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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-kui Liu xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

放电等离子烧结快速凝固Al_(75)Si_(25)合金的组织及力学性能

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北京理工大学学报 2016年第10期36卷 1089-1095页

作者：赵占奎张晓东王明罡刘学杰长春工业大学材料科学与工程学院吉林长春130012 中国人民公安大学国际警务执法学院北京100038

高硅铝合金粗大的初晶硅严重影响其力学性能与机械加工性能.本文利用熔融纺丝快速凝固技术、球磨与放电等离子烧结相结合的方法制备了Al_(75)Si_(25)合金.研究发现,放电等离子烧结Al_(75)Si_(25)能够遗传其快速凝固组织的特点.500MPa,32... 详细信息

高硅铝合金粗大的初晶硅严重影响其力学性能与机械加工性能.本文利用熔融纺丝快速凝固技术、球磨与放电等离子烧结相结合的方法制备了Al_(75)Si_(25)合金.研究发现,放电等离子烧结Al_(75)Si_(25)能够遗传其快速凝固组织的特点.500MPa,320℃烧结条件可获得密度达到98%以上的块体,其初晶硅弥散分布,组织尺寸细小,具有超细晶粒特征.此外,硅元素过饱和固溶于α(Al)基体.维氏硬度值和抗压强度分别达到298Hv和674MPa,具有优异的力学性能.

关键词：高硅铝合金快速凝固放电等离子烧结固溶度

Insight into the particle shape on the impact of dry granular flow against a rigid barrier: A DEM study

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Journal of Earth Science 2025年

作者： Rui-xiao zhan Dong Su Xiang-Sheng Chen Yuan-Jun Jiang Guo-Ping Lei Jing-Jing Yu Key Laboratory for Resilient Infrastructures of Coastal Cities (MOE)， Shenzhen University College of Civil and Transportation Engineering， Shenzhen University School of Architecture and Urban Planning， Shenzhen University Shenzhen Key Laboratory of Green， Efficient and Intelligent Construction of Underground Metro Station， Shenzhen University Institute of Mountain Hazards and Environment， Chinese Academy of Sciences School of Transportation， Civil Engineering & Architecture， Foshan University

The effect of particle shape on the impact of dry granular flow remains an open area for further investigation. Five distinct particle shapes were examined in this study using discrete element simulations after calibrating the numerical model using a published work. The findings indicated that the particle shape had a significant influence on granular mobility. With negligible variations in normalized kinetic energy between particles of different shapes， the effect of particle shape on the increasing rate of kinetic energy became more obvious. All irregular particle scenarios had longer accumulated particle lengths down the channel than spherical particles. Variations in particle shape led to adjustments in the distribution of impact forces on the barrier. These findings substantially enhance our understanding of the distinctive effects of particle shapes on the impact mechanism of dry granular flow.

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao zhang Li Jia Xiu-Jun zhan Charity Ngina Qing-Rui zhang xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Incorporation of nano/micron-SiC particles in Ni-based composite coatings towards enhanced mechanical and anti-corrosion properties

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International Journal of Minerals,Metallurgy and Materials 2022年第1期29卷 153-160页

作者： Bowei zhang Qiao zhang zhan zhang kui xiao Qiong Yao Guojia Ma Gang Sun Junsheng Wu Institute for advanced materials and technology University of Science and Technology BeijingBeijing 100083China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Key Laboratory of Space Lauching Site Reliability Technology Haikou 571000China Department of Materials Application Research China Aviation Manufacturing Technology InstituteBeijing 100024China

Ni-based composite coatings incorporated with nano/micron SiC particles were fabricated via electrochemical co-deposition in Watts bath,followed by the evaluation of their mechanical and anti-corrosion *** micrographic observations suggest that the SiC particles with various sizes can be well incorporated to the Ni substrate.X-ray diffraction(XRD)patterns indicate that SiC particles with smaller sizes could weaken the preferential growth of Ni along(200)*** addition,it is found that the incorporated SiC particles with medium micron sizes(8 and 1.5μm)could significantly enhance the micro-hardness of the Ni composite ***,electrochemical measurements demonstrate that micron-sized SiC particles would weaken the corrosion resistance of Ni composite coatings ascribed to the structure defects *** contrast,the combined incorporation of nanosized(50 nm)SiC particles with medium micron(1.5μm)ones is capable of promoting the compactness of the composite coatings,which is beneficial to the long-term corrosion resistance with negligible micro-hardness loss.

