检索结果-南通市图书馆

维普期刊数据库博看期刊

晚清乌托邦小说对历史与未来的思考——以《新小说》与《月月小说》为例

在线全文

学校读者我要写书评

暂无评论

艺术科技 2024年第5期37卷 38-40,81页

作者：陈泽群扬州大学文学院江苏扬州225009

目的:作为晚清报刊重地的《新小说》与《月月小说》汇聚了大批先进知识分子,他们借文学创作探讨建构崭新的国族想象、激励文化身份认同,其中晚清乌托邦小说成为晚清时人实践自身理想的阵地。因而文章以《新小说》与《月月小说》作家群... 详细信息

目的:作为晚清报刊重地的《新小说》与《月月小说》汇聚了大批先进知识分子,他们借文学创作探讨建构崭新的国族想象、激励文化身份认同,其中晚清乌托邦小说成为晚清时人实践自身理想的阵地。因而文章以《新小说》与《月月小说》作家群的乌托邦小说作为参照对象,从另一角度思考晚清时人如何处理严峻的时空危机。方法:文章采用文献研究法与对照法,结合历史背景勾勒出潜藏于文本之下的不同作家群体的思想转变。结果:《新小说》作家群利用历史与政治小说为宣扬自身乌托邦思想开辟了道路,虽然梁启超的《新中国未来记》第一次超越了时间间隔,将“未来”置于中国人的视野之中,却无法弥合“现在”与“未来”的历史裂缝。《月月小说》作家群创造出的乌托邦同样是未完成的,但与《新小说》的作家相比,他们试图真正迈出前进的一步,寻找一切可利用的经验去构筑“新中国”。而作为两份报刊的衔接人物——吴趼人尝试构建出真正的“理想国”,但这份努力始终萦绕着困惑与迷离,他无法进一步想象未来的不同方向,以及进化过程本身的各种变数。结论:虽然《新小说》与《月月小说》作家群将乌托邦小说作为改革利器与“未来”试验蓝图的尝试均以失败告终,但他们的尝试与求索开启了五四石破天惊的光明神话。

关键词：晚清乌托邦小说历史叙述未来想象《新小说》《月月小说》

Nice结渐进牵张技术在Gustilo ⅢA及ⅢB型开放性胫骨骨折创面闭合中的应用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国修复重建外科杂志 2024年第1期38卷 46-50页

作者：姚志鹏王敏行朱文雄王善仪黄弘轩陈泽群南方医科大学第十附属医院(东莞市人民医院)骨科东莞市骨科常见骨病基础、临床与数字化研究重点实验室广东东莞523059 东莞市妇幼保健院医院感染管理科广东东莞523059

目的探讨应用Nice结渐进牵张技术闭合Gustilo ⅢA、ⅢB型开放性胫骨骨折创面的疗效。方法回顾性分析2021年6月—2022年6月收治且符合选择标椎的22例Gustilo ⅢA、ⅢB型开放性胫骨骨折患者临床资料,均采用Nice结渐进牵张技术闭合创面。... 详细信息

目的探讨应用Nice结渐进牵张技术闭合Gustilo ⅢA、ⅢB型开放性胫骨骨折创面的疗效。方法回顾性分析2021年6月—2022年6月收治且符合选择标椎的22例Gustilo ⅢA、ⅢB型开放性胫骨骨折患者临床资料,均采用Nice结渐进牵张技术闭合创面。男15例,女7例;年龄18~67岁,平均41.9岁。致伤原因:交通事故伤11例,高处坠落伤7例,重物砸伤4例。骨折侧别:左侧9例,右侧13例。骨折Gustilo分型:ⅢA型9例,ⅢB型13例。创面广泛软组织挫裂伤,未合并血管、神经损伤。受伤至清创时间3~8 h,平均6.5 h。测量术前及术后2周时创面面积,计算创面愈合率;记录创面愈合时间以及愈合等级;创面愈合时采用温哥华瘢痕量表(VSS)评分评定创面瘢痕情况,并计算瘢痕优良率。结果22例术前创面面积为21.0~180.0 cm^(2),平均57.82 cm^(2);术后2周时为1.2~27.0 cm^(2),平均6.57 cm^(2)。术后2周创面愈合率为76%~98%,平均88.6%。2例因皮肤切割重新调整Nice结缝合,1例创面出现软组织感染;其余患者创面均顺利愈合。创面愈合时间18~44 d,平均27.8 d;创面愈合等级:甲级13例、乙级9例。创面愈合时VSS评分为2~9分,平均4.1分;获优10例、良10例、可2例,创面瘢痕优良率为90.9%。所有患者均获随访,随访时间9~24个月,平均14.6个月。随访期间均未发生深部感染及骨髓炎。2例发生骨折不愈合,行手术加压固定及自体髂骨植骨处理;其余患者骨折均顺利愈合,愈合时间85~190 d,平均148.2 d。结论Nice结渐进牵张技术可用于闭合Gustilo ⅢA、ⅢB型开放性胫骨骨折创面,操作简便,疗效满意。

