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Non-coding RNA: a key regulator of the pathogenicity and immunity of Flaviviridae viruses infection

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Cellular & Molecular Immunology 2018年第2期15卷 185-186页

作者： Zhiyi Zhang Lifang Jiang gucheng zeng Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Key Laboratory for Tropical Diseases Control of the Ministry of Education Sun Yat-sen UniversityGuangzhou510080China

Flaviviridae is a family of viruses that mainly spread through arthropod vectors,such as *** members of the Flaviviridae family include dengue virus(DENV),yellow fever virus,Zika virus(ZIKV),West Nile virus and hepatitis C virus(HCV).As Flaviviridae viruses remain a major global public health threat,elucidation of the exact mechanisms of pathogenesis during infection is required for the successful control of these deadly viruses.

关键词： immunity infection pathogenesis

PROBING MOLECULAR INTERACTION BETWEEN TRANSFERRIN AND ANTI-TRANSFERRIN BY ATOMIC FORCE MICROSCOPE

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Chinese Science Bulletin 2006年第4期51卷 405-408页

作者： ZHENG Zhiwen YANG Peihui zeng gucheng CAI Jiye Key Laboratory of Specially Functional Materials and AdvancedManufacturing Technology Ministry of Education South China University of Technology Guangzhou 510640 China Department of Chemistry Jinan University Guangzhou 510632 China

The interaction between transferrin (Tf) and its antibody was investigated by atomic force microscope. Tf-antibody was immobilized on the Au-coated glass slide, and the specific combination between antibody and antigen was also character-ized by AFM. The results showed that holo-transferrin was jogged with anti-transferrin, and binded anti-tran- sferrin more tightly than apo-transferrin. The force- distance curves revealed that the affinity of anti-trans- ferrin and holo-transferrin was much stronger than that of apo-transferrin.

关键词：转铁球蛋白抗转铁球蛋白分子间相互作用原子力显微镜生物大分子

Nutrition Metabolism and Infections

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Infectious Microbes & Diseases 2021年第3期3卷 134-141页

作者： Fang Yang Yi Yang Lingchan zeng Yiwei Chen gucheng zeng Department of Microbiology Zhongshan School of MedicineKey Laboratory for Tropical Diseases Control of the Ministry of EducationSun Yat-sen UniversityGuangzhouGuangdongChina Clinical Research Center Department of Medical Records ManagementGuanghua School of StomatologyHospital of StomatologySun Yat-sen UniversityGuangzhouGuangdongChina

Infection and nutrition are intricately interacted and further influence human *** are a worldwide health problem and malnutrition plays a significant role in the emergence of *** evidence suggests that the optimization of dietary nutrients intake is crucial in maintaining systemic immunity and may help improve resistance to *** this review,we explore a wide range of topics including interactions between nutrients and various infectious *** also discuss the role of diet-induced gut microbiota in the infection-nutrition cycle and review how dietary-microbiome crosstalk may affect disease development and progression,which may provide an attractive option to the design of a diet leading to favorable outcomes in the *** will also present evidence and propose mechanisms of nutrients that may specifically modulate host immunity and metabolism to infectious pathogens and also cover its influence on nutrition,focusing on *** provide representative nutrients in the present review based on their intensive studies and wide acceptance of their immuno-modulating ***,the efficacy and translational cost of their plausible utility to be anti-infective nutrients are also ***,we highlight the current progress and challenges to gain a better understanding of the research into microbiota,infectious diseases,and nutrition with an emphasis on future research directions.

关键词： nutrition infection metabolism

Neutrophils, reverse traffic and detrimental potential

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Cellular & Molecular Immunology 2012年第2期9卷 99-100页

作者： gucheng zeng Zheng W. Chen Department of Microbiology Zhongshan School of Medicine Sun Yat-sen University Guangzhou China ahd Department of Microbiology and immunology Center for Primate Biomedical Research University of Illinois College of Medicine Ch cago L USA

