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重庆市7～16岁儿童青少年代谢综合征组分的调查及影响因素的分析

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重庆医科大学学报 2016年第10期41卷 1069-1075页

作者：王嫣嫣熊丰张亚妮杨彬林琴朱岷曾燕罗雁红宋萃朱高慧重庆医科大学附属儿童医院内分泌科重庆400014 重庆市沙坪坝区中小学生卫生保健所重庆400030

目的：探讨重庆市7~16岁儿童青少年代谢综合征（metabolic syndrome,MS）的组分及其影响因素,为有针对性的干预提供流行病学依据。方法：按照整群随机抽样方法抽取重庆市5所中小学7~16岁在校生共4481名进行代谢指标及影响因素问卷调查... 详细信息

目的：探讨重庆市7~16岁儿童青少年代谢综合征（metabolic syndrome,MS）的组分及其影响因素,为有针对性的干预提供流行病学依据。方法：按照整群随机抽样方法抽取重庆市5所中小学7~16岁在校生共4481名进行代谢指标及影响因素问卷调查。按照体质指数（body mass index,BMI）法分为正常组、超重组、肥胖组。对各代谢指标进行分析,对MS影响因素进行Logistic回归分析,并比较MS影响因素的性别差异。结果：（1）重庆地区7~16岁儿童青少年总超重率9.8%,其中男生12.0%,女生7.4%。总肥胖率5.4%,其中男生7.3%,女生3.4%。男生超重率、肥胖率均高于女生（P〈0.05）。（2）随着BMI的增加,收缩压、舒张压、甘油三酯、胆固醇、低密度脂蛋白胆固醇、非高密度脂蛋白胆固醇、腰围有升高的趋势,高密度脂蛋白胆固醇呈降低趋势（P〈0.05）。（3）MS总体检出率为0.45%。肥胖组MS的患病率（6.9%）明显高于超重组（0.5%）和正常组（0.0%）（P〈0.05）,且男生患病率高于女生（P〈0.05）。肥胖儿童MS出现单项异常的检出率依次为高腰围（37.9%）、高甘油三酯（22.7%）、低高密度脂蛋白（19.7%）、高非高密度脂蛋白（7.4%）、高血压（4.4%）、高空腹血浆葡萄糖（2.0%）。（4）MS影响因素logistic回归分析结果显示,有3个因素与MS相关：腰围、每次肉类摄入量、高血脂家族史均与MS的发病率呈正相关。男生高腰围、每次肉类摄入量≥3两检出率高于女生（P〈0.05）。结论：MS组分异常已在重庆地区超重肥胖儿童青少年中发生。高腰围、高甘油三酯、低高密度脂蛋白是重庆肥胖儿童最常见的代谢异常,应引起社会的重视。

关键词：儿童青少年肥胖代谢综合征组分影响因素

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Establishment of mixed plantations of Pinus sylvestris *** and Populus×xiaozhuanica may not be appropriate:evidence from litter decomposition

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Journal of Plant Ecology 2019年第5期12卷 857-870页

作者： Huan-Huan song Tao yan De-Hui zeng CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Daqinggou Ecological Station Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China

Aims Mongolian pine(Pinus sylvestris ***)and Xiaozhuan poplar(Populus×xiaozhuanica)are two predominant afforestation tree species in the semi-arid sandy lands of northeast china,which are characterized by poor soil *** litter decomposition plays a critical role in regulating nutrient cycling in terrestrial *** of broadleaf litter to conifer litter is expected to improve litter decomposition and soil fertility,and thus ***,the effects on the decomposition of litter mixture of the above two tree species are not well ***,it is essential to assess the decomposition performance of litter mixture with the aim of improving forest nutrient management and the establishment of mixed *** forest manage-ment practice is critical for the sustainability of site productivity in plantation *** We conducted a field litterbag decomposition transplant experi-ment for single pine litter,single poplar litter and their mixture in a pine stand,a poplar stand and an adjacent grassland for 16 months in the Keerqin Sandy Lands,northeast *** Findings After 16 months of incubation,there remained significantly more litter mass of pine(73.8%)than of poplar(67.2%).the mass remaining was positively correlated with litter carbon(c):nitrogen(N),c:phosphorus(P)and lignin:N ratios,and negatively with litter N and P concentrations,which suggests that initial litter chemical properties were an important factor affecting litter ***,net N and P immobilizations were observed during *** indicates that litter decomposition in this area was N-limited as N was progressively immobilized,and then tended to induce P ***,we strongly recommend prohibiting litter harvesting by local residents to maintain soil fertility in this nutrient-poor *** results do not support the home-field advantage hypothesis,as illustrated by the fact that,in most cases,mass loss of