关键词： Watts bath Ni coating SiC particles corrosion resistance electrodeposition

An Estimation of the Initial Period of Pulsars

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Chinese Journal of Astronomy and Astrophysics 2003年第2期3卷 166-174页

作者： zhan-kui Huang Xin-Ji Wu DepartmentofAstronomy PekingUniversityBeijing100871 ChineseAcademyofSciences-PekingUniversityJointBeijingAstrophysicsCenter Beijing100871 NationalAstronomicalObservatories UromqiAs

The initial period of a pulsar is an important factor in our understanding of the formation of neutron stars and of the nature of the equation of state of neutron star matter. Up to now this quantity can only be obtained for a few pulsars for which accurate age and braking index are known. Based on the theory of the off-center dipole emission, in which pulsars obtain their high velocities depending on the initial periods, we calculate the initial period using the proper motion data. Because the orbital velocity of the progenitor and asymmetric kick in the supernova explosion may also contribute to the observed velocity of the pulsar, the derived values of initial periods are lower limits. For normal pulsars, the initial periods are in the range of 0.6 - 2.6ms. For the millisecond pulsars, the initial periods are comparable to their current periods, and the ratio between the initial period and the current period increases with the decrease of the current period. For PSR B1937+21 with the shortest period of 1.56ms, the ratio is 0.77.

关键词： pulsaxs - stars: neutron

LADA strategy for the synthesis of unnatural amino acids and direct modifications of peptides

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Science China Chemistry 2023年第6期66卷 1788-1794页

作者： Jun-Liang Zhou Yun-Qi Liu zhan-kui Sun Shanghai Frontiers Science Center for Drug Target Identification and Drug Delivery School of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Pharm-X CenterSchool of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China AI Pharma Center Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Unnatural amino acids(UAAs)are important building blocks in organic synthesis and drug *** are also frequently integrated into peptides or proteins for biological ***,the direct and simplified synthesis of UAAs remains a great *** the same time,vast known peptide modifications are based on carbon-heteroatom *** are no general methods for peptide modifications via the construction of C–C *** address this challenge,herein we propose the LADA strategy,which is composed of two steps:the selective labeling and activation of cysteine residues,the desulfurization to generate carbon-centered radical and the radical addition to alkenes to build C–C *** one-pot protocol has obvious advantages such as good functional group tolerance,biocompatible reaction conditions,and retained *** strategy was successfully utilized for the synthesis of unnatural amino acids and direct modifications of peptides.

关键词： unnatural amino acids peptide modifications desulfurization cysteine radical addition

A Microstructural Damage Model toward Simulating the Mullins Effect in Double-Network Hydrogels

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Acta Mechanica Solida Sinica 2022年第4期35卷 682-693页

作者： Lin zhan Rui xiao State Key Laboratory of Fluid Power and Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceDepartment of Engineering MechanicsZhejiang UniversityHangzhou310027China

The damage models based on the eight-chain model and the affine full-chain network model are not adequate to describe the damage behaviors in double-network(DN)*** overcome this limitation,we propose a combined chain stretch model with new damage flow *** is demonstrated that the new proposed micro-chain stretch is a reduced form of the complete representation for the transversely isotropic tensor *** a result,the damage models based on the eight-chain model and the affine model are incorporated as special *** effects of chain affineness and network entangling are simultaneously involved in the new model,while only one of these two effects can be characterized in either the eight-chain model or the affine *** is further shown that the new model can effectively capture the Mullins features of the DN hydrogels and achieve better agreement with the experimental data than the affine model and the eight-chain model.

关键词： Mullins effect Double-network hydrogel Full-network model Microstructural model