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Performance value of high risk factors in colorectal cancer screening in China

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World Journal of Gastroenterology 2009年第48期15卷 6111-6116页

作者： Wen Meng Shan-Rong Cai Lun Zhou Qi Dong Shu Zheng su-zhan zhang Cancer Institute (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education Key Laboratory of Molecular Biology in Medical Sciences Zhejiang Province China) The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China Department of Cardiothoracic surgery Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China

AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in ***:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire *** with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo ***:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced *** iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and *** sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous *** for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra ***:The iFOBT may be the best marker for screening for advanced neoplasias and *** unique high risk factors may play an important role in CRC screening in China.

关键词： Colorectal cancer Cancer screening Feces Occult blood Risk factors Predictive value of tests

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions： finding of 18F-FDG PET/CT

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Frontiers of Medicine 2017年第3期11卷 440-444页

作者： zhan su Fengyu Wu Weiyu Hu Xiaodan Liu Shaoling Wu Xianqi Feng Zhongguang Cui Jie Yang Zhenguang Wang Hongzai Guan Hongguo Zhao Wei Wang Chunting Zhao Jun Peng Department of Haematology Qilu Hospital Shandong University Jinan 250012 China Department of Haematology The Affiliated Hospital of Qingdao University Qingdao 266000 China PET/CT Center The Affiliated Hospital of Qingdao University Qingdao 266000China Department of Hepatobiliary surgery The Affiliated Hospital of Qingdao University Qingdao 266000 China Department of Haematology Qingdao University Medical College Qingdao 266071 China

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lyric lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography （18F-FDG PET/CT） result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lyric bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type （de novo or blast crisis） remained unclear.

关键词： Philadelphia chromosome acute myeloid leukemia mass osteolysis positron emission tomography

NEW METHOD OF SIMULATING CONCENTRATED DRAIN HOLES IN SEEPAGE CONTROL ANALYSIS

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Journal of Hydrodynamics 1999年第3期11卷 27-35页

作者： zhan Mei li, su Bao yu , Liu Jun yong, Shen Zhen zhong College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, P.R.China (Received Aug.1, 1998)

In this paper, based upon the basic solution of sink, the approximate solution of single drain hole in finite elements is derived by use of the superposition principle. Then, the theoretical solution is extended to the case of some drain holes in one finite element, and the method is used in seepage control analysis with quick convergence and high accuracy. On the other hand, if the positions of the drain holes are changed, only some control factors of drain holes are changed, but the finite element grid need not to be reformed. Therefore, the method is more suitable in optimal research of seepage control.

关键词： concentrated drain hole approximate solution seepage control optimal research

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气的医学层次哲学性认识的唯物观

中西医结合学报 2005年第2期3卷 88-90页

作者：苏占清南京医科大学脑科医院中医科江苏南京210029

从医学层次哲学性认识的唯物观对气和气的具体形态进行了区分,并阐述了气的物质性和多样性。物质性指它的客观实在性,是与人密切相联系的各种事物或现象的总和;多样性是指各种具体物质形态都具有各自特殊的质的规定性。在假定两个基... 详细信息

从医学层次哲学性认识的唯物观对气和气的具体形态进行了区分,并阐述了气的物质性和多样性。物质性指它的客观实在性,是与人密切相联系的各种事物或现象的总和;多样性是指各种具体物质形态都具有各自特殊的质的规定性。在假定两个基本概念“象”、“象集”的基础上,结合中西医的认识,分别从宏观、微观、生理(正常)、病理(异常)诸角度将气的具体形态作了初步阐述,并指出寻找气的不同侧面或层次的具体形态,特别是其在微观层次上相应的存在形式,将有助于把中医辨证推向微观化。

关键词：气物质象象集

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卡培他滨辅助治疗结肠癌的研究进展

中华肿瘤杂志 2010年第11期32卷 801-803页

作者：张苏展浙江大学附属第二医院肿瘤中心杭州310009

结直肠癌是最常见的恶性肿瘤之一,据统计,2007年全球新发病例120万,居恶性肿瘤第3位,同年死亡病例为60万.手术切除是治愈结直肠癌最好的手段,而术后辅助化疗能减少复发和转移风险,进一步提高疗效.除传统药物5-氟尿嘧啶（5-Fu）外,近年来... 详细信息

结直肠癌是最常见的恶性肿瘤之一,据统计,2007年全球新发病例120万,居恶性肿瘤第3位,同年死亡病例为60万.手术切除是治愈结直肠癌最好的手段,而术后辅助化疗能减少复发和转移风险,进一步提高疗效.除传统药物5-氟尿嘧啶（5-Fu）外,近年来,出现了很多被证明对结肠癌有确实疗效的药物,如卡培他滨、伊立替康和奥沙利铂,这些药物都在全球范围内进行并完成了结肠癌的临床试验,其中卡培他滨和奥沙利铂被证明应用于辅助治疗有效.这些循证医学的证据使得结肠癌的辅助化疗发生了很大的变化,并趋于规范.本文在循证医学证据的基础上,就结肠癌的辅助治疗,尤其是卡培他滨应用方面的进展进行回顾.

