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Proximal Femur Bionic Nail (PFBN): A Panacea for Unstable Intertrochanteric Femur Fracture

Engineering 2024年第6期37卷 152-158页

作者： Kaixuan zhang wei Chen Yingze zhang School of Medicine Nankai UniversityTianjin 300071China Department of Orthopedic Surgery of Hebei Province The Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institute of Hebei ProvinceShijiazhuang 050051China National Health Commission(NHC)Key Laboratory of Intelligent Orthopeadic Equipment The Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Chinese Academy of Engineering Beijing 100088China

With the aging population,intertrochanteric femur fracture in the elderly has become one of the most serious public health issues and a hot topic of research in trauma *** to the limitations of internal fixation techniques and the insufficient mechanical design of nails,the occurrence of complications delays patient recovery after surgical *** of a proximal femur bionic nail(PFBN)based on zhang’s N triangle theory provides triangular supporting fixation,which dramatically decreases the occurrence of complications and has been widely used for clinical treatment of unstable intertrochanteric femur fracture *** this work,we developed an equivalent biomechanical model to analyze improvement in bone remodeling of unstable intertrochanteric femur fracture through PFBN *** results show that compared with proximal femoral nail antirotation(PFNA)and InterTan,PFBN can dramatically decrease the maximum strain in the proximal *** on Frost’s mechanostat theory,the local mechanical environment in the proximal femur can be regulated into the medium overload region by using a PFBN,which may render the proximal femur in a state of physiological overload,favoring post-operative recovery of intertrochanteric femur fracture in the *** work shows that PFBN may constitute a panacea for unstable intertrochanteric femur fracture and provides insights into improving methods of internal fixation.

关键词： Intertrochanteric femur fracture Internal fixation Proximal femur bionic nail(PFBN) Biomechanics Bone remodeling

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Deciphering and integrating invariants for neural operator learning with various physical mechanisms

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National Science Review 2024年第4期11卷 111-122页

作者： Rui zhang qi Meng Zhi-Ming Ma Academy of Mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional *** to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants

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Magnesium promotes vascularization and osseointegration in diabetic states

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International Journal of Oral Science 2024年第1期16卷 122-133页

作者： Linfeng Liu Feiyu Wang wei Song Danting zhang weimin Lin qi Yin qian Wang Hanwen Li Quan Yuan Shiwen zhang State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Implantology West China Hospital of StomatologySichuan UniversityChengduChina

Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral *** has been proved to promote bone healing under normal ***,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic *** generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased *** then developed Mg-coating implants with hydrothermal *** implants successfully improved the vascularization and osseointegration in diabetic ***,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under ***,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.

关键词： healing diabetic impaired

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A novel fracture-cavity reservoir outcrop geological knowledge base construction method considering parameter collection and processing, mutual transformation of data-knowledge, application and update

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Petroleum Science 2024年第4期21卷 2184-2202页

作者： qi-qiang Ren Jin-Liang Gao Peng Zhu Meng-Ping Li Jian-wei Feng qiang Jin San zhang Institute of Sedimentary Geology Chengdu University of Technology PetroChina Research Institute of Petroleum Exploration and Development School of Energy Chengdu University of Technology School of Resources and Geosciences China University of Mining and Technology School of Geosciences China University of Petroleum (East China) School of Geosciences Yangtze University

This study endeavors to formulate a comprehensive methodology for establishing a Geological Knowledge Base(GKB) tailored to fracture-cavity reservoir outcrops within the North Tarim Basin. The acquisition of quantitative geological parameters was accomplished through diverse means such as outcrop observations, thin section studies, unmanned aerial vehicle scanning, and high-resolution cameras. Subsequently, a three-dimensional digital outcrop model was generated, and the parameters were standardized. An assessment of traditional geological knowledge was conducted to delineate the knowledge framework, content, and system of the GKB. The basic parameter knowledge was extracted using multiscale fine characterization techniques, including core statistics, field observations, and microscopic thin section analysis. Key mechanism knowledge was identified by integrating trace elements from filling, isotope geochemical tests, and water-rock simulation experiments. Significant representational knowledge was then extracted by employing various methods such as multiple linear regression, neural network technology, and discriminant classification. Subsequently, an analogy study was performed on the karst fracture-cavity system(KFCS) in both outcrop and underground reservoir settings. The results underscored several key findings:(1) Utilization of a diverse range of techniques,including outcrop observations, core statistics, unmanned aerial vehicle scanning, high-resolution cameras, thin section analysis, and electron scanning imaging, enabled the acquisition and standardization of data. This facilitated effective management and integration of geological parameter data from multiple sources and scales.(2) The GKB for fracture-cavity reservoir outcrops, encompassing basic parameter knowledge, key mechanism knowledge, and significant representational knowledge, provides robust data support and systematic geological insights for the intricate and in-depth examination of the genetic

