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Simulation Study of Solid Rocket Motor C/C Throat Liner Ablation Based on Two Regions

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Journal of Power and Energy Engineering 2024年第4期12卷 1-19页

作者： Guanneng Chen Yihua Xu Xiaojiang zha Hemeng Shi bing Liu School of Aircraft Engineering Nanchang Hangkong University Nanchang China

Based on the ablation micro-morphological characteristics, thermo-chemical ablation mechanism, and mechanical stripping mechanism, a dual-region solid rocket motor C/C throat liner ablation model and physical model are established. The ablation program was written and the experimental data of 70 lb BATES engine platform was used for model validation. The relative errors between the simulation calculation results and the experimental results were −6.83% - 10.20%. The ablation program was applied to study the effects of combustion chamber temperature, pressure, oxidation component concentration, throat particle concentration and particle scouring angle on the nozzle throat liner, which provides a reference for the design of the nozzle throat liner and the estimation of solid rocket motor ablation.

关键词： Dual-Area Ablation Model C/C Throat Liner Ablation Environment Ablation Program

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long JIANG Li-ying FENG Jie zha Jing-wei YAO Yin LI Xian-ming DENG bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

Geometric Error Identification of Gantry-Type CNC Machine Tool Based on Multi-Station Synchronization Laser Tracers

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 150-162页

作者： Jun zha Huijie zhang School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University Suzhou Academy Suzhou 215123China

Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial *** propose a geometric error identification method based on multi-station synchronization laser tracers to enable the rapid and high-precision measurement of geometric errors for gantry-type computer numerical control(CNC)machine *** method also improves on the existing measurement efficiency issues in the single-base station measurement method and multi-base station time-sharing measurement *** consider a three-axis gantry-type CNC machine tool,and the geometric error mathematical model is derived and established based on the combination of screw theory and a topological analysis of the machine kinematic *** four-station laser tracers position and measurement points are realized based on the multi-point positioning principle.A self-calibration algorithm is proposed for the coordinate calibration process of a laser tracer using the Levenberg-Marquardt nonlinear least squares method,and the geometric error is solved using Taylor’s first-order linearization *** experimental results show that the geometric error calculated based on this modeling method is comparable to the results from the Etalon laser *** a volume of 800 mm×1000 mm×350 mm,the maximum differences of the linear,angular,and spatial position errors were 2.0μm,2.7μrad,and 12.0μm,respectively,which verifies the accuracy of the proposed *** research proposes a modeling method for the precise measurement of errors in machine tools,and the applied nature of this study also makes it relevant both to researchers and those in the industrial sector.

关键词： Multi-point positioning Multi-station synchronization CNC machine tool Geometric error Error separation

Graves病患者^(131)I治疗前后CD4^+CD25^+ Foxp3^+调节性T细胞的变化

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中国免疫学杂志 2012年第11期28卷 1032-1035页

作者：查兵兵刘军查英王芳盛励丁和远陈灶萍徐炯复旦大学上海医学院上海市第五人民医院内分泌科上海200240

目的:通过对Graves病患者131I治疗前后外周血各淋巴细胞亚群和CD4+CD25+ Foxp3+调节性T细胞含量以及相关基因Foxp3mRNA表达水平的测定,探讨131I治疗方法是否可以通过改变调节性T细胞的含量从而改善Graves病患者的免疫功能异常。方法:采... 详细信息

目的:通过对Graves病患者131I治疗前后外周血各淋巴细胞亚群和CD4+CD25+ Foxp3+调节性T细胞含量以及相关基因Foxp3mRNA表达水平的测定,探讨131I治疗方法是否可以通过改变调节性T细胞的含量从而改善Graves病患者的免疫功能异常。方法:采集30例Graves病患者131I治疗前及治疗后1个月的外周血,流式细胞仪检测外周血CD3+、CD3+CD4+、CD3+CD8+、CD3-CD19+、CD3-CD16+CD56+淋巴细胞亚群及CD4+CD25+ Foxp3+调节性T细胞的百分率,Real-TimePCR检测外周血单个核细胞Foxp3mRNA的表达水平。结果:和治疗前相比,Graves病患者131I治疗1个月后外周血CD3+CD4+T细胞和CD3-CD19+B细胞百分率都明显减少(P<0.05),CD3-CD16+CD56+NK细胞百分率明显增加(P<0.05),CD3-CD8+T细胞、CD4+CD25+ Foxp3+调节性T细胞百分率和Foxp3mRNA的表达水平无明显变化。结论:131I不能通过增加调节性T细胞的含量而改善Graves病患者的免疫耐受障碍,但可以通过减少CD4+T和B淋巴细胞的含量和增加NK细胞的含量来控制过度的免疫应答。

