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Ruxolitinib attenuates secondary injury after traumatic spinal cord injury

Neural Regeneration Research 2022年第9期17卷 2029-2035页

作者： zhan-yang qian Ren-Yi Kong Sheng zhang Bin-Yu Wang Jie Chang Jiang Cao Chao-Qin Wu Zi-Yan Huang Ao Duan Hai-Jun Li Lei yang Xiao-Jian Cao Spine Center Zhongda Hospital of Southeast UniversityNanjingJiangsu ProvinceChina Medical School Southeast UniversityNanjingJiangsu ProvinceChina Department of Orthopedics First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Orthopedics Hospital Affiliated 5 to Nantong University(Taizhou People’s Hospital)TaizhouJiangsu ProvinceChina Taizhou Clinical Medical School of Nanjing Medical University Taizhou People’s HospitalTaizhouJiangsu ProvinceChina

Excessive inflammation post-traumatic spinal cord injury(SCI)induces microglial activation,which leads to prolonged neurological ***,the mechanism underlying microglial activation-induced neuroinflammation remains poorly ***(RUX),a selective inhibitor of JAK1/2,was recently reported to inhibit inflammatory storms caused by SARS-CoV-2 in the ***,its role in disrupting inflammation post-SCI has not been *** this study,microglia were treated with RUX for 24 hours and then activated with interferon-γfor 6 *** results showed that interferon-γ-induced phosphorylation of JAK and STAT in microglia was inhibited,and the mRNA expression levels of pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,interleukin-6,and cell proliferation marker Ki67 were *** further in vivo experiments,a mouse model of spinal cord injury was treated intragastrically with RUX for 3 successive days,and the findings suggest that RUX can inhibit microglial proliferation by inhibiting the interferon-γ/JAK/STAT ***,microglia treated with RUX centripetally migrated toward injured foci,remaining limited and compacted within the glial scar,which resulted in axon preservation and less ***,the protein expression levels of tumor necrosis factor-α,interleukin-1β,and interleukin-6 were *** neuromotor function of SCI mice also *** findings suggest that RUX can inhibit neuroinflammation through inhibiting the interferon-γ/JAK/STAT pathway,thereby reducing secondary injury after SCI and producing neuroprotective effects.

关键词： functional recovery glial scar inflammation interferon-γ JAK/STAT signaling microglia Ruxolitinib spinal cord injury

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Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： qian Gao Lin Tang Jun zhan Yiyuan Xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

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Effect of treatment process on consolidation efficiency of fugitive dust cemented by bio-activated cementitious material based on CO2 capture

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Science China(Technological Sciences) 2016年第8期59卷 1194-1200页

作者： zhan QiWei qian ChunXiang School of Materials Science and Engineering Southeast University Jiulonghu Campus Nanjing 211189 China Research Institute of Green Construction Materials Southeast University Jiulonghu Campus Nanjing 211189 China

As a new green and environmental material, bio-activated cementitious material is attracting extensive attention. This study confirmed that the bio-activated cementitious material could mineralize and cement fugitive dust into the cal- cite-consolidation-layer based on CO2 capture and utilization. The results illustrated that treatment processes （non-pressure spraying, pressure spraying, non-pressure blending and pressure blending） had a strong effect on the microstructure and prop- erties of calcite-consolidation-layer. According to the analysis of X-ray diffraction （XRD） and Fourier transform infrared （FTIR）, calcite was prepared by bio-activated cementitious material during the cementation process. Meanwhile, scanning electron microscopy （SEM） and thermogravimetric-differenfial scanning calorimetry （TG-DSC） were adopted to measure the corresponding variation of porous characteristics and calcite content caused by different treatment processes. The results indi- cated that the microstructure of calcite-consolidation-layer from the spraying process had lower porosity and higher content of calcite than from blending processes. In addition, the mechanical properties of calcite-consolidation-layer were also tested. The hardness and compressive strength, which reached 19.5 GPa and 0.6 MPa, respectively, of calcite-consolidation-layer from the pressure spraying process were higher than those from the other three treatment processes. Compared with the non-treatment process, the four treatment processes had superior wind erosion resistance. Under the wind speed of 12 m/s, the mass loss of calcite-consolidation-layer from the pressure spraying process decreased from 2150.2 to 23.8 g/（m^2 h）.

