检索结果-南通市图书馆

Effect of coronary artery revascularization on in-hospital outcomes and long-term prognoses in acute myocardial infarction patients with prior ischemic stroke

引用

Journal of Geriatric Cardiology 2016年第2期13卷 145-151页

作者： Bo-Yu LI Xiao-Ming LI Yan zhanG zhan-yun wei Jing LI Qi HUA Department of Cardiology Xuanwu Hospital Capital Medical University Beijing China School of Nursing Capital Medical University Beijing China Department of Geriatrics Xuanwu Hospital Capital Medical University Beijing China

Objective To investigate whether coronary artery revascularization therapies （CART）, including percutaneous coronary intervention （PCI） and coronary artery bypass grafting （CABG）, can improve the in-hospital and long-term outcomes for acute myocardial infarction （AMI） patients with prior ischemic stroke （IS）. Methods A total of 387 AMI patients with prior IS were enrolled consecutively from January 15, 2005 to December 24, 2011 in this cohort study. All patients were categorized into the CART group （n = 204） or the conservative medications （CM） group （n = 183）. In-hospital cardiocerebral events and long-term mortality of the two groups after an average follow-up of 36 months were recorded by Kaplan-Meier survival curves and compared by Logistic regression and the Cox regression model. Results The CART patients were younger （66.5 ± 9.7 years vs. 71.7 ± 9.7 years, P 〈 0.01）, had less non-ST segment elevation myocardial infarction （11.8% vs. 20.8%, P = 0.016） and more multiple-vascular coronary lesions （50% vs. 69.4%, P = 0.031）. The hospitalization incidence of cardiocerebral events in the CART group was 9.3% while 26.2% in the CM group （P 〈 0.01）. CART significantly reduced the risk of in-hospital cardiocerebral events by 65% [adjusted odds ratio （OR） = 0.35, 95% CI： 0.13-0.92]. By the end of follow-up, 57 cases （41.6%） died in CM group （n = 137） and 24 cases （12.2%） died in CART group （n = 197）. Cox regression indicated that CART decreased the long-term mortality by 72% [adjusted hazard ratio （HR） = 0.28, 95% CI： 0.064）.46], while categorical analysis indicated no s{gnificant dif- ference between PCI and CABG. Conclusions CART has a significant effect on improving the in-hospital and long-term prognoses for AMI patients with prior IS.

关键词： Acute myocardial infarction Conservative medications Coronary artery bypass grafting Coronary artery revascularization Ischemic stroke Percutaneous coronary intervention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Listeria monocytogenes bacteremia in a centenarian and pathogen traceability:A case report

引用

World Journal of Clinical Cases 2021年第18期9卷 4873-4880页

作者： Zhong-Ying zhang Xiao-Ai zhang Qian Chen Jie-Yu Wang yun Li zhan-yun wei Zi-Chen Wang Department of Geriatric Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Center for Disease Prevention and Control Institute for Nutrition and Food HygieneBeijing 100053China Research Centre for Preventive Medicine of Beijing Beijing 100053China

BACKGROUND Early diagnosis and appropriate antibiotic treatment are important to survival of Listeria monocytogenes(***)*** tends to be the most commonly used ***,there are limited data on antibiotic use in elderly patients with serious *** describe the clinical presentation,antibiotic therapy,and traceability of *** in a centenarian with a history of eating frozen *** SUMMARY A 102-year-old man suffered from high fever with chill after *** diagnoses were lower gastrointestinal hemorrhage and localized *** and ornidazole were the empirical *** patient did not respond and developed multiple system dysfunction even after teicoplanin was added to the *** was identified from blood cultures on day 5 of *** patient had a history of consuming frozen ***/ornidazole/teicoplanin were replaced with meropenem/*** patient gradually became *** received meropenem/linezolid for 10 d,and piperacillin/tazobactam was applied as step-down treatment for 2 wk with good clinical *** was no sign of relapse during follow-up after *** isolates from the patient and frozen dumplings belonged to different serotypes and sequence types(STs):1/2b and ST5 from the patient and 1/2c and ST9 from the *** More awareness of listeriosis should be *** might be an option for listeriosis in elderly people with serious complications.

关键词： Listeria monocytogenes Centenarian Bacteremia Traceability Antibiotics Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

引用

Science China Chemistry 2025年第1期68卷 157-162页

作者： Rong-De He yun-Lei Luo Qiu-Quan Pan Qi-wei Yao Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关键词： nickel alkenylation asymmetric cross-coupling alkenes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Synthesis and Neuroprotective Activity of Novel C-4, C-7 Derivatives in the Tetracycline Series

Synthesis and Neuroprotective Activity of Novel C-4, C-7 Der...

