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Facile electrochemical surface-alloying and etching of Au wires to enable high-performance substrates for surface enhanced Raman scattering

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Nano Materials Science 2024年第3期6卷 305-311页

作者： Yawen zhan Guobin zhang Junda Shen Binbin Zhou Chenghao Zhao Junmei Guo Ming Wen Zhilong Tan Lirong Zheng Jian lu Yang Yang Li Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Kunming Institute of Precious Metals Sino-platinum Metals Co.Ltd.KunmingYunan ProvinceChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute8 Yuexing 1st RoadShenzhen Hi-Tech Industrial ParkNanshan DistrictShenzhenChina Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Institute of High Energy Physics Beijing100049China

Surface-enhanced Raman Spectroscopy(SERS)is a nondestructive technique for rapid detection of analytes even at the single-molecule ***,highly sensitive and reliable SERS substrates are mostly fabricated with complex nanofabrication techniques,greatly restricting their practical applications.A convenient electrochemical method for transforming the surface of commercial gold wires/foils into silver-alloyed nanostructures is demonstrated in this *** substrates are treated with repetitive anodic and cathodic bias in an electrolyte of thiourea,in a one-pot one-step manner.X-rays absorption fine structure(XAFS)spectroscopy confirms that the AuAg alloy is induced at the *** unique AuAg alloyed surface nanostructures are particularly advantageous when served as SERS substrates,enabling a remarkably sensitive detection of Rhodamine B(a detection limit of 10^(-14)M,and uniform strong response throughout the substrates at 10^(-12)M).

关键词： Electrodeposition Dealloying Surface-alloyed Noble metals Surface enhanced Raman spectroscopy substrates

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Advances in the Mechanisms of Hemorrhagic Transformation and Therapeutic Agents after Intravenous Thrombolysis in Ischemic Stroke

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Yangtze Medicine 2024年第1期8卷 29-40页

作者： Yue Dai Yongyi zhan Mingtian lu Zehua He Yu Liu Zhuhai Clinical Medical College of Jinan University (Zhuhai People’s Hospital) Zhuhai China

Ischemic stroke is an important disease leading to death and disability for all human beings, and the key to its treatment lies in the early opening of obstructed vessels and restoration of perfusion to the local infarcted area. Intravenous thrombolysis with tissue plasminogen activator (tPA) is one of the effective therapies to achieve revascularization, but it faces strict indications with a narrow therapeutic time window, and significantly increases the incidence of hemorrhagic transformation, HT, after reperfusion of the infarcted foci, which greatly reduces the incidence of patients with ischemic stroke. which significantly increases the incidence of hemorrhagic transformation (HT) after reperfusion of the infarcted focus, greatly reducing patient utilization and clinical benefit. Since the mechanism of HT has not been fully elucidated, and the related molecular mechanisms are complex and interactive, there is no specific and effective therapy to avoid the occurrence of HT. In this article, we focus on the research progress on the mechanism of HT after tPA intravenous thrombolysis in ischemic stroke patients from the aspects of vascular integrity disruption, oxidative stress, and neuroinflammatory response and the corresponding therapeutic strategies, in order to improve the safety and prognosis of tPA intravenous thrombolysis in the clinic.

关键词： Hemorrhagic Transformation Tissue-Type Fibrinogen Activator Acute Ischemic Stroke Blood-Brain Barrier

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Preparation and characteristic study of Schottky diodes based on GaOthin films

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The Journal of China Universities of Posts and Telecommunications 2024年

作者： zhang Xuhui Chen Haifeng Liu Xiangtai lu Qin Wang zhan Cheng Hang Che lujie Guan Youyou Han Xiaocong School of Electronic Engineering Xi’an University of Posts and Telecommunications

This study uses atomic layer deposition (ALD) to grow Ga2O3films on SiO2substrates and investigates the influence of film thickness and annealing temperature on film quality. Schottky diode devices are fabricated based on the grown Ga2O3films， and the effects of annealing temperature， electrode size， and electrode spacing on the electrical characteristics of the devices are studied. The results show that as the film thickness increases， the breakdown voltage of the fabricated devices also increases. A Schottky diode with a thickness of 240 nm can achieve a reverse breakdown voltage of 300 V. The film quality significantly improves as the annealing temperature of the film increases. At a voltage of 5 V， the current of the film annealed at 900℃ is 64 times that of the film annealed at 700℃. The optimum annealing temperature for Ohmic contact electrodes is 450℃. At 550℃， the Ohmic contact metal tends to burn， and the performance of the device is reduced. Reducing the electrode spacing increases the forward current of the device but decreases the reverse breakdown voltage. Increasing the Schottky contact electrode size increases the forward current， but the change is not significant， and there is no significant change in the reverse breakdown voltage. The device also performs well at high temperatures， with a reverse breakdown voltage of 220 V at 125℃.

