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Neutrophils, reverse traffic and detrimental potential

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Cellular & Molecular Immunology 2012年第2期9卷 99-100页

作者： gucheng zeng Zheng W. Chen Department of Microbiology Zhongshan School of Medicine Sun Yat-sen University Guangzhou China ahd Department of Microbiology and immunology Center for Primate Biomedical Research University of Illinois College of Medicine Ch cago L USA

Transmigration of leukocytes through venular walls into the inflamed tissues plays a central role in innate immune res- ponses against infection or injury. Trans- endothelial migration （TEM） was widely believed to be the final step in the process of leukocyte emigration into inflamed tissues. Leukocyte TEM is driven by large-scale, comlicated molecular interactions that allow leukocyte TEM to occur with minimal disruption to the complex and delicate structures of vessel walls.1,2 However, the molecu- lar mechanisms underlying the leukocyte

关键词： Neutrophils reverse traffic potential

Non-coding RNA: a key regulator of the pathogenicity and immunity of Flaviviridae viruses infection

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Cellular & Molecular Immunology 2018年第2期15卷 185-186页

作者： Zhiyi Zhang Lifang Jiang gucheng zeng Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Key Laboratory for Tropical Diseases Control of the Ministry of Education Sun Yat-sen UniversityGuangzhou510080China

Flaviviridae is a family of viruses that mainly spread through arthropod vectors,such as *** members of the Flaviviridae family include dengue virus(DENV),yellow fever virus,Zika virus(ZIKV),West Nile virus and hepatitis C virus(HCV).As Flaviviridae viruses remain a major global public health threat,elucidation of the exact mechanisms of pathogenesis during infection is required for the successful control of these deadly viruses.

关键词： immunity infection pathogenesis

PROBING MOLECULAR INTERACTION BETWEEN TRANSFERRIN AND ANTI-TRANSFERRIN BY ATOMIC FORCE MICROSCOPE

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Chinese Science Bulletin 2006年第4期51卷 405-408页

作者： ZHENG Zhiwen YANG Peihui zeng gucheng CAI Jiye Key Laboratory of Specially Functional Materials and AdvancedManufacturing Technology Ministry of Education South China University of Technology Guangzhou 510640 China Department of Chemistry Jinan University Guangzhou 510632 China

The interaction between transferrin (Tf) and its antibody was investigated by atomic force microscope. Tf-antibody was immobilized on the Au-coated glass slide, and the specific combination between antibody and antigen was also character-ized by AFM. The results showed that holo-transferrin was jogged with anti-transferrin, and binded anti-tran- sferrin more tightly than apo-transferrin. The force- distance curves revealed that the affinity of anti-trans- ferrin and holo-transferrin was much stronger than that of apo-transferrin.

关键词：转铁球蛋白抗转铁球蛋白分子间相互作用原子力显微镜生物大分子

Nutrition Metabolism and Infections

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Infectious Microbes & Diseases 2021年第3期3卷 134-141页

作者： Fang Yang Yi Yang Lingchan zeng Yiwei Chen gucheng zeng Department of Microbiology Zhongshan School of MedicineKey Laboratory for Tropical Diseases Control of the Ministry of EducationSun Yat-sen UniversityGuangzhouGuangdongChina Clinical Research Center Department of Medical Records ManagementGuanghua School of StomatologyHospital of StomatologySun Yat-sen UniversityGuangzhouGuangdongChina

Infection and nutrition are intricately interacted and further influence human *** are a worldwide health problem and malnutrition plays a significant role in the emergence of *** evidence suggests that the optimization of dietary nutrients intake is crucial in maintaining systemic immunity and may help improve resistance to *** this review,we explore a wide range of topics including interactions between nutrients and various infectious *** also discuss the role of diet-induced gut microbiota in the infection-nutrition cycle and review how dietary-microbiome crosstalk may affect disease development and progression,which may provide an attractive option to the design of a diet leading to favorable outcomes in the *** will also present evidence and propose mechanisms of nutrients that may specifically modulate host immunity and metabolism to infectious pathogens and also cover its influence on nutrition,focusing on *** provide representative nutrients in the present review based on their intensive studies and wide acceptance of their immuno-modulating ***,the efficacy and translational cost of their plausible utility to be anti-infective nutrients are also ***,we highlight the current progress and challenges to gain a better understanding of the research into microbiota,infectious diseases,and nutrition with an emphasis on future research directions.