关键词： Geological knowledge base Karst fracture-cavity system Mutual transformation of data-knowledge Knowledge base content and application Tarim basin

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TaRLK-6A promotes Fusarium crown rot resistance in wheat

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Journal of Integrative Plant Biology 2024年第1期66卷 12-16页

作者： Haijun qi Xiuliang Zhu Wenbiao Shen Xia Yang Chaozhong zhang Genying Li Feng Chen Xuening wei Zengyan zhang Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural SciencesChangchun 130000China The National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China College of Life Science Nanjing Agricultural UniversityNanjing 210095China Agronomy College/National Key Laboratory of Wheat and Maize Crop Science/CIMMYT‐China(Henan)Joint Center of Wheat and Maize Henan Agricultural UniversityZhengzhou 450002China Department of Plant Sciences University of CaliforniaDavisCA 95616USA Crop Research Institute Shandong Academy of Agricultural SciencesJinan 250100China

Fusariumcrown rot(FCR),mainly caused by the soil‐borne fungus Fusarium pseudograminearum,is a devastatingdisease of wheat(Triticum aestivum(Ta)).Fusariumcrown rotcauses substantial yield losses and generates mycotoxins inwheat grains that can cause serious health problems in hu-mans and livestock(Powell et al.,2017).Identifying genes thatprovide resistance *** character-izing the molecular mechanisms underlying such resistance arekey to breeding wheat varieties that are resistant to this dev-astating fungus.

关键词： aestivum breeding soil

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Enhancement of comprehensive properties of Nb-Si based in-situ composites by Ho rare earth doping

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Rare Metals 2024年第9期43卷 4508-4520页

作者： wei wei qi Wang Rui-Run Chen Chao-Wen Zheng Yan-qing Su National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

This study examines the microstructure,mechanical properties(with a focus on room-temperature toughness),and oxidation resistance of Ho-doped NbDSi based in-situ *** base alloy consists of the coarse primary Nb_(5)Si_(3)phase and the Nb_(5)Si_(3)+Nbss(Nb solid solution)eutectic *** doping influences the solidification *** the Ho doping is higher than0.2 at%,the alloys transform into eutectic *** can be solid-solved in trace amounts in the Nbss ***,most of Ho forms a stable Ho oxide phase,which alleviates oxygen contamination problem to some ***,the interface separation between Ho oxide and other phases reduces the plastic deformation ***,with 0.4 at%Ho doping,the K_(Q)value is18.03 MPa·m^(1/2),which is 31.1%higher than that of the base *** strength of the Ho-doped alloys does not deteriorate with an increase in ***,the large network-like Ho_(2)O_(3)in the 0.8Ho alloy causes a decrease in toughness and *** addition,the Ho oxide phase effectively blocks the inward oxygen *** 0.8 at%Ho doping,the oxidation mass gain per unit area is 10.16 mg·cm^(2),which is 39.7%lower than that of the base alloy.

关键词： Nb-Si based composites Rare earth elements Ho Microstructure Properties

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Dynamic failure process of expanded polystyrene particle lightweight soil under cyclic loading using discrete element method

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 815-828页

作者： Zhou wei Hou Tianshun Chen Ye Wang qi Luo Yasheng zhang Yafei College of Water Resources and Architectural Engineering Northwest A&F UniversityXianyang 712100China Xi’an Key Laboratory of Geotechnical and Underground Engineering Xi’an University of Science and TechnologyXi’an 710054China Hanjiang to weihe River Valley Water Diversion Project Construction Co. Ltd.Xi’an 710011China

