to evaluate effective measurements in this *** searched relevant documents and literature,and designed a questionnaire from six aspects,including psychological status,epidemic situation,study,daily life,sports,and interpersonal communication,with 51 items in *** sent the questionnaire on the Wenjuanxing Web platform,from April 2 to 8,*** evaluated the mental status according to parts of the Generalized Anxiety Disorder-7(GAD-7)and Depression Anxiety Stress Scales-21(DASS-21),and investigated the influencing risk factors and *** analysis was performed by using the Chi-square test and multi-variable logistic *** total,508 college respondents were recruited in our survey,and the pooled prevalence of mild anxiety(GAD score≥5,or DASS-21 anxiety score≥8)or stress(DASS-21 pressure score≥14)caused by the new round of COVID-19 pandemic quarantine was 19.69%(100/508).The prevalence of the anxiety or stress in college students with COVID-19 quarantine between different genders,regions,and majors was not significantly *** risk factors for the mild anxiety or stress of undergraduates by COVID-19 quarantine included learning efficiency or duration[OR=1.36,95%CI(1.14—1.62),P=0.001],based on the combined analysis of Chi-square test analysis with multi-variable logistic regression ***,the mental well-beings before COVID-19 epidemic quarantine[OR=0.22,95%CI(0.130.36),P<0.0001],more low-intensity exercise[OR=0.36

关键词： COVID-19 psychological investigation college students anxiety stress

脸面驱动的农民城镇化——脸面观视角下农村青年的城镇化动力及策略

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中国青年研究 2024年第7期 22-29页

作者：张红阳魏长青赵煌中共浙江省委党校浙江省“八八战略”创新发展研究院浙江省委党校公共管理教研部清华大学社会科学学院社会与金融研究中心浙江警察学院马克思主义学院武汉市社会科学院文化与历史研究所

基于脸面观的个体动力具有鲜明的内部精神属性,是认识农村青年县城化动力与策略的全新视角与阐释工具。脸面压力驱动的动力机制在于:脸面压力下的排斥力;脸面观念的新型转变;脸面竞争重心的转移。脸面压力形塑的发展策略包括:决策的果断... 详细信息

基于脸面观的个体动力具有鲜明的内部精神属性,是认识农村青年县城化动力与策略的全新视角与阐释工具。脸面压力驱动的动力机制在于:脸面压力下的排斥力;脸面观念的新型转变;脸面竞争重心的转移。脸面压力形塑的发展策略包括:决策的果断性;行动的策略性;融入的系统性。脸面压力下的策略行动反映了中国城镇化具有很强的自主性动力,有利于重新认识农民在现代化、城镇化进程中的主体能动性。这启发我们,新时代推进中国式现代化需要充分依靠基层农民的民间智慧和自发行动。

关键词：城镇化脸面观农村青年县域城镇化中国式现代化

绿电制氢装置并网与离网供电稳定控制方案研究

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炼油技术与工程 2024年第3期54卷 40-46页

作者：李君陶丽楠张洪阳中石化(大连)石油化工研究院有限公司辽宁省大连市116045

针对绿电制氢装置并网向离网切换的过程中,有功功率和无功功率不平衡引起的微电网频率、电压振荡以及变流器过载退出运行等问题,以制氢并离网切换稳定运行为目标,提出储能多模式控制策略。首先,建立储能系统功率转换方程,分析储能控制... 详细信息

针对绿电制氢装置并网向离网切换的过程中,有功功率和无功功率不平衡引起的微电网频率、电压振荡以及变流器过载退出运行等问题,以制氢并离网切换稳定运行为目标,提出储能多模式控制策略。首先,建立储能系统功率转换方程,分析储能控制器功率、频率调节关系;其次,研究储能多模式切换策略,分析离网切换稳定关键因素,比较储能容量、控制器参数对系统影响;最后,以典型绿电制氢微电网为例,仿真计算不同储能容量及调差系数下的切换性能。结果表明:储能容量占比越高,储能视在功率超调越少,设备过载风险越小;同样储能容量下,调差系数越小,视在功率峰值越小,过载风险越低,但同时要求变流器电流过载能力强;调差系数取0.20时,可满足并网、离网中多种运行工况。

关键词：绿电制氢装置并网离网供电稳定性储能系统调差系数微电网频率视在功率

社会发展水平、社会公平感与主观幸福感的关系研究——基于CGSS 2018数据的实证分析

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东北大学学报（社会科学版） 2024年第4期26卷 29-41页