关键词： bio-activated cementitious material treatment process mineralization cementation fugitive dust

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Research progress on gel polymer electrolytes for lithium-sulfur batteries

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Journal of Energy Chemistry 2021年第5期30卷 420-437页

作者： Jie qian Biyu Jin Yuanyuan Li Xiaoli zhan yang Hou Qinghua zhang College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina Institute of Zhejiang University-Quzhou Quzhou 324000ZhejiangChina

Lithium-sulfur(Li-S)batteries have become a promising candidate for advanced energy storage system owing to low cost and high theoretical specific *** the last decade,in pursuit of Li-S batteries with enhanced safety and energy density,the investigation on the electrolytes has leaped form liquid organic electrolytes to solid polymer ***,such solid-state Li-S battery system is greatly limited by unfavorable ionic conductivity,poor interfacial contact and narrow electrochemical windows on account of the absence of any liquid *** address these issues,gel polymer electrolytes(GPEs),the incorporation of liquid electrolytes into solid polymer matrixes,have been newly *** the excellent ionic transport and low interfacial resistance provided by GPEs have prompted numerous researchers to make certain progress on high-performance Li-S coins,a comprehensive review on GPEs for Li-S batteries remains ***,this review focuses on recent development and progress on GPEs in view of their physical and chemical properties for the applications in Li-S *** on the components including solid hosts,liquid solutions and fillers of GPEs are systematically summarized with particular emphasis on the relationship between components and ***,current challenges and directional outlook for fabricating GPEs-based Li-S batteries with outstanding performance are outlined.

关键词： Lithium-sulfur batteries Gel polymer electrolytes Solid hosts Liquid solutions

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Tunable perpendicular anisotropic magnetoresistance in CoO/Co/Pt heterostructures

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Rare Metals 2023年第2期42卷 579-584页

作者： qian-qian Liu Guang yang Jing-Yan zhang Guo-Nan Feng Chun Feng qian zhan Ming-Hua Li Guang-Hua Yu Department of Materials Physics and Chemistry University of Science and Technology BeijingBeijing100083China

Transport properties of magnetron-sputtered CoO/Co/Pt heterostructures were investigated by physical property measurement *** types of magnetoresistance are observed in the heterostructures,including isotropic anisotropic magnetoresistance(AMR),AMR with geometric size effect,and interfacial effect.A reversal in sign of perpendicular AMR is found in the film CoO(3 nm)/Co(3 nm)/Pt(3 nm)compared to the film CoO(3 nm)/Co(3 nm)/CoO(3 nm),which is associated with ***,perpendicular AMR is tunable in the films CoO(3 nm)/Co(3 nm)/CoO(t)/Pt(3 nm)and CoO(3 nm)/Co(3 nm)/Pt(t)/CoO(3 nm)at will,with either positive or negative value,by varying the inserting layer *** electronic structure information of the samples was measured by X-ray photoelectron spectroscopy(XPS).The spin-related transport and XPS results manifest that magnetic proximity effect,surface scattering,together with oxygen migration contribute to the tunable function of Pt.

关键词： Perpendicular anisotropic magnetoresistance Magnetic proximity effect Surface scattering X-ray photoelectron spectroscopy

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Pressure control as an effective method to modulate aggregative growth of nanoparticles

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Rare Metals 2021年第7期40卷 1808-1816页

作者： Jian Xu Yuan Shu qian Xia yang-Long Guo Guo-Jun Zhou Wang-Cheng zhan Technology Center China Tobacco Zhejiang Industrial Co.LtdHangzhou 310024China Key Laboratory for Advanced Materials and Research Institute of Industrial Catalysis East China University of Science and TechnologyShanghai 200237China

Recent studies suggested that the interactions between particles can induce aggregative nucleation and growth processes beyond those predicted by the traditional LaMer model of nanoparticle formation,but their nucleation and growth processes are still ***,we report a simple way to control the interaction between nanoparticles by manipulating the oleylamine(OAm)adsorbed on the surface of the *** size distributions of Ag nanoparticles produced at different reaction pressures were monitored as evidence for aggregative *** these kinetic data,the aggregative nucleation rate(C)of primary Ag nanoparticles under a 0.01 MPa was demonstrated to be faster than that under atmospheric *** leads to a higher uniformity of Ag nanoparticles in a shorter time(10 min)than that achievable with previous ***,Ag nanoparticles supported on TiO2 exhibited a remarkable performance in the catalytic reduction of 4-nitrophenol(4-NP).After 4 min,4-NP was completely reduced into4-aminophenol(4-AP).

关键词： Ag nanoparticles Synthesis method Pressure control Size uniformity High efficiency

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STACKING SEQUENCE OPTIMIZA-TION OF LAMINATED COMPOSITE CYLINDER SHELL FOR MAXIMAL BUCKLING LOAD

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Chinese Journal of Mechanical Engineering 2008年第4期21卷 31-34页

作者： TANG qian LIAO Xiaoyun GAO zhan State Key Laboratory of Mechanical Transmission Chongqing University Chongqing 400044 China Motor Coach Industries Winnipeg R3T IT5 Canada

A new optimization method for the optimization of stacking of composite glass fiber laminates is developed. The fiber orientation and angle of the layers of the cylindrical shells are sought considering the buckling load. The proposed optimization algorithm applies both finite element analysis and the mode-pursuing sampling （MPS）method. The algorithms suggest the optimal stacking sequence for achieving the maximal buckling load. The procedure is implemented by integrating ANSYS and MATLAB. The stacking sequence designing for the symmetric angle-ply three-layered and five-layered composite cylinder shells is presented to illustrate the optimization process, respectively. Compared with the genetic algorithms, the proposed optimization method is much faster and efficient for composite staking sequence plan.

