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Hepatitis B virus infection, infertility, and assisted reproduction

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 672-685页

作者： Lingjian zhang fangfang zhang Zhiyuan MA Jie JIN Department of Infectious Diseases Affiliated Hangzhou First People’s HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310003China Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Hepatitis B virus(HBV)is one of the most widespread viruses worldwide and a major cause of hepatitis,cirrhosis,and hepatocellular *** studies have revealed the impacts of HBV infection on *** increasing number of infertile couples with chronic hepatitis B(CHB)virus infection choose assisted reproductive technology(ART)to meet their fertility *** the high prevalence of HBV,the effects of HBV infection on assisted reproduction treatment remain limited and ***:The aim of this study was to provide a comprehensive overview of the effect of HBV infection on fertility and discuss its effects on pregnancy outcomes,vertical transmission,pregnancy complications,and viral activity during ART ***:We conducted a literature search in PubMed for studies on HBV infection and ART published from 1996 to ***:HBV infection negatively affected fertility in both males and *** research shows that HBV infection may increase the risk of pregnancy complications in couples undergoing assisted reproduction *** impact of HBV infection on the pregnancy outcomes of ART is still *** evidence does not support that ART increases the risk of vertical transmission of HBV,while relevant studies are *** the development of ART,the risk of HBV reactivation(HBVr)is increasing,especially due to the wide application of immunosuppressive ***:Regular HBV infection screening and HBVr risk stratification and management are essential to prevent HBVr during *** determination of optimal strategy and timing of prophylactic anti-HBV therapy during ART still needs further investigation.

关键词： Assisted reproductive technology(ART) Hepatitis B virus(HBV) Immunosuppressive agent Pregnancy

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Optimized nitrogen application for maximizing yield and minimizing nitrogen loss in film mulching spring maize production on the Loess Plateau,China

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Journal of Integrative Agriculture 2024年第5期23卷 1671-1684页

作者： Qilong Song Jie zhang fangfang zhang Yufang Shen Shanchao Yue Shiqing Li State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau College of Natural Resources and EnvironmentNorthwestA&FUniversityYangling712100China Life Science Department Luoyang Normal UniversityLuoyang 471934China

Excessive use of N fertilizers(driven by high-yield goals)and its consequent environmental problems are becoming increasingly acute in agricultural systems.A 2-year field experiment was conducted to investigate the effects of three N application methods(application of solid granular urea once(OF)or twice(TF),application of solid granular urea mixed with controlled-release urea once(MF),and six N rates(0,60,120,180,240,and 300 kg N ha^(-1))on maize yield,economic benefits,N use efficiency,and soil N balance in the maize(Zea mays L.)film mulching system on the Loess Plateau,*** grain yield and economic return of maize were significantly affected by the N rate and application *** with the OF treatment,the MF treatment not only increased the maize yield(increased by 9.0-16.7%)but also improved the economic return(increased by 10.9-25.8%).The agronomic N use efficiency(NAE),N partial factor productivity(NPFP)and recovery N efficiency(NRE)were significantly improved by 19.3-66.7,9.0-16.7 and 40.2-71.5%,respectively,compared with the OF *** economic optimal N rate(EONR)of the OF,TF,and MF was 145.6,147.2,and 144.9 kg ha^(-1) in 2019,and 206.4,186.4,and 146.0 kg ha^(-1) in 2020,*** apparent soil N loss at EONR of the OF,TF,and MF were 97.1-100.5,78.5-79.3,and 50.5-68.1 kg ha^(-1),*** results support MF as a one-time N application method for delivering high yields and economic benefits,with low N input requirements within film mulching spring maize system on the Loess Plateau.