关键词： nutrition infection metabolism

Suppressed expression of miR-378 targeting gzmb in N cells is required to control dengue virus infection

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Cellular & Molecular Immunology 2016年第5期13卷 700-708页

作者： Shuyan Liu Lingming Chen Ying zeng Lulu Si Xiaolan Guo Junmei Zhou Danyun Fang gucheng zeng Lifang Jiang Department of Microbiology Zhongshan School of Medicine Key Laboratory for Tropical Diseases Control of the Ministry of Education Sun Yat-sen University Guangzhou 510080 China Department of Neurology The First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China

Dengue virus （DENV） remains a major public health threat because no vaccine or drugs are available for the prevention and treatment of DENV infection, and the immunopathogenesis mechanisms of DENV infection are not fully understood. Cytotoxic molecules, such as granzyme B （GrzB）, may be necessary to control viral infections. However, the exact role of GrzB during DENV infection and the mechanisms regulating GrzB expression during DENV infection are not clear. This study found that miR-27a~, miR-3Oe, and miR-378 were down-regulated in DENV-infected patients, and DENV infection in humans induced a significant up-regulation of GrzB in natural killer （NK） cells and CD8＋ T cells. Further investigation indicated that NK cells, but not CD8＋ T cells, were the major sources of GrzB, and miR-378, but not miR-27a~ or miR-3Oe, suppressed GrzB expression in NK cells. Notably, we found that overexpression of miR-378 using a miR-378 agomir in DENV-infected mice inhibited GrzB expression and promoted DENV replication. These results suggest the critical importance of miR-378 in the regulation of GrzB expression and a protective role for GrzB in controlling DENV replication in vivo. Therefore, this study provides a new insight into the immunopathogenesis mechanism of DENV infection and a biological basis for the development of new therapeutic strategies to control DENV infection.

关键词： dengue virus granzyme B miRNA-378 NK ceils

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生物安全实验室全面开放的安全监督管理模式

实验技术与管理 2013年第12期30卷 210-213页

作者：袁广卿陈省平曾谷城彭毅李研陈宏贤中山大学中山医学院广东广州510080

根据中山大学生物安全实验室承担教学和科研项目的运行管理与实践,构建了实验室全面开放的安全监督管理模式。该安全监督管理模式是通过运行实验室生物安全管理体系与现代化网络和信息技术、RFID技术、视频监控系统等相结合的管理模式,... 详细信息

根据中山大学生物安全实验室承担教学和科研项目的运行管理与实践,构建了实验室全面开放的安全监督管理模式。该安全监督管理模式是通过运行实验室生物安全管理体系与现代化网络和信息技术、RFID技术、视频监控系统等相结合的管理模式,在确保实验室生物安全的同时提高开放管理的效率,为优秀学生的培养提供了基础研究条件和保障。

关键词：生物安全实验室实验室开放监督管理网络化

Progress and challenges in multi-stack fuel cell system for high power applications:Architecture and energy management

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Green Energy and Intelligent Transportation 2023年第2期2卷 105-127页

作者： Yuqi Qiu Tao zeng Caizhi Zhang gucheng Wang Yaxiong Wang Zhiguang Hu Meng Yan Zhongbao Wei College of Mechanical and Vehicle Engineering The State Key Laboratory of Mechanical TransmissionsChongqing Automotive Collaborative Innovation CentreChongqing UniversityChongqing400044China School of Electrical Engineering Chongqing UniversityChongqing400044China Chongqing Changan New Energy Vehicle Technology Co. Ltd.Chongqing400000China Clean Energy Research Center Sch Engn SingaporeTemasek Polytechnic529757Singapore School of Computing National University of Singapore117543Singapore Beijing Institute of Technology National Engineering Laboratory for Electric VehiclesBeijing100081China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350108China FTXT Energy Technology Co. Ltd.Chaoyang StreetBaodingHebe071000China

With the development of fuel cells,multi-stack fuel cell system(MFCS)for high power application has shown tremendous development potential owing to their obvious advantages including high efficiency,durability,reliability,and ***,the state-of-the-art of MFCS is summarized and analyzed to advance its ***,the MFCS applications are presented in high-power scenarios,especially in transportation ***,to further investigate the MFCS,MFCS including hydrogen and air subsystem,thermal and water subsystem,multi-stack architecture,and prognostics and health monitoring are *** is noted that prognostics and health monitoring are investigated rarely in MFCS compared with previous *** addition,the efficiency and durability of MFCS are not only related to the application field and design principle but also the energy management strategy(EMS).The reason is that the EMS is crucial for lifespan,cost,and efficiency in the multi-stack fuel cell ***,the challenge and development potential of MFCS is proposed to provide insights and guidelines for future research.

