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Communications in Computational Physics 2014年第4期15卷 981-995页

作者： T.S.Ramazanov S.K.Kodanova M.K.Issanova N.Kh.Bastykova zh.A.Moldabekov IETP Al-Farabi Kazakh National University71Al-Farabi av.Almaty050040Kazakhstan

In this paper we present a software package based on modern information technologies that allows rapid analysis and visualization of the properties of complex *** properties of plasma are simulated by two *** of all,we have applied the molecular dynamics simulation method which numerically solves the equations of motions for plasma ***,we calculate microscopic properties of plasma by using the Boltzmann equation with additional relations,initial and boundary conditions.

关键词： Molecular dynamics simulation method modern information technology software package program software

Fast magnetic energy dissipation in relativistic plasma induced by high order laser modes

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High Power Laser Science and Engineering 2016年第2期4卷 85-89页

作者： Y.J.Gu Q.Yu O.Klimo T.zh.Esirkepov S.V.Bulanov S.Weber G.Korn Institute of Physics of the ASCR Institute of Modern Physics Fudan University FNSPE Czech Technical University in Prague Kansai Photon Science Institute Japan Atomic Energy Agency

Fast magnetic field annihilation in a collisionless plasma is induced by using TEM(1,0) laser pulse. The magnetic quadrupole structure formation, expansion and annihilation stages are demonstrated with 2.5-dimensional particle-in-cell simulations. The magnetic field energy is converted to the electric field and accelerate the particles inside the annihilation plane. A bunch of high energy electrons moving backwards is detected in the current sheet. The strong displacement current is the dominant contribution which induces the longitudinal inductive electric field.

关键词： high order laser mode laser–plasma interaction magnetic annihilation

Manufacture of HTR Fuel Element

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High Technology Letters 1995年第1期1卷 87-90页

作者： Shijiang, X. Chunhe, T. zhichang, X. Junguo, zh. Xueliang, Q. Ende, L. Tsinghua univ Beijing China

The HTR Fuel Element R & D Program,set in 1987,aims to develop the manufacturetechnology of HTR fuel element and to produce the fuel element for the first core of our 10MW experimental *** the work on laboratory scale... 详细信息

关键词： High temperature reactor Coated fuel particles Spherical fuel element Irradiation qualification

Bolshoi ussuriisky Island: Issues

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Bolshoi Ussuriisky Island: Issues

作者： zh.zh.Chimitdorzhiev Valerii Spidlen Khabarovsk State Academy of Economics and Law room 709 60Serysheva Str.680031KhabarovskRussia

The article explores the development model of Bolshoi ussuriisky Island within the format of"One island–two countries".The author analyses the existing concepts of the island development and assesses possible scenari...

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Preface

Preface

基于深度学习的镜下矿石矿物的智能识别实验研究

2009国际工业设计研讨会暨第十四届全国工业设计学术年会

作者： Ligang zh

Innovation has become a key element in the growing strategies of Industrial *** new products can play a critical role in building competitive advantage and may contribute significantly to a company’s growth and profitability. With "Promote Design Industrial Development,Promote Business Transformation and upgrading" as its theme,the 2009 International Conference on Industrial Design & the 14th China Industrial Design Annual Meeting aims to encourage products innovation and promote products competence of the Chinese enterprises.

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岩石学报 2018年第11期34卷 3244-3252页

作者：徐述腾周永章广东省地质过程与矿产资源探查重点实验室广州510275 中山大学地球环境与地球资源研究中心广州510275 中山大学地球科学与工程学院广州510275

矿石矿物鉴定的智能化是智能地质学和智能矿床学的基础技术之一。计算机视觉技术和深度学习理论使矿石矿物鉴定的智能化成为可能。本研究基于深度学习系统Tensor Flow,以吉林夹皮沟金矿和河北石湖金矿的黄铁矿、黄铜矿、方铅矿、闪锌矿... 详细信息

矿石矿物鉴定的智能化是智能地质学和智能矿床学的基础技术之一。计算机视觉技术和深度学习理论使矿石矿物鉴定的智能化成为可能。本研究基于深度学习系统Tensor Flow,以吉林夹皮沟金矿和河北石湖金矿的黄铁矿、黄铜矿、方铅矿、闪锌矿等硫化物矿物为例,设计有针对性的unet卷积神经网络模型,有效自动提取矿相显微镜下矿石矿物的深层特征信息,实现镜下矿石矿物智能识别与分类。实验显示,模型在训练过程中,随着训练次数的增加,模型精度在不断增大,损失函数不断减小;经过3000个批处理之后,模型精度和损失函数基本趋于稳定。训练出的模型对测试集中的显微镜镜下矿石矿物照片的识别成功率均高于90%,说明实验所建立的模型,具有很好的图像特征提取能力,能完成镜下矿石矿物智能识别的任务。

关键词：卷积神经网络算法深度学习矿物自动识别地质大数据智能地质学机器学习

Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP

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Journal of Molecular Cell Biology 2023年第2期15卷 3-16页

