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Pediatric dysphagia overview:best practice recommendation study by multidisciplinary experts

World Journal of Pediatrics 2022年第11期18卷 715-724页

作者： Ebru Umay Sibel Eyigor Esra Giray Evrim Karadag Saygi Bulent Karadag Nihal Durmus Kocaaslan Deniz Yuksel Arzu Meltem Demir Engin Tutar Canan Tikiz Eda Gurcay Zeliha Unlu Pelin Celik Ece Unlu Akyuz Guven Mengu Serkan Bengisu Sibel Alicura Necati Unver Nida Yekteusaklari Cuma Uz Merve Cikili Uytuni Fatih Bagcier Elif Tarihci Mazlum Serdar Akaltun Iclal Ayranci Sucakli Damla Cankurtaran zeynep aykin Resa Aydin Fatma Nazli Department of Physical Medicine and Rehabilitation Ankara University of Health Sciences TurkeyAnkara Diskapi Yildirim Beyazit Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Ege UniversityIzmirTurkey Department of Physical Medicine and Rehabilitation Fatih Sultan Mehmet Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Marmara UniversityIstanbulTurkey Department of Pediatric Pulmonology Marmara UniversityIstanbulTurkey Department of Plastic Reconstructive and Aesthetic SurgeryMarmara UniversityIstanbulTurkey Department of Pediatric Neurology University of Health SciencesAnkara Dr Sami Ulus MaternityChildren's Health and Diseases Training and Research HospitalAnkaraTurkey Department of Pediatric Gastroenterology Ankara City HospitalAnkaraTurkey Department of Pediatric Gastroenterology Marmara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Celal Bayar UniversityManisaTurkey University of Health Sciences Turkey Gaziler Physical Medicine and Rehabilitation Training and Research HospitalAnkaraTurkey Department of Developmental Pediatric Ankara City HospitalAnkaraTurkey Department of Western Languages and Literatures Ankara Haci Bayram Veli UniversityEnglish Language and Literature DivisionAnkaraTurkey Department of Speech and Language Therapy Uskudar UniversityIstanbulTurkey Department of Otolaryngology Head and Neck SurgeryUniversity of Health SciencesAnkara Diskapi Yildirim Beyazit Training and Research HospitalAnkaraTurkey Department of Otolaryngology Head and Neck SurgeryMarmara UniversityIstanbulTurkey Department of Child and Adolescent Psychiatry Ankara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Istanbul Basaksehir Cam and Sakura City HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Istanbul UniversityIstanbulTurkey Department of Physical Medicine and Rehabilitation Gaziantep UniversityGazian

Background Currently,there is no comprehensive and multidisciplinary recommendation study covering all aspects of pediatric dysphagia(PD).This study aimed to generate PD management recommendations with methods that can be used in clinical practice to fill this gap in our country and in the world,from the perspective of experienced multidisciplinary *** This recommendation paper was generated by a multidisciplinary team,using the seven-step process and a three-round modified Delphi survey via ***,ten open-ended questions were created,and then detailed recommendations including management,diagnosis,treatment,and follow-up were created with the answers from these *** recommendation item was voted on by the experts as overall consensus(strong recommendation),approaching consensus(weak recommendation)and divergent consensus(not recommended).Results In the 1st Delphi round,a questionnaire of 414 items was prepared based on the experts’responses to ten open-ended *** the 2nd Delphi round,59.2%of these items were accepted as *** the 3rd Delphi round,62.6%of 246 items were accepted for inclusion in the *** final version recommendations consisted of 154 *** This study includes comprehensive and detailed answers for every problem that could be posed in clinical practice for the management of PD,and recommendations are for all pediatric patients with both oropharyngeal and esophageal dysphagia.