引用

中国化学会第四届有机化学学术会议

作者： ZHOU, zhan-yun WANG, Xiao-wei zhanG, Zhi-Li YANG, Hua CHEN, Yan-Li LIU, Jun-Yi (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083)

＜正＞In recent years, doxycycline and minocycline have been shown to have neuroprotective effects in models of global and focal ischemia. Although a very large number of tetracycline derivatives have been synthesized over the past years, there has been no report for dedimethylamino-derivatives of minocycline and doxycycline at C-4 or C-7.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

蜀南长垣坝构造带嘉陵江组储层特征

引用

四川地质学报 2008年第3期28卷 197-203页

作者：蒋成思战薇芸邓川西南石油大学成都610500 西南油气田分公司研究院成都610051 四川石油管理局地球物理勘探公司成都610213

近年来蜀南嘉陵江组勘探获得重大突破,表明长垣坝构造带嘉陵江组仍有一定的勘探潜力。通过储层岩性、储集空间、物性及储层分布特征的研究,确定出长垣坝构造带储层分布有以下特征:纵向上由多套储层组成,分布位置较稳定,其单层厚度变化较... 详细信息

近年来蜀南嘉陵江组勘探获得重大突破,表明长垣坝构造带嘉陵江组仍有一定的勘探潜力。通过储层岩性、储集空间、物性及储层分布特征的研究,确定出长垣坝构造带储层分布有以下特征:纵向上由多套储层组成,分布位置较稳定,其单层厚度变化较大;平面分布上,嘉四1～嘉三3储层分散,嘉二储层和嘉二1～嘉一储层连片分布。长垣坝构造带嘉陵江组主要发育Ⅱ类和Ⅲ类储层,Ⅲ类分布广泛,Ⅱ类分布分散。

关键词：长垣坝构造嘉陵江组储层特征蜀南

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

引用

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng Li Hai-wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

引用

Science China Chemistry 2025年

作者： Si-Min Zeng Di-wei Zheng Ting Pan Xing-Lan Ding yun zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

引用

Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou wei-Jin Jiang Ji Yu Mao-Jun Yao yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kinematics-based four-state trajectory tracking control of a spherical mobile robot driven by a 2-DOF pendulum

引用

Chinese Journal of Aeronautics 2019年第6期32卷 1530-1540页

作者： wei LI Qiang zhan Robotics Institute Beihang UniversityBeijing 100083China Ecole Centrale de Pékin Beihang UniversityBeijing 100083China

Spherical mobile robot has compact structure, remarkable stability, and flexible motion,which make it have many advantages over traditional mobile robots when applied in those unmanned environments, such as outer planets. However, spherical mobile robot is a special highly under-actuated nonholonomic system, which cannot be transformed to the classic chained form. At present, there has not been a kinematics-based trajectory tracking controller which could track both the position states and the attitude states of a spherical mobile robot. In this paper, the four-state(two position states and two attitude states) trajectory tracking control of a type of spherical mobile robot driven by a 2-DOF pendulum was studied. A controller based on the shunting model of neurodynamics and the kinematic model was deduced, and its stability was demonstrated with Lyapunov’s direct method. The control priorities of the four states were allocated according to the magnification of each state tracking error in order to firstly ensure the correct tracking of the position states. The outputs(motor speeds) of the controller were regulated according to the maximum speeds and the maximum accelerations of the actuation motors in order to solve the speed jump problem caused by initial state errors, and continuous and bounded outputs were obtained. The effectiveness including the anti-interference ability of the proposed trajectory tracking controller was verified through MATLAB simulations.

关键词： Kinematics Lyapunov methods Neurodynamics Nonholonomic systems Spherical mobile robot Trajectory tracking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics of temperature fluctuation in two-dimensional turbulent Rayleigh-Bénard convection

引用

Chinese Physics B 2022年第1期31卷 395-402页

作者： Ming-wei Fang Jian-Chao He zhan-Chao Hu yun Bao School of Aeronautics and Astronautics Sun Yat-sen UniversityGuangzhou 510275China

We study the characteristics of temperature fluctuation in two-dimensional turbulent Rayleigh–Benard convection in´a square cavity by direct numerical *** Rayleigh number range is 1×10^(8)≤Ra≤1×10^(13),and the Prandtl number is selected as Pr=0.7 and Pr=*** is found that the temperature fluctuation profiles with respect to Ra exhibit two different distribution *** the thermal boundary layer,the normalized fluctuationθrms/θrms,max is independent of Ra and a power law relation is identified,i.e.,θrms/θrms,max∼(z/δ)0.99±0.01,where z/δis a dimensionless distance to the boundary(δis the thickness of thermal boundary layer).Out of the boundary layer,when Ra≤5×10^(9),the profiles ofθrms/θrms,max descend,then ascend,and finally drop dramatically as z/δ*** for Ra≥1×10^(10),the profiles continuously decrease and finally overlap with each *** two different characteristics of temperature fluctuations are closely related to the formation of stable large-scale circulations and corner ***,there is a critical value of Ra indicating the transition,beyond which the fluctuation hθrmsiV has a power law dependence on Ra,given by hθrmsiV∼Ra−0.14±0.01.

关键词： Rayleigh-Benard temperature fluctuation distribution patterns critical value

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：