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Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： chu Xie Cong Sun Mu-Sheng zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

Intelligent Predetermination of Generator Tripping Scheme: Knowledge Fusion-based Deep Reinforcement Learning Framework

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 66-75页

作者： Lingkang zeng Wei Yao ze Hu Hang Shuai Zhouping Li Jinyu Wen Shijie Cheng State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronics EngineeringHuazhong University of Science and TechnologyWuhan 430074China Dispatching and Control Center Central China Branch of State Grid Corporation of ChinaWuhan 430077China. Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA

Generator tripping scheme(GTS)is the most commonly used scheme to prevent power systems from losing safety and ***,GTS is composed of offline predetermination and real-time scenario ***,it is extremely time-consuming and labor-intensive for manual predetermination for a large-scale modern power *** improve efficiency of predetermination,this paper proposes a framework of knowledge fusion-based deep reinforcement learning(KF-DRL)for intelligent predetermination of ***,the Markov Decision Process(MDP)for GTS problem is formulated based on transient instability ***,linear action space is developed to reduce dimensionality of action space for multiple controllable ***,KF-DRL leverages domain knowledge about GTS to mask invalid actions during the decision-making *** can enhance the efficiency and learning ***,the graph convolutional network(GCN)is introduced to the policy network for enhanced learning *** simulation results obtained on New England power system demonstrate superiority of the proposed KF-DRL framework for GTS over the purely data-driven DRL method.

关键词： Deep reinforcement learning generator tripping scheme graph convolutional network invalid action masking knowledgefusion

Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-Hang He Guang-Feng Liu ze-Kun Zhou Zhen Liu Yi-Shu zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research Institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

Comparative study on interaction between rare earth oxide refractories and rare earth treated steel

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Journal of Iron and Steel Research(International) 2024年第6期31卷 1493-1501页

作者： ze Meng Guang-qiang Li Cheng Yuan Yi-jiang Zhao Qing Zheng Bin zeng Yu Liu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Technical Center Lianyuan Iron and Steel Co.Ltd.Loudi417009HunanChina

Refractories have an important effect on the cleanliness of molten *** interaction between CeAlO_(3) refractories and Ce treated steel was explored and compared with that between Al_(2)O_(3) refractories and Ce treated *** results show that the Ce content in steel decreases sharply after contact with Al_(2)O_(3) refractories and the pick-up of dissolved Al *** with the test of Al_(2)O_(3) refractories,the loss of Ce content is less in the test of CeAlO_(3) refractory,and the total oxygen content and dissolved Al content in steel increase *** dense and continuous Ce_(2)O_(2)S interface layer is observed at the CeAlO_(3) refractories/steel interface,which can serve as the metallurgical isolation layer and hinder the further interaction between refractories and ***,the higher steel cleanliness and less penetration of refractories by molten steel are obtained in the test of CeAlO_(3) *** CeAlO_(3) refractories show a promising prospect in the production of clean Ce treated steel.

关键词： CeAlO_(3)refractory Steel Cleanliness Interaction Rare earth

Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3

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Bone Research 2024年第2期12卷 438-452页

作者： Bowen Fu Jianlin Shen Xuenong Zou Nian Sun ze Zhang zengping Liu Canjun zeng Huan Liu Wenhua Huang Guangdong Medical Innovation Platform for Translation of 3D Printing Application The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangdong Provincial Key Laboratory of Digital Medicine and BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510145 GuangdongChina Department of Foot and Ankle Surgery Center for Orthopedic SurgeryThe Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Department of Orthopedics Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Central Laboratory Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080 GuangdongChina Nanfang Hospital Southern Medical UniversityGuangzhou 510515 GuangdongChina Guangzhou Blood Center Guangzhou 510095 GuangdongChina Department of Orthopedics The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000 SichuanChina

Extracellular matrix(ECM)stiffening is a typical characteristic of cartilage aging,which is a quintessential feature of knee osteoarthritis(KOA).However,little is known about how ECM stiffening affects chondrocytes and other molecules *** study mimicked the physiological and pathological stiffness of human cartilage using polydimethylsiloxane(PDMS)*** demonstrated that epigenetic Parkin regulation by histone deacetylase 3(HDAC3)represents a new mechanosensitive mechanism by which the stiffness matrix affected chondrocyte *** found that ECM stiffening accelerated cultured chondrocyte senescence in vitro,while the stiffness ECM downregulated HDAC3,prompting Parkin acetylation to activate excessive mitophagy and accelerating chondrocyte senescence and osteoarthritis(OA)in ***,intra-articular injection with an HDAC3-expressing adeno-associated virus restored the young phenotype of the aged chondrocytes stimulated by ECM stiffening and alleviated OA in *** findings indicated that changes in the mechanical ECM properties initiated pathogenic mechanotransduction signals,promoted the Parkin acetylation and hyperactivated mitophagy,and damaged chondrocyte *** results may provide new insights into chondrocyte regulation by the mechanical properties of ECM,suggesting that the modification of the physical ECM properties may be a potential OA treatment strategy.

