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Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma

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World Journal of Gastroenterology 2006年第18期12卷 2941-2944页

作者： Ze-Yu Wu Jing-hua Li Wen-hua zhan Yu-Long He Department of Gastrointestinal and Pancreatic Surgery the First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 Guangdong Province China Zhong Shan Medical College Sun Yat-sen University Guangzhou 510089 Guangdong Province China Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To examine matrix metalloproteinase-2 （MMP-2） expression in gastric cancer tissues and to evaluate its relationship with lymph node micrometastasis. MATERIALS： The authors studied 850 lymph nodes resected from 30 patients with gastric carcinoma who underwent gastrectomy with lymphadenetomy using reverse transcription polymerase chain reaction （RT-PCR） assay in addition to H-E staining. MMP-2 expression of the tumor tissues was detected by immunohistochemical technique （EliVision^TM plus）. RESULTS： MMP-2 expression was positive in 21 （70%） cases and negative in g （30%） cases. No significant correlations were found between MMP-2 expression and other variables such as age, gender, tumor location, tumor diameter, Lauren classification and lymphatic invasion. In contrast, MMP-2 expression correlated significantly with depth of tumor infiltration （P = 0.022）, lymph node metastasis （P = 0.030） and tumor differentiation （P = 0.043）. Lymph node micrometastases were detected in 77 （12.5%） lymph nodes of 14 （46.7%） gastric carcinoma patients. MMP-2 expression was positive in 12 （85.7%） of the 14 patients with lymph node micrometastasis, and in g （56.3%） of the 16 patients without lymph node micrometastasis （P = 0.118）. CONCLUSIONS： Our results demonstrate that MMP-2 expression has significant correlation with tumor invasion, tumor differentiation and lymph node metastases. MMP-2 expression may be an important biological characteristics and significant prognostic parameter of gastric carcinoma. We also conclude that MMP-2 may participate in the development of lymph node micrometastasis of gastric carcinoma. Further investigations are needed to draw a conclusion.

关键词： Gastric carcinoma Lymph node micrometastasis MMP-2 RT-PCR Immunohistochemistry

Fine Structure in the Electron Emission Process for Two DX-Like Centers in Sn-Doped AlGaAs

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Chinese Physics Letters 1998年第1期15卷 60-61页

作者： zhan hua-han KANG Jun-yong huaNG Qi-sheng Department of Physics Xiamen UniversityXiamen 361005

Fine structure in the electron emission process for DX(Sn)centers in AlGaAs has been studied with high resolution Laplace defect *** influence of the different local configuration of Al and Ga atoms around the centers on the electron thermal emissions was *** experimental evidence for the microscopic structure of two DX-like centers in Sn-doped AlGaAs is provided.

关键词： AlGaAs centers DX

Transanal natural orifice specimen extraction for laparoscopic anterior resection in rectal cancer

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World Journal of Gastroenterology 2013年第43期19卷 7751-7757页

作者： Fang-Hai Han Li-Xin hua Zhi Zhao Jian-Hai Wu Wen-hua zhan Department of Gastrointestinal Surgery The First Affiliated Hospital of Sun Yat-Sen University

AIM: To investigate whether transanal natural orifice specimen extraction (NOSE) is a better technique for rectal cancer resection.METHODS: A prospectively designed database of a consecutive series of patients undergoing laparoscopic low anterior resection for rectal cancer with various tumor-node-metastasis classi?cations from March 2011 to February 2012 at the First Affiliated Hospital of Sun Yat-Sen University was analyzed. Patient selection for transanal specimen extraction and intracorporeal anastomosis was made on the basis of tumor size and distance of rectal lesions from the anal verge. Demographic data, operative parameters, and postoperative outcomes were assessed.RESULTS: None of the patients was converted to laparotomy. Respectively, there were 16 cases in the low anastomosis and five in the ultralow anastomosis groups. Mean age of the patients was 45.4 years, and mean body mass index was 23.1 kg/m2. Mean distance of the lower edge of the lesion from the anal verge was 8.3 cm. Mean operating time was 132 min, and mean intraoperative blood loss was 84 mL. According to the principle of rectal cancer surgery, we performed D2 lymph node dissection in 13 cases and D3 in eight. Mean lymph nodes harvest was 17.8, and the number of positive lymph nodes was 3.4. Median hospital stay was 6.7 d. No serious postoperative complication occurred except for one anastomotic leakage. All patients remained disease free. Mean Wexner score was 3.7 at 11 mo after the operation.CONCLUSION: Transanal NOSE for total laparoscopic low/ultralow anterior resection is feasible, safe and oncologically sound. Further studies with long-term outcomes are needed to explore its potential advantages.

