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Prevalence and risk factors of depression among patients with perianal fistulizing Crohn’s disease

World Journal of Psychiatry 2024年第5期14卷 715-725页

作者： Jing Li Wing-Yi ng Li-Chao Qiao Fen Yuan Xing Lan Li-Bei zhu Bo-Lin Yang zh.ng-Qiu Wang Department of Radiology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Acupuncture and Rehabilitation Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Psychological distress,especially depression,associated with perianal fistulizing Crohn’s disease(PFCD)is widespread and ***,there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with *** To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with *** The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical *** symptoms,life quality,and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9,Inflammatory Bowel Disease Patient Quality of Life Questionnaire(IBDQ),and Inflammatory Bowel Disease(IBD)Fatigue Patient Self-assessment *** basic demographic information,overall disease features,perianal clinical information,and laboratory inflammation indicators were also *** regression analysis was ultimately used to ascertain the risk factors of depression associated with *** A total of 123 patients with PFCD were involved,and 56.91%were suffering from *** to multivariate logistic regression analysis,Perianal Disease Activity Index(PDAI)score[odds ratio(OR)=0.69,95%confidence interval(CI):0.50 to 0.95],IBDQ score(OR=0.93,95%CI:0.88 to 0.97),modified Van Assche index(OR=1.24,95%CI:1.01 to 1.53),and IBD Fatigue score(OR=1.72,95%CI:1.23 to 2.42)were independent risk factors of depression-related prevalence among patients with PFCD(Png perianal modified Van Assche index(βvalue=0.166,95%CI:0.02 to 0.31)and decreasing IBDQ score(βvalue=-0.116,95%CI:-0.14 to-0.09)were independently associated with the severity of depression(P<0.05).CONCLUSION Depressive symptoms in PFCD patients have significantly high *** score,modified Van Assche index,quality of life,and fatigue severity

关键词： Crohn’s disease Fistula Depression Inflammatory bowel diseases Risk factors

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Effectiveness of mindfulness-based interventions on the well-being of healthcare workers:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 335-344页

作者： Natasha Yixuan Ong Finn Jing Jie Teo Jane Zi Ying Ee Chun En Yau Julian Thumboo Hiang Khoon Tan Qin Xiang ng NUS Yong Loo Lin School of Medicine National University of SingaporeSingapore Health Services Research Unit Singapore General HospitalSingapore SingHealth Duke-NUS Medicine Academic Clinical Programme Duke-NUS Medical SchoolSingapore Singhealth Duke-NUS Global Health Institute Singapore Duke Global Health Institute Duke UniversityDurhamNorth CarolinaUSA Division of Surgery and Surgical Oncology Singapore General HospitalSingapore Saw Swee Hock School of Public Health National University of Singapore and National University Health SystemSingapore

Background Growing evidence attests to the efficacy of mindfulness-based interventions(MBIs),but their effectiveness for healthcare workers remains *** To evaluate the evidence for MBIs in improving healthcare workers’psychological *** A systematic literature search was conducted on Medline,Embase,Cumulative Index for Nursing and Allied Health Literature,PsycINFO and Cochrane Central Register of Controlled Trials up to 31 August 2022 using the keywords‘healthcare worker’,‘doctor’,‘nurse’,‘allied health’,‘mindfulness’,‘wellness’,‘workshop’and‘program’.Randomised controlled trials with a defined MBI focusing on healthcare workers and quantitative outcome measures related to subjective or psychological well-being were eligible for inclusion.R V.4.0.3 was used for data analysis,with the standardised mean difference as the primary outcome,employing DerSimonian and Laird’s random effects *** of Recommendations,Assessment,Development and Evaluation framework was used to evaluate the quality of ***’s Risk of Bias 2 tool was used to assess the risk of bias in the included *** A total of 27 studies with 2506 participants were included,mostly from the USA,involving various healthcare *** such as stress reduction programmes,apps,meditation and training showed small to large effects on anxiety,burnout,stress,depression,psychological distress and job strain outcomes of the *** effects were also seen in self-compassion,empathy,mindfulness and ***,long-term outcomes(1 month or longer postintervention)varied,and the effects were not consistently *** MBIs offer short-term benefits in reducing stress-related symptoms in healthcare *** review also highlights limitations such as intervention heterogeneity,reduced power in specific subgroup analyses and variable study quality.