关键词： Nice结渐进牵张技术开放性胫骨骨折创面闭合

金银花光形态建成因子LjCOP1基因克隆及表达模式分析

在线全文

学校读者我要写书评

暂无评论

浙江农业学报 2024年第6期36卷 1290-1299页

作者：宛燕周晓春房海灵林沂亓希武于盱陈泽群梁呈元南京中医药大学江苏南京210023 江苏省中国科学院植物研究所江苏南京210014 盐城市大丰区林场江苏盐城224100

光是影响植物生长发育及次生代谢合成的最重要的环境因子之一,COP1 E3连接酶是光信号转导的分子开关。该研究基于金银花转录组数据库,从金银花(Lonicera japonica Thunb.)中克隆得到LjCOP1基因,并对其进行生物信息学及表达模式分析。结... 详细信息

光是影响植物生长发育及次生代谢合成的最重要的环境因子之一,COP1 E3连接酶是光信号转导的分子开关。该研究基于金银花转录组数据库,从金银花(Lonicera japonica Thunb.)中克隆得到LjCOP1基因,并对其进行生物信息学及表达模式分析。结果表明,该基因包含13个外显子,编码区(CDS)长度为2034 bp,编码677个氨基酸残基。多序列比对显示,LjCOP1与其他植物COP1序列具有较高保守性,均包含环形锌指结合域、卷曲螺旋形和WD40重复序列等特殊结构域。基于SWISS-MODEL对金银花LjCOP1基因进行的蛋白结构预测显示其与拟南芥AtCOP1在蛋白质三级结构层面高度保守。启动子顺式作用元件分析表明,LjCOP1启动子序列中含有大量激素响应元件、光响应元件和胁迫响应元件。系统发生分析表明,LjCOP1与莴笋LsCOP1基因亲缘关系较近。表达模式分析显示,LjCOP1在金银花不同部位及花发育时期均有表达,且在叶中高量表达。与黑暗条件相比,白光下LjCOP1基因表达丰度最高,且对黑暗转蓝光响应更强烈。

关键词：金银花 LjCOP1基因表达模式

同方期刊数据库

油气藏注CO_(2)提高采收率技术研究进展

在线全文

学校读者我要写书评

暂无评论

精细石油化工 2024年第4期41卷 69-74页

作者：魏源董沅武陈泽群张馨月胡浩唐善法长江大学石油工程学院湖北武汉430100 油气钻采工程湖北省重点实验室湖北武汉430100

对不同CO_(2)驱替类型、注入方式、注CO_(2)驱提高采收率技术机理进行了归纳,指出现有CO_(2)驱亟待解决的问题主要包括气源、气窜、腐蚀、固相沉积以及最小混相压力过高等,并提出了相应解决措施。基于技术和经济方面,认为CO_(2)驱油与... 详细信息

对不同CO_(2)驱替类型、注入方式、注CO_(2)驱提高采收率技术机理进行了归纳,指出现有CO_(2)驱亟待解决的问题主要包括气源、气窜、腐蚀、固相沉积以及最小混相压力过高等,并提出了相应解决措施。基于技术和经济方面,认为CO_(2)驱油与埋存的经济性评价技术、CO_(2)驱油与埋存安全性评价技术、CO_(2)混相调节技术、CO_(2)腐蚀与防护技术、CO_(2)流度控制技术及注CO_(2)驱用化学辅助添加剂的研发等是未来的研究重点。

关键词：二氧化碳提高采收率机理二氧化碳驱油与埋存流度控制碳中和

Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第5期32卷 911-923页

作者： JINGJING chen DAN WANG zequn WANG MENGYUAN HAN HOUQING YIN WENTING ZHOU RIBAI YAN YAN PAN Department of Pharmacology School of PharmacyChangzhi Medical CollegeChangzhiChina2 Department of PharmacologySchool of Basic Medical SciencesHealth Science CenterPeking UniversityBeijingChina3 Beijing Key Laboratory of Tumor Systems BiologyPeking UniversityBeijingChina4 Department of PharmacologyXinjiang Medical UniversityUrumqiChina5 School of Pharmaceutical SciencesPeking UniversityBeijingChina

Photodynamic therapy(PDT)is a promising cancer *** study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,*** apoptosis-and autophagy-related proteins were examined using western *** sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after *** results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 *** ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced ***-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or *** level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA *** Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle ***-protein interaction results demonstrated that cdk1 and rps27a ranked in the top 10 interacting ***,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling *** associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.

