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Alkaloids from Stems of Ervatamia yunnanensis （Ⅱ）

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Chinese Chemical Letters 2006年第6期17卷 783-786页

作者： Shuang LIANG Xin Gen LUO Hai Sheng CHEN xiao dong zhanG Mao HUANG Wen Yong LIU College of Pharmacy Second Military Medical University Shanghai 200433 Deoartment of Pharmacy Guangzhou Military General Hospital Guangzhou 510010 Center of New Drug Evaluation Institute of Basic Medical Sciences Second Military Medical University Shanghai 200433

Six indole alkaloids were isolated from the stems of Ervatamia yunnanensis. Among them, 10-hydroxy-19, 20-dihydroisositsirikine （I） is new. The other five are known alkaloids, namely： matrine （Ⅱ）, 19, 20-dihydroisositsirikine （Ⅲ）, 19-s-voacangarine （Ⅳ）, 1 l＇-methoxyl-19s- heyneanine （Ⅴ）, conodurine （Ⅵ）. The structural elucidation of the alkaloids was based on spectral means.

关键词： Ervatamia yunnanensis indole alkaloids.

Effect of Polysaccharides from Fruit Body of Ganoderma tsugae on Bidirectional Regulation of Proinflammatory Cytokine Production in THP-1 Cells

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Chemical Research in Chinese Universities 2009年第4期25卷 487-491页

作者： LIU Ai-dong ZHENG Ke-yan MIAO Qing-fang IKEJIMA Takashi zhanG Jie FEI xiao-fang College of Life Science Jilin University Changchun 130021 P. R. China College of Chemistry Jilin University Changchun 130021 P. R. China Department of Pharmacy the Affiliated Hospital Changchun University of Traditional Chinese Medicine Changchun 130021 P. R. China Department of Cardiology the Affiliated Hospital Changchun University of Traditional Chinese Medicine Changchun 130021 P. R. China China-Japan Research Institute of Medical and Pharmaceutical Sciences Shenyang Pharmaceutical University Shenyang 110016 R R. China

The polysaccharides,FIII-2,FIII-2-a,FIII-2-b and FIII-2-c were purified from the fruit body of Ganoderma tsugae（***） to study the effects of the four polysaccharides on the productions of human proinflammatory cytokines,interleukin-1α（IL-1α） and tumor necrosis factor α（TNFα）.The results show that the polysaccharides up-regulated the production of IL-1α and TNFα in THP-1 cells under non-stimulatory condition or under stimulation of both lower concentration lipopolysaccharide（LPS） and phorbol myristate acetate（PMA）,and they down-regulated the secretion of IL-1α and TNFα under stronger stimulatory *** four polysaccharides promoted the expression of TNFα *** of TNFα protein reflects the quantity of TNFα *** polysaccharides purified from Ganoderma tsugae bodies exhibit bidirectional regulation effects on cytokine production under different cell stimulatory conditions.

关键词： Polysaccharide Bidirectional regulation Cytokine

Relativistic Magnetosonic Solitary Wave in Magnetized Multi-Ion Plasma

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Communications in Theoretical Physics 2009年第6期51卷 1121-1124页

作者： WANG Yun-Liang ZHOU Zhong-Xiang LU Yan-Zhen NI xiao-dong SHEN Jiang zhanG Yu Department of Physics School of Applied Science University of Science and Technology Beijing Beijing 100083 China Department of Physics Harbin Institute of Technology Harbin 150001 China

In the presence of an applied uniform magnetic field Bo, the properties of 2-dimensional （2D） magnetosonic solitary waves of relativistic amplitude in the plasma containing electron, light ions He^＋, and heavy ions O＋ are presented. In the weakly relativistic limit, a Kadomtsev Petviashvili （KP） equation is derived by reductive perturbation method. We give the N-soliton solution of the KP equation and find dromion solutions of a potential of the physical field. The interaction law of the dromions is obtained, which shows there is no exchange of energy, momentum, and angular momentum before and after interaction of the dromions except for phase shifts.