Transmigration of leukocytes through venular walls into the inflamed tissues plays a central role in innate immune res- ponses against infection or injury. Trans- endothelial migration （TEM） was widely believed to be the final step in the process of leukocyte emigration into inflamed tissues. Leukocyte TEM is driven by large-scale, comlicated molecular interactions that allow leukocyte TEM to occur with minimal disruption to the complex and delicate structures of vessel walls.1,2 However, the molecu- lar mechanisms underlying the leukocyte

关键词： Neutrophils reverse traffic potential

Suppressed expression of miR-378 targeting gzmb in N cells is required to control dengue virus infection

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Cellular & Molecular Immunology 2016年第5期13卷 700-708页

作者： Shuyan Liu Lingming Chen Ying zeng Lulu Si Xiaolan Guo Junmei Zhou Danyun Fang gucheng zeng Lifang Jiang Department of Microbiology Zhongshan School of Medicine Key Laboratory for Tropical Diseases Control of the Ministry of Education Sun Yat-sen University Guangzhou 510080 China Department of Neurology The First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China

Dengue virus （DENV） remains a major public health threat because no vaccine or drugs are available for the prevention and treatment of DENV infection, and the immunopathogenesis mechanisms of DENV infection are not fully understood. Cytotoxic molecules, such as granzyme B （GrzB）, may be necessary to control viral infections. However, the exact role of GrzB during DENV infection and the mechanisms regulating GrzB expression during DENV infection are not clear. This study found that miR-27a~, miR-3Oe, and miR-378 were down-regulated in DENV-infected patients, and DENV infection in humans induced a significant up-regulation of GrzB in natural killer （NK） cells and CD8＋ T cells. Further investigation indicated that NK cells, but not CD8＋ T cells, were the major sources of GrzB, and miR-378, but not miR-27a~ or miR-3Oe, suppressed GrzB expression in NK cells. Notably, we found that overexpression of miR-378 using a miR-378 agomir in DENV-infected mice inhibited GrzB expression and promoted DENV replication. These results suggest the critical importance of miR-378 in the regulation of GrzB expression and a protective role for GrzB in controlling DENV replication in vivo. Therefore, this study provides a new insight into the immunopathogenesis mechanism of DENV infection and a biological basis for the development of new therapeutic strategies to control DENV infection.

关键词： dengue virus granzyme B miRNA-378 NK ceils

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生物安全实验室全面开放的安全监督管理模式

实验技术与管理 2013年第12期30卷 210-213页

作者：袁广卿陈省平曾谷城彭毅李研陈宏贤中山大学中山医学院广东广州510080

根据中山大学生物安全实验室承担教学和科研项目的运行管理与实践,构建了实验室全面开放的安全监督管理模式。该安全监督管理模式是通过运行实验室生物安全管理体系与现代化网络和信息技术、RFID技术、视频监控系统等相结合的管理模式,... 详细信息

根据中山大学生物安全实验室承担教学和科研项目的运行管理与实践,构建了实验室全面开放的安全监督管理模式。该安全监督管理模式是通过运行实验室生物安全管理体系与现代化网络和信息技术、RFID技术、视频监控系统等相结合的管理模式,在确保实验室生物安全的同时提高开放管理的效率,为优秀学生的培养提供了基础研究条件和保障。

关键词：生物安全实验室实验室开放监督管理网络化

Progress and challenges in multi-stack fuel cell system for high power applications:Architecture and energy management

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Green Energy and Intelligent Transportation 2023年第2期2卷 105-127页

作者： Yuqi Qiu Tao zeng Caizhi Zhang gucheng Wang Yaxiong Wang Zhiguang Hu Meng Yan Zhongbao Wei College of Mechanical and Vehicle Engineering The State Key Laboratory of Mechanical TransmissionsChongqing Automotive Collaborative Innovation CentreChongqing UniversityChongqing400044China School of Electrical Engineering Chongqing UniversityChongqing400044China Chongqing Changan New Energy Vehicle Technology Co. Ltd.Chongqing400000China Clean Energy Research Center Sch Engn SingaporeTemasek Polytechnic529757Singapore School of Computing National University of Singapore117543Singapore Beijing Institute of Technology National Engineering Laboratory for Electric VehiclesBeijing100081China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350108China FTXT Energy Technology Co. Ltd.Chaoyang StreetBaodingHebe071000China