关键词： chondrocyte osteoarthritis stiffness

Genesis of the Jianbeigou Gold Deposit on the Southern Margin of the North China Craton: Insights from Fluid Inclusions, H-O-S Isotopes, and Pyrite in situ Trace Element Analyses

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 969-991页

作者： LI Fengchun zeng Qingdong ZHU Rixiang chu Shaoxiong XIE Wei YU Bing WU Jinjian LI Xinghui Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Science and Engineering Hebei University of EngineeringHandanHebei 056038China

The Jianbeigou gold deposit is a typical lode gold deposit in the Qinling metallogenic belt, located on the southern margin of the North China Craton. Three stages of the hydrothermal process can be distinguished, including the quartz ± pyrite, quartz-polymetallic sulfide, and quartz-carbonate ± pyrite stages. From the early to late stages, the homogenization temperatures of primary fluid inclusions are 281–362°C, 227–331°C, and 149–261°C, respectively. The corresponding salinities estimated for these fluids are 3.9–9.9 wt%, 0.4–9.4 wt%, and 0.7–7.2 wt% Na Cl equiv. Combined with laser Raman spectroscopy data, the ore-forming fluid belongs to a H_(2)O-CO_(2)-Na Cl ± CH_4 system with medium–low temperature and salinity. The δ~(18)Ofluid and δD values for the quartz veins are-1.0‰ to 6.0‰ and-105‰ to-84‰, respectively, which indicates that the ore-forming fluid is of mixed source, mainly derived from magma, with a contribution from meteoric water. Pyrite has been identified into three generations based on mineral paragenetic sequencing, including Py1, Py2, and Py3. The pyrites have δ~(34)S sulfur isotopic compositions from three stages between 3.7‰ and 8.4‰, indicating that sulfur mainly originated from magma. Te, Bi, Sb, and Cu contents in pyrite were all high and showed a strong correlation with Au concentrations. Native gold and the Au-Ag-Bi telluride minerals were formed concurrently, and the As concentration was low and decoupled from the Au content. Therefore, Te, Bi, Sb and other low-melting point chalcophile elements play an important role for gold mineralization in arsenic-deficient ore-forming fluid. Combined with the geological setting, evolution of pyrite, and ore-fluids geochemistry, we propose that the Jianbeigou deposit can be classified as a magmatic–hydrothermal lode gold deposit. Gold mineralization on the southern margin of the North China Craton is related to Early Cretaceous magmatism and formed in an extensional setting.

关键词： ore genesis H-O-S isotopes fluid inclusions in-situ trace element Jianbeigou gold deposit

Stable alkali halide vapor assisted chemical vapor deposition of 2D HfSe2 templates and controllable oxidation of its heterostructures

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Frontiers of physics 2024年第3期19卷 29-38页

作者： Wenlong chu Xilong Zhou ze Wang Xiulian Fan Xuehao Guo Cheng Li Jianling Yue Fangping Ouyang Jiong Zhao Yu Zhou School of Physics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing100190China Department of Applied Physics The Hong Kong Polytechnic UniversityKowloonHong KongChina

Two-dimensional hafnium-based semiconductors and their heterostructures with native oxides have been shown unique physical properties and potential electronic and optoelectronic ***,the scalable synthesis methods for ultrathin layered hafnium-based semiconductor laterally epitaxy growth and its heterostructure are still restricted,also for the understanding of its formation ***,we report the stable sublimation of alkali halide vapor assisted synthesis strategy for high-quality 2D HfSe_(2) nanosheets via chemical vapor ***-crystalline ultrathin 2D HfSe_(2) nanosheets were systematically grown by tuning the growth parameters,reaching the lateral size of 6‒40μm and the thickness down to 4.5 *** scalable amorphous HfO_(2)and HfSe_(2)heterostructures were achieved by the controllable oxidation,which benefited from the approximate zero Gibbs free energy of unstable 2D HfSe_(2) *** crystal structure,elemental,and time dependent Raman characterization were carried out to understand surface precipitated Se atoms and the formation of amorphous Hf−O bonds,confirming the slow surface oxidation and lattice incorporation of oxygen *** relatively smooth surface roughness and electrical potential change of HfO_(2)−HfSe_(2) heterostructures indicate the excellent interface quality,which helps obtain the high performance memristor with high on/off ratio of 105 and long retention period over 9000 *** work introduces a new vapor catalysts strategy for the synthesis of lateral 2D HfSe_(2) nanosheets,also providing the scalable oxidation of the Hf-based heterostructures for 2D electronic devices.