关键词：卡培他滨结肠肿瘤肿瘤辅助治疗

The 2002 AJCC TNM classification is a better predictor of primary small cell esophageal carcinoma outcome than the VALSG staging system

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Chinese Journal of Cancer 2013年第6期32卷 342-352页

作者： Sheng-Ye Wang Wei-Ming Mao Xiang-Hui Du Ya-Ping Xu su-zhan zhang Department of Radiation Oncology Zhejiang Cancer Hospital Department of Oncology Τhe Second Affiliated Hospital Zhejiang University

Small cell carcinoma of the esophagus (SCCE) is a rare and aggressive malignant tumor with a poor prognosis. The optimal disease staging system and treatment approaches have not yet been defined. This study aimed to evaluate the prediction of different staging systems for prognosis and treatment options of SCCE. We retrospectively accessed the clinicopathologic characteristics, treatment strategy, and prognosis of 76 patients diagnosed with primary SCCE between 2001 and 2011. The 1-, 2-, 3-, and 5-year overall survival rates were 58%, 31%, 19%, and 13%, respectively. Univariate analysis showed that the 2002 American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) classification (P=0.002), Veterans Administration Lung Study Group (VALSG) stage (P=0.001), predisposing factors (Psurvival. Multivariate analysis showed that the 2002 AJCC TNM stage (Psurvival. The value of the area under the receiver operator characteristic (ROC) curve (AUC) of the 2002 AJCC TNM staging system was larger than that of VALSG staging system with regard to predicting overall survival (0.774 vs. 0.620). None of the single treatment regimens showed any benefit for survival by Cox regression analysis. Thus, the 2002 AJCC TMN staging system improved the prediction of SCCE prognosis; however, the optimal treatment regimen for SCCE remains unclear.

关键词：系统预测 TNM 食管癌细胞原发性治疗方案分类病理特征

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计算机模拟的认识不透明性

自然辩证法通讯 2021年第11期43卷 39-45页

作者：梁丽苏湛中国科学院大学人文学院北京100049

计算机模拟具有与实验同等的地位,其可靠性问题本质上是由认识不透明性带来的。认识不透明性不是一个二元属性,而是具有程度之分的,大体可以分为认识不透明性(EO)和本质认识不透明性(EEO)。基于理论的计算机模拟具有的是本质认识不透明... 详细信息

计算机模拟具有与实验同等的地位,其可靠性问题本质上是由认识不透明性带来的。认识不透明性不是一个二元属性,而是具有程度之分的,大体可以分为认识不透明性(EO)和本质认识不透明性(EEO)。基于理论的计算机模拟具有的是本质认识不透明性,它受作为认知主体的人类的认知本质的限制;而基于主体的计算机模拟的不透明性程度除了受认知本质限制,还与主体的知识状态有关。本质认识不透明性不可消除,但主体可根据需要通过减少计算复杂性来降低其程度。计算复杂性不仅与计算模型有关,还与数学解析技术有关。

关键词：计算机模拟认识不透明性计算复杂性

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关于医疗、科研的一点认识

医学与哲学（A） 2014年第10期35卷 1-3,16页

作者：苏占清南京医科大学附属脑科医院中医科江苏南京210029

临床医疗是医院的根本使命,在权重上医疗自然重于科研。医疗实践是科研的出发点与归宿,决定了科研的基本走向。当前,科研工作受到前所未有的重视,科研作为医疗人员绩效考核的权重过大,偏离了医院的根本使命,会对科研、医疗、医护人员乃... 详细信息

临床医疗是医院的根本使命,在权重上医疗自然重于科研。医疗实践是科研的出发点与归宿,决定了科研的基本走向。当前,科研工作受到前所未有的重视,科研作为医疗人员绩效考核的权重过大,偏离了医院的根本使命,会对科研、医疗、医护人员乃至整个社会造成伤害。SCI论文与临床关系不密切,不宜用来评价临床医师的水准。应该建立科学的考评机制,考核标准应细化、全面,对科研的奖励应适度。对于医护人员的考核应以医疗为主、科研为辅。

关键词：医疗科研 SCI论文

一种基于改进K核分解的合作网络关键节点集识别方法

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数据分析与知识发现 2024年第5期8卷 80-90页

作者：张大勇门浩苏展哈尔滨工业大学互动媒体设计与装备服务创新重点实验室哈尔滨150001 哈尔滨工业大学计算机科学与技术学院哈尔滨150001

【目的】针对关键节点集识别算法中广泛存在的退化性问题,提出一种以半局域中心性为基础的改进型K-shell分解算法。【方法】算法根据节点一阶邻居信息构建半局域中心性指标,在考虑剩余节点的半局域信息和已移除节点的半局域信息基础上,... 详细信息

【目的】针对关键节点集识别算法中广泛存在的退化性问题,提出一种以半局域中心性为基础的改进型K-shell分解算法。【方法】算法根据节点一阶邻居信息构建半局域中心性指标,在考虑剩余节点的半局域信息和已移除节点的半局域信息基础上,通过递归移除方式确定最终的关键节点集。【结果】6组实际合作网络数据实验表明,改进的K-shell分解算法能够有效消除原有算法中的退化性问题,具有较高的计算准确性和较低的计算复杂度,适用于大规模合作网络中关键节点集的识别。【局限】受网络结构属性的影响,在部分样本网络中计算准确性低于介数中心性方法。【结论】通过对改进的K-shell分解算法计算所得的核心节点集的有效保护,能够提升合作网络的稳定性,有利于合作网络目标的实现。

关键词：合作网络分解算法关键节点集计算复杂度