关键词： maize yield N management economic optimal N rate Loess Plateau

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Geology and genesis of the Aqishan Pb-Zn deposit,NW China:Insights from mineralogy,geochemistry,and in situ U-Pb geochronology

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Geoscience Frontiers 2024年第5期15卷 489-514页

作者： Kang Wang Yinhong Wang Jun Deng Jiajun Liu fangfang zhang Wei zhang Hui zhang Wenxin Gu Hong Chen State Key Laboratory of Geological Processes and Mineral Resources and School of Earth Sciences and ResourcesChina University of GeosciencesBeijing 100083China

The unique ore-forming processes and the key factors responsible for formation of skarn deposits are still obscure,and challenges exist in the determination of timing of Pb-Zn skarns owing to lacking suitable mineral *** we present detailed paragenesis,bulk geochemistry,in situ U-Pb dating of zircon and garnet,and garnet oxygen isotopes together with in situ zircon Hf-O isotopes from the newly discovered Aqishan Pb-Zn deposit in the southern Central Asian Orogenic Belt(CAOB),northwest *** comprehensive data set revealed a Late Carboniferous subduction-related distal Pb-Zn skarn system associated with the granitic ***-ore stage garnets are generally subhedral to euhedral with oscillatory zoning and show slightly fractionated rare earth element patterns with positive Eu anomalies that point to an infiltration metasomatism origin under high water/rock *** syn-ore stage sphalerite is typically enriched in Mn and Cd and has moderate Zn/Cd ratios(337–482),with a formation temperature of 265℃to 383℃,which indicate magmatic-hydrothermal *** isocons defined by P_(2)O_(5)decipher that the principal factors for skarn formation were elevated activities of Fe,Ca,and Si species,where remobilization of Pb metals,meanwhile,contributed to ore-forming budgets to mineralizing *** U-Pb dating of zircons from granite porphyry that occurs distal to the skarns and Pb-Zn orebodies shows that these intrusions emplaced at ca.311.3–310.6 Ma,recording the subduction of the Paleo-Tianshan oceanic *** garnets in close textural association with Pb-Zn sulfides yield indistinguishable in situ LA-ICP-MS U-Pb ages of 310.5±4.1 ***-rock geochemistry and in situ zircon Hf-O isotopes(δ^(18)O=4.6‰–6.0‰)indicate that the granite porphyry was derived from partial melting of juvenile crust and influenced by subducted oceanic *** isotope compositions of garnets(δ^(18)O=8.0‰–9.0‰)demonstrate that the equilibrated ore fluids

关键词： In situ U-Pb dating Garnet O isotopes Aqishan Pb-Zn deposit Skarn mineralization Southern CAOB

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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao fangfang zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Two-dimensional-lag complex logistic map with complex parameters and its encryption application

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Chinese Physics B 2024年第5期33卷 324-335页

作者：张芳芳武金波寇磊马凤英吴黎明张雪 School of Information and Automation Engineering Qilu University of Technology (Shandong Academy of Sciences)Jinan 250353China Institute of Oceanographic Instrumentation Qilu University of Technology (Shandong Academy of Sciences)Qingdao 266000China

With the rapid development of internet technology,security protection of information has become more and more prominent,especially information *** the great advantages of chaotic encryption,we propose a 2D-lag complex logistic map with complex parameters(2D-LCLMCP)and corresponding encryption ***,we present the model of the 2D-LCLMCP and analyze its chaotic properties and system stability through fixed points,Lyapunov exponent,bifurcation diagram,phase diagram,***,a block cipher algorithm based on the 2D-LCLMCP is proposed,the plaintext data is preprocessed using a pseudorandom sequence generated by the *** on the generalized Feistel cipher structure,a round function F is constructed using dynamic S-box and DNA encoding rules as the core of the block cipher *** generalized Feistel cipher structure consists of two F functions,four XOR operations,and one permutation operation per *** symmetric dynamic round keys that change with the plaintext are generated by the ***,experimental simulation and performance analysis tests are *** results show that the block cipher algorithm has low complexit,good diffusion and a large key *** the block length is 64 bits,only six rounds of encryption are required to provide sufficient security and robustness against cryptographic attacks.

