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Advan.es in.Agin. Research 2014年第2期3卷 109-112页

作者： Romy n.hme Lama R. Bazzi Christin. P. C. Borba zeina n. chemali Departmen. of Psychiatry Massachusetts General Hospital Boston USA Division.of Foren.ic Psychiatry Case Western Reserve University Hospitals Cleveland USA

Between.crisis an. opportun.ty, old age has man. faces in.Leban.n. While old age was first seen.as a time of wisdom, the curren. tren. accen.uated by migration.an. the econ.mic crisis sets a challen.e for the Leban.se elder;they may be left behin. un.ess somethin. is don. in.all commun.ties at a n.tion.l level. In.this short commun.cation. we attempt to broaden.the scope of thin.in. about train.n. programs to target population.shift an. create a true chan.e. We reflect on.our results as an.in.ermediate outcome of public health in.erven.ion.. We suggest that it may be worthwhile to evaluate population.shifts further an. base the success of an.in.erven.ion.on.measures of Health Related Quality of Life through the respon.e-shift created by such n.tion.l public health programs.

关键词： Capacity Buildin. Public Health Elderly Train.n. Quality of Life

Vitamin.D supplemen.ation.improves sustain.d virologic respon.e in.chron.c hepatitis C (gen.type 1)-n.ve patien.s

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World Journ.l of Gastroen.erology 2011年第47期17卷 5184-5190页

作者： Saif Abu-Mouch Zvi Fireman.Jacob Jarchovsky Abdel-Rauf zeina n.mer Assy Liver Un.t Departmen. of In.ern.l Medicin. B Hillel Yaffe Medical Center Departmen. of Gastroen.erology Hillel Yaffe Medical Center Liver Un.t Hillel Yaffe Medical Center Liver Un.t Ziv Medical Center Technion Institute

AIM: To determin. whether addin. vitamin.D, a poten. immun.modulator, improves the hepatitis C virus (HCV) respon.e to an.iviral therapy. METHODS: Seven.y-two con.ecutive patien.s with chron.c HCV gen.type 1 were ran.omized in.o two groups: the treatmen. group (n.= 36, 50% male, mean.age 47 ± 11 years) received Peg-α-2b in.erferon.(1.5 μg/kg per week) plus ribavirin.(1000-1200 mg/d) together with vitamin.D3 (2000 IU/d, target serum level > 32 n./mL), an. the con.rol group (n.= 36, 60% male, mean.age 49 ± 7 years) received iden.ical therapy without vitamin.D. HCV-Rn. was assessed by realtime polymerase chain.reaction.(sen.itivity, 10 IU/mL). The sustain.d virologic respon.e (SVR) was defin.d as un.etectable HCV-Rn. at 24 wk post-treatmen.. RESULTS: Clin.cal characteristics were similar in.both groups. The treatmen. group had a higher mean.bodymass in.ex (27 ± 4 kg/m2 vs 24 ± 3 kg/m2, P n. fibrosis score (> F2: 42% vs 19%, P n.the con.rols. At week 4, 16 (44%) treated patien.s an. 6 (17%) con.rols were HCV-Rn. n.gative (P n.s an. 17 (48%) con.rols were HCV-Rn. n.gative (P n. (SVR), 31 (86%) treated patien.s an. 15 (42%) con.rols were HCV-Rn. n.gative (P n.ed fibrosis an. vitamin.D supplemen.ation.were stron.ly an. in.epen.en.ly associated with SVR (multivariate an.lysis). Adverse even.s were mild an. typical of Peg-α-2b/ribavirin. COn.LUSIOn. Addin. vitamin.D to con.en.ion.l Peg-α-2b/ribavirin.therapy for treatmen.-n.■ve patien.s with chron.c HCV gen.type 1 in.ection.sign.fican.ly improves the viral respon.e.

关键词： Hepatitis C Vitamin.D Sustain.d viral respon.e Gen.type 1 Fibrosis

Extraction.of Total Phen.lic Compoun.s, Flavon.ids, An.hocyan.n. an. Tan.in. from Grape Byproducts by Respon.e Surface Methodology. In.luen.e of Solid-Liquid Ratio, Particle Size, Time, Temperature an. Solven. Mixtures on.the Optimization.Process

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Food an. n.trition.Scien.es 2014年第4期5卷 397-409页

作者： Hiba n. Rajha n.da El Darra zeina Hobaika n.dia Boussetta Eugen. Vorobiev Richard G. Maroun.n.colas Louka Cen.re d’An.lyses et de Recherche UR TVA Faculté des Sciences Université Saint-Joseph de Beyrouth Lebanon Cen.re d’An.lyses et de Recherche UR TVA Faculté des Sciences Université Saint-Joseph de Beyrouth Lebanon UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Transformations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France. UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Transformations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France.

The curren. work con.ern. the optimization.process of phen.lic compoun.s solid liquid extraction.from grape byproducts at high temperatures an. short in.ubation.times. The effect of five experimen.al parameters (solidliquid ratio, particle size, time, temperature an. solven. mixture) mostly believed to affect the extraction.process was un.ertaken. A first respon.e surface methodology experimen.al design.was used to optimize the solid-liquid ratio an. millin. time parameters. A secon. design.was used for the optimization.of the quan.itative an. qualitative parameters. The quan.itative parameters studied are: total phen.lic compoun.s, flavon.id con.en., total mon.meric an.hocyan.n.composition.an. tan.in.con.en.ration. The qualitative parameters an.lyzed are: an.iradical activity an. an.ioxidan. capacity. The secon. design.was based on.the use of time, temperature an. solven. mixture as optimization.parameters. The assays were first con.ucted separately revealin. the best experimen.al con.ition. for the maximization.of each respon.e variable alon.. A simultan.ous respon.e surface methodology of all the respon.es taken.together was then.con.ucted, showin. the optimal extraction.con.ition. to be: 93 min.tes at 94?C an. in.66% ethan.l/water solven.. The maximal respon.e values obtain.d for each parameter are: Total Phen.lic Compoun.s yield (5.5 g GAE/100g DM), Flavon.id Con.en. (5.4 g GAE/100g DM), Total Mon.meric An.hocyan.n.yield (70.3 mg/100g DM), Tan.in.Con.en.ration.(12.3 g/L), An.iradical Activity (67.3%) an. Total An.ioxidan. Capacity (393 mgAAE/L). All of the optimal values were acquired at 3 mL/g solid-liquid ratio an. 6.8 min.millin. time. The obtain.d extracts could be used as n.tural bioactive compoun.s in.several in.ustrial application..

关键词： Phen.lic Compoun.s Grape Byproducts Extraction Optimization Respon.e Surface Methodology An.ioxidan.

不带引号的马克思——福柯、规治和新自由主义的批判

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现代哲学 2007年第4期 28-34页

作者：托马斯·莱姆克[英] Marc chemali译[法] 陈元（译） Marc chemali[法]（译）法兰克福社会研究学院不详中山大学外国语学院法语教授

“即使人们承认马克思主义现在已经消亡，但它将来某一天肯定会复活。我所希望做的……不完全是为一种真正的马克思平反昭雪，但肯定是为了把马克思从党的教条中解放出来并还其本来面目，因为这种教条长期以来打着传播马克思主义的幌子... 详细信息

“即使人们承认马克思主义现在已经消亡，但它将来某一天肯定会复活。我所希望做的……不完全是为一种真正的马克思平反昭雪，但肯定是为了把马克思从党的教条中解放出来并还其本来面目，因为这种教条长期以来打着传播马克思主义的幌子而将其禁锢并僵化”

关键词：马克思主义新自由主义福柯引号批判规治平反昭雪本来面目

Multiple Respon.e Optimization.of High Temperature, Low Time Aqueous Extraction.Process of Phen.lic Compoun.s from Grape Byproducts

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Food an. n.trition.Scien.es 2014年第4期5卷 351-360页

作者： Hiba n. Rajha n.colas Louka n.da El Darra zeina Hobaika n.dia Boussetta Eugèn. Vorobiev Richard G. Maroun Cen.re d’An.lyses et de Recherche UR TVA Faculté des Sciences Université Saint-Joseph de Beyrouth Lebanon Cen.re d’An.lyses et de Recherche UR TVA Faculté des Sciences Université Saint-Joseph de Beyrouth Lebanon UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Transformations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France. UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Transformations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France

In.this study phen.lic compoun.s extraction.from grape byproducts was con.ucted usin. pure water as a solven.. High temperatures an. low time in.ubation.periods were used in.the aim of reducin. the cost of the process an. heighten.n. the phen.lic compoun.s yield. Respon.e surface methodology (RSM) was realized to study the effect of time an. temperature on.crushed an. un.rushed grape pomace. The phen.lic con.en. was evaluated con.iderin. the quan.ity (total phen.lics (TPC), flavon.ids (FC), total mon.meric an.hocyan.n. (TMA) an. tan.in. (TC)), an. quality (an.iradical activity (AA) an. an.ioxidan. capacity (AC)) of the extracts. High temperature low time extraction.design.used in.this study was compared to the extraction.process at moderate temperatures with relatively lon. periods of time. This was proved to ameliorate the quan.itative extraction.of phen.lic compoun.s from grape pomace without affectin. their bioactivity. Moreover, multiple respon.e optimization.showed the optimal extraction.parameters to be 81?C an. 140 min.tes for the un.illed pomace samples, an. 88?C an. 5 min.tes for the milled. TPC, FC, TMA, TC, AA an. AC are almost the same for both optimums. Thus the possibility of replacin. the millin. process by the extraction.time prolon.ation.(for the un.illed pomace) of 135 min.tes seems to be very plausible. HPLC an.lysis showed differen. quan.ity an. diversity of extracted phen.lics for the optimums. However this differen.e did n.t sign.fican.ly affect the overall activity, showin. that PC in.the differen. extracts act in.complete syn.rgy all together leadin. to importan. biological properties. The obtain.d results usin. the extraction.strategy adopted in.this work could lead to several in.ustrial application..

关键词： Phen.lic Compoun.s Grape Byproducts Optimization Aqueous Extraction Respon.e Surface Methodology

n.Acetyl Cystein. to Treat <i>Polygon.m multiflorum</i>Hepatotoxicity: A Case Report

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Case Reports in.Clin.cal Medicin. 2021年第1期10卷 1-7页

作者： Musa S. ALfaifi Kassem A. Barada Ziad n. Kazzi zeina S. Mn.imn.h Evelin. A. Hitti Maher A. Malaeb San.in. A. Mustapha Melissa H. Gittin.er Emory Un.versity School of Medicin. Atlanta USA American.Un.versity of Beirut Beirut Lebanon

Backgroun.: Polygon.m multiflorum (bran. n.me Fo-ti) is a Chin.se herb used as an.an.ioxidan., an.iagin. agen., an. liver an. kidn.y health. It can.cause acute hepatotoxicity an. even.death. There is n. published data... 详细信息

n.>Backgroun.:n.> Polygon.m multiflorum (bran. n.me Fo-ti) is a Chin.se herb used as an.an.ioxidan., an.iagin. agen., an. liver an. kidn.y health. It can.cause acute hepatotoxicity an. even.death. There is n. published data on.the effectiven.ss of n.Acetyl cystein. (n.C) as a sole effective therapy. n.>Case:n.> A 23-year-old, healthy male, presen.ed with jaun.ice an. malaise of on.-mon.h duration. He had been.takin. a Chin.se herb n.med Fo-Ti for 2 mon.hs. Physical examin.tion.revealed jaun.ice, with n. stigmata of chron.c liver disease. His laboratory results showed tran.amin.tis with markedly elevated tran.amin.ses. Testin.s for in.ectious an. autoimmun. causes were un.emarkable. The patien. was admitted to the hospital. Fo-Ti was stopped an. he was started on.oral n.C as peroral protocol. He was discharged home on.esomeprazole an. oral n.C. He return.d on.the secon. day with worsen.n. jaun.ice. He was readmitted an. esomeprazole was discon.in.ed. n.C was con.in.ed an. his liver en.ymes even.ually improved. The supplemen. was tested by gas-chromatography mass spectrometry an. measured the presen.e of emodin. n.>Discussion.n.> This case highlights the poten.ial ben.fit of n.C as treatmen. of Polygon.m multiflorum in.uced hepatotoxicity. The proposed mechan.sm of emodin.in.uced liver in.ury is through disturbin. glutathion. metabolism in.liver cells. This could explain.the favorable respon.e as n.C has the ability to replen.sh in.racellular glutathion.. n.>Con.lusion.n.> Polygon.m multiflorum use has been.associated with severe an. prolon.ed hepatotoxicity. Oral n.C should be con.idered in.the treatmen. of these patien.s due to the favorable risk-ben.fit ratio.

关键词： Polygon.m multiflorum n.Ace Tylcystein. Hepatotoxicity