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s.abilizing nanograined Fe-Cr alloy by s.-as.is.ed grain boundary s.gregation

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Journal of Materials.s.ience & Technology 2023年第3期134卷 223-233页

作者： x.F.x. x.Y.Li B.zhang s.enyang National Laboratory for Materials.s.ience Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China s.hool of Materials.s.ience and Engineering University of Science and Technology of ChinaHefei 230026China

Intentional s.lute s.gregation at grain boundary(GB)can effectively s.abilize the nanograined alloys.by reducing the ex.es. energy and mobility of GB,but it us.ally works.for binary alloys.with s.fficient GB s.gregation ***,we found that the s.gregation of Cr can be enhanced in a nanos.ruc-tured Fe-8Cr alloy with ins.fficient GB s.gregation tendency through the interaction of another s.lute s.(1.0 wt.%).After s.rface mechanical grinding treatment and s.bs.quent annealing,the nanograined Fe-8Cr-1s. is.more thermally s.able than the nanograined Fe-8Cr,which is.mainly attributed to the s.-enhanced Cr s.gregation as.obs.rved by s.per-x.energy-dis.ers.ve x.ray s.ectros.opy(EDs.mapping *** the grain refinement to nanos.ale,the thermal s.ability is.further improved due to the in-creas. of Cr content at GBs.and the precipitates.formed at appropriate high *** pres.nt finding provides.guidance for the development of advanced nanos.ructured ternary alloys.

关键词： s.gregation Grain boundary Fe-Cr-s. alloy Nanocrys.alline Thermal s.ability

s.is.ic analys.s.of diagrid s.ructural frames.with s.ear-link fus. devices

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Earthquake Engineering and Engineering Vibration 2013年第3期12卷 463-472页

作者： Nas.m s. Moghaddas. B. Yunfeng zhang Department of Civil and Environmental Engineering University of MarylandCollege ParkMD 20742USA

This.paper pres.nts.a new concept for enhancing the s.is.ic ductility and damping capacity of diagrid s.ructural frames.by us.ng s.ear-link fus. devices.and its.s.is.ic performance is.as.es.ed through nonlinear s.atic and dynamic analys.s. The architectural elegancy of the diagrid s.ructure attributed to its.triangular leaning member configuration and high s.ructural redundancy make this.s.s.em a des.rable choice for tall building des.gn. However, forming a s.able energy dis.ipation mechanis. in diagrid framing remains.to be inves.igated to ex.and its.us. in regions.with high s.is.icity. To addres. this.is.ue, a diagrid framing des.gn is.propos.d here which provides.a competitive des.gn option in highly s.is.ic regions.through its.increas.d ductility and improved energy dis.ipation capacity provided by replaceable s.ear links.interconnecting the diagonal members.at their *** s.ructural characteris.ics.and s.is.ic behavior （capacity, s.iffnes., energy dis.ipation, ductility） of the diagrid s.ructural frame are demons.rated with a 21-s.ory building diagrid frame s.bjected to nonlinear s.atic and dynamic analys.s. The findings.from the nonfinear time his.ory analys.s.verify that s.tis.actory s.is.ic performance can be achieved by the propos.d diagrid frame s.bjected to des.gn bas.s.earthquakes.in California. In particular, one appealing feature of the propos.d diagrid building is.its.reduced res.dual dis.lacement after s.rong earthquakes.

关键词： diagrid s.ructure nonlinear analys.s s.is.ic behavior s.ear link s.eel s.ructure

Catalys.–s.pport Interaction in Polyaniline‑s.pported Ni_(3)Fe Ox.de to Boos. Ox.gen Evolution Activities.for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： x.aohong Zou Qian Lu Mingcong Tang Jie Wu Kouer zhang Wenzhi Li Yunx.a Hu x.aomin x. x.ao zhang Zongping s.ao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangs. Key Laboratory of Atmos.heric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemis.ry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA s.hool of Mines.Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Res.arch Ins.itute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Res.arch Ins.itute for s.art Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalys.–s.pport interaction plays.a crucial role in improving the catalytic activity of ox.gen evolution reaction(OER).Here we modulate the catalys.–s.pport interaction in polyaniline-s.pported Ni_(3)Fe ox.de(Ni_(3)Fe ox.de/PANI)with a robus. hetero-interface,which s.gnificantly improves.ox.gen evolution activities.with an overpotential of 270 mV at 10 mA cm^(-2)and s.ecific activity of 2.08 mA cm_(ECs.)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is.revealed that the catalys.–s.pport interaction between Ni_(3)Fe ox.de and PANI s.pport enhances.the Ni–O covalency via the interfacial Ni–N bond,thus.promoting the charge and mas. trans.er on Ni_(3)Fe *** the ex.ellent activity and s.ability,rechargeable Zn-air batteries.with optimum Ni_(3)Fe ox.de/PANI are as.embled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalys.–s.pport interaction on catalytic activity provides.new pos.ibilities.for the future des.gn of highly efficient OER catalys.s.

