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公路工程施工中联锁块路面施工技术的运用

中国高新科技 2024年第9期 131-132,46页

作者：张春晓沂水县农村公路服务中心山东临沂276400

联锁块路面是工程造价低、结构强度大、使用寿命长、维护较为便利的新型路面结构形式,施工过程中无需应用重型机械设备,可节约施工后期养护的时间及资金成本,在公路工程建设中具有较高的应用价值。文章从联锁块路面施工的基本流程、基... 详细信息

联锁块路面是工程造价低、结构强度大、使用寿命长、维护较为便利的新型路面结构形式,施工过程中无需应用重型机械设备,可节约施工后期养护的时间及资金成本,在公路工程建设中具有较高的应用价值。文章从联锁块路面施工的基本流程、基层作业、面层施工、特殊部位处理4个方面,探讨公路工程中联锁块路面施工技术的正确应用方式。

关键词：公路工程联锁块路面施工

基于星点亚像元误差补偿的大视场红外相机在轨检焦方法

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航天返回与遥感 2024年第4期45卷 58-70页

作者：杨舒琪张春晓程普邢坤北京空间机电研究所北京100094 海军潜航学院青岛266000

针对大视场红外相机在轨调焦时受大气条件、地物丰富度、月相角等因素影响导致对地调焦和对月调焦周期长、效率低的问题,文章提出一种基于星点亚像元误差补偿的红外相机在轨检焦方法,通过对未经大气退化的星点图像进行精准质心定位提取... 详细信息

针对大视场红外相机在轨调焦时受大气条件、地物丰富度、月相角等因素影响导致对地调焦和对月调焦周期长、效率低的问题,文章提出一种基于星点亚像元误差补偿的红外相机在轨检焦方法,通过对未经大气退化的星点图像进行精准质心定位提取清晰度评价指标,有效规避外界因素的影响,提升在轨检焦效率,保障在轨检焦精度。首先对星点图像分别采用自适应阈值质心法和高斯拟合法提取质心估计值;依据图像信噪比、星点目标能量集中度确定最佳因子,构建误差补偿模型进行精确质心定位;再提取图像点扩散函数的波形半高宽(Full Width at Half Maximum,FWHM)作为在轨检焦清晰度评价指标;设置不同谱段、不同能量集中度的星点红外图像作为在轨检焦图像,分别采用质心法、高斯拟合法及星点亚像元误差补偿方法进行目标质心提取并估计FWHM,实验结果表明:三种方法的质心提取平均误差分别为0.1195、0.0107、0.0027,均方根误差分别为0.1210、0.0124、0.0085,星点亚像元误差补偿方法质心提取误差最小,稳定性最好。能量集中度为0.4~0.8之间时,采用星点亚像元误差补偿方法质心提取平均误差均小于0.01,优于其他方法。在此基础上,采用该方法提取的FWHM平均精度提升了三倍以上,且不受星点质心位置随机性的影响,对于实现基于恒星的在轨检焦具有较高的可靠性和稳定性,满足在轨检焦要求。

关键词：大视场红外相机误差补偿在轨检焦能量集中度提取质心

Sex differences in estrogen receptor promoter expression in the area postrema

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Neural Regeneration Research 2013年第2期8卷 149-155页

作者： chunxiao zhang Tomohiro Hamada Department of Physiology Norman Bethune College of Medicine Jilin University Department of Physiology Nippon Medical School

Estrogen receptor a is widely distributed in the rat brain, but the tissue- or target-specificity of the estrogen receptor a gene promoters remains unknown. In the present study, we used transgenic rats expressing enhanced green fluorescent protein under the control of the estrogen receptor a 0/B promoter to examine expression driven by this promoter in two significant nuclei that regulate cardiovascular activity, the area postrema and the nucleus tractus solitarius. Immunohistochemistry showed that enhanced green fluorescent protein-labeled cells were distributed in the area postrema and the nucleus tractus solitarius of both female and male transgenic rats, and a neural network of enhanced green fluorescent protein-positive fibers was seen between the area postrema and the nucleus tractus solitarius. The number of enhanced green fluorescent protein-labeled cells in the area postrema of female rats was significantly higher than in the males, but no significant difference was found in the number of enhanced green fluorescent protein-labeled cells in the nucleus tractus solitarius. The sex differences in the number of enhanced green fluorescent protein-labeled cells in the area postrema was not affected after ovariectomy or 1713-estradiol benzoate treatment in adult rats. Our results suggest that the effects of estrogen in the area postrema are related to the expression of estrogen receptor a under the control of the 0/B promoter, and changes in the sex hormone environment in the adult period do not affect estrogen receptor a expression in the area postrema or the nucleus tractus solitarius.

