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Effect of silicone oil removal on central corneal thickness

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 374-376页

作者： Gul Arikan zeynep ozbek F Hakan Oner Ismet Durak A Osman Saatci Department of Ophthalmology Dokuz Eylul UniversityIzmirTurkey

AIM:To evaluate the effect of silicone oil removal(SOR) on central corneal thickness(CCT) in aphakic and pseudophakic eyes prospectively.· METHODS:Patients who underwent SOR surgery between June 2005-August 2007 were included in this *** oil was actively removed behind the posterior capsule through the pars plana sclerotomy site(posterior approach) in pseudophakic eyes and through the pupil and the corneal tunnel incision(anterior approach) in aphakic eyes with the 18-gauge *** was assessed with Orbscan II corneal topography system preoperatively and at one month and three months postoperatively.A total of 34 eyes of 34 patients(26 males,8 females) comprised the study *** age was(55.6±12.3) years(Range:25-80 years).Twenty-six eyes(76.5%) were pseudophakic and 8(23.5%) *** time between silicone oil injection and removal was(15.1±13.6) months(Range:5-54 months).At baseline,CCT was 576.4±46.0μm in pseudophakic eyes and 611.6±36.2μm in aphakic eyes.· RESULTS:At the first postoperative month CCT was(573.3±40.1)μm and(630.9±72.9)μm in pseudophakic and aphakic eyes *** the third postoperative month,CCT was(582.7±49.5)μm and(614.5±82.4)μm in pseudophakic and aphakic eyes *** was no statistically significant difference in CCT measurements one month and 3 months after SOR when compared to preoperative values in both aphakic and pseudophakic eyes(P> 0.05).· CONCLUSION:Active SOR either by anterior or posterior approach did not affect the CCT.·

关键词： Aphakia central corneal thickness silicone oil pseudophakia

Ahmed青光眼阀治疗难治性青光眼的长期疗效(英文)

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国际眼科杂志 2012年第7期12卷 1221-1225页

作者： Mahmut Kaya zeynep ozbek Aylin Yaman Ismet Durak Dokuz Eylul大学眼科

评估Ahmed青光眼阀(Ahmed glaucoma valve,AGV)植入治疗难治性青光眼的长期疗效及并发症。方法:回顾性分析13例13眼接受Ahmed青光眼阀植入,最短随访18mo的难治性青光眼患者。所有患者均在术前及术后1,3,6mo,1a及1a以后行全面的眼科检查... 详细信息

评估Ahmed青光眼阀(Ahmed glaucoma valve,AGV)植入治疗难治性青光眼的长期疗效及并发症。方法:回顾性分析13例13眼接受Ahmed青光眼阀植入,最短随访18mo的难治性青光眼患者。所有患者均在术前及术后1,3,6mo,1a及1a以后行全面的眼科检查,眼压测量,记录并发症及抗青光眼的药物需求。结果:患者平均年龄27.3±16.0岁。所有患眼(100%)接受至少一次前置小切口手术。平均随访61.3±30.8mo。在少量药物的作用下,12mo时眼压由35.0±7.0mmHg降至18.2±7.9mmHg,96mo时降至17.0±4.1mmHg,76.9%患者需其他辅助治疗以达到预期的成功疗效。最常见的并发症包括包裹性囊肿8眼(61.5%),置管脱出4眼(30.8%)。结论:包裹性囊肿是最常见的并发症,阻碍了Ahmed青光眼阀植入治疗难治性青光眼。虽然囊肿被抗纤维化药物切除,但没有抗青光眼药物的治疗,眼压仍旧不能很好控制。

关键词： Ahmed青光眼阀包裹性囊肿眼压难治性青光眼

An Effective Discrete Artificial Bee Colony Based SPARQL Query Path Optimization by Reordering Triples

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Journal of Computer Science & Technology 2021年第2期36卷 445-462页

作者： zeynep Banu Ozger Nurgul Yuzbasioglu Uslu Department of Computer Engineering Sutcu Imam UniversityKahramanmaras 46040Turkey Department of Computer Engineering Yildiz Technical UniversityIstanbul 34220Turkey

Semantic Web has emerged to make web content machine-readable,and with the rapid increase in the number of web pages,its importance has *** description framework(RDF)is a special data graph format where Semantic Web data are stored and it can be queried by SPARQL query *** challenge is to find the optimal query order that results in the shortest period of *** this paper,the discrete Artificial Bee Colony(dABCSPARQL)algorithm is proposed,based on a novel heuristic approach,namely reordering SPARQL *** processing time of queries with different shapes and sizes is minimized using the dABCSPARQL *** performance of the proposed method is evaluated on chain,star,cyclic,and chain-star queries of different sizes from the Lehigh University Benchmark(LUBM)*** results obtained by the proposed method are compared with those of ARQ(a SPARQL processor for Jena)query engine,the Ant System,the Elitist Ant System,and MAX-MIN Ant System *** experiments demonstrate that the proposed method significantly reduces the processing time,and in most queries,the reduction rate is higher compared with other optimization methods.