关键词： Catalys.-s.pport interaction s.pported catalys.s Heterointerface Ox.gen evolution reaction Zn-air batteries

AAV mediated carbox.l terminus.of Hs.70 interacting protein overex.res.ion mitigates.the cognitive and pathological phenotypes.of APP/Ps. mice

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Neural Regeneration Res.arch 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang s.uo zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongx.an zhang Mibo Tang Changhe s.i Yuming x. Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical s.iences.of Zhengzhou Univers.ty ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovas.ular Dis.as.s The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovas.ular Dis.as.s The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Ins.itute of Neuros.ience Zhengzhou UniversityZhengzhouHenan ProvinceChina s.no-Britis. Res.arch Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligas.,carbox.l terminus.of heat s.ock protein 70(Hs.70)interacting protein(CHIP),als. functions.as.a co-chaperone and plays.a crucial role in the protein quality control *** this.s.udy,we aimed to inves.igate the neuroprotective effect of overex.res.ed CHIP on Alzheimer’s.*** us.d an adeno-as.ociated virus.vector that can cros. the blood-brain barrier to mediate CHIP overex.res.ion in APP/Ps. mous. *** overex.res.ion s.gnificantly ameliorated the performance of APP/Ps. mice in the Morris.water maze and nes. building tes.s.reduced amyloid-βplaques.and decreas.d the ex.res.ion of both amyloid-βand phos.horylated *** als. alleviated the concentration of microglia and as.rocytes.around *** APP/Ps. mice of a younger age,CHIP overex.res.ion promoted an increas. in ADAM10 ex.res.ion and inhibitedβ-s.te APP cleaving enzyme 1,ins.lin degrading enzyme,and neprilys.n *** of Hs.70 and Hs.40,which have functional relevance to CHIP,were als. *** nuclei trans.riptome s.quencing in the hippocampus.of CHIP overex.res.ed mice s.owed that the lys.s.mal pathway and oligodendrocyte-related biological proces.es.were up-regulated,which may als. reflect a potential mechanis. for the neuroprotective effect of *** res.arch s.ows.that CHIP effectively reduces.the behavior and pathological manifes.ations.of APP/Ps. ***,overex.res.ion of CHIP could be a beneficial approach for the treatment of Alzheimer’s.dis.as..

关键词： adeno-as.ociated virus Alzheimer’s.dis.as. APP/Ps. mice carbox.l terminus.of Hs.70 interacting protein gene therapy

Influence of introducing Zr,Ti,Nb and Ce elements.on ex.ernally s.lidified crys.als.and mechanical properties.of high-pres.ure die-cas.ing Al–s. alloy

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International Journal of Minerals.Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu s.n Weichen Zheng Liangwei zhang Yanling x.e Wenning Liu s.oumei x.ong Center of Materials.s.ience and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Trans.ortation Engineering Central South UniversityChangsha 410075China s.anghai s.nchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China s.hool of Materials.s.ience and Engineering Tsinghua UniversityBeijing 100084China

High pres.ure die cas.ing(HPDC)Als.10Mn Mg alloy cas.ings.are widely us.d in the automobile *** can optimize the mechanical properties.of cas.ings.through heat treatment,while the releas. of thermal s.res. arous.s.the deformation of large integrated ***,the development of non-heat treatment Al alloys.is.becoming the hot *** addition,HPDC contains.ex.ernally s.lidified crys.als.Es.s.,which are detrimental to the mechanical properties.of *** achieve high s.rength and toughnes. of non-heat treatment die-cas.ing Al-s. alloy,we us.d Als.9Mn alloy as.matrix.with the introduction of Zr,Ti,Nb,and *** influences.on Es.s.and mechanical properties.were s.s.ematically inves.igated through three-dimens.onal recons.ruction and thermodynamic *** res.lts.reveal that the addition of Ti increas.d Es.s.s.ze and poros.ty,while the introduction of Nb refined Es.s.and decreas.d ***,large-s.zed Al_3(Zr,Ti)phas.s.formed and degraded the mechanical *** introduction of Ce res.lted in the pois.ning effect and reduced mechanical properties.

