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Glycated Haemoglobin in Diagnosis of Diabetes Mellitus and Pre-diabetes among Middle-aged and Elderly Population:Shanghai Changfeng Study

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Biomedical and Environmental Sciences 2013年第3期26卷 155-162页

作者： MA Hui GAO Xin LIN Huan dong HU Yu LI xiao Ming GAO Jian ZHAO Nai Qing Department of Endocrinology and Metabolism Zhongshan HospitalFudan University Department of Geriatrics Clinical Epidemiology CenterZhongshan HospitalFudan University Department of Clinical Nutrition Zhongshan HospitalFudan University Department of Biostatistics College of Public HealthFudan University

Objective To investigate the optimal glycated haemoglobin （HbAlc） cut off points and evaluate the impact of HbAlc on diabetes and pre-diabetes in middle-aged and elderly population. Methods Subjects were recruited from Shanghai Changfeng Study. A total of 1 973 community-based participants （age_〉45） without known diabetes underwent oral glucose tolerance test （OG3-r） by using a 75-g oral glucose load and HbAlc was measured by using high performance liquid chromatography （HPLC）. Subjects were classified as normal glucose tolerance （NGT）, pre-diabetes（impaired glucose regulation, IGR） and new diagnosed diabetes （NDD） per 1999 WHO criteria. Two tests are compared with receiver operating characteristic curve （ROC）. Results Among 1973 subjects, 271 （13.7%） were diagnosed as NDD and 474 （24.0%） as IGR by using OGTT. HbAlc was 5.7%_＋0.7% in this population. Use of 6.5% as the HbAIC cutoff point has sensitivity of 38.7% and specificity of 98.5%. We recommend 6.0% as a better cutoff value for diagnosis of diabetes in this population （AUC 0.829, 95% CI 0.798-0.860, P〈0.001） with its sensitivity and specificity as 66.1% and 86.8%. For IGR, the results showed low sensitivity （44.9%） and specificity （66.7%） with an AUC of 0.571 for HbAlc when 5.8% was used as the cutoff point. Participants detected with HbAlc_〉6.0% were associated with nearly the same metabolic characteristics, including body mass index （BMI）, blood pressure, lipid profile and urine albumin-creatinine ratio （uACR） compared with diabetic subjects detected by OGTT. Conclusion The optimum HbAlc cutoff point for diabetes in our study population was lower than ADA criteria, and HbAlc may not be used to identify IGR.

关键词： Glycated haemoglobin(HbAlc) Diabetes Pre-diabetes Impaired glucose regulation (IGR)

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Perioperative complications of radical retropubic prostatectomy in patients with locally advanced prostate cancer： a comparison with clinically localized prostate cancer

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Asian Journal of Andrology 2013年第2期15卷 241-245,I0007,I0008页

作者： Xu-dong Yao xiao-Jun Liu Shi-Lin zhang Bo Dai Hai-Liang zhang Ding-Wei Ye Department of Urology Cancer Hospital Fudan University Shanghai 200032 China Shanghai Medical College Fudan University Shanghai 200032 China

Radical prostatectomy （RP） continues to be an effective surgical therapy for prostate carcinoma, particularly for organ-confined prostate cancer （PCa）. Recently, RP has also been used in the treatment of locally advanced prostate cancer. However, little research has been performed to elucidate the perioperative complications associated with RP in patients with clinically localized or locally advanced PCa. We sought to analyse the incidence of complications in these two groups after radical retropubic prostatectomy （RRP）. From June 2002 to July 2010, we reviewed 379 PCa patients who underwent RRP in our hospital. Among these cases, 196 had clinically localized PCa （Tla-T2c group 1）, and 183 had locally advanced PCa （ ≥ T3,： group 2）. The overall complication incidence was 21.9%, which was lower than other studies have reported. Perioperative complications in patients with locally advanced PCa mirror those in patients with clinically localized PCa （26.2% vs. 17.8%, P=0.91）. Our results showed that perioperative complications could not be regarded as a factor to consider in regarding RP in patients with cT3 or greater.

