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ntraoperative ultrasound assistance in the resection of small, leep-seated, or ill-defined intracerebral lesions

chinese Medical Journal 2011年第20期124卷 3302-3308页

作者： WANG Yi-da WANG Yi MAO Ying WANG Yong zee chi-shing Department of Ultrasound Huashan Hospital Affiliated to Fudan University Shanghai 200040 China Department of Neurosurgery Huashan Hospital Affiliated to Fudan University Shanghai 200040 China Department of Radiology Keck School of Medicine University of Southern California Los Angeles CA 90089 USA

Background Intraoperative ultrasound （IOUS） has been procedures. In this study, we aimed to evaluate the potential the resection of small, deep-seated, or ill-defined lesions. ncreasingly used as a guiding tool during neurosurgical application of intraoperative ultrasound assisted surgery in Methods Eighty-six consecutive patients with small, deep-seated, or ill-defined intracerebral lesions were studied prospectively. An improved intraoperative imaging technique and surgical setup were practiced during the surgery. IOUS was performed in three orthogonal imaging planes （horizontal, coronal and sagittal）. Results Histopathological diagnoses of these 86 cases included cavernomas, metastases, hemangioblastomas, gliomas, and radiation necrosis. Forty-seven of the 86 lesions （54.7%） were small and deep-seated, 34/86 （39.5%） were ill-defined, and 5/86 （5.8%） were small, deep-seated, and ill-defined. Sonograms in the horizontal plane were obtained in all 86 cases. Sonograms in the sagittal plane and in the coronal plane were obtained only in 52 cases and in 46 cases, respectively, due to technical limitation. In 13 cases, sonograms in all three orthogonal planes were available. All lesions were successfully identified and localized by IOUS. Total resection was performed in 67 lesions （77.9%） and partial resection was performed in 19 lesions （22.1%）. Conclusions We propose IOUS to be performed in three orthogonal planes when surgery is planned for small, deep-seated, or ill-defined brain lesions. By applying this simple, improved technique, surgeons can perform resection of these lesions precisely.

关键词： brain neoplasms neurosurgery intraoperative ultrasound magnetic resonance imaging

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Differentiation of white and red thrombus with magnetic resonance imaging： a phantom study

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chinese Medical Journal 2012年第11期125卷 1889-1892页

作者： HU Xing-yue GE Zu-feng zee chi-shing GONG Xiang-yang Department of Neurology Sir Run Run Shaw Hospital Zhejiang University College of Medicine Hangzhou Zhejiang Province 310016 China Department of Radiology Sir Run Run Shaw Hospital Zhejiang University College of Medicine Hangzhou Zhejiang Province 310016 China Department of Radiology Fenghua People＇s Hospital Ningbo 315500 Zhejiang Province China Department of Radiology USC University Hospital Los Angels CA 90033 USA

Background An early identification of the composition of arterial thrombus may have diagnostic, therapeutic, and prognostic implications. The variation of magnetic resonance （MR） signal intensity between white and red thrombi, especially in the susceptibility sensitive MR sequence, remains unknown. Our research was to evaluate the feasibility of MRI in differentiating of white and red thrombi with a phantom study. Methods A total of 12 red and 12 white thrombi were prepared with the venous blood. Examination of the phantom was completed using a 3.0T MR unit, including fluid attenuated inversion recovery （FLAIR） T1, T2-weighted imaging （T2WI）, FLAIR T2, T2＊ gradient echo （T2＊GRE） imaging, and susceptibility weighted angiography sequences （SWAN）. MR signal intensity patterns of the thrombi were objectively classified as hyperintensity, isointensity and hypointensity, compared with the background agar. The volume of thrombus was calculated and correlated with its signal intensity. Results For white thrombi, 11/12 clots showed hyperintensity and 1/12 showed isointensity in FLAIR T1 images. In T2WI, 6/12 clots showed hyperintensity, 3/12 isointensity, and 3/12 hypointensity. In FLAIR T2, 8/12 clots showed hyperintensity and 4/12 showed isointensity. In T2＊GRE, 3/12 clots showed hyperintensity and the remaining 9/12 clots showed isointensity. In SWAN, 5/12 clots demonstrated hyperintensity and 7/12 isointensity. For the red thrombus, 12/12 clots demonstrated hyperintensity in FLAIR T1, T2WI, and FLAIR T2 sequences. In T2＊GRE and SWAN sequences, 3/12 clots displayed hypointensity and the remaining 9/12 clots showed slight hyperintensity. Thrombi with hypointensity displayed in T2＊GRE and SWAN sequences were significantly larger than those with hyperintensity. Conclusions Differentiation of white and red thrombi with conventional MR sequence is unreliable, because both kinds of thrombi do not possess unique signal intensity features in these sequences. Red thrombus may or m

关键词： thrombus magnetic resonance imaging, phantom study susceptibility weighted imaging

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磁共振弥散张量成像定量分析复发-缓解型多发性硬化患者表现正常的脑干白质纤维束

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中国医学影像技术 2010年第3期26卷 460-463页

作者：周福庆 zee chi-shing 龚洪翰张兴伟 SHIROISHI Mark 南昌大学第一附属医院影像科江西南昌330006 Department of Neuroradiology Keck School of MedicineUniversity of Southern Californialosangeles90033 复旦大学附属中山医院放射科上海200032

目的应用磁共振弥散张量成像(DTI)定量分析复发-缓解型多发性硬化(RRMS)患者表现正常的脑干白质纤维束的改变。方法对50例RRMS患者(RRMS组)及25名年龄和性别相匹配的健康志愿者(对照组)行磁共振扫描,获取常规MR图像和DTI图像。比较两组... 详细信息

目的应用磁共振弥散张量成像(DTI)定量分析复发-缓解型多发性硬化(RRMS)患者表现正常的脑干白质纤维束的改变。方法对50例RRMS患者(RRMS组)及25名年龄和性别相匹配的健康志愿者(对照组)行磁共振扫描,获取常规MR图像和DTI图像。比较两组脑干主要纤维束(皮质脊髓束/皮质脑桥束、小脑上、中、下脚纤维束和内侧丘系纤维束)的部分各向异性分数(FA)和平均弥散系数(MD)的变化。结果排除年龄、性别等因素影响后,经ANCOVA协方差分析,RRMS组患者皮质脊髓束/皮质脑桥束(L:P=0.030;R:P=0.020)、小脑下脚(L:P=0.030;R:P=0.037)、小脑上脚(L:P=0.036;R:P=0.041)、内侧丘系(L:P=0.014;R:P=0.035)的FA值较对照组明显降低。RRMS组患者皮质脊髓束/皮质脑桥束(L:P=0.004;R:P=0.046)、小脑下脚(L:P=0.047;R:P=0.011)、小脑上脚(L:P=0.021;R:P=0.011)、内侧丘系(L:P=0.002;R:P=0.044)的MD值较对照组明显增高。小脑中脚的MD值及FA值两组间差异均无统计学意义(P>0.05)。RRMS患者表现正常脑干白质纤维束的MD值及FA值与脑实质分数(BPF)、T2病灶容积之间均无相关性。结论RRMS患者表现正常脑干白质纤维束DTI的异常发现,提示上述纤维束存在微观病变,推测病变可能是局部隐匿性病灶导致的髓鞘脱失、轴突破坏。

关键词：多发性硬化,复发-缓解型弥散张量成像部分各向异性分数神经纤维脑干

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Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs W.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

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Subtraction Perfusion CT: A Technical Note

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Advances in Computed Tomography 2013年第3期2卷 91-95页

作者： Xiu-Jun Yang Wei Li chi-shing zee Department of Radiology Keck School of Medicine University of Southern California Los Angeles USA Department of Radiology Shanghai Eighth People’s Hospital Shanghai China

It is challenging to attempt to obtain CT perfusion (CTP) images of the hyperdense tissues, which could conceal the density of contrast material during perfusion study. We report a new technique of subtraction CTP (SCTP) to compensate the shortcomings. SCTP post-processed by perfusion software for the data of post-perfusion images subtracting pre-perfusion corresponding images slice by slice in CTP source images is technically feasible without any adverse effects on patients. It provides a new functional imaging with quantitatively hemodynamic indexes of tissue microcirculation and reflects accurately the change of blood flow in tissues and organs.