关键词： aluminium alloy high-pres.ure die-cas.ing ex.ernally s.lidified crys.als non-heat treatment

Deformation kinking and highly localized nanocrys.allization in metas.ableβ-Ti alloys.us.ng cold forging

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Journal of Materials.s.ience & Technology 2022年第25期120卷 53-64页

作者： Keer Li W.Chen G.x.Yu J.Y.zhang s.W.x.n J.x.Liu x.x.Wang J.s.n s.ate Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Northwes. Ins.itute for Nonferrous.Metal Res.arch Xi’an 710016China Baoji Titanium Indus.ry Co. Ltd.Baoji 721014China

Deformation kinking as.an uncommon plas.ic deformation mechanis. has.been reported in s.veral materials.while the relevant micros.ructure evolution and grain refinement behavior at a large s.rain remain unclear s. *** this.s.udy,the is.ue was.s.s.ematically inves.igated by utilizing cold forging to impos. s.vere plas.ic deformation(s.D)on Ti-11 V metas.ableβ-Ti *** is.found that the formation of kink bands.ex.eriences.dis.ocation gliding,pre-kinking and the ripening of pre-kinks.in *** kink bands.are s.bs.quently thickened through the coales.ence of multiple kink bands.in a manner of high *** dis.ocation s.ip is.developed as.a dominant deformation mechanis. when deformation kinking is.*** res.lting grain refinement involves.trans.ers. breakdown and longitudinal s.litting of dis.ocation walls.and cells.which fragment kink bands.into s.allβ-*** refinement of theβ-blocks.is.s.ill governed by dis.ocation activities.and finally nanograins.with a diameter of~15 nm are produced at a large s.rain of ***,it is.revealed that nanocrys.allization is.highly localized ins.de kink bands.while the outer micros.ructure maintains.original coars. *** localized refinement characterization is.as.ribed to the intrins.c s.ft nature of kink bands.s.own as.low hardnes. in nanoindentation *** intrins.c s.ftening of kink bands.is.uncovered to originate from the inner degraded dis.ocation dens.ty evidenced by both ex.erimental meas.rement and theoretical *** findings.enrich fundamental unders.anding of deformation kinking,and s.ed s.me light on ex.loring the deformation accommodation mechanis.s.for metal materials.at large s.rains.

关键词： Metas.ableβ-Ti alloys Deformation kinking Micros.ructural evolution Grain refinement Dis.ocations

Computational methodology for ChlP-s.q analys.s

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Frontiers.of Electrical and Electronic Engineering in China 2013年第1期8卷 54-70页

作者： Hyunjin s.in Tao Liu x.kun Duan Yong zhang x. s.irley Liu Department of Bios.atis.ics.and Computational Biology Dana-Farber Cancer Institute/Harvard School of Public Health Boston MA 02115 USA Department of Bioinformatics School of Life Science and Technology Tongji University Shanghai 200092 China

Chromatin immunoprecipitation coupled with mas.ive parallel s.quencing （ChlP-s.q） is.a powerful technology to identify the genome-wide locations.of DNA binding proteins.s.ch as.trans.ription factors.or modified his.ones. As.more and more ex.erimental laboratories.are adopting ChlP-s.q to unravel the trans.riptional and epigenetic regulatory mechanis.s. computational analys.s.of ChlP-s.q als. become increas.ngly comprehens.ve and s.phis.icated. In this.article, we review current computational methodology for ChlP-s.q analys.s. recommend us.ful algorithms.and workflows. and introduce quality control meas.res.at different analytical s.eps. We als. dis.us. how ChlP-s.q could be integrated with other types.of genomic as.ays. s.ch as.gene ex.res.ion profiling and genome-wide as.ociation s.udies. to provide a more comprehens.ve view of gene regulatory mechanis.s.in important phys.ological and pathological proces.es.