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具有平带的一维十字型晶格中重返局域化现象

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物理学报 2024年第3期73卷 236-242页

作者：陆展鹏徐志浩山西大学理论物理研究所量子光学与光量子器件国家重点实验室太原030006 山西大学极端光学协同创新中心太原030006

数值研究了在具有平带的一维十字型晶格中引入准周期调制所诱导的重返局域化现象.当参数Δ≠0时,此平带系统等价于存在一个双频率调制的行为.通过数值求解分形维度、平均逆参与率、平均归一化参与率等序参量证明了在一维十字型晶格中随... 详细信息

数值研究了在具有平带的一维十字型晶格中引入准周期调制所诱导的重返局域化现象.当参数Δ≠0时,此平带系统等价于存在一个双频率调制的行为.通过数值求解分形维度、平均逆参与率、平均归一化参与率等序参量证明了在一维十字型晶格中随着调制强度的增加会经历2次局域转变,即发生第1次局域化转变进入完全局域相后,继续增加调制强度,一些局域态重新恢复成了退局域化态,进一步增加调制强度,系统将再次进入完全局域化相.最后给出了局域化相图.当参数Δ=0时,此系统仅存在单频率调制.通过解析和数值求解证明了,系统存在解析的迁移率边,但不存在重返局域化.该研究结果为平带系统中重返局域化的研究提供了参考,也为重返局域化的研究提供了新的视角.

关键词：无序迁移率边局域化

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基于固体前体构建集成催化剂及CO_(2)加氢研究进展

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化工进展 2024年第5期43卷 2786-2802页

作者：卢欣欣蔡东仁詹国武华侨大学集成催化剂研究中心福建厦门361021

针对催化剂活性位点和微观结构不可控的问题,采用固体前体作为缓释的金属离子源制备微观结构可控、活性位点空间位置明确的金属基集成催化剂有望解决该问题,并实现催化剂的定制化设计。本文介绍了4类固体前体材料用于制备CO_(2)热催化... 详细信息

针对催化剂活性位点和微观结构不可控的问题,采用固体前体作为缓释的金属离子源制备微观结构可控、活性位点空间位置明确的金属基集成催化剂有望解决该问题,并实现催化剂的定制化设计。本文介绍了4类固体前体材料用于制备CO_(2)热催化加氢反应的催化剂,包括过渡金属层状硅酸盐、层状双金属氢氧化物、金属有机骨架材料以及钒酸铋材料。总结了这4类集成催化材料的制备过程机制及其在CO_(2)热催化加氢中的应用实例,并对固体前体制备多组分集成催化剂的研究前景进行了展望。

关键词：催化二氧化碳加氢纳米材料固体前体集成催化剂

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近代长江中游地区民船运输的发展与转型

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深圳大学学报（人文社会科学版） 2024年第4期41卷 134-148页

作者：吴琦占路华中师范大学历史文化学院湖北武汉430079 湖北师范大学历史文化学院湖北黄石435002

明清以降,依托纵横的水网和民船运输,长江中游地区的商品流通日趋活跃。近代,汉口、沙市开埠通商,促使这一区域的贸易和交通运输地位不断提高。在此背景下,轮船、铁路等新式运输方式相继开通,然而传统民船运输并未退出历史舞台,反而呈... 详细信息

明清以降,依托纵横的水网和民船运输,长江中游地区的商品流通日趋活跃。近代,汉口、沙市开埠通商,促使这一区域的贸易和交通运输地位不断提高。在此背景下,轮船、铁路等新式运输方式相继开通,然而传统民船运输并未退出历史舞台,反而呈现延续与趋新的发展态势。一方面表现在民船的来源更加广泛,船型也显著增加,数量庞大的划船、南船、川船以及陕豫赣等地民船广泛分布于长江中游各港口商埠。另一方面,为适应大宗商品运输的需要,民船运输业灵活应变,积极寻找新的合作方式和业务来源,其经营方式呈现多样化;为应对运输过程中的流弊,当地官方与民间行业组织协同作用,以政府政策为导向,不断强化民船运输的监督与管理,促使其逐步走向规范化,实现近代民船运输业的初步转型。但在此过程中长久以来形成的传统行业习惯仍在延续。长江中游地区民船运输业在近代的持续发展是多方面因素促成的,主要受到近代贸易格局和商路变迁的影响。同时,区域工业化的发展,对棉花、煤炭等原料和燃料的需求大增,民船凭借其在大宗货物上的运输优势及灵活多样的经营方式,在近代运输业中占据重要地位。

关键词：近代长江中游地区民船运输转型商路变迁区域工业化

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一维非厄米十字晶格中的退局域-局域转变

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物理学报 2024年第13期73卷 262-268页

作者：刘辉陆展鹏徐志浩山西大学理论物理研究所量子光学与光量子器件国家重点实验室太原030006 山西大学极端光学协同创新中心太原030006

本文研究了在具有平带的一维非厄米十字晶格中引入准周期调制所诱导的退局域-局域的转变.通过解析推导和数值分析分形维度和能谱的实复转变,发现在非厄米单平带十字晶格中引入对称的准周期调制会引起扩展相到局域相的转变,而反对称准周... 详细信息

