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Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 101-110页

作者： da zhang Xiaoqing zhang Li Yang Yan Zhao Xingang Hu School of Life Sciences Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participants with different levels of red blood ***:Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy,blood deficiency,and anemia groups(30 individuals in the healthy and blood deficiency group respectively,and 13 in the anemia group).The physical and mental conditions of the participants were evaluated through questionnaires,and emotional fluctuations were assessed through an emotion-inducing experiment,in which participants watched video segments designed to induce specific *** expression levels of miR191,Riok3,and Mxi1 from venous blood samples were also ***:The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms,depression,anxiety,and other negative *** gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia *** the emotional score of disgust on video stage,the main effect was significant(F=335.58,P<.001),which showed that watching the three videos caused participants to have a dominant emotion,and there is a difference on group(F=5.35,P=.01),with higher disgust scores in the anemia and blood deficiency *** symptoms of blood deficiency and anemia,such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression(r=-0.38 and-0.31 respectively),but was significantly positively correlated with miR191 expression(r=0.29).Conclusion:We determined that a close relationship exists between red blood cell levels and emotional *** findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological pro

关键词： Anemia Blood deficiency Emotional regulation miR191-Riok3-Mxi1 pathway Emotion-inducing experiments

Asymmetry in circulation system and cardiovascular diseases

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Medicine in Novel Technology and Devices 2024年第1期21卷 1-9页

作者： Chang Liu Sheng Xie Yangchen Li da zhang Deyu Li Chi zhang Key Laboratory of Biomechanics and Mechanobiology Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Radiology China-Japan Friendship HospitalBeijing100029China Children’s Hospital Capital Institute of Pediatrics Beijing100020China Department of Physics Sichuan Cancer HospitalChengdu610041China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing100191China

Asymmetries in the human vascular system and cardiovascular disease are *** physiological asymmetry can manifest in the morphological structure and blood flow state,whereas pathological asymmetry can reflect differences in the occurrence and cure of bilateral vascular *** causes associated with these asymmetrical differences may be demand-driven or due to vascular grading or asymmetries in other physiological *** article aims to review the asymmetry of several typical arteries,including cerebral,cervical,and limb arteries,and lists possible causes to emphasize the necessity of considering asymmetric factors in the prevention,treatment,and rehabilitation of vascular *** research on asymmetries in the vascular system may improve the risk assessment and personalized treatment of vascular diseases.

关键词： Vascular morphology Hemodynamics Cardiovasculardiseases Asymmetry

基于区块链和星际文件系统技术的高校师德档案信息数据共享平台建构策略

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档案学研究 2024年第2期 126-133页

作者：张达黑龙江大学人事处(教师工作部) 哈尔滨150080

随着区块链技术的发展,其受到档案行业的高度关注。从数据信息管理的角度看,区块链技术利用其去中心化、去信任化、防篡改、匿名、开放、自治、可追溯等特性,能够增强数据管理的安全性、可靠性,这与师德档案信息管理需求高度契合。本文... 详细信息

随着区块链技术的发展,其受到档案行业的高度关注。从数据信息管理的角度看,区块链技术利用其去中心化、去信任化、防篡改、匿名、开放、自治、可追溯等特性,能够增强数据管理的安全性、可靠性,这与师德档案信息管理需求高度契合。本文设计了基于星际文件系统(IPFS)和联盟区块链技术的师德档案信息数据共享平台,利用Hyperledger Fabric建立所有参与者共同管理交易的系统,建构链上、链下相结合的师德档案信息数据存储策略,设计基于属性的加密机制策略实现细粒度的师德信息数据访问控制,从理论层面解决了师德档案信息数据的数据孤岛、数据存储成本昂贵以及数据安全传输的问题。

关键词：师德档案区块链星际文件系统

Effectiveness and Safety of Qishen Yiqi Dripping Pill in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention:3-Year Results from a Multicentre Cohort Study

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Chinese Journal of Integrative Medicine 2024年第10期30卷 877-885页