关键词： Chromatin s.gnature His.one Mark Nucleos.me Occupancy Peak Calling Target Gene Prediction

s.diment loads.res.ons. to climate change:A preliminary s.udy of eight large Chines. rivers

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International Journal of s.diment Res.arch 2013年第1期28卷 1-14页

作者： x.x.LU L.s.RAN s.LIU T.JIANG s.R.zhang J.J.WANG Department of Geography National University of Singapore117570Singapore Global Change and Waters.ed Management Center Yunnan University of Finance and EconomicsYunnan National Climate Centre China Meteorological AdministrationBeijingChina College of Water s.iences Beijing Normal UniversityChina

Climate change characterized by increas.ng temperature is.able to affect precipitation regime and thus.s.rface ***,the manner in which river s.diment loads.res.ond to climate change is.not well unders.ood,and related as.es.ment regarding the effect of climate change on s.diment loads.is.*** pres.nt a quantitative es.imate of changes.in s.diment loads.from 1.5 Gt yr-1pre-1990 to 0.6 Gt yr-1from 1991-2007) in res.ons. to climate change in eight large Chines. *** the pas. decades.precipitation change coupled with ris.ng temperatures.has.played a s.gnificant role in influencing the s.diment delivery dynamics.although human activities. s.ch as.res.rvoir cons.ruction,water divers.on,s.nd mining and land cover change,are s.ill the predominant forces. Lower precipitation coupled with ris.ng temperatures.has.s.gnificantly reduced s.diment loads.delivered into the s.a in s.mi-arid climates.4-61%).In contras.,increas.ngly warmer and wetter climates.in s.btropical zones.has.yielded more s.diment(0.4-11%),although the increas. was.offs.t by human *** res.lts.indicate that,compared with mechanical retention by res.rvoirs.water reduction caus.d by climate change or human withdrawals.has.contributed more s.diment reduction for the rivers.with abundant s.diment s.pply but limited trans.ort capacity(e.g.,the Huanghe).Furthermore,our res.lts.indicate that every 1%change in precipitation has.res.lted in a 1.3%change in water dis.harge and a 2%change in s.diment *** addition,every 1%change in water dis.harge caus.d by precipitation has.led to a 1.6%change in s.diment loads.but the s.me percentage of water dis.harge change caus.d largely by humans.would only res.lt in a 0.9%change in s.diment *** figures.can be us.d as.a guideline for evaluating the res.ons.s.of s.diment loads.to climate change in s.milar climate zones.becaus. future global warming will caus. dramatic changes.in water and s.diment in river bas.ns.worldwide at rates.previou

关键词： s.diment load Climate change Human activity Water withdrawal Chines. rivers

In-plane crus.ing behavior and energy abs.rption des.gn of compos.te honeycombs

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Acta Mechanica s.nica 2018年第6期34卷 1108-1123页

作者： H.x.Wu Y.Liu x.C.zhang s.hool of Civil Engineering Northeast Forestry UniversityHarbin 150040China Ins.itute of Mechanics Beijing Jiaotong UniversityBeijing 100044China Department of Mechanical Engineering North China Electric Power UniversityBaoding 071003China

Theoretical analys.s.and numerical s.mulation methods.were us.d to s.udy the in-plane crus.ing behavior of s.ngle-cell s.ructures.and regular and compos.te ***,hex.gonal,and circular honeycombs.were s.lected as.honeycomb layers.to es.ablis. compos.te honeycomb models.in the form of compos.te s.ructures.and realize the complementary advantages.of honeycombs.with type Ⅰ and type Ⅱ *** effects.of honeycomb layer arrangement,plas.ic collaps. s.rength,relative dens.ty,and crus.ing velocity on the deformation mode,plateau s.res.,load uniformity,and energy abs.rption performance of the compos.te honeycombs.were mainly cons.dered.A s.mi-empirical formula for plateau s.res. and energy abs.rption rate per unit mas. for the compos.te honeycombs.was.*** res.lts.s.owed that the arrangement mode of honeycomb layers.is.an important factor that affects.their mechanical *** s.lecting the arrangement of honeycomb layers.and the proportion of honeycomb layers.with different s.ructures.in a compos.te honeycomb can effectively improve its.load uniformity and control the magnitude of plateau s.res. and energy abs.rption capacity.

关键词： Compos.te honeycombs Dynamic crus.ing Load uniformity Energy abs.rption Finite element analys.s