关键词： litter mass remaining nutrient immobilization litter mixture additive effect home-field advantage nutrient-poor area

Simulation-optimization model of reservoir operation based on target storage curves

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Water Science and Engineering 2014年第4期7卷 433-445页

作者： Hong-bin FANG Tie-song HU Xiang zeng Feng-yan WU State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Hubei Water Resources Research Institute

This paper proposes a new storage allocation rule based on target storage curves. Joint operating rules are also proposed to solve the operation problems of a multi-reservoir system with joint demands and water transfer-supply projects. The joint operating rules include a water diversion rule to determine the amount of diverted water in a period, a hedging rule based on an aggregated reservoir to determine the total release from the system, and a storage allocation rule to specify the release from each reservoir. A simulation-optimization model was established to optimize the key points of the water diversion curves, the hedging rule curves, and the target storage curves using the improved particle swarm optimization （IPSO） algorithm. The multi-reservoir water supply system located in Liaoning Province, China, including a water transfer-supply project, was employed as a case study to verify the effectiveness of the proposed join operating rules and target storage curves. The results indicate that the proposed operating rules are suitable for the complex system. The storage allocation rule based on target storage curves shows an improved performance with regard to system storage distribution.

关键词： reservoir operation joint operating rules simulation-optimization model improvedparticle swarm optimization

High-temperature self-powered X-ray detection in a bilayered hybrid ferroelectric halide perovskite

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Science China Chemistry 2025年

作者： Yingying Zheng Panpan Yu Yunpeng Yao Shihai You zeng-Kui Zhu Junhua Luo School of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University School of Environmental and Material Engineering Yantai University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

X-ray detectors which convert X-ray irradiation into electrical signals play an important role in diverse applications including medical diagnosis, security examination, nondestructive inspection, personal X-ray dosimeters and fundamental research[1–5]. Recently, metal halide perovskites（MHP） have been developed as a promising family for X-ray detection contributing to their intrinsic advantages, e.g.,simple synthesis, efficient X-ray absorption and excellent semiconducting properties[5–10].

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Shake table experimental study of cable-stayed bridges with two different design strategies of H-shaped towers

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 483-493页

作者： Xu yan Cui Cunyu zeng zeng zeng Shijie State Key Laboratory for Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China China Three Gorges Project Development Co. LtdChengdu 610041China

As one of the main load-carrying components of cable-stayed bridges,bridge towers are typically required to remain elastic even when subjected to severe ground motions with a 2%-3%probability of exceedance in 50 *** fulfill this special requirement imposed by current seismic design codes,reinforcement ratios in the bridge towers have to be kept significantly higher than if limited ductility behavior of the tower is *** addition,since the foundation capacity is closely related to the moment and shear capacities of the bridge tower,a large increase in bridge construction cost for elastically designed cable-stayed bridge is *** further investigate the possibility of limited ductility bridge tower design strategies,a new 1/20-scale cable-stayed bridge model with H-shaped bridge towers designed according to strong strut-weak tower column design was *** shake table experimental results are compared with a previous strong tower column-weak strut designed full bridge model.A comparison of the results show that ductility design with plastic hinges located on tower columns,i.e.,strong strut-weak tower column design,is another effective seismic design strategy that results in only small residual displacement at the top of the tower column,even under very severe earthquake excitations.

关键词： cable-stayed bridge shake table experiment limited ductility design H-shaped bridge tower seismic design

Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1

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Protein & Cell 2013年第8期4卷 620-627页

作者： yan yan Wenfeng zeng Shujun song Fayun Zhang Wenxi He Wei Liang Zhongying Niu Department of Endodontics School of StomatologyFourth Military Medical UniversityXi’an710032China Protein and Peptide Pharmaceutical Laboratory Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Treatment Center of Oral Diseases the 306th Hospital of People’s Liberation ArmyBeijing 100101China Department of Pathology and Experimental Medicine the 306th Hospital of People’s Liberation ArmyBeijing 100101China

The differentiation of periodontal ligament(PDL)progenitor cells is important for maintaining the homeostasis of PDL tissue and alveolar *** C(VC),a water-soluble nutrient that cannot be biosynthesized by humans,is vital for mesenchymal stem cells differentiation and plays an important role in bone ***,the objective of this study was to determine the function and mechanism of VC in PDL progenitor cells osteogenic differentiation at the molecular *** demonstrated that VC could induce the osteogenic differentiation and maturation of PDL progenitor cell without other osteogenic *** the process,VC preferentially activated ERK1/2 but did not affect JNK or ***-treatment with ERK inhibitor effectively decreased the Vitamin C-induced expression of *** inhibitor also abrogated Vitamin C-induced the minimized nodules ***1,a nuclear receptor co-regulator,was up-regulated under VC ***1 knockdown inhibited ERK *** overexpression of PELP1 had a positive relationship with Runx2 *** together,we could make a conclude that VC induces the osteogenic differentiation of PDL progenitor cells via PELP1-ERK *** fi nding implies that VC may have a potential in the regeneration medicine and application to periodontitis treatment.