关键词： Diagnosis Dysphagia Pediatric Recommendation Rehabilitation

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Evaluating different levels of information on the calibration of building energy simulation models

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Building Simulation 2024年第4期17卷 657-676页

作者： Siyu Cheng zeynep Duygu Tekler Hongyuan Ji Wenxin Li Adrian Chong Department of the Built Environment College of Design and EngineeringNational University of Singapore4 Architecture DriveSingapore117566Singapore School of Civil Engineering and Architecture Chongqing University of Science and TechnologyChongqing401331China School of Energy and Environment Southeast UniversityNanjing210096China

A poorly calibrated model undermines confidence in the effectiveness of building energy simulation, impeding the widespread application of advanced energy conservation measures (ECMs). Striking a balance between information-gathering efforts and achieving sufficient model credibility is crucial but often obscured by ambiguities. To address this gap, we model and calibrate a test bed with different levels of information (LOI). Beginning with an initial model based on building geometry (LOI 1), we progressively introduce additional information, including nameplate information (LOI 2), envelope conductivity (LOI 3), zone infiltration rate (LOI 4), AHU fan power (LOI 5), and HVAC data (LOI 6). The models are evaluated for accuracy, consistency, and the robustness of their predictions. Our results indicate that adding more information for calibration leads to improved data fit. However, this improvement is not uniform across all observed outputs due to identifiability issues. Furthermore, for energy-saving analysis, adding more information can significantly affect the projected energy savings by up to two times. Nevertheless, for ECM ranking, models that did not meet ASHRAE 14 accuracy thresholds can yield correct retrofit decisions. These findings underscore equifinality in modeling complex building systems. Clearly, predictive accuracy is not synonymous with model credibility. Therefore, to balance efforts in information-gathering and model reliability, it is crucial to (1) determine the minimum level of information required for calibration compatible with its intended purpose and (2) calibrate models with information closely linked to all outputs of interest, particularly when simultaneous accuracy for multiple outputs is necessary.

关键词： calibration building energy simulation(BES) energy conservation measure(ECM) level of information field measurements

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Management of cytomegalovirus infection after liver transplantation

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World Journal of Transplantation 2024年第3期14卷 30-39页

作者： zeynep Burcin Yilmaz Funda Memisoglu Sami Akbulut Infectious Diseases and Clinical Microbiology Inonu University Faculty of MedicineMalatya 44280Türkiye Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Türkiye

Cytomegalovirus(CMV)infection is one of the primary causes of morbidity and mortality following liver transplantation(LT).Based on current worldwide guidelines,the most effective strategies for avoiding post-transplant CMV infection are antiviral prophylaxis and pre-emptive ***-IgG serology is the established technique for pretransplant screening of both donors and *** clinical presentation of CMV infection and disease exhibits variability,prompting clinicians to consistently consider this possibility,partic-ularly within the first year post-transplantation or subsequent to heightened *** annual symposia to discuss CMV prevention and how treatment outcomes can be improved,evidence on the incorporation of immune functional tests into clinical practice is presented,and the results of studies with new antiviral treatments are *** there are ongoing studies on the use of letermovir and maribavir in solid organ transplantation,a consensus reflected in the guidelines has not been *** the most appro-priate strategy at the individual level appears to be the key to enhancing *** prevention strategies reduce the risk of CMV disease,the disease can still occur in up to 50%of high-risk patients.A balance between the risk of infection and disease development and the use of immunosuppressants must be considered when talking about the proper management of CMV in solid organ transplant *** objective of this study was to establish a compre-hensive framework for the management of CMV in patients who have had LT.

关键词： Liver transplantation Cytomegalovirus Antiviral prophylaxis Preemptive treatment Valganciclovir Ganciclovir

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The Impact of Black Sea Sand Treatment Effectively Reducing Different Type of Pain

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Open Journal of Therapy and Rehabilitation 2024年第1期12卷 18-27页