作者： Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng zhang Fei Li Yiqing Wu Chunhong Huang Xiaolong yang Joachim Kremerskothen Jianmin zhang Chunbo zhang Shuo Tu zhihua Li zh.un Luo zhenghong Lin Xiaohua yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330031China Department of Rheumatology and Clinical Immunology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Pathology and Molecular Medicine Queen’s UniversityKingstonON K7L 3N6Canada Department of Nephrology Hypertension and RheumatologyUniversity Hospital MünsterMünster 48149Germany Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNY 14203USA School of Pharmacy Nanchang University Jiangxi Medical CollegeNanchang 330008China Key Laboratory of Breast Diseases of Jiangxi Province Nanchang People’s HospitalNanchang 330025China Department of Pathology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330006China School of Life Sciences Chongqing UniversityChongqing 405200China

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little ***, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner.

关键词： TGF-β TEAD4 p300 signaling regulation transcriptional activity hepatocellular carcinoma

瘦素受体与核转录因子-κB在结直肠腺癌组织中的表达及意义

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世界华人消化杂志 2006年第28期14卷 2759-2764页

作者：熊枝繁晏泽辉华中科技大学同济医学院附属梨园医院消化内科湖北省武汉市430077

目的:研究瘦素受体(Ob-R)在结直肠腺癌组织中的表达,探讨Ob-R在肿瘤血管生成中的作用及其可能机制．方法:免疫组织化学方法检测35例结直肠腺癌组织、24例结直肠腺瘤组织和35例正常对照组织中Ob-R、CD105、核转录因子-κBp65(NF-κBp65)... 详细信息

目的:研究瘦素受体(Ob-R)在结直肠腺癌组织中的表达,探讨Ob-R在肿瘤血管生成中的作用及其可能机制．方法:免疫组织化学方法检测35例结直肠腺癌组织、24例结直肠腺瘤组织和35例正常对照组织中Ob-R、CD105、核转录因子-κBp65(NF-κBp65)的表达,以图像分析软件进行半定量测定．结果:以CD105标记的微血管密度(MVD)在癌症组、腺瘤组、正常对照组间呈递减改变(23．63±2．08 vs 10．83±1．25 vs 1．97±0.37．P<0．05)．Ob-R和NF-κB(p65)的表达部位相似．癌症组中Ob-R和NF-κB(p65)的积分光密度均比对照组高(27．41±2．21 vs 20．45±1．63, 45．88±5．46 vs 29．11±3．89,P<0．05)．癌症组中Ob-R,NF-κBp65的积分光密度,MVDS三者间呈两两正相关．癌症组63．6％的标本中可见Ob-R血管内皮细胞染色阳性,其MVD较阴性者高(38．21±2．78 vs 27．50±2．95,t=2．602, P<0．05);68．6％的癌症标本中可见NF-κBp65血管内皮细胞核表达阳性,其MVD较阴性者高(37．53±3．07 vs 28．42±2．63,t=2．146, P<0．05)．Ob-R和NF-κBp65的表达与结直肠腺癌临床病理因素间未见相关性．结论:结直肠腺癌组织中Ob-R表达增多对肿瘤血管生成起促进作用,并且该作用可能是通过NF-κB途径来实现的．

关键词：瘦素受体核转录因子-κB 结直肠腺癌

A New Method for Locating Calculation of Arbitrary Spatial Straight Line or Plane in NC Machining

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厦门大学学报（自然科学版） 2002年第S1期41卷 149-150页

作者： yan Shu-tian, LIu Tao, Wu Zai-xin, Hu Chi-bing, Hu Li-zh i (College of Mechano-Electronic Engineering, Gansu university of Techn ology, Lanzh.u 730050, China)

In the manufacturing process, we often encounter so me location machining of space arbitrary straight lines and planes that are not on ly unparalleled but also not vertical with the machine tool spindle or the cutti ng tool. In the past, we can do the location machining through the methods of dr awing line and making level in the ordinary machine tool. In the numerical contr ol machining of the CNC machine tool and manufacturing center, however, the spac e location and angle of the arbitrary straight lines and planes must be precisel y calculated in advance. So that precisely locating can be guaranteed in machini ng. Therefore, how to work out the space location angle of the arbitrary straigh t lines and planes to be machined both conveniently and precisely, turns out to be the must-be-solved chief problem in the numerical control machining. In thi s paper, through the deeply research of this problem, a new kind of calculating formula that calculates and defines the space location angle of the arbitrary st raight lines and planes by using the methods of analytic calculating. The formul a has been applied in the practical manufacturing calculation. It is proved that the new space angle calculating methods of arbitrary straight lines and planes is convenient in calculating and precise in locating. And it provides us a n ew, brief and precise calculating method in the numerical control machining of t he numerical control machine tool and manufacturing center.

关键词： arbitrary straight line arbitrary plane pr ojected angle inclination location

Preconditions for diversification development process in industry production

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Preconditions for diversification development process in ind...