关键词： chemical vapor deposition HfSe_(2)−HfO_(2) nanoelectronics

A pure blue light emitting binaphthyl derivative:Synthesis and properties

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Chinese Chemical Letters 2008年第4期19卷 431-434页

作者： Qing Guo He zeng ze chu Gang Tie Lei An Jun Qin Hong Zhen Lin Feng Lian Bai Jian Gong Cheng Yong Qiu Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Key Laboratory of Organic Solids Centre for Molecular ScienceInstitute of ChemistryChinese Academy of SciencesBeijing 100080China Department of Chemistry Tsinghua UniversityBeijing 100084China

A binaphthyl derivative with pyrene on 3 and 3＇ positions was synthesized and characterized via Suzuki coupling reaction. Emission maximum in solution was located at 390 nm with a quantum efficiency of 68% by taking 9,10-diphenyl anthracene as reference,while it is shifted to 450 nm with FWHM of 104 nm resulting from aggregation state in solid *** transition temperature（Tg）and decomposition temperature were measured to be 184 and 447℃,respectively,by DSC and *** its photoluminescence spectrum,electroluminescent spectrum peaked at about 460 nm and shows a FWHM of 69 nm corresponding to a pure blue *** turn-on voltage,luminance and efficiency maximum were 5 V,2953 cd/m^2 and 1.37cd/A with CIE color coordinate of（0.16,0.15）,in the device structure of ITO/NPB（40nm）/PY-BN-PY（15nm）/BPhen（40nm）/Mg：Ag.

关键词： Binaphthyl Pyrene Suzuki reaction Photoluminescence Electroluminescence

Cascade utilization of full spectrum solar energy for achieving simultaneous hydrogen production and all-day thermoelectric conversion

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Journal of Energy Chemistry 2024年第9期96卷 318-327页

作者： Tuo Zhang Liang Dong Baoyuan Wang Jingkuo Qu Xiaoyuan Ye Wengao zeng ze Gao Bin Zhu Ziying Zhang Xiangjiu Guan Liejin Guo International Research Center for Renewable Energy(IRCRE) State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina

Solar-driven photocatalytic water/seawater splitting holds great potential for green hydrogen ***,the practical application is hindered by the relatively low conversion efficiency resulting from the inadequate utilization of solar spectrum with significant waste in the form of ***,current equipment struggles to maintain all-day operation subjected to the lack of light during ***,a novel hybrid system integrating photothermal catalytic(PTC)reactor,thermoelectric generator(TEG),and phase change materials(PCM)was proposed and designed(named as PTC-TEG-PCM)to address these challenges and enable simultaneous overall seawater splitting and 24-hour power *** PTC system effectively maintains in an optimal temperature range to maximize photothermal-assisted photocatalytic hydrogen *** TEG component recycles the low-grade waste heat for power generation,complementing the shortcoming of photocatalytic conversion and achieving cascade utilization of full-spectrum solar ***,exceptional thermal storage capability of PCM allow for the conversion of released heat into electricity during nighttime,contributing significantly to the overall power output and enabling PTC-TEG-PCM to operate for more than 12 h under the actual *** to traditional PTC system,the overall energy conversion efficiency of the PTC-TEG-PCM system can be increased by∼500%,while maintaining the solar-to-hydrogen *** advancement of this novel system demonstrated that recycling waste heat from the PTC system and utilizing heat absorption/release capability of PCM for thermoelectric application are effective strategies to improve solar energy *** flexible parameter designing,PTC-TEG-PCM can be applied in various scenarios,offering high efficiency,stability,and sustainability.

关键词： Hybrid solar energy conversion system Photocatalytic overall seawatersplitting Thermoelectric power generation Phase change materials All-day operation