With the development of fuel cells,multi-stack fuel cell system(MFCS)for high power application has shown tremendous development potential owing to their obvious advantages including high efficiency,durability,reliability,and ***,the state-of-the-art of MFCS is summarized and analyzed to advance its ***,the MFCS applications are presented in high-power scenarios,especially in transportation ***,to further investigate the MFCS,MFCS including hydrogen and air subsystem,thermal and water subsystem,multi-stack architecture,and prognostics and health monitoring are *** is noted that prognostics and health monitoring are investigated rarely in MFCS compared with previous *** addition,the efficiency and durability of MFCS are not only related to the application field and design principle but also the energy management strategy(EMS).The reason is that the EMS is crucial for lifespan,cost,and efficiency in the multi-stack fuel cell ***,the challenge and development potential of MFCS is proposed to provide insights and guidelines for future research.

关键词： High-power MFCS Reliability Multi-stack architecture Energy management

海南岛东部主要农作物和土壤中重金属的相关性及富集特征研究

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中国农学通报 2023年第5期39卷 75-80页

作者：王鹏王军广陈旸许国强张固成曾广骅张东强海南省地质综合勘察院海口570206 海南师范大学地理与环境科学学院海口571158 海南省地质调查院海口570206

采用野外采样和室内分析的方法,对海南岛东部主要农作物和土壤中重金属元素含量进行了分析,结果表明研究区土壤中As(变异系数1.58)的含量很不稳定;Zn和Pb的含量比较均匀,土壤中重金属间均为正相关可能具有同源性。水稻和胡椒中重金属的... 详细信息

采用野外采样和室内分析的方法,对海南岛东部主要农作物和土壤中重金属元素含量进行了分析,结果表明研究区土壤中As(变异系数1.58)的含量很不稳定;Zn和Pb的含量比较均匀,土壤中重金属间均为正相关可能具有同源性。水稻和胡椒中重金属的变异系数均小于0.50,重金属含量比较均匀。槟榔鲜果中As的(变异系数1.20)含量很不均匀,Zn和Pb的分布比较均匀。水稻、胡椒和槟榔鲜果中重金属间有正相关关系,也有负相关关系,但胡椒和槟榔鲜果中正相关显著多于负相关,重金属间存在明显协同吸收。农产品中重金属主要来源于土壤吸收,但槟榔鲜果部分重金属元素含量高于其土壤元素。水稻和胡椒对Zn、Cr、As、Pb、Cu和Cd 6种重金属元素的富集能力较弱,但槟榔鲜果对6种重金属元素的富集能力较强。

关键词：特征重金属农作物土壤相关性海南岛

富硒农产品产地认定技术方法——以海南万宁富硒槟榔为例

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中国农学通报 2020年第19期36卷 114-120页

作者：张固成马荣林郭跃品张家友王鹏郝宇曾广骅陈旸李亮海南省海洋地质资源与环境重点实验室海口570206 海南省地质调查院海口570206 海南地质综合勘察设计院海口570206

基于海南万宁市槟榔园1:10000农业地质调查数据、万宁市槟榔林权数据及富硒槟榔鲜果标准,试点万宁富硒槟榔产地认定工作,总结富硒农产品产地认定技术方法。富硒农产品产地认定技术方法主要包含资料准备、评价图斑赋值、土壤质量地球化... 详细信息

基于海南万宁市槟榔园1:10000农业地质调查数据、万宁市槟榔林权数据及富硒槟榔鲜果标准,试点万宁富硒槟榔产地认定工作,总结富硒农产品产地认定技术方法。富硒农产品产地认定技术方法主要包含资料准备、评价图斑赋值、土壤质量地球化学评价、农产品质量地球化学评价、富硒农产品产地认定、制作与颁发产地认定证书等技术环节。事实证明,富硒农产品产地认定技术方法科学、简洁,便于推广;富硒农产品产地认定技术方法的应用能产生较好的社会经济效益,值得推广;富硒农产品产地认定技术方法开拓了农业地质新领域,具有积极的示范效应。

关键词：槟榔海南富硒产地认定技术方法