关键词： neural regeneration basic research estrogen receptor a promoter green fluorescent protein sexdifferences area postrema nucleus tractus solitarius medulla estrogen rats grant-supportedpaper photographs-containing paper neuroregeneration

血清CA125和HE4的动态变化在预测卵巢高级别浆液性腺癌无进展生存期方面的价值研究

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南京医科大学学报（自然科学版） 2024年第9期44卷 1207-1216页

作者：何乐伟王充杨诗敏张春晓席晓薇南京医科大学附属上海一院临床医学院妇产科上海200080 上海交通大学医学院附属第一人民医院妇产科上海200080

目的:研究血清糖类抗原125(carbohydrate antigen 125,CA125)和人附睾蛋白4(human epididymal protein 4,HE4)在术前以及术后化疗过程中的动态变化与卵巢癌患者无进展生存期(progression-free survival,PFS)及铂敏感性之间的关系。方法:回顾性分析上海交通大学医学院附属第一人民医院妇科肿瘤病房收治的经过规范化治疗的卵巢癌患者术前、术后化疗前,以及化疗中至少2次血清CA125及HE4水平,并收集对铂类药物敏感性、PFS等数据。主要统计学方法包括卡方检验、t检验、方差分析和Logistic回归分析及Cox比例风险回归分析等。结果:对117例卵巢高级别浆液性腺癌患者的分析结果提示,CA125和HE4阳性与肿瘤较高期别、多腹水量、不满意减灭、腹水细胞学阳性相关。通过Cox回归分析验证得出CA125和HE4均是预后的危险因素(OR=4.29,P=0.010;OR=1.77,P=0.049)。CA125、HE4均阳性患者组与仅CA125阳性的患者组比较,预后差异无统计学意义(P>0.05)。根据公式t_(1/2)=t_(1)/[2×lg(c_(1)/c_(2))]计算CA125和HE4半衰期,截取术前CA125和HE4、术后CA125和HE4最低值、CA125和HE4半衰期的最优cut-off值,分别为436 U/L和400 pmol/L、12 U/L和35 pmol/L、21 d和25 d,预后分析提示除了HE4最低值与预后无关,其余均和预后相关,其中CA125半衰期>21 d的HR值最高为3.28,中位PFS下降57.5%(P21 d(AUC=0.76)、CA125最低值>12 U/L(AUC=0.70)及第3程化疗后CA125未回归正常(AUC=0.71)这3项指标对于预测存在3年内复发有一定的临床价值,其灵敏度分别为71.8%、68.3%、68.2%,特异度分别为79.6%、71.7%、72.6%。结论:CA125半衰期、CA125化疗过程中最低值、第3程化疗后CA125未回归正常及6项指标中≥2项阳性这4个指标对于预测存在3年内复发有一定的临床价值,而对于预测铂敏感性的价值有待进一步探索。

关键词：卵巢高级别浆液性腺癌无进展生存期 CA125 HE4 临床研究

Transient Polymer Hydrogels Based on Dynamic Covalent Borate Ester Bonds

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Chinese Journal of Chemistry 2022年第23期40卷 2794-2800,I0002页

作者： chunxiao zhang Haoyue Lu Xu Wang Shenzhen Research Institute of Shandong University Shenzhen Guangdong 518057China National Engineering Research Centerfor Colloidal Materials School of Chemistry and Chemical EngineeringShandong University JinanShandong 250100China

