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Management of cytomegalovirus infection after liver transplantation

World Journal of Transplantation 2024年第3期14卷 30-39页

作者： zeynep burcin yilmaz Funda Memisoglu Sami Akbulut Infectious Diseases and Clinical Microbiology Inonu University Faculty of MedicineMalatya 44280Türkiye Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Türkiye

Cytomegalovirus(CMV)infection is one of the primary causes of morbidity and mortality following liver transplantation(LT).Based on current worldwide guidelines,the most effective strategies for avoiding post-transplant CMV infection are antiviral prophylaxis and pre-emptive ***-IgG serology is the established technique for pretransplant screening of both donors and *** clinical presentation of CMV infection and disease exhibits variability,prompting clinicians to consistently consider this possibility,partic-ularly within the first year post-transplantation or subsequent to heightened *** annual symposia to discuss CMV prevention and how treatment outcomes can be improved,evidence on the incorporation of immune functional tests into clinical practice is presented,and the results of studies with new antiviral treatments are *** there are ongoing studies on the use of letermovir and maribavir in solid organ transplantation,a consensus reflected in the guidelines has not been *** the most appro-priate strategy at the individual level appears to be the key to enhancing *** prevention strategies reduce the risk of CMV disease,the disease can still occur in up to 50%of high-risk patients.A balance between the risk of infection and disease development and the use of immunosuppressants must be considered when talking about the proper management of CMV in solid organ transplant *** objective of this study was to establish a compre-hensive framework for the management of CMV in patients who have had LT.

关键词： Liver transplantation Cytomegalovirus Antiviral prophylaxis Preemptive treatment Valganciclovir Ganciclovir

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Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in patients with pseudoexfoliation syndrome

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 332-336页

作者： Mehmet Cuneyt Ozmen zeynep Aktas burcin Kepez Yildiz Murat Hasanreisoglu Berati Hasanreisoglu Department of Ophthalmology Gazi University Medical School

AIM: To compare retinal artery-vein diameters(RAVDs)of patients with pseudoexfoliation(PSX) syndrome with healthy controls and investigate the correlations between retinal nerve fiber layer(RNFL) thickness parameters and ***: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All participants underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera(Topcon 501X).RAVDs were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal,temporal and average RNFL thicknesses were *** and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation ***: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group(P =0.009, P =0.038,respectively). No statistically significant difference regarding RAVDs was found between two ***: RAVDs seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and RAVDs show significant correlations in both groups. This correlation doesn’t seem to be specific to PSX.

关键词： pseudoexfoliation retinal nerve fiber layer thickness retinal artery-vein diameters

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