关键词： Graves病 CD4+CD25+ Foxp3+调节性T细胞 Foxp3

微波消融术治疗血钙正常的原发性甲状旁腺功能亢进(NPHPT)老年患者1例

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复旦学报（医学版） 2019年第4期46卷 566-568页

作者：李晓莹查兵兵徐彬黄新梅杨倩刘军复旦大学附属上海市第五人民医院内分泌科

血钙正常的原发性甲状旁腺功能亢进(normocalcemic primary hyperparathyroidism,NPHPT)是原发性甲状旁腺功能亢进(PHPT)的一种特殊类型,是指血钙水平持续正常,而血甲状旁腺激素(parathyroid hormone,PTH)水平升高,同时需除外继发性甲... 详细信息

血钙正常的原发性甲状旁腺功能亢进(normocalcemic primary hyperparathyroidism,NPHPT)是原发性甲状旁腺功能亢进(PHPT)的一种特殊类型,是指血钙水平持续正常,而血甲状旁腺激素(parathyroid hormone,PTH)水平升高,同时需除外继发性甲状旁腺功能亢进的因素。NPHPT发病机制、临床表现、自然进程及转归尚不清楚,治疗存在争议,首选手术治疗,但对于不能或不愿手术治疗的患者尚无统一意见,本文报道1例2017年7月行微波消融术治疗NPHPT老年患者,术后患者临床症状及PTH水平基本缓解。微波消融对于不愿手术的老年PHPT患者有一定的应用前景。

关键词：血钙原发性甲状旁腺功能亢进(PHPT) 微波消融术

Identification of the Hammerstein nonlinear system with noisy output measurements

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Control Theory and Technology 2024年第2期22卷 203-212页

作者： Qiming zha Feng Li Ranran Liu School of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001JiangsuChina School of Automobile and Traffic Engineering Jiangsu University of TechnologyChangzhou213001JiangsuChina

In this research, we present a methodology to identify the Hammerstein nonlinear system with noisy output measurements. The Hammerstein system presented is comprised of neural fuzzy model (NFM) as its static nonlinear block and auto-regressive with extra input (ARX) model as its dynamic linear block, and a two-step procedure is accomplished using signal combination. In the first step, in the case of input–output of Gaussian signals, the correlation function-based least squares (CF-LS) technique is utilized to identify the linear block, solving the problem that the intermediate variable connecting nonlinear and linear blocks cannot be measured. In the second step, to improve the identification accuracy of the nonlinear block parameters, an improved particle swarm optimization technique is developed under input–output of random signals. The validity and accuracy of the presented scheme are verified by a numerical simulation and a practical nonlinear process, and the results illustrate that the proposed methodology can identify well the Hammerstein nonlinear system with noisy output measurements.

关键词： Hammerstein nonlinear system Signal combination Auto-regressive with extra input Improved particle swarm optimization

2型糖尿病(T2DM)患者血清25羟维生素D[25(OH)D]与振动感觉阈值(VPT)的相关性

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复旦学报（医学版） 2020年第1期47卷 89-92页