作者： BAI Rui-na GU Feng CHE Qian-zi zhang Xuan CAI Ya-jie XI Rui-xi ZHAO Yang GUO Ming DONG Guo-ju GAO Zhu-ye FU Chang-geng WANG Pei-li DU Jian-peng zhang da-wu DUAN Wen-hui LI Li-zhi YANG Qiao-ning SHI da-zhuo Department of Cardiovascular Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing100091China Department of Evidence-Based Medicine Basic Research Laboratory Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing100700China Department of Traditional Chinese Medicine Beijing Shangdi HospitalBeijing100193China National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Traditional Chinese MedicineBeijing100091China

Objectives:To evaluate the effectiveness and safety of Qishen Yiqi Dripping Pill(QSYQ)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods:This multicentre prospective cohort study was conducted at 40 centers in *** with ACS after PCI entered either the QSYQ or Western medicine(WM)groups naturally based on whether they had received QSYQ before *** group received QSYQ(0.52 g,3 times a day for 12 months)in addition to *** primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent *** secondary endpoint included rehospitalization due to ACS,heart failure,stroke,and other thrombotic *** of life was assessed by the Seattle Angina Questionnaire(SAQ).Results:A total of 936 patients completed follow-up of the primary endpoint from February 2012 to December ***,487 patients received QSYQ and *** a median follow-up of 566 days(inter quartile range,IQR,517–602),the primary endpoint occurred in 46(9.45%)and 65(14.48%)patients in QSYQ and WM groups respectively[adjusted hazard ratio(HR)0.60,95%confidence interval(CI)0.41–0.90;P=0.013].The secondary endpoint occurred in 61(12.53%)and 74(16.48%)patients in QSYQ and WM groups,respectively(adjusted HR 0.76,95%CI 0.53–1.09;P=0.136).In sensitivity analysis,the results still demonstrated that WM combined with QSYQ reduced the risk of the primary endpoint(HR 0.67,95%CI 0.46–0.98;P=0.039).Moreover,QSYQ improved the disease perception domain of the SAQ(P<0.05).Conclusions:In patients with ACS after PCI,QSYQ combined with WM reduced the incidence of the primary *** findings provide a promising option for managing ACS after PCI and suggest the potential treatment for reducing the risk of primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent revascularization through intermittent administration of QSYQ.(Registration *** CTR-OOC-14005552).

关键词： Qishen Yiqi Dripping Pill acute coronary syndrome percutaneous coronary intervention primary and secondary endpoint

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数据中心纳入全国碳排放权交易市场机制研究

中国电机工程学报 2024年第14期44卷 5562-5573,I0010页

作者：朱子恒张策丁肇豪张达清华大学能源环境经济研究所北京市海淀区100084 清华大学智能产业研究院北京市海淀区100084 新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

当前,我国数据中心产业发展迅速,耗电量同步快速增长,导致了大量的间接温室气体排放。在“碳达峰、碳中和”目标提出的背景下,将数据中心纳入全国碳排放权交易市场(简称全国碳市场)可以引导数据中心提升能效和使用清洁电力。该文参考全... 详细信息

当前,我国数据中心产业发展迅速,耗电量同步快速增长,导致了大量的间接温室气体排放。在“碳达峰、碳中和”目标提出的背景下,将数据中心纳入全国碳排放权交易市场(简称全国碳市场)可以引导数据中心提升能效和使用清洁电力。该文参考全国碳市场运行基本原则,从数据中心各组成部分的运行特征出发,提出数据中心纳入全国碳市场后的碳排放配额分配方法、碳排放核算方法、数据质量控制与绿色电力交易等管理机制,并提出纳入全国碳市场的数据中心责任主体与规模边界建议。

关键词：数据中心全国碳排放权交易市场机制设计电力负荷

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Antagonistic MADS-box transcription factors SEEDSTICK and SEPALLATA3 form a transcriptional regulatory network that regulates seed oil accumulation

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Journal of Integrative Plant Biology 2024年第1期66卷 121-142页