关键词： complications clinically localized prostate cancer locally advanced prostate cancer prostate cancer (PCa) prostatectomy radical retropubic prostatectomy (RRP)

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Increased Oxidative Stress and Damage in Patients With Chronic Bacterial Prostatitis

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Biomedical and Environmental Sciences 2006年第6期19卷 481-486页

作者： JIAN-GUO LOU JIE dong Yt-CHUN ZHENG SHU-MEI zhanG WEJ-QIANG xiao AND JUN-FU ZHOU Laboratory for Free Radical Medicine Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China Department of Traditional Chinese Medicine Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China Department of Urology Medical College Second Hospital Zhejiang University Hangzhou 310009 Zhejiang China

Objective To investigate whether chronic bacterial prostatitis （CBP） increases oxidative stress and damage in patients with CBP, and to explore its possible mechanism. Methods Eighty patients with CBP and 80 healthy adults as controls were enrolled in a case-control study, in which levels of nitric oxide （NO）, vitamin C （VC）, and vitamin E （VE） in plasma, as well as malondialdehyde （MDA）, activities of superoxide dismutase （SOD）, and eatalase （CAT） in erythrocytes were determined by spectrophotometry. Results Compared with the average values of NO, VC, VE, MDA, SOD, and CAT in the healthy control group, those of plasma N O and erythrocyte MDA in the CBP group were significantly increased （P〈0.00 1）, and those of plasma VC and VE as well as erythrocyte SOD and CAT in the CBP group were significantly decreased （P〈0.001）. Findings from partial correlation analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in 80 patients with CBP, adjusted for age, suggested that with prolonged course of the disease, values of NO and MDA were gradually increased （P〈0.001）, and those of VC, VE, SOD, and CAT were gradually decreased （P〈0.05-0.001）. The findings from stepwise regression analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in CBP group suggested that the model of stepwise regression was Y = -19.1160 ＋0.3112MDA ＋ 0.0337NO, F = 22.1734, P〈0.001, r = 0.6045, P〈0.001. The findings from the reliability analysis for VC, VE, SOD, CAT, NO, and MDA in the CBP group showed that the reliability coefficients＇ alpha （6 items） was 0.7195, P〈0.0001, and the standardized item alpha was 0.9307, P〈0.0001. Conclusion There exist increased oxidative stress and damage induced by chronic bacterial prostatitis in patients, and such a phenomenon is closely related to the course of disease.

关键词： Chronic bacterial prostatitis Oxidative stress Oxidative damage Free radicals Oxidation Lipid peroxidation Antioxidant Antioxidative enzyme Nitric oxide Malondialdehyde

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Interferon-alpha restrains growth and invasive potential of hepatocellular carcinoma induced by hepatitis B virus X protein

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World Journal of Gastroenterology 2008年第36期14卷 5564-5569页

作者： Jian-Qing Yang Guang-dong Pan Guang-Ping Chu Zhen Liu Qiang Liu Yi xiao Lin Yuan Department of Surgery The People's Hospital of Liuzhou City Liuzhou 545001Guangxi Zhuang Autonomous Region China

AIM: To investigate the effects of interferon-alpha (IFN-α) to restrain the growth and invasive potential of hepatocellular carcinoma (HCC) induced by hepatitis B virus (HBV) X protein. METHODS: The pcDNA3.1-HBx plasmid was transfected into Chang cells by Lipofectamine in vitro, and Chang/HBx was co-cultured with IFN-α. Cell survival growth curve and clonogenicity assay were used to test the growth potential of Chang/pcDNA3.1, Chang/HBx and IFN-α-Chang/HBx in vitro. Growth assay in nude mice was used to detect the growth potential of Chang/ pcDNA3.1, Chang/HBx and IFN-α-Chang/HBx in vivo. Wound healing and transwell migration assays were used to detect the invasive ability of Chang/pcDNA3.1, Chang/HBx and IFN-α-Chang/HBx. RESULTS: Compared with CCL13 cells transfected with pcDNA3.1, CCL13 with stable expression of hepatitis B virus X protein showed the characteristics of malignant cells with high capability of growth and invasion by detecting their growth curves, colony forming efficiency, wound healing , transwell migration assays and growth assays in nude mice. Its capability of growth and invasion could be controlled by IFN-α. CONCLUSION: IFN-α can restrain the growth and invasive potential of HCC cells induced by HBx protein, which has provided an experimental basis for IFN-α therapy of HCC.

