检索结果-南通市图书馆

Chinese Chemical Letters 2024年第6期35卷 353-357页

作者： jinyan zhang Fen Liu Qian jin Xueyi Li Qiong zhan Mu Chen Sisi Wang Zhenlong Wu Wencai Ye Lei Wang State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative Drugs and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)*** 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage *** structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical *** pathways for compounds 1-5 were proposed on the basis of the coexisting *** by the biogenetic pathways,the biomimetic synthesis of compound 1 was also ***,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关键词： Phloroglucinol-triterpenoid adduct Myrtaceae Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity

Development and validation of a machine learning-based early prediction model for massive intraoperative bleeding in patients with primary hepatic malignancies

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第1期16卷 90-101页

作者： jin Li Yu-Ming Jia Zhi-Lei zhang Cheng-Yu Liu zhan-Wu Jiang Zhi-Wei Hao Li Peng Department of Hepatological Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of General Surgery II Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Surgical resection remains the primary treatment for hepatic malignancies,and intraoperative bleeding is associated with a significantly increased risk of ***,accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective *** To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and *** The retrospective analysis enrolled patients diagnosed with primary hepatic malignancies who underwent surgery at the Hepatobiliary Surgery Department of the Fourth Hospital of Hebei Medical University between 2010 and *** regression analysis was performed to identify potential risk factors for intraoperative bleeding.A prediction model was developed using Python programming language,and its accuracy was evaluated using receiver operating characteristic(ROC)curve *** Among 406 primary liver cancer patients,16.0%(65/406)suffered massive intraoperative *** regression analysis identified four variables as associated with intraoperative bleeding in these patients:ascites[odds ratio(OR):22.839;Plues for the model’s ability to predict intraoperative bleeding were 0.844 in the training set and 0.80 in the prediction *** The developed and validated model predicts significant intraoperative blood loss in primary hepatic malignancies using four preoperative clinical factors by considering four preoperative clinical factors:ascites,history of alcohol consumption,TNM staging,and albumin-bilirubin ***

关键词： Primary liver cancer Intraoperative bleeding Machine learning Model

A tectono-thermal perspective on the petroleum generation,accumulation and preservation in the southern Ordos Basin, North China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 1459-1473页

作者： Peng Yang zhan-Li Ren jin-Hua Fu Hong-Ping Bao Hui Xiao Zheng Shi Kun Wang Yuan-Yuan zhang Wen-Hui Liu Wen-Hou Li State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069ShanxiChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an710018ShaanxiChina Shaanxi Key Lab of Petroleum Accumulation Geology School of Earth Science and EngineeringXi'an Shiyou UniversityXian710065ShaanxiChina Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxi214126JiangsuChina

The southern Ordos Basin has excellent petroleum exploration ***,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are *** this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution *** the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern *** paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source *** vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation *** Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation *** southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and *** event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and *** southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic *** southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the *** str

关键词： Fission-track dating Vitrinitereflectance Geothermal field Tectono-thermal evolution Petroleum geology Ordos Basin

Critical Review on Improved Electrochemical Impedance Spectroscopy-cuckoo Search-Elman Neural Network Modeling Methods for Whole-life-cycle Health State Estimation of Lithium-ion Battery Energy Storage Systems

在线全文

学校读者我要写书评

暂无评论

Protection and Control of Modern Power Systems 2024年第2期9卷 75-100页

作者： Ran Xiong Shunli Wang Paul Takyi-Aninakwa Siyu jin Carlos Fernandez Qi Huang Weihao Hu Wei zhan School of Information Engineering Southwest University of Science and TechnologyMianyangChina School of Information Engineering Southwest University of Science and TechnologyMianyang621010 China Mechanical Engineering from Kwame Nkrumah Uni-versity of Science and Technology Ghana Northeastern University ShenyangChina Robert Gordon University Scotland Southwest University of Science and Technology(SWUST) Mian-yangChina University of Electronic Science and Technology of China ChengduChina Xi’an Jiaotong University Xi’anChina SPIC Southwest Energy Research Institute ChengduChina

