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Analysis of TLR4 and TLR2 polymorphisms in inflammatory bowel disease in a Guangxi Zhuang population

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World Journal of Gastroenterology 2012年第46期18卷 6856-6860页

作者： Lan Chen Mei-Jiao Lin ling-ling zhan Xiao-Ping Lv Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University (West) Department of Clinical Experimental Medicine the First Affiliated Hospital of Guangxi Medical University

AIM: To study the polymorphisms of toll-like receptor 4 (TLR4) gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp and susceptibility to inflammatory bowel disease (IBD) in the Zhuang population from Guangxi, China. METHODS: A case-control study was performed from February 2007 to October 2011 which included 146 Zhuang patients with IBD in the experimental group and 164 healthy Zhuang subjects who acted as the control group. All patients and healthy subjects were from the Guangxi Zhuang Autonomous Region of China. Genomic DNA was extracted from intestinal tissue by the phenol chloroform method. TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp were amplified by polymerase chain reaction (PCR), and then detected by PCR-restriction fragment length polymorphism (RFLP). RESULTS: The TLR4 gene Asp299Gly was digested using Nco Ⅰ restriction enzyme, and a single band of 249 bp was observed which showed that it was a wild type (AA). The TLR4 gene Thr399Ile was digested using Hinf Ⅰrestriction enzyme and only the wild type (CC) was detected. In addition, the TLR2 gene Arg-677Trp was digested using Aci Ⅰ restriction enzyme and only the wild type (CC) was detected. The TLR2 gene Arg753Gln was digested using Pst Ⅰ restriction enzyme. Only the wild type (GG) as a single band of 254 bp was observed during RFLP. Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China. CONCLUSION: The TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp polymorphisms may not be associated with IBD in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.

关键词： Toll-like receptor 2 Toll-like receptor 4 Inflammatory bowel disease Gene polymorphism

Modelling and Verification of Real-Time Publish and Subscribe Protocol Using UPPAAL and Simulink/Stateflow

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Journal of Computer Science & Technology 2020年第6期35卷 1324-1342页

作者： Qian-Qian Lin Shu-ling Wang Bo-Hua zhan Bin Gu State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China Beijing Institute of Control Engineering Beijing 100081China

Real-Time Publish and Subscribe (RTPS) protocol is a protocol for implementing message exchange over an unreliable transport in data distribution service (DDS). Formal modelling and verification of the protocol provide stronger guarantees of its correctness and efficiency than testing alone. In this paper, we build formal models for the RTPS protocol using UPPAAL and Simulink/Stateflow. Modelling using Simulink/Stateflow allows analyzing the protocol through simula-tion, as well as generate executable code. Modelling using UPPAAL allows us to verify properties of the model stated in TCTL (Timed Computation Tree Logic), as well as estimate its performance using statistical model checking. We further describe a procedure for translation from Stateflow to timed automata, where a subset of major features in Stateflow is supported, and prove the soundness statement that the Stateflow model is a refinement of the translated timed automata model. As a consequence, any property in a certain fragment of TCTL that we have verified for the timed automata model in UPPAAL is preserved for the original Stateflow model.

关键词： Real-Time Publish and Subscribe(RTPS) modelling verification UPPAAL Simulink/Stateflow

Potential Transmission Choice for Internet of Things(IoT):Wireless and Batteryless Communications and Open Problems

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China Communications 2021年第2期18卷 241-249页

作者： zhan Xu Guanjie Hu Minzheng Jia Lan dong School of Information and Communication Engineering and with Key Laboratory of Modern Measurement&Control Technology Ministry of EducationBeijing Information Science&Technology UniversityChina Beijing Key Lab of Transportation Data Analysis and Mining School of Computer and Information TechnologyBeijing Jiaotong UniversityBeijingChina Department of Information Engineering Beijing Polytechnic CollegeBeijingChina

The 5th generation mobile communications aims at connecting everything and future Internet of Things(IoT)will get everything smartly *** realize it,there exist many *** key challenge is the battery problem for small devices,such as sensors or *** backscatter,also referred to as or battery-free backscatter,is a new potential technology to address this *** early and typical type of batteryless backscatter is ambient ***,batteryless backscatter utilizes environmental wireless signals to enable battery-free devices to communicate with each *** devices first harvest energy from ambient wireless signals and then backscatter these signals so as to transmit their own *** paper reviews the current studies about batteryless backscatter,including various backscatter schemes and theoretical works,and then introduces open problems for future research.