In nature, biological systems maintain their unique structures and functions by using nonequilibrium processes driven by chemical fuels. Inspired by natural systems, transient hydrogel systems based on chemical reaction networks have been developed that are in thermodynamically nonequilibrium states. The formation of dynamic covalent bonds is an effective tool for designing analogous systems. Herein, we design a transient polymer hydrogel based on fuel-mediated covalent borate ester bonds. The pH-sensitive covalent borate ester bond is formed by the reaction between polyvinyl alcohol (PVA) and boric acid (B(OH)_(3)). Sodium hydroxide (NaOH) and 1,3-propanesulfonate (PrS) are used together as the chemical fuels to temporally control the pH of the system. Meanwhile, the lifetime of the transient hydrogel can be simply controlled by adjusting the composition of the chemical fuel, and the cyclic phase transitions can also be achieved. These programmable transient hydrogels have potential applications in the fields of information transmission and fluid guidance.

关键词： Polymers Gels Nonequilibrium processes Transition states Borate ester bonds

Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion

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Neural Regeneration Research 2011年第14期6卷 1086-1090页

作者： Haiyan Xu Chengwei zhang chunxiao zhang Department of Physiology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China Department of Anesthesiology the Second Hospital of Jilin University Changchun 130041 Jilin Province China

The present study aimed to observe cortical expression of Bcl-2 and Bax,cysteine-dependent aspartate directed proteases-3 activity and apoptotic cell death in a rat model of middle cerebral artery occlusion pretreated with *** showed that,propofol pretreatment significantly reduced oxidative stress levels and attenuated neuronal apoptosis in the cortex of *** pretreatment upregulated Bcl-2 expression,and downregulated Bax expression and cysteine-dependent aspartate directed proteases-3 *** findings indicate that propofol pretreatment inhibits cell apoptosis during focal cerebral ischemia/reperfusion *** neuroprotective effect is most likely achieved through the Bcl-2/Bax/cysteine-dependent aspartate directed proteases-3 pathway.

关键词： propofol cerebral ischemia/reperfusion apoptosis neuroprotection neural regeneration

OGDHL、FHL1在非小细胞肺癌组织中的表达及其临床意义

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实用癌症杂志 2024年第2期39卷 200-204页

作者：张春晓张群妹鲁广建新乡医学院第一附属医院 453100

目的分析OGDHL、4个半LIM结构域蛋白1(FHL1)在非小细胞肺癌组织中的表达水平及其临床意义。方法选取80例非小细胞肺癌患者癌组织标本、癌旁组织标本(距肿瘤边缘4cm处),采用免疫组织化学染色法检测所有标本组织中OGDHL、FHL1表达水平。... 详细信息

目的分析OGDHL、4个半LIM结构域蛋白1(FHL1)在非小细胞肺癌组织中的表达水平及其临床意义。方法选取80例非小细胞肺癌患者癌组织标本、癌旁组织标本(距肿瘤边缘4cm处),采用免疫组织化学染色法检测所有标本组织中OGDHL、FHL1表达水平。采用χ^(2)检验分析OGDHL、FHL1表达与患者病理特征的关系,采用Kaplan-Meier生存曲线分析OGDHL、FHL1表达与患者预后的关系,多因素Cox回归模型分析非小细胞肺癌患者预后的影响因素。结果非小细胞肺癌患者癌组织OGDHL高表达率明显低于癌旁组织(35.00%vs 62.50%,P<0.05),FHL1高表达率明显高于癌旁组织(67.50%vs 40.00%,P<0.05)。OGDHL、FHL1表达水平与非小细胞肺癌患者TNM分期、淋巴结转移、分化程度密切相关(P<0.05)。OGDHL高表达患者术后5年总生存率为82.14%,低表达患者术后5年总生存率为36.54%,两者比较差异有统计学意义(P<0.05);FHL1高表达患者术后5年总生存率为40.74%,低表达患者术后5年总生存率为76.92%,两者比较差异有统计学意义(P<0.05)。单因素分析得出,TNM分期、淋巴结转移、分化程度、OGDHL表达、FHL1表达均与非小细胞肺癌患者预后密切相关(P<0.05)。TNMⅢ期、淋巴结转移、低分化、OGDHL低表达、FHL1高表达均为影响非小细胞肺癌患者预后的独立危险因素(P<0.05)。结论非小细胞肺癌患者癌组织中OGDHL蛋白呈低表达,FHL1蛋白呈高表达,两者表达水平与非小细胞肺癌患者的临床病理特征及预后密切相关,能够作为评估患者预后的有效指标。