关键词： magnetosonic solitary wave magnetized plasma weakly relativistic

Neuroprotective effect of ischemic postconditioning on sciatic nerve transection

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Neural Regeneration Research 2018年第3期13卷 492-496页

作者： xiao-bin Zhou Na Liu dong Wang De-xin Zou Chang-wei Wei Jun-lin Zhou Department of Orthopedics Beijing Chaoyang Hospital Capital Medical University Department of Traumatic Orthopedics the Third Hospital of Shijiazhuang Department of Internal Neurology the First Hospital of Hebei Medical University Department of Spine Surgery Yan Tai-Shan Hospital Department of Anesthesia Beijing Chaoyang Hospital Capital Medical University

Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes ＋ reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored. These findings indicate that ischemic postconditioning can effectively protect injured sciatic nerve. The protective effect is possibly associated with upregulation of insulin-like growth factor 1.

关键词： nerve regeneration ischemic postconditioning nerve injury insulin-like growth factor 1 sciatic nerve ischemia/reperfusion neural regeneration

基于机载雷达数据的输电线弛度在线监测系统设计

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自动化技术与应用 2024年第6期43卷 150-155页

作者：齐鸣朱庆林贺新钢李彧尚晓东国网黑龙江省送变电工程有限公司黑龙江哈尔滨150070 国网黑龙江省电力有限公司黑龙江哈尔滨150000

架空输电线弛度是电力架线施工验收的重要指标,为解决利用传统经纬仪测量弛度受通视条件限制且测量范围小的问题,设计一种基于机载雷达数据的输电线弛度在线监测系统。利用模糊统计法对雷达数据进行分类,提取测点数据利用悬链方程进行... 详细信息

架空输电线弛度是电力架线施工验收的重要指标,为解决利用传统经纬仪测量弛度受通视条件限制且测量范围小的问题,设计一种基于机载雷达数据的输电线弛度在线监测系统。利用模糊统计法对雷达数据进行分类,提取测点数据利用悬链方程进行弛度拟合分析,数据无线通信满足在线检测要求。所设计的弛度在线监测系统应用于施工现场,系统运行稳定且最大误差不超过±1%,能够有效解决检测中面临的复杂地形、线路大跨度远距离弧垂测量难度大的问题,能够实时指导现场施工,且低成本,具有较好的推广应用价值。

关键词：机载雷达架空输电线弧垂在线监测无人机监测

β^--Decay Half-Lives for Waiting Point Nuclei Around N=126

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Communications in Theoretical Physics 2019年第3期71卷 293-297页

作者： Ji-Lin You Qing-dong Wu xiao-Ping zhang Qi-Jun Zhi School of Physics and Electronic Sciences Guizhou Normal University Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal University State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and Technology

We have systematically analyzed the experimental β--decay half-lives of waiting point heavy nuclei around neutron number N = 126. A new set of parameters for the exponential formula of β^--decay half-lives is proposed. The forbidden transition effects are included in the new set of parameters self-consistently. Theoretical β^--decay half-lives of nuclei around N = 126 are compared with recent theoretical results and experimental data. It is found that the new theoretical results are in better agreement with experimental data. The unknown β^--decay half-lives of some nuclei in this region are predicted for studies on nuclear structure far from stability and the nucleosynthesis in stars.

关键词： β^--decay half-lives waiting point nuclei nucleosynthesis

Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment

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Chinese Chemical Letters 2023年第5期34卷 449-455页

作者： Lu Tang Mengying Xie Jing Li Yijun Mei Yuqi Cao Qiaqia xiao Haijuan dong Yuhui zhang Wei Wang Department of Pharmaceutics State Key Laboratory of Natural MedicinesSchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical UniversityNanjing 210009China The Public Laboratory Platform China Pharmaceutical UniversityNanjing 210009China Department of Spine Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy ***,there are very limited researches for IMSCT treatment using *** fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT *** this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of *** to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery.