作者：李卓王延涛张红阳清华大学社会科学学院北京100084 司法部预防犯罪研究所北京100871 中共浙江省委党校公共管理教研部浙江杭州311121

不断提高人民群众的幸福感,是党和政府的重要工作目标。基于CGSS 2018数据,构建分层线性模型,对社会发展水平、社会公平感与主观幸福感之间的关系进行实证分析。研究结果表明:社会发展水平和社会公平感均对居民的主观幸福感具有显著的... 详细信息

不断提高人民群众的幸福感,是党和政府的重要工作目标。基于CGSS 2018数据,构建分层线性模型,对社会发展水平、社会公平感与主观幸福感之间的关系进行实证分析。研究结果表明:社会发展水平和社会公平感均对居民的主观幸福感具有显著的正向影响;社会公平感对主观幸福感的影响受社会发展水平的调节,社会发展水平与社会公平感对主观幸福感的影响具有替代效应;在社会发展水平较低的省份、中西部及农村地区,社会公平感对主观幸福感影响更大。因此,社会发展水平较低的省份和地区,未来面临着推动社会发展和促进社会公平的双重压力,要避免发展不足与不公平对居民幸福感造成的负面效应叠加;社会发展水平较高的省份和地区,要注重发展总量向更高发展质量转型,提升发展的公平性,为提高居民幸福感“锦上添花”。

关键词：社会发展社会公平感主观幸福感调节效应

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双层索引驱动的隧洞海量点云高效管理方法

水力发电学报 2024年第6期43卷 11-22页

作者：张宏阳张礼兵刘全马刚胡诗言武汉大学水资源工程与调度全国重点实验室武汉430072 中国电建集团昆明勘测设计研究院有限公司昆明650051

针对隧洞表观性态监测,三维激光扫描获取的点云具有数据量巨大、非结构化以及狭长线状非均匀分布等特点,给隧洞点云数据处理极大的压力,也制约了隧洞工程点云监测应用的发展。为此,本文结合隧洞工程空间分布特点,提出一种基于双层索引... 详细信息

针对隧洞表观性态监测,三维激光扫描获取的点云具有数据量巨大、非结构化以及狭长线状非均匀分布等特点,给隧洞点云数据处理极大的压力,也制约了隧洞工程点云监测应用的发展。为此,本文结合隧洞工程空间分布特点,提出一种基于双层索引结构的隧洞海量点云管理方法。该方法设计了一种基于Hough变换的隧洞水平中线粗提取方法,指导隧洞点云数据沿水平中线进行点云自动分段;而后利用“自下而上”的归并构建策略建立分段点云八叉树索引。在此基础上,利用非冗余的多层次细节(LOD)建模方法和内外存动态调度技术实现海量点云数据快速可视化。实验结果显示,本文方法有效提高了隧洞点云水平轴线提取效率,基于双层索引结构的隧洞点云管理在点云检索、海量点云数据可视化等方面表现出优异性能。

关键词：点云数据隧洞工程大数据处理双层空间索引内外存动态调度

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基于视觉跟踪和模式识别的缆机吊运效率分析

清华大学学报（自然科学版） 2024年第9期64卷 1646-1657页

作者：王浩杨启贵刘全赵春菊张宏阳武汉大学水工程科学研究院武汉430072 长江设计集团有限公司武汉430010 武汉大学水资源工程与调度全国重点实验室武汉430072 湖北工业大学土木建筑与环境学院武汉430068

缆机是拱坝施工中主要的混凝土入仓设备。监测缆机吊运过程并分析其施工效率,对于支撑工程现场调度优化、资源配置和指导施工至关重要。该文提出一种基于视觉跟踪和模式识别的缆机吊运混凝土效率智能分析方法,首先训练YOLO模型作为目标... 详细信息

缆机是拱坝施工中主要的混凝土入仓设备。监测缆机吊运过程并分析其施工效率,对于支撑工程现场调度优化、资源配置和指导施工至关重要。该文提出一种基于视觉跟踪和模式识别的缆机吊运混凝土效率智能分析方法,首先训练YOLO模型作为目标检测器,并引入轨迹片段特征改进DeepSORT算法,实现对缆机吊罐移动轨迹的多目标跟踪;然后基于轨迹数据的时序特征建立缆机吊运混凝土工作状态识别模型,实现从海量轨迹数据中快速准确识别缆机工作状态和计算吊运效率。拱坝工程的实例分析结果表明:该方法实现了高精度完整跟踪吊罐的移动轨迹,MOTA指标和IDF1指标分别高达90.0%和94.8%,准确识别出了缆机的6种工作状态,精准计算出了缆机的浇筑强度等效率指标,具备可靠性和准确性。

关键词：水利工程施工缆机多目标跟踪模式识别目标识别