作者：丁和远石蕾盛励李苗苗查兵兵刘军复旦大学附属上海市第五人民医院内分泌科上海200240 复旦大学附属上海市第五人民医院神经内科上海200240

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清25羟维生素D[25 hydroxyvitamin D,25(OH)D]与振动感觉阈值(vibrating perception threshold,VPT)的相关性。方法入选T2DM患者766例,根据VPT进行分层:振动觉正常组(vibration sensation normal group,VSN)(n=394)、振动觉减退组(vibration sensation impaired group,VSI)(n=227)及振动觉缺失组(vibration sensation deficiency group,VSD)(n=145)。比较各组血清25(OH)D水平差异,采用Spearman相关分析和Stepwise多元逐步回归分析评价血清25(OH)D与VPT相关性。结果与VSN组相比,VSI组和VSD组的年龄、病程和血清肌酐(serum creatinine,Scr)显著增加(P<0.001),体重指数(body mass index,BMI)、舒张压(diastolic blood pressure,DBP)、血清谷丙转氨酶(alanine transaminase,ALT)和25(OH)D显著降低(P<0.01)。与VSI组相比,VSD组的病程更长(P<0.01),糖化血红蛋白(hemoglobin A1c,HbA1c)显著升高(P<0.05)。Spearman相关分析显示,年龄、病程和Scr与VPT呈显著正相关,BMI、DBP、ALT和25(OH)D与VPT呈显著负相关。多元逐步回归分析显示年龄、病程、DBP、HbA1c、Scr及25(OH)D是VPT的独立危险因素。结论血清25(OH)D与VPT呈显著负相关,可能是VPT的独立危险因素。

关键词： 2型糖尿病(T2DM) 25羟维生素D[25(OH)D] 振动感觉阈值(VPT) 糖尿病周围神经

外周血CD4+CD25+调节性T细胞在Graves病发病中的作用

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中华内分泌代谢杂志 2012年第6期28卷 499-500页

作者：查兵兵刘军洪晓武查英王芳盛励丁和远陈灶萍徐炯上海复旦大学附属上海市第五人民医院内分泌科复旦大学免疫学系

测定不同阶段Graves病患者外周血中淋巴细胞亚群含量及CD4+CD25+调节性T细胞功能。结果显示CD4+CD25+调节性T细胞免疫功能减弱导致CD4+T细胞增殖失控可能是Graves病发病的重要原因,药物治愈患者其免疫功能难以完全恢复正常导致Graves病... 详细信息

测定不同阶段Graves病患者外周血中淋巴细胞亚群含量及CD4+CD25+调节性T细胞功能。结果显示CD4+CD25+调节性T细胞免疫功能减弱导致CD4+T细胞增殖失控可能是Graves病发病的重要原因,药物治愈患者其免疫功能难以完全恢复正常导致Graves病容易复发。

关键词：格雷夫斯病 CD4+CD25+调节性T细胞 Foxp3

Preparing cyclic polymers at high concentrations via self-folding cyclization technique by adjusting the contents of hydrophilic units in linear precursors

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Chinese Chemical Letters 2024年第2期35卷 283-288页

作者： Hao zha Zuowei Wang Chao Liu Chunyan Hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Cyclic polymers are a class of polymers that feature endless topology,and the synthesis of cyclic polymers has attracted the attention of many ***,cyclic polymers were efficiently constructed by self-folding cyclization technique at high *** poly((oligo(ethylene glycol)acrylate)-co-(dodecyl acrylate))(P(OEGA-co-DDA))precursors with different ratios of hydrophilic and hydrophobic moieties were synthesized by reversible addition-fragmentation chain transfer(RAFT)polymerization using a bifunctional chain transfer agent with two anthryl end *** amphiphilic linear precursors underwent the self-folding process to generate polymeric nanoparticles in *** irradiating the aqueous solution of the nanoparticles with 365 nm UV light,cyclic polymers were synthesized successfully via coupling of anthryl *** effects of the ratios of hydrophilic and hydrophobic moieties in linear P(OEGA-co-DDA)copolymers and polymer concentration on the purity of the obtained cyclic polymers were explored in detail via ^(1)H nuclear magnetic resonance(^(1)H NMR),dynamic light scattering(DLS),UV‒visible(vis)analysis,three-detection size exclusion chromatography(TD-SEC)and transmission electron microscopy(TEM).It was found that by adjusting the content of the hydrophilic segments in linear precursors,single chain polymeric nanoparticles(SCPNs)can be generated at high polymer ***,cyclic polymers with high purity can be constructed *** method overcomes the limitation of traditional ring-closure method,which is typically conducted in highly dilute conditions,providing an efficient method for the scalable preparation of cyclic polymers.

关键词： Cyclic polymers Self-folding cyclization technique Single chain polymeric nanoparticles RAFT polymerization Direct visualization