作者： Shuangcheng He Yuanchang Min Zijin Liu Fang Zhi Rong Ma Ankang Ge Shixiang Wang Yu Zhao danshuai Peng da zhang Minshan Jin Bo Song Jianjun Wang Yuan Guo Mingxun Chen State Key Laboratory for Crop Stress Resistance and High‐Efficiency Production National Yangling Agricultural Biotechnology&Breeding CenterShaanxi Key Laboratory of Crop HeterosisCollege of AgronomyNorthwest A&F UniversityYangling 712100China State Key Laboratory for Crop Stress Resistance and High‐Efficiency Production Shaanxi Key Laboratory of AppleCollege of HorticultureNorthwest A&F UniversityYangling 712100China

Transcriptional regulation is essential for balancing multiple metabolic pathways that influence oil accumulation in *** far,the transcriptional regulatory mechanisms that govern seed oil accumulation remain largely ***,we identified the transcriptional regulatory network composed of MADS-box transcription factors SEEDSTICK(STK)and SEPALLATA3(SEP3),which bridges several key genes to regulate oil accumulation in *** found that STK,highly expressed in the developing embryo,positively regulates seed oil accumulation in Arabidopsis(Arabidopsis thaliana).Furthermore,we discovered that SEP3 physically interacts with STK in vivo and in *** oil content is increased by the SEP3 mutation,while it is decreased by SEP3 *** chromatin immunoprecipitation,electrophoretic mobility shift assay,and transient dual-luciferase reporter assays showed that STK positively regulates seed oil accumulation by directly repressing the expression of MYB5,SEP3,and SEED FATTY ACID REDUCER 4(SFAR4).Moreover,genetic and molecular analyses demonstrated that STK and SEP3 antagonistically regulate seed oil production and that SEP3 weakens the binding ability of STK to MYB5,SEP3,and ***,we demonstrated that TRANSPARENT TESTA 8(TT8)and ACYL-ACYL CARRIER PROTEIN DESATURASE 3(AAD3)are direct targets of MYB5 during seed oil accumulation in ***,our findings provide the transcriptional regulatory network antagonistically orchestrated by STK and SEP3,which fine tunes oil accumulation in seeds.

关键词： seed oil accumulation SEP3 STK transcription factor transcriptional regulation

The 2022 report of synergetic roadmap on carbon neutrality and clean air for China:Accelerating transition in key sectors

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Environmental Science and Ecotechnology 2024年第3期19卷 4-18页

作者： Yu Lei Zhicong Yin Xi Lu Qiang zhang Jicheng Gong Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Renjie Chen Shi Chen Wenhui Chen Jing Cheng Xiyuan Chi Hancheng dai Xiangzhao Feng Guannan Geng Jianlin Hu Shan Hu Cunrui Huang Tiantian Li Wei Li Xiaomei Li Jun Liu Xin Liu Zhu Liu Jinghui Ma Yue Qin dan Tong Xuhui Wang Xuying Wang Rui Wu Qingyang Xiao Yang Xie Xiaolong Xu Tao Xue Haipeng Yu da zhang Ning zhang Shaohui zhang Shaojun zhang Xian zhang Xin zhang Zengkai zhang Bo Zheng Yixuan Zheng Jian Zhou Tong Zhu Jinnan Wang Kebin He Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental PlanningBeijing100041China Center for Carbon Neutrality Chinese Academy of Environmental PlanningBeijing100041China Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing210044China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China State Key Joint Laboratory for Environment Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and HealthPeking UniversityBeijing100871China National Center for Climate Change Strategy and International CooperationBeijing100035China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China School of Public Health Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of HealthFudan UniversityShanghai200032China School of Economics and Management Beijing University of Chemical TechnologyBeijing100029China Department of Earth System Science University of CaliforniaIrvineCA92697USA National Meteorological Center China Meteorological AdministrationBeijing100081China College of Environmental Sciences and Engineering Peking UniversityBeijing100871China Policy Research Center for Environment and Economy Ministry of Ecology and Environment of the People's Republic of ChinaBeijing100029China Jiangsu Key Laboratory of Atmospheric Environment Monitoring