关键词： batteryless backscatter battery-free channel state information(CSI) channel estimation multiple antennas signal detection symbiotic communication

Effects of Structural Changes in Subchondral Bone on Articular Cartilage in a Beagle Dog Model

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Biomedical and Environmental Sciences 2017年第3期30卷 194-203页

作者： YAN dong LIU Tong Xi LIU Bao Yue WANG ling QIAN zhan Hua CHENG Xiao Guang LI Kun Cheng Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Radiology Beijing Jishuitan HospitalFourth Clinical Hospital of Peking University Health ScienceCenterBeijing 100035China Department of Pathology Beijing Jishuitan HospitalFourth Clinical Hospital of Peking University Health Science CenterBeijing 100035China

Objective Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. Methods Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group （n = 12） and a bone cement group （n = 12）. Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side. The T2 value for articular cartilage at the medial tibial plateau was measured at postoperative weeks 4, 8, 16, and 24. The articular cartilage specimens were stained with hematoxylin and eosin, and evaluated using the Mankin score. Results There was a statistically significant difference （P 〈 0.05） in Mankin score between the bone defect group and the cement group at postoperative weeks 16 and 24. There was a statistically significant difference in the T2 values between the bone defect group and its sham group （P 〈 0.05） from week 8, and between the cement group and its sham group （P 〈 0.05） from week 16. There was significant difference in T2 values between the two experimental groups at postoperative week 24 （P 〈 0.01）. The T2 value for articular cartilage was positively correlated with the Mankin score （ρ = 0.758, P 〈 0.01）. Conclusion Structural changes in subchondral bone can lead to degeneration of the adjacent articular cartilage. Defects in subchondral bone cause more severe degeneration of cartilage than subchondral bone filled with cement. The T2 value for articular cartilage increases with the extent of degeneration. MR T2-mapping images and the T2 value for articular cartilage can indicate earlycartilage degeneration.

关键词： MR T2-mapping Subchondral bone Articular cartilage Degeneration

Strain Localized Deformation Variation of a Small-Scale Ductile Shear Zone

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Journal of Earth Science 2023年第2期34卷 409-430页

作者： Lefan zhan Shuyun Cao Yanlong dong Wenyuan Li State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China

A continental-scale strike-slip shear zone frequently presents a long-lasting deformation and physical expression of strain localization in a middle to lower crustal ***,the deformation evolution of strain localization at a small-scale remains *** study investigated slip ***,coarse-grained aggregates in the mylonite of the shear zone were deformed predominantly by dislocation creep,while ultra-plastic flow by viscous grain boundary sliding was an essential deformation process in the extremely fine-grained(~50μm)mixed-phases in the ***-derived strain rates calculated from quartz paleopiezometry were on the order of 10^(-15) to 10^(-13) s^(-1)from low-strain mylonite to high strained *** localization and strain ratelimited process was fluid-assisted precipitation presenting transitions of compositions as hydrous retrogression of hornblende to mica during increasing deformation and ***,the potential occurrence of the small-scale shear zone was initiated at a middle-deep crust seated crustal condition dominated by the temperature-controlled formation and rheological weakening.

关键词： strain localization ductile deformation ultramylonite microstructure EBSD texture Gaoligong shear zone

Ruyi Zhenbao Pills for Patients with Motor and Sensory Dysfunction after Stroke: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2022年第10期28卷 872-878页

作者： ling Shan-shan PAN Rui-huan zhan Le-chang LI Mei YANG Zhi-jing YANG Hao-dong CHEN Hong-xia Department of Rehabilitation The Second Afﬁliated HospitalGuangzhou University of Chinese MedicineGuangzhou(510120)China The Second Institute of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou(510120)China

Objective: To evaluate the efficacy and safety of Tibetan medicine Ruyi Zhenbao Pills(RZPs) in the treatment of patients with motor and sensory dysfunction after stroke. Methods: A total of 120 convalescent stroke patients hospitalized in the Rehabilitation Department of Guangdong Provincial Hospital of Chinese Medicine from June 2017 to December 2019 were enrolled in this trial. Patients were assigned to control(60 cases) and research(60 cases) groups by computer random assignment. All patients received internal treatment and modern rehabilitation training. On this basis, the research group was given oral RZPs for 4 weeks, while the control group was given oral placebo. The primary outcome was motor function of the affected side evaluated by simplified FuglMeyer Motion Assessment Scale(FMA-M). The secondary outcomes included sensory function, activity of daily living(ADL), quality of life, balance function, and pain, which were assessed by Fugl-Meyer Sensory Assessment Scale(FMA-S), Modified Barthel Index(MBI), Special Scale of the Quality of Life(SS-QOL), Berg Balance Scale(BBS), and Visual Analogue Scale(VAS), respectively. All of the assessments were performed before treatment, and 4 and 8 weeks after treatment. Vital signs, liver and kidney functions, routine blood test, blood coagulation profile, and routine urinalysis of patients were monitored. Results: After 4-week treatment, the FMA-M, BBS and FMA-S scores in the research group significantly increased compared with the control group(P0.05). Moreover, after treatment, there was no significant difference in vital signs, liver and kidney functions, blood coagulation function, blood routine and urinalysis between the 2 groups(P>0.05). Conclusion: RZPs improved limb motor, balance, and sensor