Efficient and accurate health state estimation is crucial for lithium-ion battery(LIB)performance monitoring and economic *** estimating the health state of LIBs online is the key but is also the most difficult task for energy storage *** high adaptability and applicability advantages,battery health state estimation based on data-driven techniques has attracted extensive attention from researchers around the *** neural network(ANN)-based methods are often used for state estimations of *** one of the ANN methods,the Elman neural network(ENN)model has been improved to estimate the battery state more efficiently and *** this paper,an improved ENN estimation method based on electrochemical impedance spectroscopy(EIS)and cuckoo search(CS)is established as the EIS-CS-ENN model to estimate the health state of ***,the paper conducts a critical review of various ANN models against the EIS-CS-ENN *** demonstrates that the EIS-CS-ENN model outperforms other *** review also proves that,under the same conditions,selecting appropriate health indicators(HIs)according to the mathematical modeling ability and state requirements are the keys in estimating the health state *** the calculation process,several evaluation indicators are adopted to analyze and compare the modeling accuracy with other existing *** the analysis of the evaluation results and the selection of HIs,conclusions and suggestions are put ***,the robustness of the EIS-CS-ENN model for the health state estimation of LIBs is verified.

关键词： Lithium-ion battery health state esti-mation elman neural network electrochemical imped-ance spectroscopy cuckoo search health indicators

2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng Minru Liao Wenke jin Wei Liu Zixiang Li Zhichao Fan Ling Zou Siwei Chen Lingjuan Zhu Qian Zhao Gu zhan Liang Ouyang Cheng Peng Bo Han jin zhang Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun N-terminal kinase(JNK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RNA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PYCR1)axis was closely assoiated with *** activating PYCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism

Determination of molecular energies via variational-based quantum imaginary time evolution in a superconducting qubit system

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 1-11页

作者： Zhiwen Zong Sainan Huai Tianqi Cai Wenyan jin Ze zhan Zhenxing zhang Kunliang Bu Liyang Sui Ying Fei Yicong Zheng Shengyu zhang Jianlan Wu Yi Yin Zhejiang Province Key Laboratory of Quantum Technology and Device School of PhysicsZhejiang UniversityHangzhou 310027China Tencent Quantum Laboratory Shenzhen 518057China

As a valid tool for solving ground state problems,imaginary time evolution(ITE)is widely used in physical and chemical *** ITE-based algorithms in their quantum counterpart have recently been proposed and applied to some real *** experimentally realize the variational-based quantum imaginary time evolution(QITE)algorithm to simulate the ground state energy of hydrogen(H_2)and lithium hydride(Li H)molecules in a superconducting qubit *** H_2 molecule is directly simulated using the 3-qubit circuit with unitary-coupled clusters(UCC)*** also combine QITE with the cluster mean-field(CMF)method to obtain an effective *** Li H molecule is correspondingly simulated using the 3-qubit circuit with hardware-efficient *** comparison,the Li H molecule is also directly simulated using the 4-qubit circuit with UCC ansatz at the equilibrium *** the experimental results show a convergence within 4 iterations,with high-fidelity ground state energy *** a more complex system in the future,the CMF may allow further grouping of interactions to obtain an effective Hamiltonian,then the hybrid QITE algorithm can possibly simulate a relatively large-scale system with fewer qubits.

关键词： quantum computation quantum algorithm superconducting qubit

Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 355-366页

作者： jing-Yi Jia Guang-Hui Chen Ting-Ting Shu Qi-Yong Lou Xia jin Jiang-Yan He Wu-Han Xiao Gang Zhai zhan Yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ARE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

Identification of the non-stationarity of extreme temperature events and teleconnections with solar activity and large-scale atmospheric circulation: A case study in the Yangtze River Economic Belt

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年

作者： Lin zhang jingyun Ling Shengzhi Huang Hongbin zhan Yi Wu Menggui jin Qiang Huang State Key Laboratory of Eco-hydraulics in Northwest Arid Region， Xi'an University of Technology College of Design and Engineering， National University of Singapore Yinshanbeilu Grassland Eco-Hydrology National Observation and Research Station， China Institute of Water Resources and Hydropower Research Department of Geology and Geophysics， Texas A&M University， College Station School of Earth System Science， Tianjin University School of Environmental Studies， China University of Geosciences