China is now confronting the intertwined challenges of air pollution and climate *** the high synergies between air pollution abatement and climate change mitigation,the Chinese government is actively promoting synergetic control of these two *** Synergetic Roadmap project was launched in 2021 to track and analyze the progress of synergetic control in China by developing and monitoring key *** Synergetic Roadmap 2022 report is the first annual update,featuring 20 indicators across five aspects:synergetic governance system and practices,progress in structural transition,air pollution and associated weather-climate interactions,sources,sinks,and mitigation pathway of atmospheric composition,and health impacts and benefits of coordinated *** to the comprehensive review presented in the 2021 report,the Synergetic Roadmap 2022 report places particular emphasis on progress in 2021 with highlights on actions in key sectors and the relevant *** milestones include the proportion of non-fossil power generation capacity surpassing coal-fired capacity for the first time,a decline in the production of crude steel and cement after years of growth,and the surging penetration of electric ***,in 2022,China issued the first national policy that synergizes abatements of pollution and carbon emissions,marking a new era for China's pollution-carbon *** changes highlight China's efforts to reshape its energy,economic,and transportation structures to meet the demand for synergetic control and sustainable ***,the country has witnessed a slowdown in carbon emission growth,improved air quality,and increased health benefits in recent years.

关键词： Synergetic roadmap Carbon neutrality Clean air

基于MIBBPSO-SdaE的液压系统故障诊断

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机床与液压 2024年第16期52卷 207-215页

作者：郑坤张达青岛科技大学自动化与电子工程学院山东青岛266061

为了监测液压系统的故障状态,需要安装多种传感器,采集的数据庞大且复杂,通过多特征计算可以得到多种特征。为了使诊断更加准确,提出一种MIBBPSO-SdaE的故障诊断方法。基于互信息的粒子群(MIBBPSO)特征选择方法以及标签相关性的蜂群初... 详细信息

为了监测液压系统的故障状态,需要安装多种传感器,采集的数据庞大且复杂,通过多特征计算可以得到多种特征。为了使诊断更加准确,提出一种MIBBPSO-SdaE的故障诊断方法。基于互信息的粒子群(MIBBPSO)特征选择方法以及标签相关性的蜂群初始化策略,利用特征和类标签之间的相关性来加速收敛;利用2个局部搜索算子增强算法的利用性能;使用一种自适应翻转变异算子找出最优的特征子集。然后将筛选出的特征子集进行数据融合,输入到经过训练的堆叠降噪自编码器(SdaE)的模型中进行故障诊断。结果表明:MIBBPSO-SdaE方法对柱塞泵、冷却器、节流阀以及蓄能器4种元件的诊断准确率分别为99.5%、100%、96.52%和98.1%,能够较准确地识别故障类型。

关键词：液压系统堆叠降噪自编码器(SdaE) 基于互信息的粒子群(MIBBPSO) 特征选择故障诊断

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舰载机阻拦着舰系统建模与仿真

机床与液压 2024年第14期52卷 179-186页

作者：郑坤张达青岛科技大学自动化与电子工程学院山东青岛266061

阻拦装置作为保障舰载机安全着舰的关键装备,其稳定运行对舰载机执行训练以及作战任务具有重要意义。以MK7-3型液压阻拦装置为参考,研究其结构组成以及工作原理,并搭建相应的数学模型,应用MATLAB的可视化仿真工具Simulink对阻拦系统进... 详细信息

阻拦装置作为保障舰载机安全着舰的关键装备,其稳定运行对舰载机执行训练以及作战任务具有重要意义。以MK7-3型液压阻拦装置为参考,研究其结构组成以及工作原理,并搭建相应的数学模型,应用MATLAB的可视化仿真工具Simulink对阻拦系统进行仿真模拟,建立舰载机在不同的质量、速度及偏航状态下着舰的阻拦系统模型。结果表明:在偏移量不超过跑道宽度25%内,此阻拦系统模型可以在100 m内对舰载机进行拦截,用时为3~4 s,且将结果与美军标中MK7-3型液压拦阻装置阻拦力曲线进行对比可知,所建立的模型能够准确描述阻拦着舰中阻拦系统的工作过程,达到安全着舰的目的。

关键词： Simulink仿真舰载机阻拦装置对中阻拦偏航