Expanded polystyrene(EPS)particle-based lightweight soil,which is a type of lightweight filler,is mainly used in road *** stability of subgrades under dynamic loading is attracting increased research *** traditional method for studying the dynamic strength characteristics of soils is dynamic triaxial testing,and the discrete element simulation of lightweight soils under cyclic load has rarely been *** study the meso-mechanisms of the dynamic failure processes of EPS particle lightweight soils,a discrete element numerical model is established using the particle flow code(PFC)*** contact force,displacement field,and velocity field of lightweight soil under different cumulative compressive strains are *** results show that the hysteresis curves of lightweight soil present characteristics of strain accumulation,which reflect the cyclic effects of the dynamic *** the confining pressure increases,the contact force of the particles also *** confining pressure can restrain the motion of the particle system and increase the dynamic strength of the *** the confining pressure is held constant,an increase in compressive strain causes minimal change in the contact force between soil ***,the contact force between the EPS particles decreases,and their displacement direction points vertically toward the center of the *** an increase in compressive strain,the velocity direction of the particle system changes from a random distribution and points vertically toward the center of the *** the compressive strain is 5%,the number of particles deflected in the particle velocity direction increases significantly,and the cumulative rate of deformation in the lightweight soil ***,it is feasible to use 5%compressive strain as the dynamic strength standard for lightweight *** element methods provide a new approach toward the dynamic performance evaluation of lightw

关键词： lightweight soil cyclic loading dynamic triaxial test discrete element method hysteresis curve

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Optimal AP Deployment in Cell-Free Massive MIMO Systems with LoS/NLoS Transmissions:A Stochastic Geometry Approach

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China Communications 2024年第9期21卷 146-158页

作者： Jiang Ling zhang qi Zhu Hongbo Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Cell-free massive multiple-input multipleoutput(MIMO)is a promising technology for future wireless communications,where a large number of distributed access points(APs)simultaneously serve all users over the same time-frequency *** users and APs may locate close to each other,the line-of-sight(Lo S)transmission occurs more frequently in cell-free massive MIMO ***,in this paper,we investigate the cell-free massive MIMO system with Lo S and non-line-of-sight(NLo S)transmissions,where APs and users are both distributed according to Poisson point *** tools from stochastic geometry,we derive a tight lower bound for the user downlink achievable rate and we further obtain the energy efficiency(EE)by considering the power consumption on downlink payload transmissions and circuitry *** on the analysis,the optimal AP density and AP antenna number that maximize the EE are *** is found that compared with the previous work that only considers NLo S transmissions,the actual optimal AP density should be much smaller,and the maximized EE is actually much higher.

关键词： cell-free massive MIMO energy efficiency LoS/NLoS transmissions stochastic geometry

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Efficiently simulating the work distribution of multiple identical bosons with boson sampling

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Frontiers of physics 2024年第3期19卷 197-206页

作者： Wen-qiang Liu zhang-qi Yin Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements(MOE) School of PhysicsBeijing Institute of TechnologyBeijing 100081China

Boson sampling has been theoretically proposed and experimentally demonstrated to show quantum computational ***,it still lacks the deep understanding of the practical applications of boson *** we propose that boson sampling can be used to efficiently simulate the work distribution of multiple identical *** link the work distribution to boson sampling and numerically calculate the transition amplitude matrix between the single-boson eigenstates in a one-dimensional quantum piston system,and then map the matrix to a linear optical network of boson *** work distribution can be efficiently simulated by the output probabilities of boson sampling using the method of the grouped probability *** scheme requires at most a polynomial number of the samples and the optical *** work opens up a new path towards the calculation of complex quantum work distribution using only photons and linear optics.

关键词： quantum simulation quantum work distribution boson sampling linear optic

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Cobalt(Ⅲ)hydride HAT mediated enantioselective intramolecular hydroamination access to chiral pyrrolidines

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Science China Chemistry 2024年第6期67卷 2002-2008页

作者： qi Meng Tao qin Huanran Miao Ge zhang qian zhang Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis Department of ChemistryNortheast Normal UniversityChangchun130024China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China

Enantioenriched pyrrolidines and derivatives are ubiquitous substructures in compounds of importance to medicinal and biological ***,we report an efficient cobalt-catalyzed intramolecular asymmetric hydroamination reaction that produces chiral pyrrolidines with good to excellent yield and *** with previously reported radicalinvolved methodologies for enantioenriched pyrrolidines,these conditions feature two elegant versatilities,enabling(1)the use of cobalt-catalyzed hydrogen atom transfer(HAT)to generate organocobalt intermediates that bring radical reaction to organometallic chemistry,and(2)enantioselective intramolecular C-N bond forging through an S_(N)2-like displacement involving dynamic kinetic resolution(DKR).This approach provides a new alternative and efficient methodology for enantioselective radical-involved C-N bond construction that can be used in the synthesis of both chiral pyrrolidines and homologous nitrogen heterocycles.

关键词： asymmetric catalysis radical hydroamination cobalt catalysis hydrogen atom transfer

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