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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao hu Si Wang Weiqi zhang Jing Qu Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao zhang Zhanyu Li Yijia Lei Baozeng Sun Xiaoyu yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

Nitrate Leaching in an Irrigated Wheat-Maize Rotation Field in the North China Plain

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Pedosphere 2005年第2期15卷 196-203页

作者： zhangyu-Ming huChun-Sheng zhangJia-Bao CHENDe-Li LIXiao-Xin InstituteofGeneticandDevelopmentalBiology ChineseAcademyofSciencesShijiazhuang050021（China） InstituteofSoilScience ChineseAcademyofSciencesNanjing210008（China） DepartmentofResourceManagementandHorticulture InstituteofLandandFoodResourcetheUniversityofMelbourneParkville3052Victoria（Australia）

Soil water deep drainage and nitrate (NO-3) leaching losses below the root zone were investigated in a 1 ha wheat-maize rotation field under traditional agricultural management that local farmers generally follow in the North China Plain, using the soil water balance method and NO3-N concentration in suction samples. Water drainage, and NO3-N distribution and leaching losses exhibited pronounced spatial and temporal variability. Soil water deep drainage and NO3-N leaching loss mostly occurred during the sum…

关键词： deep drainage nitrate leaching soil water

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光刻胶段差对光刻图形的影响与改善

液晶与显示 2018年第8期33卷 653-660页

作者：张玉虎李亚文刘小波马小辉张旭合肥京东方光电科技有限公司安徽合肥230012

TFT光刻制程中,光刻胶段差使光胶在同一个光刻平面上,各区域的光刻程度不同,严重影响着光刻图形的质量。文章从光刻胶段差对光刻图形影响的原因进行分析,根据光强在投影光刻机光刻系统中焦点附近与光刻胶内部的变化特点,推导并计算出光... 详细信息

TFT光刻制程中,光刻胶段差使光胶在同一个光刻平面上,各区域的光刻程度不同,严重影响着光刻图形的质量。文章从光刻胶段差对光刻图形影响的原因进行分析,根据光强在投影光刻机光刻系统中焦点附近与光刻胶内部的变化特点,推导并计算出光刻胶段差区域内光强变化量为零时,光刻系统中光刻平面所应处于的位置,同时结合当前光刻系统焦平面的位置,计算出光刻平面的调整量,并以该调整量对当前光刻平面进行调整。结果表明:对于极限分辨率为2.41μm的投影光刻机,要使厚0.52μm的光刻胶段差内光强变化量为零,光刻平面调整量为9.434 42μm,且对光刻平面调整后10μm后,在DICD(Develop Inspection Critical Dimension)变化量较小的情况下,可显著改善沟道长为2.5μm的GOA(gate drive on array)区域的光刻胶残留。

关键词：段差光刻胶光刻光刻面光强

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo yu Zhenyu Sun Weichen Zheng Liangwei zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

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星宿菜化学成分的研究

中国中药杂志 2007年第7期32卷 596-599页

作者：黄新安蔡佳仲胡英杰张玉虎广州中医药大学热带医学研究所药理室广东广州510405

目的：研究星宿菜95％乙醇提取物醋酸乙酯萃取部位中化学成分。方法：采用反复硅胶柱色谱分离化学成分，根据NMR数据和参考相关文献，鉴定化合物结构。结果：分离到9个化合物，分别为24-烯-环阿尔廷酮（1），24-乙基-△^7.22-胆甾二烯-3... 详细信息

目的：研究星宿菜95％乙醇提取物醋酸乙酯萃取部位中化学成分。方法：采用反复硅胶柱色谱分离化学成分，根据NMR数据和参考相关文献，鉴定化合物结构。结果：分离到9个化合物，分别为24-烯-环阿尔廷酮（1），24-乙基-△^7.22-胆甾二烯-3-酮（2），正三十五烷醇（3），β-豆甾醇（4），24-乙基-△^7.22-胆甾二烯-3β-醇（5），棕榈酸（6），异鼠李黄素（7），山柰酚（8）和槲皮素（9）。结论：化合物1～9均为首次从该植物中发现，化合物1，2，5为首次从该属植物中发现。

关键词：星宿菜化学成分

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北京城区旅游气候变化及风险分析

干旱区地理 2016年第3期39卷 654-661页

作者：向柳张玉虎陈秋华首都师范大学资源环境与旅游学院北京100048 资源环境与地理信息系统北京市重点实验室北京100048 首都师范大学数学科学学院北京100048

考虑温度、湿度、降水、风速、日照要素构建旅游气候指数(TCI),利用信息扩散理论,构建旅游气候风险定量评估模型,并对北京城区旅游气候变化及风险进行实证分析。结果表明:(1)基于多气候要素的TCI可有效反映旅游气候对气候变化的响应,基... 详细信息

考虑温度、湿度、降水、风速、日照要素构建旅游气候指数(TCI),利用信息扩散理论,构建旅游气候风险定量评估模型,并对北京城区旅游气候变化及风险进行实证分析。结果表明:(1)基于多气候要素的TCI可有效反映旅游气候对气候变化的响应,基于信息扩散模型(IDM)构建的旅游气候风险评估模型能有效分析单气候要素变化风险对旅游气候的影响,可为旅游气候风险评估提供新的途径。(2)1951-2014年,北京城区TCI持续升高,趋势线从1951年的Ⅲ级(65)升高到2014年Ⅱ级(73),平均增加1.17·(10 a)^(-1),且四季旅游舒适度呈上升趋势,双峰型旅游气候格局的峰区逐渐变宽,旅游气候持续改善,成为促进旅游业发展的有利因素。(3)低降水概率(p≤0.4)风险下,北京城区TCI介于45~71,仍处于可开展旅游活动的II^IV级,且随着时间推移,TCI呈增长趋势,降水对旅游气候的不利影响减弱。

关键词：气候变化旅游气候信息扩散模型风险北京城区

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帕金森病的神经调控治疗研究进展

中国实用内科杂志 2023年第10期43卷 831-838页

作者：聂坤张玉虎王丽娟南方医科大学附属广东省人民医院(广东省医学科学院)神经科广东省神经科学研究所广州市神经退行性疾病诊治研究重点实验室广东广州510080

帕金森病是一种神经系统退行性疾病,主要由多巴胺神经元丢失引起的相关运动及非运动症状。神经调控治疗作为帕金森病的重要治疗手段之一,包括脑深部电刺激、核团毁损术、重复经颅磁刺激、经颅直流电刺激等其他新兴治疗方法,有效改善了... 详细信息

帕金森病是一种神经系统退行性疾病,主要由多巴胺神经元丢失引起的相关运动及非运动症状。神经调控治疗作为帕金森病的重要治疗手段之一,包括脑深部电刺激、核团毁损术、重复经颅磁刺激、经颅直流电刺激等其他新兴治疗方法,有效改善了患者症状和提高了生活质量。文章总结了当前帕金森病神经调控治疗的主要进展和挑战,以期实现更安全和有效的治疗策略。

关键词：帕金森病神经调控脑深部电刺激经颅磁刺激经颅直流电刺激

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非相干扩频测控体制的多址干扰效应研究

上海航天 2014年第5期31卷 31-36页

作者：张玉虎上海宇航系统工程研究所上海201109

对非相干扩频测控系统的多用户目标应用产生的多址效应进行了研究,分析了非相干扩频测控体制的原理和特点,给出了多址信道模型,讨论了多址效应的主要成因及解决措施。某应用样例表明:分析结果与实际测试数据一致。

关键词：非相干扩频测控多址效应 Gold码唐检测器