关键词： artificial bee colony resource description framework(RDF) query optimization reordering triple pattern SPARQL

Performance Comparison of Commercial and Home-Made Lipases for Synthesis of Poly(δ-Valerolactone)Homopolymers

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Journal of Renewable Materials 2019年第4期7卷 335-343页

作者： Cansu Ulker zeynep Gok Yuksel Guvenilir Istanbul Technical University Department of Chemical EngineeringAyazaga CampusIstanbul34469Turkey

Novozyme 435,which is the commercially available immobilized form of Candida antarctica lipase B,has been successfully conducted ring opening polymerization of lactones in organic *** this paper,it was aimed to introduce an alternative biocatalyst for Novozyme *** antarctica lipase B immobilized onto rice husk ashes via physical adsorption(with a specific activity of 4.4 U/mg)was prepared in previous studies and used as a biocatalyst for poly(δ-valerolactone)synthesis in the present *** reactions were proceeded at various reaction temperatures and periods via both two immobilized enzyme *** resulting products were characterized spectroscopically and *** highest molecular weight(Mn=9010 g/mol)was obtained via Novozyme 435 catalysis at 40℃and 24 *** performance of home-made lipase,which resulted in a molecular weight of 8040 g/mol,was close to commercial one.

关键词： Poly(δ-valerolactone) Candida antarctica lipase B Novozyme 435 immobilization enzymatic ring opening polymerization

Solving vehicle routing problem with time windows using metaheuristic approaches

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International Journal of Intelligent Computing and Cybernetics 2023年第1期16卷 121-138页

作者： zeynep Aydınalp DoganÖzgen Yıldız Technical University IstanbulTurkey

Purpose-Drugs are strategic products with essential functions in human *** optimum design of the pharmaceutical supply chain is critical to avoid economic damage and adverse effects on human *** vehicle-routing problem,focused on finding the lowest-cost routes with available vehicles and constraints,such as time constraints and road length,is an important aspect of *** this paper,the vehicle routing problem(VRP)for a pharmaceutical company in Turkey is ***/methodology/approach-A mixed-integer programming(MIP)model based on the vehicle routing problem with time windows(VRPTW)is presented,aiming to minimize the total route cost with certain *** the model provides an optimum solution for small problem sizes with the GUROBI®solver,for large problem sizes,metaheuristic methods that simulate annealing and adaptive large neighborhood search algorithms are proposed.A real dataset was used to analyze the effectiveness of the metaheuristic *** proposed simulated annealing(SA)and adaptive large neighborhood search(ALNS)were evaluated and compared against GUROBI®and each other through a set of real problem ***-The model is solved optimally for a small-sized dataset with exact algorithms;for solving a larger dataset,however,metaheuristic algorithms require significantly lesser *** the problem addressed in this study,while the metaheuristic algorithms obtained the optimum solution in less than one minute,the solution in the GUROBI®solver was limited to one hour and three hours,and no solution could be obtained in this time ***/value-The VRPTW problem presented in this paper is a real-life *** vehicle fleet owned by the factory cannot be transported between certain suppliers,which complicates the solution of the problem.

关键词： Pharmaceutical supply chain Network design Mixed-integer linear programming Vehicle routing problem Simulated annealing Adaptive large neighborhood search

Effect of exercise on colorectal cancer prevention and treatment

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World Journal of Gastrointestinal Oncology 2019年第5期11卷 348-366页

作者： zeynep Oru? Muhammed Ali Kaplan Department of Medical Oncology Mersin City Hospital Department of Medical Oncology Faculty of Medicine Dicle University

In recent years, because of improved cancer screening, detection and treatment modalities, a rapid increase in the population of colorectal and other cancer survivors has been observed. The increasing population has justified the requirement of preventive strategies such as lifestyle modifications with regard to obesity, physical activity, diet and smoking. Physical activity may prevent approximately 15% of the colon cancers. Furthermore, several observational studies have demonstrated the efficacy and dose-dependent and anti-cancer effects of exercise on decreasing the mortality and risk of recurrence before and after the colorectal cancer(CRC) diagnosis. However, the required exercise dose,type and intensity are yet unclear. The results of randomised prospective studies are expected to determine the optimal amount, type and intensity of exercise and formulate the most appropriate exercise plan and guidelines, according to the requirements and comorbidities of the patients. In addition, recent studies have focused on the molecular and genetic mechanisms underlying the effect of physical activity on disease outcomes and recurrence rates. This review aimed to investigate the effects of physical activity and the biological basis of these effects in preventing the risk and recurrence of CRC and decreasing the hazards of cancer and cancer treatment.