关键词： Photodynamic therapy ROS Apoptosis Autophagy Bioinformatic analysis

Electrically programmable phase-change photonic memory for optical neural networks with nanoseconds in situ training capability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Photonics 2023年第4期5卷 42-50页

作者： Maoliang Wei Junying Li zequn chen Bo Tang Zhiqi Jia Peng Zhang Kunhao Lei Kai Xu Jianghong Wu Chuyu Zhong Hui Ma Yuting Ye Jialing Jian Chunlei Sun Ruonan Liu Ying Sun Wei.E.I.Sha Xiaoyong Hu Jianyi Yang Lan Li Hongtao Lin Zhejiang University College of Information Science and Electronic EngineeringState Key Laboratory of Modern Optical InstrumentationKey Laboratory of Micro-Nano Electronics and Smart System of Zhejiang ProvinceHangzhouChina Westlake University School of EngineeringKey Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang ProvinceHangzhouChina Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhouChina Institute of Microelectronics of the Chinese Academy of Sciences BeijingChina Peking University School of PhysicsFrontiers Science Center for Nano-optoelectronicsState Key Laboratory for Mesoscopic PhysicsBeijingChina

Optical neural networks (ONNs), enabling low latency and high parallel data processing withoutelectromagnetic interference, have become a viable player for fast and energy-efficient processing andcalculation to meet the increasing demand for hash rate. Photonic memories employing nonvolatile phase-change materials could achieve zero static power consumption, low thermal cross talk, large-scale, andhigh-energy-efficient photonic neural networks. Nevertheless, the switching speed and dynamic energyconsumption of phase-change material-based photonic memories make them inapplicable for in situ ***, by integrating a patch of phase change thin film with a PIN-diode-embedded microring resonator,a bifunctional photonic memory enabling both 5-bit storage and nanoseconds volatile modulation wasdemonstrated. For the first time, a concept is presented for electrically programmable phase-changematerial-driven photonic memory integrated with nanosecond modulation to allow fast in situ training and zerostatic power consumption data processing in ONNs. ONNs with an optical convolution kernel constructedby our photonic memory theoretically achieved an accuracy of predictions higher than 95% when testedby the MNIST handwritten digit database. This provides a feasible solution to constructing large-scalenonvolatile ONNs with high-speed in situ training capability.

关键词： phase-change materials optical neural networks photonic memory silicon photonics reconfigurable photonics

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong Zheng zequn Yin Xuerui Wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli chen chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan Xiaoxiao Yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the *** is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key ***(API)is a natural flavonoid with anti-inflammatory and immunoregulatory ***,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse *** results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic *** differentiation of immune cells was restored in API-treated ***,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A ***,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)***,API reduced expression of inflammatory cytokines through inactivation of NF-κ*** together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)

Free-spectral-range-free filters with ultrawide tunability across the S+C+L band

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2021年第6期9卷 1013-1018页

作者： CHUNLEI SUN CHUYU ZHONG MAOLIANG WEI HUI MA YE LUO zequn chen RENJIE TANG JIALING JIAN HONGTAO LIN LAN LI Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China School of Microelectronics Zhejiang UniversityHangzhou 310027China

Optical filters are essential parts of advanced optical communication and sensing *** them,the ones with an ultrawide free spectral range(FSR)are especially *** are promising to provide access to numerous wavelength channels highly desired for large-capacity optical transmission and multipoint multiparameter *** schemes for wide-FSR filters either suffer from limited cavity length or poor fabrication tolerance or impose an additional active-tuning control *** theoretically and experimentally demonstrate a filter that features FSR-free operation capability,subnanometer optical bandwidth,and acceptable fabrication *** one single deep dip within a record-large waveband(S+C+L band)is observed by appropriately designing a side-coupled Bragg-grating-assisted Fabry–Perot filter,which has been applied as the basic sensing unit for both the refractive index and temperature *** such basic units are also cascaded in series to demonstrate a multichannel *** work provides a new insight to design FSR-free filters and opens up a possibility of flexible large-capacity integration using more wavelength channels,which will greatly advance integrated photonics in optical communication and sensing.

关键词： free desired insight

在线全文

学校读者我要写书评

暂无评论

证信副词“确实”的分布定位与语义提取

语言教学与研究 2022年第3期 90-100页

作者：赵春利陈泽群暨南大学文学院中文系 510632

本文按照语义语法“句法反映语义而语义决定句法”的本体论原则,从句法层面的典型话语关联、复句选择到单句分布,逐层细化并提取副词“确实”语义层面的“证知传信”的语法意义。首先,从语义界定、句法分布、功能解释和语法演变四个角... 详细信息

本文按照语义语法“句法反映语义而语义决定句法”的本体论原则,从句法层面的典型话语关联、复句选择到单句分布,逐层细化并提取副词“确实”语义层面的“证知传信”的语法意义。首先,从语义界定、句法分布、功能解释和语法演变四个角度综述前人的研究成果,并指出界定语义、逻辑思路、验证方法存在的问题。其次,从话语分布角度,正反验证“确实”句在“经证知信”话语关联中具有结论性和知信性特征。第三,从复句选择角度,“确实”句的结论性、知信性决定了其主要选择偏正类复句的结论句和推断类复句的前提句,排斥平行类复句关系。第四,从句法分布角度,正反验证副词“确实”对知信陈述句、是非疑问句和有界感叹句的状语位置、同现成分的选择,并据此提取“确实”具有的“证知传信”义。

关键词： “确实” 经证知信分布规律话语关联