关键词： Ruyi Zhenbao Pills post-stroke motor dysfunction sensory dysfunction Tibetan medicine randomized controlled trial

Some kinds of falling fuzzy filters of lattice implication algebras

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Applied Mathematics(A Journal of Chinese Universities) 2015年第3期30卷 299-316页

作者： MA Xue-ling zhan Jian-ming JUN Young-Bae Department of Mathematics Hubei University for Nationalities Department of Mathematics Education Gyeongsang National University

In this paper, the concepts of falling fuzzy(implicative, associative) filters of lattice implication algebras based on the theory of falling shadows and fuzzy sets are presented at first. And then the relations between fuzzy(implicative, associative) filters and falling fuzzy(implicative, associative) filters are provided. In particular, we put forward an open question on a kind of falling fuzzy filters of lattice implication algebras. Finally, we apply falling fuzzy inference relations to lattice implication algebras and obtain some related results.

关键词： falling shadow filter fuzzy filter falling fuzzy(implicative associative) filter falling fuzzy inference relation lattice implic

Pre-conceptional and prenatal exposure to secondhand smoke and autism spectrum disorder:a national multi-center study in China

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World Journal of Pediatrics 2023年第8期19卷 761-769页

作者： Li-Zi Lin Xiao-Xuan Ou Xiao-ling zhan Xin Wang Li Cai Xiu-Hong Li Jin Jing Guang-Hui dong Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen University74 Zhongshan 2nd RoadYuexiu DistrictGuangzhou510080China Department of Maternal and Child Health School of Public HealthSun Yat-Sen University74 Zhongshan 2Nd RoadYuexiu DistrictGuangzhou510080China

Background Despite extensive research evaluating the association between prenatal exposure to secondhand smoke(SHS)and the development of autism spectrum disorders(ASD),no study has investigated the association by considering the pre-conceptional *** study aimed to investigate the associations of pre-conceptional and prenatal SHS exposure and the development of ASD among *** In this cross-sectional study,parents of 6049 toddlers aged 16–30 months were recruited from 7 tertiary hospitals,21 communities,and 7 kindergartens located in seven cities in six provinces from five geographical regions of *** analyzed the associations of SHS exposure and the odds of ASD among toddlers in different exposure windows(pre-conceptional and/or prenatal periods).Data were analyzed from November 2021 to January *** Among the 6049 toddlers included in the analysis[22.7(4.1)months;44.8%girls],71 were identified and diagnosed with *** with the unexposed toddlers,toddlers with pre-conceptional SHS exposure had higher odds of ASD(OR 2.30,95%CI 1.36–3.84),while we observed a non-significantly positive association regarding prenatal SHS *** considering both pre-conceptional and prenatal periods,toddlers who were continuously exposed to SHS during these two periods had higher odds than those without SHS exposure(OR 2.32,95%CI 1.24–4.14).Conclusion We reported positive SHS–ASD associations when exposed during the pre-conceptional period and continuously exposed during pre-conceptional and prenatal periods,emphasizing the critical window of pre-conception for targeted intervention on smoking.

关键词： Autism spectrum disorder China Epidemiology Pre-conception Secondhand smoke

Solid Phase Synthesis of 4H-Pyrimido[2,1-b] Benzothiazol-4-ones from Resin-Bound Cyclic Malonic Ester

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Chinese Chemical Letters 2003年第3期14卷 247-248页

作者： zhan Xiang LIU Lu ling WU Xian HUANG Department of Chemistry Zhejiang University(Campus Xixi)Hangzhou 310028

The solid phase synthesis of 4H-pyrimido[2,1-b] benzothiazol-4-ones has been reported.

关键词： H-pyrimido[2,1-b]benzothiazol-4-ones Meldrum's acid solid phase synthesis.