检索结果-南通市图书馆

Precise Control of Self-assembly in vivo Based on Polymer-Peptide Conjugates

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第23期40卷 2815-2824页

作者： Yin-Sheng Xu Hao Wang zeng-ying qiao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100190China

The self-assembled nanomaterials based on peptides,which have not only good biocompatibility and low toxicity but also high stability and performance,are increasingly becoming an important way for cancer *** this review,we highlight the progress of in vivo self-assembled polymer-peptide conjugates(PPCs)and their application,showing the recent advances in the development of“in vivo self-assembly”strategy for cancer *** the diverse microenvironments of tumor cells,different responsive assembly strategies(enzyme,pH,redox,temperature,etc.)have been developed to precisely control the assembly at different biological levels,realizing enhanced drug delivery and improved anticancer efficacy.

关键词： Polymer-peptide conjugates Drug design In vivo self-assembly Drug delivery Antitumor agents

An ＂In Vivo Self-assembly＂ Strategy for Constructing Superstructures for Biomedical Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第10期36卷 1103-1113页

作者： Man-Zhu Zhao Dong-Bing Cheng Zhao-Ru Shang Lei Wang zeng-ying qiao Jing-Ping' Zhang Hao Wang School of Chemistry Northeast Normal University Changchun 130024 China Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) Beijing 100190 China

The interfacing study of biopolymer and supramolecular chemistry enables a better understanding of fundamental biochemical processes and the creating of new high-performance biomaterials. In this review, we introduced an ＂in vivo self-assembly＂ strategy which means in situ construction of functional self-assembled superstructures in specific physiological or pathological conditions in cell, tissue or animal levels that exhibit diverse biomedical effects. By using this strategy, unexpected phenomena and insights, e.g, assembly/aggregation induced retention （AIR） effect have been demonstrated where the self-assembled nanostructures showed extraordinary enhanced accumulation and retention of therapeutics in targeted sites.

关键词： In vivo self-assembly Supramolecular polymer Therapy Imaging

Peptide-Based AIEgens:From Molecular Design,Stimuli Responsiveness to Biomedical Application

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2022年第2期4卷 437-455页

作者： Ben-Li Song Xue-Hao Zhang zeng-ying qiao Hao Wang School of Pharmaceutical Sciences Henan Institute of Advanced TechnologyZhengzhou UniversityHenan 450001 CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190

Luminogens with aggregation-induced emission(AIEgens)have a wide range of biomedical applications in bioimaging,photodynamic anticancer,antibacterial therapy,and other fields,owing to their unique photophysical *** precise structural design and modification of AIE molecules have aroused great interest in the past *** peptides-AIE hybrid materials,peptide-based AIEgens generally have better solubility,biocompatibility,and lower systemic *** functional diversity,modularity,and portability of peptides provide more possibilities for the intelligent structure and functional design of *** review summarizes the recent research progress of peptide-based AIEgens nanomaterials,from molecular design,stimuli responsiveness to biomedical application,focusing on the advantages of peptides and AIE molecules as ***,a summary of the challenges and opportunities of peptide-based AIEgens nanomaterials for future clinical biomedical applications is presented.

关键词： peptide AIEgens nanomaterials responsive bioimaging anticancer

Endogenous formaldehyde responsive fluorescent probe for bioimaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2023年第12期16卷 13029-13041页

作者： Ning-Bo Yi Xing-Jie Hu Fei Wang Si-Yi Chen Xiao-Xue Xu Xin Li Hao Wang Taolei Sun zeng-ying qiao Dong-Bing Cheng Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases School of ChemistryChemical Engineering&Life ScienceWuhan University of TechnologyWuhan 430070China CAS Center for Excellence in Nanoscience Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China Department of Biology and the School of Natural Sciences Went Worth CollegeUniversity of YorkHeslingtonYorkYO105DDUK