作者： Mahmut Tokaç Abdulbari Bener Fatma Nur Kesiktaş Bahar Dernek Semra Alkal Akkaya zeynep Esra Akgün Department of Medicine and Education Unit School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Biostatistics & Medical Informatics School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences The University of Manchester Manchester UK Faculty of Medicine Health Sciences University Istanbul Physiotherapy Rehabilitation Training and Research Hospital Istanbul Türkiye Faculty of Medicine Health Sciences University Department of Physical Medicine and Rehabilitation Umraniye Training and Research Hospital Istanbul Türkiye Physical Medicine and Rehabilitation Vatan Clinics School of Medicine Istanbul Medipol University Istanbul Türkiye

Purpose: Low back pain (LBP), Gonarthrosis, knee, and Carpal Tunnel Syndrome have been regarded as affecting more than three-quarters’ of individuals in their lifetime. The aim of this study was conducted to determine and compare the effects of topical patients with sand compared with control related to Gonarthrosis, LBP, knee, and Carpal Tunnel Syndrome pain. Methods: This is a prospective case and control designed study based on 101 pain case with Sand and 101 control subjects. The interventional groups in addition either topical sand or without sand 2 months after the intervention were assessed. We assessed tolerability of an established pain perception scale by the Numeric Rating Scale (NRS). Categorical variables were compared using the chi-square (χ2) test. The paired t-test was used to compare the two groups before and after the intervention. One-way analysis of variance (ANOVA) was employed for comparison of several group means. Results: The study was based on 202 patients, 41 males (20.3%) and 161 females (79.7%). There were statistically significant differences between subjects with and without Sand in term of Gonarthrosis, Rheumatoid Arthritis LBP, knee, and Carpal Tunnel Syndrome pain (p = 0.033). Majority of patients were over age 55 years old (55%) and females 78 (77.2%). The mean score of total pain experience before and after the intervention was 7.41 ± 1.1 for black sand, and 4.24 ± 2.38 for without sand as control group. The mean scores of these 5 groups were highly significant before and after the intervention (p There was statistically highly significant in regarding subjects with Sand as compared with those before Sand after treatment mean score specifically with gonarthrosis before pain 7.23 ± 1.86 vs after treatment 4.54 ± 2.18 p < 0.001;rheumatoid arthritis before 8.28 ± 1.48 vs after treatment 4.80 ± 3.71 p < 0.001;Low Back Pain before 8.42 ± 1.83 vs after treatment 4.37 ± 1.52 p < 0.001;knee pain before 8.93 ± 0.89 vs after treat

关键词： Therapies Sand LBP Musculoskeletal Rheumatoid Arthritis Carpal Tunnel Syndrome

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An Effective Discrete Artificial Bee Colony Based SPARQL Query Path Optimization by Reordering Triples

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Journal of Computer Science & Technology 2021年第2期36卷 445-462页

作者： zeynep Banu Ozger Nurgul Yuzbasioglu Uslu Department of Computer Engineering Sutcu Imam UniversityKahramanmaras 46040Turkey Department of Computer Engineering Yildiz Technical UniversityIstanbul 34220Turkey

Semantic Web has emerged to make web content machine-readable,and with the rapid increase in the number of web pages,its importance has *** description framework(RDF)is a special data graph format where Semantic Web data are stored and it can be queried by SPARQL query *** challenge is to find the optimal query order that results in the shortest period of *** this paper,the discrete Artificial Bee Colony(dABCSPARQL)algorithm is proposed,based on a novel heuristic approach,namely reordering SPARQL *** processing time of queries with different shapes and sizes is minimized using the dABCSPARQL *** performance of the proposed method is evaluated on chain,star,cyclic,and chain-star queries of different sizes from the Lehigh University Benchmark(LUBM)*** results obtained by the proposed method are compared with those of ARQ(a SPARQL processor for Jena)query engine,the Ant System,the Elitist Ant System,and MAX-MIN Ant System *** experiments demonstrate that the proposed method significantly reduces the processing time,and in most queries,the reduction rate is higher compared with other optimization methods.