关键词：非小细胞肺癌 OGDHL 4个半LIM结构域蛋白1 预后

Simultaneous CO_(2) capture and thermochemical heat storage by modified carbide slag in coupled calcium looping and CaO/Ca(OH)2 cycles

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Chinese Journal of Chemical Engineering 2021年第8期34卷 76-85页

作者： chunxiao zhang Yingjie Li Zhiguo Bian Wan zhang Zeyan Wang School of Energy and Power Engineering Shandong UniversityJinan 250061China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China

The simultaneous CO_(2) capture and heat storage performances of the modified carbide slag with byproduct of biodiesel were investigated in the process coupled calcium looping and CaO/Ca(OH)2 thermochemical heat storage using air as the heat transfer *** modified carbide slag with by-product of biodiesel exhibits superior CO_(2) capture and heat storage capacities in the coupled calcium looping and heat storage *** hydration conversion and heat storage density of the modified carbide slag after 30 heat storage cycles are 0.65 mol·mol^(-1) and 1.14 GJ·t^(-1),respectively,which are 1.6 times as high as those of calcined carbide *** negative effect of CO_(2) in air as the heat storage fluid on the heat storage capacity of the modified carbide slag is overcome by introducing CO_(2) capture *** addition,the CO_(2) capture reactivity of the modified carbide slag after the multiple calcium looping cycles is enhanced by the introduction of heat storage *** introducing 10 heat storage cycles after the 10th and 15th CO_(2) capture cycles,the CO_(2) capture capacities of the modified carbide slag are subsequently improved by 32%and 43%,*** porous and loose structure of modified carbide slag reduces the diffusion resistances of CO_(2) and steam in the material in the coupled *** formed CaCO_(3)in the modified carbide slag as a result of air as the heat transfer fluid in heat storage cycles decomposes to regenerate CaO in calcium looping cycles,which improves heat storage ***,the modified carbide slag with by-product of biodiesel seems promising in the coupled calcium looping and CaO/Ca(OH)_(2) heat storage cycles.

关键词： Carbide slag Calcium looping CaO/Ca(OH)_(2)heat storage Modification By-product of biodiesel CO_(2)capture

Exothermic Performance of the Calcined Limestone Determined by Exothermic Temperature under Fluidization during CaCO_(3)/CaO Energy Storage Cycles

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Journal of Thermal Science 2023年第5期32卷 1784-1796页

作者： FANG Yi ZHAO Jianli zhang chunxiao LI Yingjie Shandong Engineering Laboratory for High-Efficiency Energy Conservation and Energy Storage Technology&Equipment School of Energy and Power EngineeringShandong UniversityJi'nan 250061China

Thermochemical energy storage based on CaO/CaCO_(3)cycles has obtained significant attention as an alternative energy storage solution for concentrated solar power *** view of the applicability of fluidized bed reactors for CaO/CaCO_(3)heat storage,it is imperative to study the factors related to the heat release performance of *** work presents an exothermic experiment on calcined limestone under fluidization,exploring the impact of initial temperature,CO_(2)concentration,particle size,superficial gas velocity,and number of cycles on the exothermic performance of *** result indicates that CaO with high initial temperature leads to higher exothermic temperature,with better exothermic stability under *** optimal initial temperature range of 600℃-650℃exists with an actual CaO conversion rate deviating merely 2%from theoretical *** CO_(2)concentration augments the exothermic temperature and rate of CaO,while also improves the effective conversion of ***,high CO_(2)concentrations exacerbate the sintering and deactivation of *** superficial gas velocity and small particle size shorten the exothermic time by increasing heat dissipation,but has minimal effect on the exothermic ***,the exothermic properties of CaO under fluidized and static conditions are *** result shows that exothermic temperature and exothermic rate of CaO under fluidization are enhanced,displaying higher heat storage performance than that under static *** study provides valuable insights for optimizing the exothermic performance of CaO in fluidized bed reactors,contributing to advanced thermochemical energy storage for concentrated solar power plants.

关键词： CaO/CaCO_(3)heat storage cycles exothermic temperature fluidization exothermic performance