关键词： nurse sustained workers

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 945-997页

作者： Jian Sheng Loh Wen Qi Mak Li Kar Stella Tan Chu Xin ng Hong Hao Chan Shiau Hueh Yeow Jhi Biau Foo Yong Sze Ong Chee Wun How Kooi Yeong Khaw School of Pharmacy Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia School of Pharmacy Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia Digital Health&Medical Advancements Taylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia School of Biosciences Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia UCL School of Pharmacy University College London29-39 Brunswick SquareLondon WC1N 1AXUK

The human gastrointestinal tract is populated with a diverse microbial *** vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology,including health maintenance,development,aging,and *** advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host *** has unveiled the bidirectional communication between the gut microbiome and the central nervous system,referred to as the“microbiota–gut–brain axis”.The microbiota–gut–brain axis represents an important regulator of glial functions,making it an actionable target to ameliorate the development and progression of neurodegenerative *** this review,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative *** the gut microbiome provides essential cues to microglia,astrocytes,and oligodendrocytes,we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative ***,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach,while also examining the role of gut microbiota-related neurotransmitters and gut ***,we examine the potential of targeting the intestinal barrier,blood–brain barrier,meninges,and peripheral immune system to counteract glial dysfunction in ***,we conclude by assessing the pre-clinical and clinical evidence of probiotics,prebiotics,and fecal microbiota transplantation in neurodegenerative diseases.A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.

关键词： degenerative therapeutic diseases

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Low-rank matrix recovery with total generalized variation for defending adversarial examples

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 432-445页

作者： Wen LI Hengyou WAng Lianzhi HUO Qiang HE Linlin CHEN zhiquan HE Wing W.Y.ng School of Science Beijing University of Civil Engineering and ArchitectureBeijing 100044China School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Guangdong Key Laboratory of Intelligent Information Processing Shenzhen 518060China Institute of Big Data Modeling and Technology Beijing University of Civil Engineering and ArchitectureBeijing 100044China

Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image *** advantage of its excellent performance in image denoising,we apply it to improve the robustness of deep neural ***,although TV regularization can improve the robustness of the model,it reduces the accuracy of normal samples due to its *** our work,we develop a new low-rank matrix recovery model,called LRTGV,which incorporates total generalized variation(TGV)regularization into the reweighted low-rank matrix recovery *** the proposed model,TGV is used to better reconstruct texture information without *** reweighted nuclear norm and Li-norm can enhance the global structure ***,the proposed LRTGV can destroy the structure of adversarial noise while re-enhancing the global structure and local texture of the *** solve the challenging optimal model issue,we propose an algorithm based on the alternating direction method of *** results show that the proposed algorithm has a certain defense capability against black-box attacks,and outperforms state-of-the-art low-rank matrix recovery methods in image restoration.

关键词： Total generalized variation Low-rank matrix Alternating direction method of multipliers Adversarial example

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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(Png cardiovascular health(Png status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(Pngs underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

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Development of Extraction and Detection Method for a Chemotherapeutic Drug with Phenytoin in Biological Samples

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Advances in Biological Chemistry 2024年第4期14卷 103-110页

作者： Michael Arnot Nicolas Brice Adan Garcia Victor Lomeli My Phuong Vu Karno ng Department of Chemistry & Biochemistry California State University San Marcos San Marcos CA U.S.A.

Dexamethasone is classified as a corticosteroid and is commonly used among cancer patients to decrease the amount of swelling around the tumor. Among patients with cancer, in particular brain tumors, seizures can become a daily routine in their everyday lives. To counteract the seizures, an antiepileptic drug such as phenytoin is administered to act as an anticonvulsant. Phenytoin and dexamethasone are frequently administrated concurrently to brain cancer patients. A previous study has shown that phenytoin serum concentration decreases when administrated concurrently with dexamethasone. Thus, it is important to monitor the concentration of these two drugs in biological samples to ensure that the proper dosages are administrated to the patients. This study aims to develop an effective extraction and detection method for dexamethasone and phenytoin. A reverse-phase high-performance liquid chromatography (HPLC) method with UV/Vis detection has been developed to separate phenytoin and dexamethasone at 219 nm and 241 nm respectively from urine samples. The mobile phase consists of a mixture of 0.01 M KH2PO4, acetonitrile, and methanol adjusted to pH 5.6 (48:32:20) and is pumped at a flow rate of 1.0 mL/min. Calibration curves were prepared for phenytoin and dexamethasone (r2 > 0.99). An efficient solid-phase extraction (SPE) method for the extraction of dexamethasone and phenytoin from urine samples was developed with the use of C-18 cartridges. The percent recovery for phenytoin and dexamethasone is 95.4% (RSD = 1.15%) and 81.1% (RSD = 3.56%) respectively.