关键词： artificial bee colony resource description framework(RDF) query optimization reordering triple pattern SPARQL

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Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms

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Biomedical and Environmental Sciences 2014年第9期27卷 718-728页

作者： Yildiz Dincer zeynep Sezgin Department of Medical Biochemistry Istanbul University Cerrahpasa Medical Faculty Department of Medical Biochemistry Yeni Yuzy?l University Medical Faculty

Ionizing radiation （IR） is a potential carcinogen. Evidence for the carcinogenic effect of IR radiation has been shown after long-term animal investigations and observations on survivors of the atom bombs in Hiroshima and Nagasaki. However, IR has been widely used in a controlled manner in the medical imaging for diagnosis and monitoring of various diseases and also in cancer therapy. The collective radiation dose from medical imagings has increased six times in the last two decades, and grow continuously day to day. A large number of evidence has revealed the increased cancer risk in the people who had frequently exposed to x-rays, especially in childhood. It has also been shown that secondary malignancy may develop within the five years in cancer survivors who have received radiotherapv, because of IR-mediated damage to healthy cells. In this article, we review the current knowledge about the role of medical x-ray exposure in cancer development in humans, and recently recognized epigenetic mechanisms in IR-induced carcinogenesis.

关键词： DNAmethylation Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms

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Performance Comparison of Commercial and Home-Made Lipases for Synthesis of Poly(δ-Valerolactone)Homopolymers

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Journal of Renewable Materials 2019年第4期7卷 335-343页

作者： Cansu Ulker zeynep Gok Yuksel Guvenilir Istanbul Technical University Department of Chemical EngineeringAyazaga CampusIstanbul34469Turkey

Novozyme 435,which is the commercially available immobilized form of Candida antarctica lipase B,has been successfully conducted ring opening polymerization of lactones in organic *** this paper,it was aimed to introduce an alternative biocatalyst for Novozyme *** antarctica lipase B immobilized onto rice husk ashes via physical adsorption(with a specific activity of 4.4 U/mg)was prepared in previous studies and used as a biocatalyst for poly(δ-valerolactone)synthesis in the present *** reactions were proceeded at various reaction temperatures and periods via both two immobilized enzyme *** resulting products were characterized spectroscopically and *** highest molecular weight(Mn=9010 g/mol)was obtained via Novozyme 435 catalysis at 40℃and 24 *** performance of home-made lipase,which resulted in a molecular weight of 8040 g/mol,was close to commercial one.

关键词： Poly(δ-valerolactone) Candida antarctica lipase B Novozyme 435 immobilization enzymatic ring opening polymerization

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Solving vehicle routing problem with time windows using metaheuristic approaches

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International Journal of Intelligent Computing and Cybernetics 2023年第1期16卷 121-138页

作者： zeynep Aydınalp DoganÖzgen Yıldız Technical University IstanbulTurkey

Purpose-Drugs are strategic products with essential functions in human *** optimum design of the pharmaceutical supply chain is critical to avoid economic damage and adverse effects on human *** vehicle-routing problem,focused on finding the lowest-cost routes with available vehicles and constraints,such as time constraints and road length,is an important aspect of *** this paper,the vehicle routing problem(VRP)for a pharmaceutical company in Turkey is ***/methodology/approach-A mixed-integer programming(MIP)model based on the vehicle routing problem with time windows(VRPTW)is presented,aiming to minimize the total route cost with certain *** the model provides an optimum solution for small problem sizes with the GUROBI®solver,for large problem sizes,metaheuristic methods that simulate annealing and adaptive large neighborhood search algorithms are proposed.A real dataset was used to analyze the effectiveness of the metaheuristic *** proposed simulated annealing(SA)and adaptive large neighborhood search(ALNS)were evaluated and compared against GUROBI®and each other through a set of real problem ***-The model is solved optimally for a small-sized dataset with exact algorithms;for solving a larger dataset,however,metaheuristic algorithms require significantly lesser *** the problem addressed in this study,while the metaheuristic algorithms obtained the optimum solution in less than one minute,the solution in the GUROBI®solver was limited to one hour and three hours,and no solution could be obtained in this time ***/value-The VRPTW problem presented in this paper is a real-life *** vehicle fleet owned by the factory cannot be transported between certain suppliers,which complicates the solution of the problem.