关键词： Colorectal cancer Exercise Physical activity

Vibration of a Two-Layer“Metal+PZT”Plate Contacting with Viscous Fluid

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Computers, Materials & Continua 2023年第2期74卷 4337-4362页

作者： zeynep Ekicioglu Kuzeci Surkay D.Akbarov Department of Mechanical Engineering Kirsehir Ahi Evran UniversityKirsehir40100Turkey Department of Mechanical Engineering Yildiz Technical UniversityYildiz CampusIstanbul34349Turkey Institute of Mathematics and Mechanics of the National Academy of Sciences of Azerbaijan Baku37041Azerbaijan

The present work investigates the mechanically forced vibration of the hydro-elasto-piezoelectric system consisting of a two-layer plate“elastic+PZT”,a compressible viscous fluid,and a rigid *** is assumed that the PZT(piezoelectric)layer of the plate is in contact with the fluid and time-harmonic linear forces act on the free surface of the elastic-metallic *** study is valuable because it considers for the first time the mechanical vibration of the metal+piezoelectric bilayer plate in contact with a *** is also the first time that the influence of the volumetric concentration of the constituents on the vibration of the hydro-elasto-piezoelectric system is *** value of the present work is the use of the exact equations and relations of elasto-electrodynamics for elastic and piezoelectric materials to describe the motion of the plate layers within the framework of the piecewise homogeneous body model and the use of the linearized Navier-Stokes equations to describe the flow of the compressible viscous *** plane-strain state in the plate and the plane flow in the fluid take *** the solution of the corresponding boundary-value problem,the Fourier transform is used with respect to the spatial coordinate on the axis along the laying direction of the *** analytical expressions of the Fourier transform of all the sought values of each component of the system are *** origins of the searched values are determined numerically,after which numerical results on the stress on the fluid and plate interface planes are presented and *** results are obtained for the case where PZT-2 is chosen as the piezoelectric material,steel and aluminum as the elastic metal materials,and Glycerin as the *** of these results allows conclusions to be drawn about the character of the problem parameters on the frequency response of the interfacial *** particular,it was found that after a certain value of the vibrat

关键词： Metal+piezoelectric two-layer plate compressible viscous fluid mechanical forced vibration interfacial stress resonance frequency

A New Segmentation Framework for Arabic Handwritten Text Using Machine Learning Techniques

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Computers, Materials & Continua 2021年第8期68卷 2727-2754页

作者： Saleem Ibraheem Saleem Adnan Mohsin Abdulazeez zeynep Orman Department of Information Technology Technical Informatics College of AkreDuhok Polytechnic UniversityDuhok42004Kurdistan RegionIraq Department of Computer Engineering Faculty of EngineeringIstanbul University-CerrahpasaIstanbul34320Turkey

The writer identification(WI)of handwritten Arabic text is now of great concern to intelligence agencies following the recent attacks perpetrated by known Middle East terrorist *** is also a useful instrument for the digitalization and attribution of old text to other authors of historic studies,including old national and religious *** this study,we proposed a new affective segmentation model by modifying an artificial neural network model and making it suitable for the binarization stage based on *** modified method is combined with a new effective rotation model to achieve an accurate segmentation through the analysis of the histogram of binary ***,propose a new framework for correct text rotation that will help us to establish a segmentation method that can facilitate the extraction of text from its *** projections and the radon transform are used and improved using machine learning based on a co-occurrence matrix to produce binary *** training stage involves taking a number of images for model *** images are selected randomly with different angles to generate four classes(0–90,90–180,180–270,and 270–360).The proposed segmentation approach achieves a high accuracy of 98.18%.The study ultimately provides two major contributions that are ranked from top to bottom according to the degree of *** proposed method can be further developed as a new application and used in the recognition of handwritten Arabic text from small documents regardless of logical combinations and sentence construction.

关键词： Writer identification handwritten Arabic biometric systems artificial neural network segmentation skew detection model

Epidemiology and etiology of chemical ocular injury:A brief review

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World Journal of Clinical Cases 2023年第6期11卷 1245-1251页

作者： zeynep Akgun Ozlem Barut Selver Department of Ophthalmology Ege University Faculty of MedicineIzmir 35100Turkey

Chemical ocular injury is one of the common ophthalmologic emergencies that can cause vision loss and serious *** all protective measures,it continues to be a serious public health problem,especially in young male *** it is known that injuries occur most frequently in the workplace and in young male patients,there is a variable frequency and distribution in different regions around the *** addition,with the coronavirus disease 2019 pandemic,there are changing trends in ocular chemical *** review aims to specify an update on the epidemiological and etiological features of ocular chemical injuries.

关键词： Chemical ocular injury Alkaline Acid COVID-19 Epidemiology Etiology