关键词： periodontal ligament progenitor cells Vitamin C PELP1 ERK signaling pathway osteogenic differentiation

Influence of carbon-partitioning treatment on the microstructure, mechanical properties and wear resistance of in situ VCp-reinforced Fe-matrix composite

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 100-111页

作者： Ping-hu Chen Yun Zhang Rui-qing Li yan-xing Liu song-sheng zeng School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China Light Alloy Research Institutes and State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China School of Mechanical Engineering DongGuan University of TechnologyDongguan 523808China Valin ArcelorMittal Automotive Steel Co. Ltd.Loudi 417000China

The wear resistance of iron(Fe)-matrix materials could be improved through the in situ formation of vanadium carbide particles(VCp)with high ***,brittleness and low impact toughness limit their application in several industries due to addition of higher carbon ***-partitioning treatment plays an important role in tuning the microstructure and mechanical properties of in situ VCp-reinforced Fe-matrix *** this study,the influences of carbon-partitioning temperatures and times on the microstructure,mechanical properties,and wear resistance of in situ VCp-reinforced Fe-matrix composite were *** experimental results indicated that a certain amount of retained austenite could be stabilized at room temperature through the carbon-partitioning *** of in situ VCp-reinforced Fematrix composite under carbon-partitioning treatment could be decreased,but impact toughness was improved accordingly when wear resistance was *** addition,the enhancement of wear resistance could be attributed to transformation-induced plasticity(TRIP)effect,and phase transformation was caused fromγ-Fe(face-centered cubic structure,fcc)toα-Fe(body-centered cubic structure,bcc)under a certain load.

关键词： carbon-partitioning treatment retained austenite phase transformation mechanical properties wear resistance

基于卡尔加里-剑桥指南的沙龙培训模式提升全科规培医师医患沟通技能的对照研究

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中国全科医学 2025年第1期28卷 71-76页

作者：彭涛邹川曾欣张焱沈静四川省成都市第五人民医院全科医学科 611130

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患... 详细信息

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患沟通培训模式来提高其医患沟通能力。目的探索基于卡尔加里-剑桥指南的沙龙培训模式在全科规培医师医患沟通技能培训中的应用效果,为构建适合我国国情的医患沟通培训体系提供参考依据。方法选取成都市第五人民医院2019—2020年度全科规培医师40名作为研究对象,按照随机数字表法分为沙龙组和对照组,每组20名,其中沙龙组使用基于卡尔加里-剑桥指南的沙龙培训模式进行医患沟通培训,对照组设置为空白对照,培训前、培训后1周分别对两组学员采用标准化病人(SP)模式进行接诊,使用医患沟通评价量表(SEGUE量表)进行现场观察评分,比较两组学员的医患沟通培训效果。结果最终纳入28名,其中沙龙组15名,对照组13名,培训后沙龙组规培医师SEGUE量表评分从(11.80±4.36)分提高至(18.07±4.11)分,对照组规培医师SEGUE量表评分从(12.15±4.63)分提高至(14.46±3.71)分。沙龙组培训后的SEGUE量表评分与培训前的比较,差异有统计学意义(t=3.250,P<0.001);对照组培训后的SEGUE量表评分与培训前比较,差异无统计学意义(t=2.582,P=0.624);培训后对SEGUE量表中的25个项目进行分析,沙龙组与对照组SEGUE量表评分比较,差异有统计学意义(P<0.05)。沙龙组以下5个项目结果优于对照组,准备阶段中的“建立个人信任关系”(93.3%比7.7%)、“保护患者的隐私/尊重患者选择权”(53.3%比15.4%);理解患者阶段中的“认同患者为疾病所付出的努力、改变及其遇到的困难”(33.3%比23.1%)、“表达关心,使患者感到温暖/树立信心”(100.0%比69.2%);结束问诊阶段中的“询问患者是否还有其他的问题需要探讨”(66.7%比23.1%)。结论基于卡尔加里-剑桥指南的沙龙培训模式对全科规培医师进行医患沟通技能培训可增强学员主动参加培训的兴趣和积极性,对于医患沟通能力的提升具有较好的培训效果,值得借鉴和推广。

关键词：全科医学全科医师规范化培训医患沟通沟通培训卡尔加里-剑桥指南