关键词： Composite Laminated cylindrical shell Stacking sequence optimization Buckling load Sampling algorithms

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Modelling and Verification of Real-Time Publish and Subscribe Protocol Using UPPAAL and Simulink/Stateflow

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Journal of Computer Science & Technology 2020年第6期35卷 1324-1342页

作者： qian-qian Lin Shu-Ling Wang Bo-Hua zhan Bin Gu State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China Beijing Institute of Control Engineering Beijing 100081China

Real-Time Publish and Subscribe (RTPS) protocol is a protocol for implementing message exchange over an unreliable transport in data distribution service (DDS). Formal modelling and verification of the protocol provide stronger guarantees of its correctness and efficiency than testing alone. In this paper, we build formal models for the RTPS protocol using UPPAAL and Simulink/Stateflow. Modelling using Simulink/Stateflow allows analyzing the protocol through simula-tion, as well as generate executable code. Modelling using UPPAAL allows us to verify properties of the model stated in TCTL (Timed Computation Tree Logic), as well as estimate its performance using statistical model checking. We further describe a procedure for translation from Stateflow to timed automata, where a subset of major features in Stateflow is supported, and prove the soundness statement that the Stateflow model is a refinement of the translated timed automata model. As a consequence, any property in a certain fragment of TCTL that we have verified for the timed automata model in UPPAAL is preserved for the original Stateflow model.

关键词： Real-Time Publish and Subscribe(RTPS) modelling verification UPPAAL Simulink/Stateflow

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A Frequency Domain Based Signal Combining Method for Distributed Antenna Arraying

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China Communications 2019年第8期16卷 176-184页

作者： Chaowei Duan Yafeng zhan qian Kong Space Center Tsinghua UniversityBeijing 100080China Beijing National Research Center for information Science and Technology (BNRist) Beijing 100080China Guangzhou Haige Communications Group Incorporated Company Guangzhou 510000China

Distributed antenna arraying is a promising technology for weak signal reception. The received signals from different antennas are aligned and combined to improve the receiving signal-to-noise ratio(SNR). However, the combining performance is serious degraded by the difference of sampling frequency between antennas. In this paper, a frequency domain based signal combining method is proposed to solve this problem. The unaligned sampled data in time domain of the received signals are transformed to frequency domain using fast Fourier transform(FFT). The received signals can be aligned in frequency domain when their spectrum resolutions are the same. Therefore the received signals with the same total sampling time can be aligned and combined in frequency domain and then the combined signal is recovered using inverse fast Fourier transform(IFFT). Numerical simulations with two typical modulation types, i.e., PSK and PCM/BPSK/PM, prove the validity and robustness of this method.

关键词： weak signal reception distributed antenna arraying signal combining fast fourier transform

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A proton-catalyzing prodrug for PDT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions

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Science China Chemistry 2024年第9期67卷 3162-3178页

作者： Miao Li Xueying Sun Xiuqin Ma yang Tan Xiaoyi Jin Yi Wang Fan yang qian Li Honglei zhan Xiaojun Peng School of Biological Engineering Dalian Polytechnic UniversityDalian 116034China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

The reactive oxygen species(ROS)generation from photosensitizer in photodynamic therapy(PDT)is limited by tumor *** type-I photosensitizers,e.g.,sulfur-substituted Nile blue,still rely on oxygen as the main center for transferring electrons to generate *** off the pathway of oxygen consumption in tumor can help photosensitizers overcome the limitation of low oxygen,in order to efficiently generate more *** is known that glycolysis inhibitor 3-bromopyruvic acid(3-BP),which could specially target mitochondria,can provide more oxygen by inhibiting oxidative ***,we successfully designed and synthesized a new 3-BP-coupled sulfur-substituted Nile blue as prodrug(NBBP)for chemical/photodynamic synergistic *** results indicated that the protons in tumor catalyzed the hydrolysis of NBBP,inhibited photoinduced electron transfer between 3-BP and the photosensitizer in NBBP and further assisted the photosensitizer to be localized in mitochondria,utilizing local oxygen as much as possible and kill tumor cells more ***,the glycolysis inhibition-induced autophagy was combined with PDT-induced autophagy,which could promote the deaths of tumor *** other remedies exploiting nanomaterials,this construction method of NBBP achieves the efficient synergy of photodynamic therapy and glycolysis inhibition,stronger than their theoretical addition,in spatiotemporal *** study provides not only a highly efficient platform for tumor therapy but also a design approach for prodrugs with synergistic effects.

关键词： photodynamic therapy prodrug glycolysis inhibition autophagy tumor synergistic therapy

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