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淡水贝类多糖提取工艺的优选

时珍国医国药 2007年第3期18卷 656-657页

作者：刘小燕李朝品湛孝东安徽理工大学医学院安徽淮南232001

目的优选淡水贝类多糖的最佳提取工艺。方法采用水提法,以多糖含量为指标,利用正交实验法对提取过程中的醇沉浓度、浸提温度、浸提比及浸提时间4个因素进行优选研究。结果最佳提取条件为:加无水乙醇至醇沉浓度为75%,浸提温度60℃,浸提比... 详细信息

目的优选淡水贝类多糖的最佳提取工艺。方法采用水提法,以多糖含量为指标,利用正交实验法对提取过程中的醇沉浓度、浸提温度、浸提比及浸提时间4个因素进行优选研究。结果最佳提取条件为:加无水乙醇至醇沉浓度为75%,浸提温度60℃,浸提比1∶2,浸提时间6 h。结论优化的淡水贝类水提醇沉工艺简便,合理,可行。

关键词：贝类多糖提取正交实验

Simplified p-i-n Perovskite Solar Cells with a Multifunctional Polyfullerene Electron Transporter

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Chinese Journal of Polymer Science 2024年第8期42卷 1060-1066页

作者： Fei-Fei Wang Tian-xiao Liu Ze-Wei Cui Ling-Yuan Wang Yun-Jie Dou xiao-Yu Shi Si-Wei Luo xiao-dong Hu Zhi-Jun Ren Yang-Yang Liu Yu Zhao Shang-Shang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 21003China

In prevailing p-i-n perovskite solar cells(PSCs),solution-processible fullerene molecules are widely used as electron-transporting layers(ETLs)but they typically suffer from poor uniformity and undesirable stability ***,a separate bathocuproine(BCP)layer is needed to block hole tran sfer,increasing fabrication complexity and ***,we address these limitations by develo ping a novel polymeric ETL(named PF BCP)synthesized by polymerizing C_(60)with *** innovative material achieves both efficient electron transport and hole blocking,while its excellent uniformity minimizes interface recombination and enhances ***,our blade-coated PSCs utilizing PFBCP achieve a high power conversion efficiency exceeding 22%and retain 91%of initial efficiency after 1200 h of light *** development not only paves the way for commercially viable PSCs but also opens avenues for future ETL design to realize even more efficient and stable PSCs.

关键词： Polyfullerene Perovskite solar cells Electron transporter Stability

Analysis on patents of health care products with substances of medicine food homology in China

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Chinese Herbal Medicines 2024年第3期16卷 412-421页

作者： Haibo Liu Yanfeng Wang Jiali Huang Zhengqi dong Peigen xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Key Laboratory of Traditional Chinese Medicine Patent Information Resources State Administration of Traditional Chinese MedicineBeijing 100080China Beijing Academy of Science and Technology Beijing 100048China

Objective:The concept of substances of medicine food homology(SMFH)has garnered significant attention in recent *** study conducts a systematic analysis of patent literature related to SMFH,and elucidates the development trends,technical hotspots,and the overall patent protection landscape of SMFH in China over the past two ***:The patent search focused on the SMFH varieties as the objects of inquiry,with retrieval conducted in patent ***,the acquired data underwent processing,analysis,and ***:While the technical threshold for pharmaceutical applications surpasses that of the food service sector,the former may assume a prominent role in the *** and development(R&D)activities in the southeast of China demonstrate robust activity than other *** and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future ***:The findings of this patent analysis indicate that China’s SMFH industry are presently undergoing a transition from an extensive model to a high-quality *** quality and technical standards of SMFH products are consistently ***,there is a need for more stringent patent application requirements to align with the evolving development needs.

关键词： patent analysis patent pattern substances of medicine food homology traditional Chinesemedicine

Axial-torsional nonlinear vibration of bottom hole assembly in the air drilling technology

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Petroleum 2024年第3期10卷 446-461页

作者： Shujie Ding Pan Fang Gao Li Junan Lu Yanmin Wang Yang Li Yutian Han dong xiao School of Mechanical Engineering Southwest Petroleum UniversityChengdu610500China Petroleum Engineering School Southwest Petroleum UniversityChengdu610500China Petrochina Tarim Oilfield CNPCKorla841000China PetroChina Huabei Oilfield Co CNPC834000China

The safety and efficiency of drilling engineering are greatly impeded by destructive vibrations of drill string in air drilling,such as stick-slip,bit-bounce and their coupled *** avoid or suppress these vibrations improving the stability of drilling operations,revealing the occurrence mechanisms of abovementioned harmful vibrations are indispensable by investigating dynamics characteristics of drill string *** this paper,an axial-torsional coupled dynamics model that can capture the motion behaviors of bottom hole assembly(BHA)is established adopting the lumped parameter ***,a rate of penetration(ROP)model appropriating for air drilling is obtained firstly by linear fitting ***,a novel discontinuous support model is established to describe the bitformation ***,BHA dynamics are discussed using numerical simulations under different vibration scenarios:normal operation;stick-slip;bit-bounce;bit-bounce and stick-slip ***,in two drilling modes:the continuous and intermittent drilling,the vibration mitigation strategies and dynamics sensibility study of BHA are carried out based on the parametric *** results show that increasing torsional stiffness of drill-pipes,appropriately adjusting rotation speed of top driven system and dynamic weight on bit(WOB)are deemed as an effective strategy suppressing or eliminating stick-slip and bit-bounce vibrations of *** that the rotation speed of top driven system and dynamic WOB are 5 rad/s and 3.5 kN,***,the constructed probability maps allow to driller to choose reasonable mechanical parameters,thereby realizing smooth drilling operation in the air drilling.