关键词： logistic map block ciphers chaotic system encryption

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新型深紫外非线性光学晶体研究进展(特邀)

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激光与光电子学进展 2024年第1期61卷 327-335页

作者：潘世烈张方方中国科学院新疆理化技术研究所晶体材料研究中心新疆功能晶体材料重点实验室新疆乌鲁木齐830011

深紫外非线性光学晶体通过非线性光学效应改变激光频率,输出波长短于200 nm的深紫外激光,是全固态深紫外激光源的核心材料,在深紫外激光光刻、半导体芯片缺陷检测、高端科研装备等领域有重要的应用价值。近年来,新型深紫外非线性光学晶... 详细信息

深紫外非线性光学晶体通过非线性光学效应改变激光频率,输出波长短于200 nm的深紫外激光,是全固态深紫外激光源的核心材料,在深紫外激光光刻、半导体芯片缺陷检测、高端科研装备等领域有重要的应用价值。近年来,新型深紫外非线性光学晶体材料的研究取得了系列进展,涌现出若干具有应用前景的候选材料。本文着重介绍基于实验测得的折射率,相位匹配波长达到深紫外区的晶体材料,综述其在材料设计、晶体制备、基本性能和结构-性能关系等方面的研究进展,探讨了实用化深紫外非线性光学晶体材料的发展趋势。

关键词：深紫外非线性光学晶体材料设计晶体制备结构-性能关系

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凹腔结构对正丁烷部分预混火焰可燃极限的影响

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化工学报 2024年第5期75卷 2081-2090页

作者：李静张方芳王帅帅徐建华张朋远安徽工业大学建筑工程学院安徽马鞍山243032 中国能源建设集团安徽省电力设计院有限公司安徽合肥230601

部分预混火焰的稳定性对燃烧装置的安全、高效、低排放运行影响重大。以带有凹腔/无凹腔的微型圆柱燃烧器为目标模型,以正丁烷为目标燃料,通过实验和数值模拟相结合的方法,研究了在典型一次空气系数条件下,部分预混火焰在这两种燃烧器... 详细信息

部分预混火焰的稳定性对燃烧装置的安全、高效、低排放运行影响重大。以带有凹腔/无凹腔的微型圆柱燃烧器为目标模型,以正丁烷为目标燃料,通过实验和数值模拟相结合的方法,研究了在典型一次空气系数条件下,部分预混火焰在这两种燃烧器中的可燃极限范围。结果表明,第一,凹腔燃烧器的火焰稳定范围要远大于无凹腔燃烧器(相差约2个数量级),特别是对于吹熄极限的影响更为显著,这主要得益于凹腔燃烧器特有的双火焰结构(驻涡火焰+外火焰);第二,凹腔燃烧器在外火焰发生回火或脱火后,凹腔内的驻涡火焰仍可以在一定的范围内继续存在;第三,驻涡火焰对壁面的加热是外火焰稳定的关键。上述结论对部分预混燃烧装置的设计有一定的指导意义。

关键词：稳定性燃料可燃极限双火焰结构数值模拟

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富含谷胱甘肽酵母制品在葡萄酒酿造中的应用进展

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食品与发酵工业 2024年第11期50卷 336-343页

作者：任天赐张方方李莹孙悦宁夏大学食品科学与工程学院宁夏银川750021 安琪酵母股份有限公司湖北宜昌443003 宁夏大学葡萄酒与园艺学院宁夏银川750021 葡萄与葡萄酒教育部工程研究中心宁夏银川750021 宁夏葡萄与葡萄酒研究院宁夏银川750021

葡萄酒酿造过程中由于存在较高浓度乙醇、大量酚类物质和溶解氧等因素,易出现发酵缓慢、葡萄酒氧化褐变、香气损失等问题。富含谷胱甘肽酵母制品(glutathione-enriched inactive dry yeast derivatives,g-IDYs)是一种以活性酵母为原料... 详细信息

葡萄酒酿造过程中由于存在较高浓度乙醇、大量酚类物质和溶解氧等因素,易出现发酵缓慢、葡萄酒氧化褐变、香气损失等问题。富含谷胱甘肽酵母制品(glutathione-enriched inactive dry yeast derivatives,g-IDYs)是一种以活性酵母为原料制得的非活性酵母制剂,其能够在葡萄酒中释放大量谷胱甘肽,具有改善发酵迟缓、提高葡萄酒抗氧化能力、增加葡萄酒风味、减少SO_(2)使用量等功能。目前,市场上g-IDYs产品多样,其有效成分差异较大,且在葡萄酒酿造中作用机制不明晰,增加了其有效解决生产问题的应用难度。该文对g-IDYs产品的主要功能成分、在葡萄酒酿造中的应用,以及各物质成分在葡萄酒酿造中作用机制及抗氧化性和测定方法进行了简要综述,为g-IDYs在葡萄酒酿造中的合理使用提供理论参考。

关键词：酵母制品谷胱甘肽葡萄酒抗氧化

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区域产业税负差异与制造业集聚——基于新经济地理学的理论与实证分析

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税务研究 2024年第6期 120-126页

作者：金强张芳芳李亚美温州商学院金融贸易学院重庆工商大学派斯学院

区域产业税负差异会引起制造业迁移和空间再分布,进而影响区域制造业集聚规模和结构调整。基于新经济地理学的理论分析及空间计量的实证研究表明,区域产业税负差异改变了要素禀赋相对价格和产业投资收益水平,导致流动性生产要素从“区... 详细信息

区域产业税负差异会引起制造业迁移和空间再分布,进而影响区域制造业集聚规模和结构调整。基于新经济地理学的理论分析及空间计量的实证研究表明,区域产业税负差异改变了要素禀赋相对价格和产业投资收益水平,导致流动性生产要素从“区位税负劣势”地区流入“区位税负优势”地区,引起制造业迁移和空间分布调整。同时,降低要素流通成本可以放大“区位税负优势”地区的虹吸效应,进一步提升制造业集聚效应水平。结合研究结论,建议进一步规制恶性税收竞争,培育良性市场竞争环境;规范区域性税收政策,逐步推动区域性税收政策向产业性税收政策转变;完善要素流通环节税收支持政策,强化税收政策产业集聚效应。

关键词：区域产业税负差异区位税负优势制造业集聚产业集聚税收政策税收竞争

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IL-36RN基因突变的儿童泛发性脓疱型银屑病1例

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皮肤科学通报 2024年第2期41卷 217-219页

作者：张芳芳大连市妇女儿童医疗中心(集团)皮肤科辽宁大连116037

患儿女,1岁10个月,出生20 d后全身反复出现大片环形红斑、脓疱,伴有反复发热,热峰39℃。皮肤科情况:周身可见弥漫环形红斑,红斑基础上可见针尖大小表浅脓疱,局部干燥脱屑,对称分布。全外显子基因测序结果显示:患儿IL36RN基因有1个纯合突... 详细信息

患儿女,1岁10个月,出生20 d后全身反复出现大片环形红斑、脓疱,伴有反复发热,热峰39℃。皮肤科情况:周身可见弥漫环形红斑,红斑基础上可见针尖大小表浅脓疱,局部干燥脱屑,对称分布。全外显子基因测序结果显示:患儿IL36RN基因有1个纯合突变,c.115+6T>C纯合突变,c.115+6T>C(splicing)受检人父亲该位点杂合变异,受检人母亲该位点杂合变异。诊断:泛发性脓疱型银屑病。IL36RN基因纯合突变可能是该例患儿发生泛发性脓疱型银屑病的原因。给予益赛普治疗患儿,能有效地控制病情。

关键词：泛发性脓疱型银屑病 IL-36RN 重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白

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