关键词： Mesenchymal stem cell Intramedullary spinal cord tumor Metformin Nanosystem Targeted drug delivery

胰岛素抵抗和糖酵解代谢与子宫内膜息肉发生的相关性研究

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岭南急诊医学杂志 2024年第5期29卷 487-491页

作者：李扬志陈亚肖陈冬梅谢小倩张超谢梅青中山大学孙逸仙纪念医院妇产科 510120

目的:探讨子宫内膜息肉(EP)的发生与子宫内膜局部胰岛素抵抗和糖酵解代谢的关系。方法:选择2023年6月至2024年2月中山大学孙逸仙纪念医院妇科诊断为EP并接受宫腔镜手术的患者230例和非EP患者220例为研究对象,行OGTT及胰岛素释放试验,比... 详细信息

目的:探讨子宫内膜息肉(EP)的发生与子宫内膜局部胰岛素抵抗和糖酵解代谢的关系。方法:选择2023年6月至2024年2月中山大学孙逸仙纪念医院妇科诊断为EP并接受宫腔镜手术的患者230例和非EP患者220例为研究对象,行OGTT及胰岛素释放试验,比较两组糖代谢异常和胰岛素抵抗的差异。从EP患者中提取EP组织及周围正常子宫内膜组织,比较两者PI3K/Akt信号通路及Glut4蛋白的表达水平,糖酵解酶和中间产物表达水平的差异。结果:***组FPG、OGTT 2h、FINS、1hINS、2hINS和HOMA-IR水平均明显高于非EP组(P均<0.05)。***患者中,与正常子宫内膜相比,EP组织中胰岛素诱导的激酶p-AKT(Ser473)、p-PI3K(Tyr458)表达均明显上调,p-IRS1(Ser307)、葡萄糖转运体Glut4、糖酵解代谢调节蛋白己糖激酶I(Hexo Ⅰ)、己糖激酶Ⅱ(HexoⅡ)、丙酮酸激酶M亚型1/2(PKM1/2)和血小板磷酸果糖激酶(PFKP)的表达均明显降低,乳酸脱氢酶A(LDHA)表达明显增加(P均<0.05)。结论:EP患者存在外周血胰岛素抵抗。Glut4诱导子宫内膜的局部胰岛素抵抗和糖酵解代谢功能障碍,可能导致EP形成。

关键词：子宫内膜息肉 Glut4 胰岛素抵抗糖酵解

Selective coordination and localized polarization in graphene quantum dots: Detection of fluoride anions using ultra-low-field NMR relaxometry

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Chinese Chemical Letters 2021年第12期32卷 3921-3926页

作者： Yongqiang Li Yi xiao Quan Tao Mengmeng Yu Li Zheng Siwei Yang Guqiao Ding Hui dong xiaoming Xie State Key Laboratory of Functional Materials of Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences(CAS)Shanghai 200050China CAS Center for Excellence in Superconducting Electronics(CENSE) Chinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The development of ultra-sensitive methods for detecting anions is limited by their low charge to radius ratios, microenvironment sensitivity, and p H sensitivity. In this paper, a magnetic sensor is devised that exploits the controllable and selective coordination that occurs between a magnetic graphene quantum dot(GQD) and fluoride anion(F–). The sensor is used to measure the change in relaxation time of aqueous solutions of magnetic GQDs in the presence of F–using ultra-low-field(118 μT) nuclear magnetic resonance relaxometry. The method was optimized to produce a limit of detection of 10 nmol/L and then applied to quantitatively detect F–in domestic water samples. More importantly, the key factors responsible for the change in relaxation time of the magnetic GQDs in the presence of F–are revealed to be the selective coordination that occurs between the GQDs and F–as well as the localized polarization of the water protons. This striking finding is not only significant for the development of other magnetic probes for sensing anions but also has important ramifications for the design of contrast agents with enhanced relaxivity for use in magnetic resonance imaging.

关键词： Graphene quantum dots Coordination Polarization Relaxometry Magnetic sensor Nuclear magnetic resonance Fluoride anion