In recent decades， extreme climate events have become a major problem worldwide. To understand the uncertainty in the response of extreme events to global warming， regional assessments are required for various climatic and geographic regions. The spatiotemporal distribution of extreme temperature events in the Yangtze River Economic Belt (YREB) from 1960 to 2019， including interannual changes and their teleconnections with solar activity and large-scale atmospheric circulation， were analyzed using eight indices of extreme temperature events. Over the past six decades， the climate in the YREB region has seen a warming trend， characterized by an increase in extreme warm events and a decrease in extreme cold events. The extreme temperature indices exhibit strong spatial variability. The warm extremes display a significant upward trend across the YREB， while cold extremes are primarily concentrated in the western part of the region. In recent decades， both warm and cold extremes have significant interannual variations， and these events predominantly oscillate over periods of less than four years. After 1985， the relationship between El Ni?o-Southern Oscillation (ENSO)， Arctic Oscillation (AO)， Pacific Decadal Oscillation (PDO) and extreme temperature events has changed significantly compared with pre-1985， and the direction of the phase angle can determine the positive and negative effects of the two time-series. ENSO， AO and PDO mainly have positive impacts on extreme temperature events， with ENSO and AO exerting greater impacts than PDO. In contrast， solar activity mainly has a negative impact on these events. Furthermore， the notable interdecadal changes in extreme temperature events， especially warm extremes， may be caused by the shift in the PDO phase. Therefore， the results of the study are important for the YREB region to take effective measures to mitigate the potential impacts of human activities on regional warming.

关键词：

Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第1期14卷 87-109页

作者： Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen Cheng Dongwei Kang Fan Yi jin-Peng Sun luis Menéndez-Arias Johan Neyts Xinyong Liu Peng zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Shenzhen Research Institute of Shandong University Shenzhen 518057China The Key Laboratory of Infection and Immunity of Shandong Province Department of PharmacologySchool of Basic Medical SciencesShandong UniversityJinan 250012China Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Centro de Biologı´a Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Cientı´ficas&Autonomous University of Madrid) Madrid 28049Spain KU Leuven Department of Microbiology and ImmunologyRega Institute for Medical ResearchLaboratory of Virology and ChemotherapyLeuven 3000Belgium

The main protease(M^(pro))of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life *** covalent M^(pro)inhibitor nirmatrelvir(in combination with ritonavir,a pharmacokinetic enhancer)and the non-covalent inhibitor ensitrelvir have shown efficacy in clinical trials and have been approved for therapeutic *** antiviral drugs are needed to fight the pandemic,while non-covalent M^(pro)inhibitors could be promising alternatives due to their high selectivity and favorable *** non-covalent M^(pro)inhibitors with desirable properties have been developed based on available crystal structures of M^(pro).In this article,we describe medicinal chemistry strategies applied for the discovery and optimization of non-covalent M^(pro)inhibitors,followed by a general overview and critical analysis of the available *** viewpoints and insights into current strategies for the development of non-covalent M^(pro)inhibitors are also discussed.

关键词： COVID-19 SARS-CoV-2 Main protease Non-covalent inhibitors Medicinal chemistry strategies

在线全文

学校读者我要写书评

暂无评论

扩展重采样次谐波大气湍流模拟相位屏研究

光子学报 2024年第8期53卷 68-79页

作者：卢文雍石岩陈建勇占春连金尚忠中国计量大学光学与电子科技学院杭州310018

提出了一种扩展重采样次谐波方法生成大气湍流相位屏,扩展了低频补偿的起始区域,并设计了低频补偿区域的新型采样方式。以Kolmogorov理论进行模拟,分析了该方法设置不同次谐波级数所生成相位屏的相位结构函数与理论值的误差,搭建大气湍... 详细信息

提出了一种扩展重采样次谐波方法生成大气湍流相位屏,扩展了低频补偿的起始区域,并设计了低频补偿区域的新型采样方式。以Kolmogorov理论进行模拟,分析了该方法设置不同次谐波级数所生成相位屏的相位结构函数与理论值的误差,搭建大气湍流模拟系统进行分析。结果表明:扩展重采样次谐波法生成相位屏的相位结构函数与理论值的相对误差为0.368%,加载此方法生成的大气湍流相位屏后,产生的湍流效应对图像调制传递函数的影响与湍流调制传递函数曲线的误差平均值为0.0336。该方法能够生成高精度的大气湍流相位屏。

关键词：大气光学大气湍流相位屏次谐波相位结构函数光学传递函数