本文研究了在具有平带的一维非厄米十字晶格中引入准周期调制所诱导的退局域-局域的转变.通过解析推导和数值分析分形维度和能谱的实复转变,发现在非厄米单平带十字晶格中引入对称的准周期调制会引起扩展相到局域相的转变,而反对称准周期调制能够诱导出精确的迁移率边.在非厄米全平带十字晶格中,对称的准周期调制情况下,系统一直处于局域相,当引入反对称的准周期调制时,系统具有从多重分形相到局域相的转变.该研究结果为非厄米平带的局域化性质研究提供了参考.

关键词：平带系统非厄米系统无序局域化

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钴催化伯胺无受体脱氢制备腈

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有机化学 2024年第6期44卷 2054-2056页

作者：应佳乐陆展浙江大学化学系杭州310027

腈类化合物是天然产物、药物和许多生物活性分子中的重要结构单元[1],发展高效构建腈类化合物的合成方法具有重要研究价值.从原子经济性角度而言,亚胺(RCH=NH)的直接脱氢或伯胺(RCH2NH2)的双重脱氢是构建C≡N键的理想方法.考虑到一级胺... 详细信息

腈类化合物是天然产物、药物和许多生物活性分子中的重要结构单元[1],发展高效构建腈类化合物的合成方法具有重要研究价值.从原子经济性角度而言,亚胺(RCH=NH)的直接脱氢或伯胺(RCH2NH2)的双重脱氢是构建C≡N键的理想方法.考虑到一级胺是普遍存在的化合物,将其转化为腈的方法很具有吸引力,但如何在没有氧化剂或氢受体的情况下直接将伯胺两次脱氢转化为相应的腈是一个具有挑战性的问题.

关键词：天然产物睛类化合物生物活性分子原子经济性伯胺结构单元 NH2 腈类化合物

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The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen Feiteng lu Miaozhen Qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua zhan Ting Zhou Qiuyun luo Wentao Pan Lin zhang Chaozhuo Lin Yan Huang Li zhang Dajun Yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages NLRP3

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Salinity fronts shape spatial patterns in zooplankton distribution in Hangzhou Bay

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Acta Oceanologica Sinica 2024年第6期43卷 96-106页

作者： Yepeng Xu Yiqi Wang Lin zhan Yijun Ou Kangning Jia Ming Mao Xuyu Zhu Zhibing Jiang Yuanli Zhu Wei Huang Ping Du Jiangning Zeng lu Shou Feng Zhou Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Key Laboratory of Nearshore Engineering Environment and Ecological Security of Zhejiang Province Hangzhou 310012China State Key Laboratory of Satellite Ocean Environment Dynamics Ministry of Natural ResourcesHangzhou 310012China Nantong Marine Environmental Monitoring Center Ministry of Natural ResourcesNantong 226002China Key Laboratory of Ocean Space Resource Management Technology Ministry of Natural ResourcesHangzhou 310012China Observation and Research Station of Marine Ecosystem in the Yangtze River Delta Ministry of Natural ResourcesZhoushan 316021China

Ocean fronts play important roles in nutrient transport and in the shaping ecological *** zones in small bays are typically small in scale,have a complex structure,and they are spatially and temporally variable,but there are limited data on how biological communities respond to this *** Bay,a mediumsized estuary in China,is an ideal place in which to study the response of plankton to small-scale ocean fronts,because three water masses(Qiantang River Diluted Water,Changjiang River Diluted Water,and the East China Sea current) converge here and form dynamic salinity fronts throughout the *** investigate zooplankton communities,and temperature,salinity and chlorophyll a(Chl a) in Hangzhou Bay in June(wet perio d) and December(dry period) of 2022 and examine the dominant environmental factors that affect zooplankton community spatial *** then match the spatial distributions of zooplankton communities with those of salinity fronts.S alinity is the most important explanatory variable to affect zooplankton community spatial variability during both wet and dry periods,in that it contributes>60% of the variability in community ***,the spatial distributions of zooplankton match well with salinity *** December,with weaker Qiantang River Diluted Water and a stronger secondary Changjiang River Plume,zooplankton communities occur in moderate salinity(MS,salinity range 15.6±2.2) and high salinity(HS,22.4±1.7) regions,and their ecological boundaries closely match the Qiantang River Diluted Water *** June,different zooplankton communities occur in low salinity(LS,3.9±1.0),MS(11.7±3.6) and HS(21.3±1.9) *** the LS region occurs abnormally in the central bay rather than its apex because of the anomalous influence of rising and falling tides during the sampling perio d,the ecological boundaries still match salinity ***-salinity or brackish-water zooplankter taxa are relatively more abunda

关键词： zooplankton spatial distribution salinity fronts Hangzhou Bay

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