关键词： Hepatitis B virus X protein Interferon-alpha Hepatocellular carcinoma Growth Invasion

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Stream Segmentation-A Data Fusion Approach for Sensor Networks

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自动化学报 2006年第6期32卷 856-866页

作者： WU Jian-Kang dong Liang BAO xiao-Ming Institute for Infocomm Research Singapore 119613 Singapore Graduate School Chinese Academy of Sciences Beijing 100049

Sensor networks provide means to link people with real world by processing data in real time collected from real-world and routing the query results to the right people. Application examples include continuous monitoring of environment, building infrastructures and human health. Many researchers view the sensor networks as databases, and the monitoring tasks are performed as subscriptions, queries, and alert. However, this point is not precise. First, databases can only deal with well-formed data types, with well-defined schema for their interpretation, while the raw data collected by the sensor networks, in most cases, do not fit to this requirement. Second, sensor networks have to deal with very dynamic targets, environment and resources, while databases are more static. In order to fill this gap between sensor networks and databases, we propose a novel approach, referred to as 'spatiotemporal data stream segmentation', or 'stream segmentation' for short, to address the dynamic nature and deal with 'raw' data of sensor networks. Stream segmentation is defined using Bayesian Networks in the context of sensor networks, and two application examples are given to demonstrate the usefulness of the approach.

关键词： Sensor networks spatiotemporal data processing databases Bayesian networks

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Low temperature laser absorption spectra of methane in the near-infrared at 1.65 μm for lower state energy determination

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Chinese Physics B 2012年第1期21卷 260-267页

作者： Gao Wei Chen Wei-dong zhang Wei-Jun Yuan Yi-Qian Gao xiao-Ming Key Laboratory of Atmospheric Composition and Optical Radiation Chinese Academy of SciencesHefei 230031China Anhui Institute of Optics and Fine Mechanics Chinese Academy of SciencesHefei 230031China Laboratoire de Physicochimie de l'Atmosphère Universitédu Littoral Côte d'Opale189AAv.Maurice Schumann59140 DunkerqueFrance

Direct absorption spectra of the 2v3 band of methane （CH4） from 6038 to 6050 cm 1 were studied at different low temperatures using a newly developed cryogenic cell in combination with a distributed feedback （DFB） diode laser. The cryogenic cell can operate at any stabilized temperature ranging from room temperature down to 100 K with temperature fluctuation less than =t=1 K within 1 hour. In the present work, the CH4 spectra in the range of 6038-6050 cm-1 were recorded at 296, 266, 248, 223, 198, and 176 K. The lower state energy Ett and the rotational assignment of the angular momentum J were determined by a ＂2-low-temperature spectra method＂ using the spectra recorded at 198 and 176 K. The results were compared with the data from the GOSAT and the recently reported results from Campargue and co-workers using two spectra measured at room temperature and 81 K. We demonstrated that the use of a 2-low-temperature spectra method permits one to complete the Ett and J values missed in the previous studies.

关键词： methane laser absorption spectroscopy cryogenic cell low temperature absorption spec-trum

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Determination of Amino Acids by Ru(bpy)_3^(2+) Cathodic Electrochemiluminescence with High Sensitivity

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Chemical Research in Chinese Universities 2010年第3期26卷 376-379页

作者： ZHOU xiao-guang YUAN Bai-qing zhanG Lei LIU Yang HAN dong-xue YOU Tian-yan Department of Chemistry and Chemical Engineering College of Science Northeast Forestry University Harbin 150040 P. R. China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changehun 130022 P. R. China College of Chemistry Jilin University Changchun 130021 P. R. China

The unique cathodic electrochemiluminescence（ECL） emission of Ru（bpy）3^2＋（bpy=2,2′-bipyridine） was observed via Nation film at Au electrode[Au/Nafion/Ru（bpy）3^2＋] at about 0.20 V（vs. Ag/AgCl） and applied to the determination of several amino acids without prior derivatization with high sensitivity. The cathodic electrochemiluminescence（ECL） exhibits the detection limits and linear ranges of several amino acids comparable to or better than those of capillary electrophoresis with conventional ECL detection method（at 1.10-1.20 V vs. Ag/AgCl） based on precolumn derivatization. The results suggest that the cathodic ECL is promising for the detection of amino acids in bioanalysis.

关键词： Cathodic electrochemiluminescence Ru(bpy)3^2+ Nation Au electrode

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The relationships between urban-rural temperature difference and vegetation in eight cities of the Great Plains

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Frontiers of Earth Science 2019年第2期13卷 290-302页

作者： Yaoping CUI Xiangming xiao Russell B DOUGHTY Yaochen QIN Sujie LIU Nan LI Guosong ZHAO Jinwei dong Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions Henan UniversityKaifeng 475004China Department of Microbiology and Plant Biology Center for Spatial AnalysisUniversity of OklahomaNormanOK 73019USA Ministry of Education Key Laboratory of Biodiversity Science and Ecological Engineering Institute of Biodiversity ScienceFudan UniversityShanghai 200438China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China