关键词： Dexamethasone Phenytoin Cancer Drug Interaction Solid Phase Extraction

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai ng Peter Ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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Development of a Simple Extraction Method for Tetracycline Analogues from Bovine Milk

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Advances in Biological Chemistry 2024年第4期14卷 111-120页

作者： Oscar Cordova Thien Le Christopher Lambert Devin Brodie Stephany Ramirez Francis Sandoval Karno ng Department of Chemistry & Biochemistry California State University San Marcos San Marcos USA

Tetracycline and analogues are among the most used antibiotics in the dairy industry. Besides the therapeutic uses, tetracyclines are often incorporated into livestock feed as growth promoters. A considerable amount of antibiotics is released unaltered through milk from dairy animals. The presence of antibiotic residues in milk and their subsequent consumption can lead to potential health impacts, including cancer, hypersensitivity reactions, and the development of antibiotic resistance. Thus, it is important to monitor residual levels of tetracyclines in milk. The purpose of this study is to develop a quick and simple method for simultaneously extracting five tetracycline analogues from bovine milk. Specifically, five tetracycline analogues: Chlortetracycline (CTC), demeclocycline (DEM), doxycycline (DC), minocycline (MC), and tetracycline (TC) were simultaneously extracted from milk using trifluoroacetic acid. Subsequently, the extracted analogues were separated by reverse-phase high-performance liquid chromatography (RP-HPLC) and detected at 355 nm using UV/Vis. Calibration curves for all five tetracycline analogues show excellent linearity (r2 value > 0.99). Percent recovery for MC, TC, DEM, CTC, and DC were: 31.88%, 96.91%, 151.29, 99.20%, and 85.58% respectively. The developed extraction method has good precision (RSD ng test.

关键词： Antibiotics Tetracyclines Extraction Milk HPLC

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Application of artifcial intelligence in cataract management:current and future directions

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Eye and Vision 2024年第1期10卷 21-30页

作者： Laura Gutierrez Jane Sujuan Lim Li Lian Foo Wei Yan ng Michelle Yip Gilbert Yong San Lim Melissa Hsing Yi Wong Allan Fong Mohamad Rosman Jodhbir Singth Mehta Haotian Lin Darren Shu Jeng Ting Daniel Shu Wei Ting Singapore Eye Research Institute SingaporeSingapore Singapore National Eye Center 11 Third Hospital AvenueSingapore 168751Singapore Academic Ophthalmology School of MedicineUniversity of NottinghamNottinghamUK zh.ngshan Ophthalmic Center Sun Yet Sen UniversityGuangzhouChina

The rise of artifcial intelligence(AI)has brought breakthroughs in many areas of *** ophthalmology,AI has delivered robust results in the screening and detection of diabetic retinopathy,age-related macular degeneration,glaucoma,and retinopathy of *** management is another feld that can beneft from greater AI *** is the leading cause of reversible visual impairment with a rising global clinical *** diagnosis,monitoring,and surgical management are necessary to address this *** addition,patients in large developing countries often sufer from limited access to tertiary care,a problem further exacerbated by the ongoing COVID-19 *** on the other hand,can help transform cataract management by improving automation,efcacy and overcoming geographical ***,AI can be applied as a telediagnostic platform to screen and diagnose patients with cataract using slit-lamp and fundus *** utilizes a deep-learning,convolutional neural network(CNN)to detect and classify referable cataracts ***,some of the latest intraocular lens formulas have used AI to enhance prediction accuracy,achieving superior postoperative refractive results compared to traditional ***,AI can be used to augment cataract surgical skill training by identifying diferent phases of cataract surgery on video and to optimize operating theater workfows by accurately predicting the duration of surgical ***,some AI CNN models are able to efectively predict the progression of posterior capsule opacifcation and eventual need for YAG laser *** advances in AI could transform cataract management and enable delivery of efcient ophthalmic *** key challenges include ethical management of data,ensuring data security and privacy,demonstrating clinically acceptable performance,improving the generalizability of AI models across heterogeneous populations,and improving the trust of e

关键词： Artifcial intelligence Telemedicine Cataract Cataract screening Cataract surgery IOL calculations Biometry Machine learning

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A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material

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Journal of Materials Science & Technology 1999年第1期15卷 1-4页

作者： zh.ng, wg Cheng, HM Su, G Fan, YY Li, F Shen, zh zhou, BL Chinese Acad Sci Met Res Inst Shenyang 110015 Peoples R China

A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusion of carbon atoms through catalyst particles is described mathematically, and the physical and chemical properties of the catalyst particles during the growth process are taken into account. From the model the growth rate and grown length of VGFC are calculated theoretically which coincides with the experimental data; and the necessity of reducing gas such as hydrogen in preparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown by the model. Fe3C formed on the surface of gamma-Fe will stop the growth of carbon fiber if they can not be reduced at once. Additionally, the growth temperature and diameter of VGFC are also discussed in the paper.

关键词： FILAMENTOUS CARBON NICKEL FIBERS IRON DECOMPOSITION CATALYSTS

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