关键词： High-power MFCS Reliability Multi-stack architecture Energy management

洪涝风险与发展潜力视角下村庄居民点布局优化——以福建省长汀县为例

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南方建筑 2024年第1期 55-63页

作者：徐建刚曾俊吴军付博明昊霖南京大学建筑与城市规划学院河南省自然资源厅

全球气候变化加剧和城镇化快速推进使得洪涝灾害发生频率和破坏性显著升高,为应对洪涝灾害利用风险评估指导村庄居民点布局优化,以福建省长汀县为例,运用模糊综合评价方法划定洪涝风险等级区,通过双重目标决策法对村庄灾害风险和发展潜... 详细信息

全球气候变化加剧和城镇化快速推进使得洪涝灾害发生频率和破坏性显著升高,为应对洪涝灾害利用风险评估指导村庄居民点布局优化,以福建省长汀县为例,运用模糊综合评价方法划定洪涝风险等级区,通过双重目标决策法对村庄灾害风险和发展潜力进行综合评价,并基于引力模型确定村庄迁移方案。结果表明,长汀县洪涝灾害高风险区域主要分布在以汀州镇与大同镇为主体的集中建设区及以部分村庄居民点,针对高风险村庄居民点,以“避灾”为导向提出了村庄迁移合并方案,实现了村庄居民点布局的适灾和减灾优化调整。对于区域防控洪涝灾害、减少灾害损失具有重要作用,对山地村庄空间防灾减灾规划实施有较强指导意义。

关键词：洪涝灾害风险评估模糊综合评价法发展潜力村庄布局

塔里木盆地肖尔布拉克组上段烃源岩分布预测及油气勘探意义

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地学前缘 2024年第2期31卷 343-358页

作者：徐兆辉胡素云曾洪流马德波罗平胡再元石书缘陈秀艳陶小晚中国石油勘探开发研究院北京100083 美国得克萨斯大学奥斯汀分校经济地质局美国奥斯汀787133 中国石油勘探开发研究院西北分院甘肃兰州730020

通常认为塔里木盆地下古生界海相烃源岩以下寒武统玉尔吐斯组泥质岩为主、中下奥陶统泥质岩为辅,下寒武统肖尔布拉克组上段(肖上段)以白云岩储层为主。塔中和塔北地区均钻遇了肖上段泥灰岩,最近钻探的京能柯探1和轮探3井肖上段泥灰岩样... 详细信息

通常认为塔里木盆地下古生界海相烃源岩以下寒武统玉尔吐斯组泥质岩为主、中下奥陶统泥质岩为辅,下寒武统肖尔布拉克组上段(肖上段)以白云岩储层为主。塔中和塔北地区均钻遇了肖上段泥灰岩,最近钻探的京能柯探1和轮探3井肖上段泥灰岩样品TOC含量多数>0.3%,少量>2%。盆地内不同地区五口井肖上段发育泥灰(云)岩烃源岩,与苏盖特布拉克露头肖上段暗色泥灰岩地化指标(TOC含量是0.41%、R o是1.14%)一致,表明肖上段泥灰岩具备生烃能力。本文基于露头、地震和钻测井资料,利用地震沉积学理论技术、属性与正演相结合,建立了肖上段台内多期叠置“礁滩源”沉积模式。发现烃源岩分布在礁前至坡脚变缓处,连片分布广、叠合厚度大,是规模有效烃源岩,可为邻近储层供烃。经测算,古城三维区肖上段泥灰岩烃源岩总生烃量超亿吨。研究认识拓展了塔里木盆地下古生界海相烃源岩类型、层系和分布范围,提升了寒武系盐下油气资源潜力,坚定了勘探重点从台缘带向台内战略转移的信心,为塔里木盆地古城地区乃至全盆地油气勘探带来新启示。

关键词：塔里木盆地肖尔布拉克组上段泥灰岩烃源岩地震沉积学油气勘探意义