关键词： Transanal specimen extraction Natural orifice specimen extraction Laparoscopic anterior resection Low/ultra-low anastomosis Total mesorectal excision

Effect of Barrier Materials on Discharge Properties in Air at Low Pressure

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高电压技术 2007年第12期33卷 80-84页

作者： LIMing LI Cheng-rong zhan hua-mao XU Jin-bao zhanG Xian-jun Beijing Key Laboratory of High Voltage ~ EMC School of Electric and Electronic Engineering North China Electric Power University Beijing 102206 China

Dielectric barrier discharge(DBD) is widely investigated in order to obtain uniform low-temperature *** studies have proved that some barrier materials,especially electrets,can improve the uniformity of *** is regarded as an available way to get atmospheric pressure glow discharge(APGD).In this paper,discharge forms with 4 different barrier materials(alumina,quartz,PTFE and PET) are investigated,and the transition of discharge form depending on the air pressure are recorded to estimate the influence of barrier materials on *** using electrets as barrier materials,homogeneous discharges can be obtained in a more wide pressure *** the same experimental conditions,discharges with electrets are more uniform or have larger uniform areas due to the storage and desorption of charges on the surface of *** electrons deposited in the surface layer can be released on next half cycle when the polarity of the applied voltage changes,and provide a number of seed electrons,which makes the discharge more *** capacitance and the permittivity of barrier materials have no effect on the discharge form directly.

关键词：放电特性低气压电子跃迁电介体表面电荷栅栏

Hydrogen embrittlement of a microalloyed bainitic forging steel

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Journal of Iron and Steel Research International 2019年第9期26卷 1011-1021页

作者： Wei-jun Hui zhan-hua Wang Zhi-bao Xu Yong-jian zhang Xiao-li Zhao Materials Science and Engineering Research Center School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Yantai Branch of China North Industries Group Corporation No. 52 Institute Co. Ltd.Yantai 264003ShandongChina

The hydrogen embrittlement (HE) of a novel microalloyed bainitic forging steel with a strength level of 1100 MPa was evaluated using electrochemical charging and slow strain rate tensile test method with notched round bar specimens. The results show that the susceptibility to HE of the as-forged bainitic forging steel is notably higher than that of the quenched and tempered (Q&T) steel at same strength level, which is ascribed primarily to the presence of a relatively high amount of large blocky martensite/austenite (M/A) constituents of the former. It was found that low-temperature tempering treatment at 200 C could significantly alleviate the susceptibility to HE by a relative decrease of * 35% of the as-forged bainitic forging steel at no expense of strength and ductility, though its resistance to HE is still a little lower than that of the Q&T steel. Thus, it is suggested that efforts concerning refining of the large blocky M/A through optimizing chemical composition and processing route could help to further alleviate the susceptibility to HE of the tested bainitic forging steel.

关键词： Hydrogen embrittlement Bainitic forging steel Microstructure Granular bainite M/A constituent

(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer

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World Journal of Gastroenterology 2011年第18期17卷 2315-2325页

作者： Bao-He Zhu hua-Yun Chen Wen-hua zhan Cheng-You Wang Shi-Rong Cai Zhao Wang Chang-hua zhang Yu-Long He Department ofGastrointestinal and Pancreatic Surgery First Affiliated HospitalSun Yat-Sen University Gastric Cancer Center of Sun Yat-SenUniversity Guangzhou 510080 Guangdong Province China Department of General Surgery First Affiliated Hospital Shenzhen University Shenzhen518035 Guangdong Province China

AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. METHODS: Human gastric cancer (AGS) cells were treated with IL-6 (50 ng/mL) and EGCG at different concentrations. VEGF, total Stat3 and activated Stat3 protein levels in the cell lyses were examined by Western blotting, VEGF protein level in the conditionedmedium was measured by enzyme-linked immunosorbent assay, and the level of VEGF mRNA was evaluated by reverse transcription polymerase chain reaction (RTPCR). Stat3 nuclear translocation was determined by Western blotting with nuclear extract, and Stat3-DNA binding activity was examined with Chromatin immunoprecipitation (ChIP) assay. IL-6 induced endothelial cell proliferation was measured with 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazoliumbromide assay, in vitro angiogenesis was determined with endothelial cell tube formation assay in Matrigel, and IL-6-induced angiogenesis in vitro was measured with Matrigel plug assay. RESULTS: There was a basal expression and secretion of VEGF in AGS cells. After stimulation with IL-6, VEGF expression was apparently up-regulated and a 2.4-fold increase was observed. VEGF secretion in the conditioned medium was also increased by 2.8 folds. When treated with EGCG, VEGF expression and secretion were dose-dependently decreased. IL-6 also increased VEGF mRNA expression by 3.1 folds. EGCG treatment suppressed VEGF mRNA expression in a dose-dependent manner. EGCG dose-dependently inhibited Stat3 activation induced by IL-6, but did not change the total Stat3 expression. When treated with EGCG or AG490, VEGF expressions were reduced to the level or an even lower level in the tumor cells not stimulated with IL-6. However, PD98059 and LY294002 did not change VEGF expression induced by IL-6. EGCG inhibited

关键词： Epigallocatechin-3-gallate Vascular endothelial growth factor Signal transducer and activator of transcription 3 Angiogenesis Gastric cancer

Are the altitudinal patterns of plant diversity derived from field surveys consistent with those from empirical integrated methods?