关键词： Pharmaceutical supply chain Network design Mixed-integer linear programming Vehicle routing problem Simulated annealing Adaptive large neighborhood search

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Effect of exercise on colorectal cancer prevention and treatment

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World Journal of Gastrointestinal Oncology 2019年第5期11卷 348-366页

作者： zeynep Oru? Muhammed Ali Kaplan Department of Medical Oncology Mersin City Hospital Department of Medical Oncology Faculty of Medicine Dicle University

In recent years, because of improved cancer screening, detection and treatment modalities, a rapid increase in the population of colorectal and other cancer survivors has been observed. The increasing population has justified the requirement of preventive strategies such as lifestyle modifications with regard to obesity, physical activity, diet and smoking. Physical activity may prevent approximately 15% of the colon cancers. Furthermore, several observational studies have demonstrated the efficacy and dose-dependent and anti-cancer effects of exercise on decreasing the mortality and risk of recurrence before and after the colorectal cancer(CRC) diagnosis. However, the required exercise dose,type and intensity are yet unclear. The results of randomised prospective studies are expected to determine the optimal amount, type and intensity of exercise and formulate the most appropriate exercise plan and guidelines, according to the requirements and comorbidities of the patients. In addition, recent studies have focused on the molecular and genetic mechanisms underlying the effect of physical activity on disease outcomes and recurrence rates. This review aimed to investigate the effects of physical activity and the biological basis of these effects in preventing the risk and recurrence of CRC and decreasing the hazards of cancer and cancer treatment.

关键词： Colorectal cancer Exercise Physical activity

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Vibration of a Two-Layer“Metal+PZT”Plate Contacting with Viscous Fluid

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Computers, Materials & Continua 2023年第2期74卷 4337-4362页

作者： zeynep Ekicioglu Kuzeci Surkay D.Akbarov Department of Mechanical Engineering Kirsehir Ahi Evran UniversityKirsehir40100Turkey Department of Mechanical Engineering Yildiz Technical UniversityYildiz CampusIstanbul34349Turkey Institute of Mathematics and Mechanics of the National Academy of Sciences of Azerbaijan Baku37041Azerbaijan

The present work investigates the mechanically forced vibration of the hydro-elasto-piezoelectric system consisting of a two-layer plate“elastic+PZT”,a compressible viscous fluid,and a rigid *** is assumed that the PZT(piezoelectric)layer of the plate is in contact with the fluid and time-harmonic linear forces act on the free surface of the elastic-metallic *** study is valuable because it considers for the first time the mechanical vibration of the metal+piezoelectric bilayer plate in contact with a *** is also the first time that the influence of the volumetric concentration of the constituents on the vibration of the hydro-elasto-piezoelectric system is *** value of the present work is the use of the exact equations and relations of elasto-electrodynamics for elastic and piezoelectric materials to describe the motion of the plate layers within the framework of the piecewise homogeneous body model and the use of the linearized Navier-Stokes equations to describe the flow of the compressible viscous *** plane-strain state in the plate and the plane flow in the fluid take *** the solution of the corresponding boundary-value problem,the Fourier transform is used with respect to the spatial coordinate on the axis along the laying direction of the *** analytical expressions of the Fourier transform of all the sought values of each component of the system are *** origins of the searched values are determined numerically,after which numerical results on the stress on the fluid and plate interface planes are presented and *** results are obtained for the case where PZT-2 is chosen as the piezoelectric material,steel and aluminum as the elastic metal materials,and Glycerin as the *** of these results allows conclusions to be drawn about the character of the problem parameters on the frequency response of the interfacial *** particular,it was found that after a certain value of the vibrat

关键词： Metal+piezoelectric two-layer plate compressible viscous fluid mechanical forced vibration interfacial stress resonance frequency

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