Formaldehyde(FA),as the simplest endogenous carbonyl molecule,participates in many biosynthesis and metabolism in living organisms,such as nucleotides and adenosine triphosphate(ATP).FA concentrations are sub-millimolar in the normal healthy body,but can rise significantly in a number of disease *** a result,detecting endogenous FA is critical for illness diagnosis and rehabilitation therapy *** studies have focused on the FA-responsive turn-on fluorescence probe,which has huge promise in the detection and visualization of FA in living cells and organisms,as well as exceptional use in disease diagnosis and therapeutic *** review summarizes the fluorescence luminescence mechanism and design concepts of FA fluorescent probes,as well as their recent applications in bioimaging and illness ***,this article indicates the present dilemma of FA-responsive fluorescent probe,including selectivity,specificity,and detection mode,which may provide references for the development of FA-responsive fluorescent probes.

关键词： endogenous formaldehyde fluorescent probe tumor cell bioimaging

Pulse electrochemical synaptic transistor for supersensitive and ultrafast biosensors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

InfoMat 2023年第11期5卷 25-39页

作者： Jianlong Ji Zhenxing Wang Fan Zhang Bin Wang Yan Niu Xiaoning Jiang zeng-ying qiao Tian-ling Ren Wendong Zhang Shengbo Sang Zhengdong Cheng Qijun Sun College of Electronics Information and Optical Engineering Taiyuan University of TechnologyTaiyuanthe People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijingthe People’s Republic of China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNorth CarolinaUSA D Artificial Intelligence Biomedical Research Institute Taiyuanthe People’s Republic of China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijingthe People’s Republic of China Institute of Microelectronics Tsinghua UniversityBeijingthe People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhouthe People’s Republic of China

High sensitivity and fast response are the figures of merit for benchmarking commercial *** to the advantages of intrinsic signal amplification,bionic ability,and mechanical flexibility,electrochemical transistors(ECTs)have recently gained increasing popularity in constructing various *** the current work,we have proposed a pulse-driven synaptic ECT for supersensitive and ultrafast *** pulsing the presynaptic input(drain bias,VD)and setting the modulation potential(gate bias)near transconductance intersection(VG,i),the synaptic ECT-based pH sensor can achieve a record high sensitivity up to 124 mV pH^(-1)(almost twice the Nernstian limit,59.2 mV pH^(-1))and an ultrafast response time as low as 8.75 ms(7169 times faster than the potentiostatic sensors,62.73 s).The proposed synaptic sensing strategy can effectively eliminate the transconductance fluctuation issue during the calibration process of the pH sensor and significantly reduce power ***,the most sensitive working point at VG,i has been elaborately figured out through a series of detailed mathematical derivations,which is of great significance to provide higher sensitivity with quasi-nonfluctuating amplification *** proposed electrochemical synaptic transistor paired with an optimized operating gate offers a new paradigm for standardizing and commercializing high-performance biosensors.

关键词： fast response pH sensor pulse electrochemical transistor supersensitive synaptic transistor

Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： ying Ma Yue qiao Xiang Gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

在线全文

学校读者我要写书评

暂无评论

肉毒神经毒素:一个老毒素的新密码

甘肃农业大学学报 2018年第6期53卷 1-9页

作者：曾巧英甘肃农业大学动物医学院甘肃兰州730070

肉毒梭菌长期进化形成了独特的旱地(草地)和湿地两套自然循环机制,厌氧和产芽胞是成就其自然循环最合理的进化选择.肉毒梭菌本身无侵袭力,致病性全取决于毒素,即肉毒神经毒素(肉毒素)(botulinum neurotoxins,BoNTs,botulin),致野生及家... 详细信息

肉毒梭菌长期进化形成了独特的旱地(草地)和湿地两套自然循环机制,厌氧和产芽胞是成就其自然循环最合理的进化选择.肉毒梭菌本身无侵袭力,致病性全取决于毒素,即肉毒神经毒素(肉毒素)(botulinum neurotoxins,BoNTs,botulin),致野生及家养脊椎动物肉毒中毒(botulism).据肉毒素抗原性将其分为不同的血清型(毒素型),目前已鉴定的毒素血清型已超过40个,产生肉毒素的细菌按遗传关系可分为7个种.毒素抗原性虽不同,但空间结构均相似,均含3个功能域:HC受体结合域、HN穿膜域和LC活性域.BoNTs-LC具Zn^(2+)依赖蛋白酶活性,降解外周运动神经元的突触融合复合体蛋白,从而阻断神经递质释放,致肌肉麻痹.