关键词： Drill string BHA Contact model ROP Stick-slip Bit-bounce

Dynamics of information diffusion and disease transmission in time-varying multiplex networks with asymmetric activity levels

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Chinese Physics B 2024年第3期33卷 690-699页

作者：谢笑笑霍良安董雅芳程英英 Business School University of Shanghai for Science and TechnologyShanghai 200093China School of Intelligent Emergency Management University of Shanghai for Science and TechnologyShanghai 200093China School of Management Henan University of Science and TechnologyLuoyang 471023China

While the interaction between information and disease in static networks has been extensively investigated,many studies have ignored the characteristics of network *** this study,we construct a new two-layer coupling model to explore the interactions between information and *** upper layer describes the diffusion of disease-related information,and the lower layer represents the disease *** then use power-law distributions to examine the influence of asymmetric activity levels on dynamic propagation,revealing a mapping relationship characterizing the interconnected propagation of information and diseases among partial nodes within the ***,we derive the disease outbreak threshold by using the microscopic Markov-chain approach(MMCA).Finally,we perform extensive Monte Carlo(MC)numerical simulations to verify the accuracy of our theoretical *** findings indicate that the activity levels of individuals in the disease transmission layer have a more significant influence on disease transmission compared with the individual activity levels in the information diffusion ***,reducing the damping factor can delay disease outbreaks and suppress disease transmission,while improving individual quarantine measures can contribute positively to disease *** study provides valuable insights into policymakers for developing outbreak prevention and control strategies.

关键词： information diffusion disease transmission asymmetric activity levels quarantine strength

Artemsieverolactones A—H,Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana

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Chinese Journal of Chemistry 2024年第10期42卷 1084-1092页

作者： Wei dong xiao-Yan Huang Tian-Ze Li Yan-Mei Weng Chang-An Geng Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academyof Sciences Beijing 100049China

Eight new guaiane-type sesquiterpenoid trimers,artemsieverolactones A—H,possessing unprecedented scaffolds via biocatalyzed[4+2]Diels−Alder cycloaddition reactions were identified from Artemisia *** structures were determined by comprehensive spectroscopic data,single-crystal X-ray diffraction analyses,and ECD *** terms of structure,artemsieverolactones A—H are first examples of sesquiterpenoid trimers from guaiane-type sesquiterpenoid through four different[4+2]Diels−Alder cycloaddition *** fibrosis assay suggested that five compounds exhibited activity against HSC-LX2 with IC_(50)values ranging from 37.8 to 117.1μmol/*** most active artemsieverolactone B(2)displayed significant inhibitory activity against HSC-LX2 with IC_(50)value of 37.8μmol/L,which was 3 times more active than the positive drug silybin(IC_(50),139.7μmol/L).Preliminary mechanism study revealed that artemsieverolactone B could inhibit the deposition of human collagen typeⅠ(ColⅠ),human hyaluronic acid(HA),and human laminin(HL)with IC_(50)values of 40.4μmol/L(Col I),55.1μmol/L(HL),47.3μmol/L(HA),which was 2 to 3-fold more potent than silybin.

关键词： Artemisia sieversiana Artemsieverolactones A-H Guaiane-type sesquiterpenoid trimers Antihepatic fibrosis Extracellular matrix Cancer NMR spectroscopy X-ray diffraction

Development and microstructure characterization of BG110E high-strength expansion pipe

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Baosteel Technical Research 2024年第1期18卷 37-42页

作者： dong xiaoming zhanG Zhonghua GAO zhan Research Institute Baoshan Iron&Steel Co.Ltd.Shanghai 201999China State Key Laboratory of Oil and Gas Equipment Shanghai 201999China

The BG110E high-strength expansion pipe was developed using medium manganese steel and subjected to a two-phase zone heat treatment *** properties and microstructure analysis results have proven that the BG110E expansion pipe exhibits uniform elongation of more than 19%.Moreover,after undergoing expan-sion deformation,its strength,toughness,and plasticity are found to meet the stringent requirements of the P110 *** microstructure of this high-strength expansion pipe,which has a strength of 110 ksi(1 ksi=6.895 MPa),consists of tempered martensite,ferrite,retained austenite,and granular *** propotion of retained austenite reaches up to 12%,ensuring high plasticity and the occurrence of the transformation-induced plasticity effect during the deformation ***,it enhances the coordinated deformation ability between different phases,which significantly improves the internal yield pressure of the BG110E high-strength expansion pipe in turn.

关键词： retained austenite two-phase zone heat treatment medium manganese steel

Effective approach for conformal subarray design based on maximum entropy of planar mappings

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Journal of Electronic Science and Technology 2024年第3期22卷 16-25页

作者： xiao-dong Zheng Sheng-Teng Shi Jun Ou-Yang Feng Yang Qammer Abbasi Abubakar Sharif School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China School of Engineering University of GlasgowScotlandG128QQUK

In this paper,an effective algorithm for optimizing the subarray of conformal arrays is *** method first divides theconformal array into several first-level *** uses the X algorithm to solve the feasible solution of first-level subarray tiling and employs the particle swarm algorithm to optimize the conformal array subarray tiling scheme with the maximum entropy of the planar mapping as the fitness ***,convex optimization is applied to optimize the subarray amplitude *** results verify that the method can effectively find the optimal conformal array tiling scheme.

关键词： Conformal array Irregular arrays Particle swarm optimal algorithm Maximum entropy model

Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu Ya zhang Meng-Di Yuan dong-Miao xiao Wei-Hua Xu Qi Zheng Qi-Wei Qin You-Hua Huang xiao-Hong Huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory