检索结果-南通市图书馆

New Era: Endoscopic treatment options in obesity–a paradigm shift

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第32期25卷 4567-4579页

作者： Jason Glass Ahson Chaudhry Muhammad S zeeshan zeeshan ramzan Department of Digestive and Liver Diseases University of Texas Southwestern Medical CenterDallasTX 75390United States Division of Gastroenterology and Hepatology Department of MedicineDallas VA Medical CenterVA North Texas Health Care SystemDallasTX 75216United States School of Medicine Temple University HospitalPhiladelphiaPA 19140United States

The prevalence of obesity continues to rise,and along with it comes a multitude of health-related *** healthcare community has consistently struggled with providing treatment options to obese patients,in part due to the reluctance of patients in pursuing the more effective(yet invasive)surgical approaches such as sleeve gastrectomy and Rou-en-Y gastric *** the other hand,the less invasive approach such as lifestyle/behavioral interventions and pharmacotherapy(Orlistat,Phenteramine,Phentermine/Topiramate,Locaserin,Naltrexon/Buproprion,and Liraglutide)have very limited efficacy,especially in the morbidly obese *** our best efforts,the epidemic of obesity continues to rise and pose enormous costs on our healthcare system and *** endoscopy is an evolving field generated to combat this epidemic through minimally invasive *** procedures can be performed in an ambulatory setting,are potentially reversible,repeatable,and pose less complications than their invasive surgical *** modalities are designed to alter gut metabolism by means of space occupation,malabsorption,or *** this review we will discuss different bariatric endoscopic options(such as intragastric balloons,endoscopic sleeve gastroplasty,endoscopic aspiration therapies and gastrointestinal bypass sleeves),their advantages and disadvantages,and suggest a new paradigm where providers may start incorporating this modality in their treatment approach for obese patients.

关键词： Bariatric endoscopy Bariatrics Obesity Intragastric balloon Bariatric medicine AspireAssist Endoscopic sleeve gastroplasty

Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2014年第7期6卷 194-210页

作者： zeeshan ramzan Ammar B Nassri Sergio Huerta VA North Texas Healthcare System-Dallas VA Medical Center University of Texas Southwestern Medical Center Dallas TX 75216 United States

Due to a wide range of clinical response in patients un-dergoing neo-adjuvant chemoradiation for rectal cancer it is essential to understand molecular factors that lead to the broad response observed in patients receiving the same form of *** extensive research in this field,the exact mechanisms still remain *** raging from DNA-repair to specific molecules lead-ing to cell survival as well as resistance to apoptosis have been ***,or in combination,there is no single pathway that has become clinically applicable to *** the following review,we describe the current status of various pathways that might lead to resistance to the therapeutic applications of ionizing radiation in rectal cancer.

关键词： Ionizing radiation DNA double-strand break Non-homologous end-joining pathway DNA-PKcs Ku proteins Complete pathological response Radiation therapy Apoptosis Angiogenesis

Lymphocyte-to-monocyte ratio can predict mortality in pancreatic adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第1期8卷 60-66页

作者： Gurshawn Singh Ammar Nassri David Kim Hong Zhu zeeshan ramzan Department of Medicine Division of Gastroenterology and HepatologyUniversity of Texas Southwestern Medical Center at Dallas Department of Internal Medicine University of Texas at Austin Dell Medical School Department of Internal Medicine University of Texas Southwestern Medical Center at Dallas Department of Clinical Science Simmons Comprehensive Cancer CenterUT Southwestern Medical Center Gastrointestinal Section Department of Internal MedicineVA North Texas Healthcare System

AIMTo determine if the lymphocyte-to-monocyte ratio (LMR) could be helpful in predicting survival in patients with pancreatic adenocarcinoma. METHODSWe retrospectively reviewed the medical records of all patients diagnosed with pancreatic adenocarcinoma in the VA North Texas Healthcare System from January 2005 to December 2010. The LMR was calculated from peripheral blood cell counts obtained at the time of diagnosis of pancreatic cancer by dividing the absolute lymphocyte count by the absolute monocyte count. A Univariable Cox regression analysis was performed using these data, and hazard ratios (HR) and 95%CI were calculated. The median LMR (2.05) was used to dichotomize patients into high-LMR and low-LMR groups and the log rank test was used to compare survival between the two groups. RESULTSWe identified 97 patients with pancreatic adenocarcinoma (all men, 66% white, 30% African-American). The mean age and weight at diagnosis were 66.0 ± 0.9 (SEM) years and 80.4 ± 1.7 kg respectively. Mean absolute lymphocyte and monocyte values were 1.50 ± 0.07 K/μL and 0.74 ± 0.03 K/μL respectively. Mean, median and range of LMR was 2.36, 2.05 and 0.4-12 respectively. In the univariable Cox regression analysis, we found that an increased LMR was a significant indicator of improved overall survival in patients with pancreatic adenocarcinoma (HR = 0.83; 95%CI: 0.70-0.98; P = 0.027). Kaplan-Meier analysis revealed an overall median survival of 128 d (95%CI: 80-162 d). The median survival of patients in the high-LMR (> 2.05) group was significantly greater than the low-LMR group (≤ 2.05) (194 d vs 93 d; P = 0.03), validating a significant survival advantage in patients with a high LMR. CONCLUSIONThe LMR at diagnosis is a significant predictor for survival and can provide useful prognostic information in the management of patients with pancreatic adenocarcinoma.

关键词： Prognosis Lymphocyte-to-monocyte ratio Pancreatic adenocarcinoma Mortality Biomarker

Pharmacotherapy for the management of achalasia: Current status, challenges and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 145-155页

作者： Ammar Nassri zeeshan ramzan Department of Internal Medicine University of Texas at Austin Dell Medical School Gastrointestinal Section Department of Internal Medicine VA North Texas Healthcare System Department of Medicine Division of Gastroen-terology and Hepatology University of Texas Southwestern Medical Center at Dallas

This article reviews currently available pharmacological options available for the treatment of achalasia, with a special focus on the role of botulinum toxin(BT) injection due to its superior therapeutic effect and side effect profile. The discussion on BT includes the role of different BT serotypes, better pharmacological formulations, improved BT injection techniques, the use of sprouting inhibitors, designer recombinant BT formulations and alternative substances used in endoscopic injections. The large body of ongoing research into achalasia and BT may provide a stronger role for BT injection as a form of minimally invasive, cost effective and efficacious form of therapy for patients with achalasia. The article also explores current issues and future research avenues that may prove beneficial in improving the efficacy of pharmacological treatment approaches in patients with achalasia.

关键词： Botulinum toxin Pharmacotherapy Botox Achalasia Sp