关键词：肉毒神经毒素肉毒梭菌血清型致病机理

Integrated Frequency-constrained Scheduling Considering Coordination of Frequency Regulation Capabilities from Multi-source Converters

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 261-274页

作者： Jiaming Li ying qiao Zongxiang Lu Wei Ma Xin Cao Rongfu Sun the Department of Electrical Engineering Tsinghua UniversityBeijing 100084China the China Suntien Green Energy Limited Company Shijiazhuang 050011China the State Grid Jibei Electric Power Company Beijing 100054China

As the proportion of renewable energy(RE)increases,the inertia and the primary frequency regulation(FR)capability of the power system ***,ensuring frequency security in the scheduling model has become a new technical requirement in power systems with a high share of *** to a shortage of conventional synchronous generators,the frequency support of multi-source converters has become an indispensable part of the system frequency resources,especially variable-speed wind turbine generation(WTG)and battery energy storage(BES).Quantitative expression of the FR capability of multi-source converters is necessary to construct frequency-constrained scheduling ***,the frequency support performance of these converter-interfaced devices is related to their working states,operation modes,and parameters,and the complex coupling of these factors has not been fully exploited in existing *** this study,we propose an integrated frequency-constrained scheduling model considering the coordination of FR capabilities from multi-source *** FR control strategies and variable FR parameters for WTG with or without reserved power are modeled,and multi-target allocation of BES capacity between tracking dispatch instruction and emergency FR is ***,the variable FR capabilities of WTG and BES are embedded into the integrated frequency-constrained scheduling *** nonlinear constraints for frequency security are precisely linearized through an improved iteration-based *** effectiveness of the proposed model is verified in a modified IEEE 24-bus standard *** results suggest that the coordinated participation of BES and WTG in FR can effectively reduce the cost of the scheduling model while meeting frequency security constraints.

关键词： Battery energy storage(BES) wind turbine generation(WTG) frequency regulation(FR) frequency security power system scheduling

Modeling of multiphase flow in low permeability porous media:Effect of wettability and pore structure properties

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1127-1139页

作者： Xiangjie Qin Yuxuan Xia Juncheng qiao Jiaheng Chen Jianhui zeng Jianchao Cai National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Beijing10083China

Multiphase flow in low permeability porous media is involved in numerous energy and environmental ***,a complete description of this process is challenging due to the limited modeling scale and the effects of complex pore structures and *** address this issue,based on the digital rock of low permeability sandstone,a direct numerical simulation is performed considering the interphase drag and boundary slip to clarify the microscopic water-oil displacement *** addition,a dual-porosity pore network model(PNM)is constructed to obtain the water-oil relative permeability of the *** displacement efficiency as a recovery process is assessed under different wetting and pore structure *** show that microscopic displacement mechanisms explain the corresponding macroscopic relative *** injected water breaks through the outlet earlier with a large mass flow,while thick oil films exist in rough hydrophobic surfaces and poorly connected *** variation of water-oil relative permeability is significant,and residual oil saturation is high in the oil-wet *** flooding is extensive,and the residual oil is trapped in complex pore networks for hydrophilic pore surfaces;thus,water relative permeability is lower in the water-wet *** the displacement efficiency is the worst in mixed-wetting systems for poor water *** negatively correlates with invading oil volume fraction due to strong capillary resistance,and a large microporosity corresponds to low residual oil *** work provides insights into the water-oil flow from different modeling perspectives and helps to optimize the development plan for enhanced recovery.

关键词： Low permeability porous media Water-oil flow Wettability Pore structures Dual porosity pore network model(PNM) Free surface model