Interpreting the relationship between urban heat island (UHI) and urban vegetation is a basis for understanding the impacts of underlying surfaces on UHL The calculation of UHI intensity (UHII) requires observations from paired stations in both urban and rural *** to the limited number of paired meteorological stations,many studies have used remotely sensed land surface temperature,but these time-series land surface temperature data are often heavily affected by cloud cover and other *** factors,together with the algorithm for inversion of land surface temperature,lead to accuracy problems in detecting the UHII,especially in cities with weak *** on meteorological observations from the Oklahoma Mesonet,a world-class network,we quantified the UHII and trends in eight cities of the Great Plains,USA,where data from at least one pair of urban and rural meteorological stations were *** examined the changes and variability in urban temperature,UHII,vegetation condition (as measured by enhanced vegetation index,EVI),and evapotranspiration (ET).We found that both UHI and urban cold islands (UCI) occurred among the eight cities during 2000-2014 (as measured by impervious surface area).Unlike what is generally considered,UHII in only three cities significantly decreased as EVI and ET increased (p < 0.1),indicating that the UHI or UCI cannot be completely explained simply from the perspective of the underlying *** vegetative cover (signaled by EVI) can increase ET,and thereby effectively mitigate the *** study station clearly showed that the underlying surface or vegetation affects urban-rural temperature,and that these factors should be considered during analysis of the UHI effect over time.

关键词： urbanization evapotranspiration urban cold island background climate air temperature

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‘红颜’草莓的假植栽培

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北方果树 2024年第4期 49-50,66页

作者：杨远杰陈晓旭马廷东王应玲丹东市圣野浆果专业合作社辽宁丹东118300

在辽宁省丹东市,有一种传统的草莓栽培模式——假植栽培。相比较于常规栽培,假植栽培能提前10~15 d上市,且盛果期相对较集中;与冷藏栽培模式比,假植栽培虽然上市时间没有优势,但是假植栽培能做到整个生产周期不断茬。根据多年的栽培管... 详细信息

在辽宁省丹东市,有一种传统的草莓栽培模式——假植栽培。相比较于常规栽培,假植栽培能提前10~15 d上市,且盛果期相对较集中;与冷藏栽培模式比,假植栽培虽然上市时间没有优势,但是假植栽培能做到整个生产周期不断茬。根据多年的栽培管理经验,现将这个栽培模式总结出来,希望能为广大种植者带来技术上的帮助。

关键词： ‘红颜’草莓假植栽培假植苗

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Turn-on fluorescence detection of specific inorganic anions by Zr(Ⅳ)-MOF with amino-functional group

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钨科技(英文) 2023年第2期5卷 217-224页

作者： Jing dong Shi-Qing Wang xiao-Yu zhang Zi-Qing Huang Xiu-Du zhang Wei-Yin Sun Coordination Chemistry Institute State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China Scientific Research Institute Nanjing Tech UniversityNanjing 211816China College of Chemistry and Materials Science Key Laboratory of Functional Molecular Solids Ministry of EducationAnhui Laboratory of Molecule-Based MaterialsAnhui Key Laboratory of Functional Molecular SolidsAnhui Normal UniversityWuhu 241002China

Inorganic anions such as phosphates and carbonates are essential in the natural system and it is important for the detec-tion of such *** this work,the fluorescence sensing capacity of Zr(IV)framework with an amino-functional group,namely UiO-66-NH_(2),towards specific inorganic anions was investigated in aqueous *** results revealed that the fluorescence emission intensity of UiO-66-NH2 could be strongly enhanced by phosphate and carbonate anions including HPO_(4)^(2-),H_(2)PO_(4)^(-),PO_(4)^(3-),P_(2)O_(7)^(4-),HCO_(3)^(-)and CO_(3)^(2-),implying its sensing capacity towards phosphate and carbonate ***,fluorescence titration experiments exhibit that the emission intensity enhancement ratio depends linearly on the concentration of anions,suggesting the possibility of quantitative detection of these *** studies suggest that the sensing of UiO-66-NH,towards HPO_(4)^(2-)/PO_(4)^(3-)/P_(2)O_(4)^(-)/HCO_(3)^(-)/CO_(2)-could be ascribed to the collapse of the framework,while that for H_(2)PO_(4)-could be attributed to the adsorption of H,PO4-by UiO-66-NH2 with hydrogen bonding interactions between H,PO4-and the amino group of UiO-66-NH_(2) supported by the different fluorescence response of UiO-66 and UiO-66-NH,towards the anions.

关键词： Zr(IV)framework UiO-66-NH_(2) Anions Sensing Turn-on fluorescence

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