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Journal of Mountain Science 2023年第5期20卷 1307-1315页

作者： zhan Qing-hua FU Zhi-hao ZHOU Ya-dong YAN Xue WANG Qing-feng School of Life Sciences Nanchang UniversityNanchang 330031China Wuhan Botanical Garden/Core Botanical Gardens Chinese Academy of SciencesWuhan 430074China Sino-Africa Joint Research Center(SAJOREC) Chinese Academy of SciencesWuhan 430074China

Field surveys and empirical integrated methods are commonly used in the ecological research to understand the altitudinal pattern of plant diversity of ***,few studies have compared the differences between the two methods on the same ***,we addressed and compared the altitudinal patterns of species richness(SR),phylogenetic diversity(PD),the standardized effect size of phylogenetic diversity(PDses)and mean phylogenetic distance(MPDses)of about 580 angiosperms growing on Mount Kenya from two independent datasets:one is based on our several times field surveys in this mountain and another one is based on empirical data integrated from *** found that the altitudinal diversity patterns of field surveys dataset were consistent with the empirical integrated *** SR and PD showed hump-shaped patterns along the altitude,and both PDses and MPDses showed monotonically decreasing patterns along the *** ratio of diversity between field surveys dataset and empirical integrated dataset were gradually increase along the *** research provides new insight for understanding the altitudinal diversity patterns of plants of a tropical mountain.

关键词： Mount Kenya Africa Surveys Interpolation method Taxonomic Phylogenetic

Anisotropy in tensile properties and fracture behaviour of 316L stainless steel parts manufactured by fused deposition modelling and sintering

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Advances in Manufacturing 2022年第3期10卷 345-355页

作者： Lin-Ju Wen Xiao-Gang Hu Zhong Li zhan-hua Wang Ji-Kai Wu Qiang Zhu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongPeople's Republic of China Department of Mechanical Engineering Polytechnic University of Milan20156 MilanItaly SUSTechAcademy for Advanced Interdisciplinary Studies Shenzhen 518055GuangdongPeople's Republic of China Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials Shenzhen 518055GuangdongPeople's Republic of China Elementplus Material Technology Co.Ltd. Shenzhen 518055GuangdongPeople's Republic of China

Fused deposition modelling and sintering(FDMS)is a potential metal additive manufacturing technology due to its low cost and high *** mixture of metal powder and binder goes through heating,extrusion,debinding and sintering processes to produce the compact finished ***,it is generally believed that parts produced by FDMS possess poor and anisotropic tensile properties,which always attributes to the weak interlayer *** current work aimed to enhance tensile properties and better understand the anisotropic fracture behavior of the 316L stainless steel prepared by *** process optimization,the yield strength and ultimate tensile strength obtained in this work are increased by 26.1%and 15.2%,based on the highest performance reported in previous *** to the ultimate tensile strength,the performance difference between the horizontal and vertical directions has been reduced to 27%.Furthermore,the experimental results indicated that the clustered irregular shape holes evolved from primitive voids prefer to distribute in the build direction,resulting in anisotropic tensile *** is suggested that the mechanical properties could be improved by applying a smaller extrusion diameter and rolling-assisted *** addition,the current FDMS parts show qualified performance for producing the customized and small batch components.

关键词： Fused deposition modelling 316L stainless steel Anisotropy Mechanical properties Fracture behaviour

Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival

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World Journal of Gastroenterology 2015年第4期21卷 1140-1147页

作者： Zhi Zhao Fang-Hai Han Shi-Bin Yang Li-Xin hua Jian-Hai Wu Wen-hua zhan Department of Gastrointestinal Surgery the First Affiliated Hospital of Sun Yat-sen University

AIM: To investigate the clinicopathological significance and prognostic value of caveolin-1(CAV-1) in both tumor and stromal cells in colorectal cancer(CRC).METHODS: A total of 178 patients with CRC were included in this study. The correlation between CAV-1expression and clinicopathologic features and survival was ***: CAV-1 expression was detected in tumor and stromal cells. The expression of stromal CAV-1 was closely associated with histological type(P = 0.022), pathologic tumor-node-metastasis stage(P = 0.047), pathologic N stage(P = 0.035) and recurrence(P = 0.000). However, tumor cell CAV-1 did not show any correlation with clinical parameters. Additionally, the loss of stromal CAV-1 expression was associated with shorter disease-free survival(P = 0.000) and overall survival(P = 0.000). Multivariate analysis revealed that the loss of stromal CAV-1 expression was an independent prognostic factor for both overall survival(P = 0.014) and disease-free survival(P = 0.006).CONCLUSION: The loss of stromal CAV-1 expression in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.

关键词： CAV-1 Stroma Colorectal cancer Prognosis