关键词： Tomography X-Ray Computed Perfusion Imaging Subtraction Technology Subtraction Computed Tomographic Perfusion

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复发-缓解型多发性硬化投射纤维束定量DTI

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放射学实践 2010年第11期25卷 1194-1197页

作者：周福庆龚洪翰 chi-shing zee 南昌大学第一附属医院影像科南昌330006 Department of Neuroradiology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCaliforniausa90033

目的:探讨复发-缓解型多发性硬化(RRMS)患者投射纤维定量扩散张量改变。方法:20例RRMS患者及年龄和性别相匹配的20例健康志愿者(对照组)行MRI扫描,获取常规MRI及DTI图像,分别进行测量分析,比较2组投射纤维的部分各向异性指数(FA)和平均... 详细信息

目的:探讨复发-缓解型多发性硬化(RRMS)患者投射纤维定量扩散张量改变。方法:20例RRMS患者及年龄和性别相匹配的20例健康志愿者(对照组)行MRI扫描,获取常规MRI及DTI图像,分别进行测量分析,比较2组投射纤维的部分各向异性指数(FA)和平均扩散系数(MD)值的变化。主要纤维束包括丘脑前辐射(atr)、丘脑上辐射(str)、丘脑后辐射(ptr)、皮质延髓束(cpt)、皮质脊髓束(cst)等。结果:RRMS组患者与健康对照组的FA值比较:ptr(左侧:0.541±0.141 vs 0.628±0.153;右侧:0.512±0.079 vs 0.560±0.102)、cpt/atr(左侧:0.421±0.118 vs 0.503±0.104;右侧:0.437±0.064 vs 0.512±0.102)、cpt/ptr(左侧:0.405±0.056 vs 0.500±0.078;右侧:0.427±0.057 vs 0.496±0.083)、cpt/cst/str(左侧:0.476±0.115 vs 0.554±0.056;右侧:0.462±0.095 vs 0.520±0.074),RRMS组的FA值均较健康对照组低,2组间差异有统计学意义(P0.05)。RRMS组患者与健康对照组的MD值比较:cpt/ptr(左侧:0.928±0.102 vs 0.853±0.105;右侧:0.949±0.165 vs 0.859±0.141)、cpt/cst/str(左侧:0.811±0.137 vs 0.772±0.093;右侧:0.868±0.167 vs 0.784±0.128)的MD值差异有统计学意义(P0.05)。结论:多发性硬化患者双侧ptr、cpt/atr、cpt/ptr、cpt/cst/str存在FA值减小,双侧cpt/ptr、cpt/cst/str存在MD值的增高,提示在投射纤维中上述白质纤维束存在结构改变,DTI可以作为反映RRMS投射纤维微观病理改变的敏感检查指标。

关键词：多发性硬化扩散张量成像投射纤维部分各向异性

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Single-molecule surface-enhanced Raman scattering： Current status and future perspective

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Frontiers of physics 2014年第1期9卷 25-30页

作者： zee Hwan Kim Department of Chemistry Korea University Seoul 136-701 Korea

The single-molecule surface-enhanced Raman scattering （smSERS） has been extensively studied after the initial observation in 1997, yet there still exist unsettled issues in the fundamental mechanism of smSERS. In th... 详细信息

关键词： plasmonics nanoparticles molecular vibration Raman scattering

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多发性硬化早期胼胝体的DTI改变

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中国临床医学影像杂志 2010年第4期21卷 233-235,260页

作者：周福庆 chi-shing zee 龚洪翰谭令 Mark Shiroishi 南昌大学第一附属医院放射科江西南昌330006 Department of Neuroradiology Keck School of Medicine University of Southern California 上海交通大学瑞金医院放射科上海200025

目的:探讨多发性硬化(MS)早期常规MR扫描表现正常的胼胝体的磁共振弥散张量成像(DTI)的改变。方法:20例病程相对较短(平均2.3年)的MS患者和20个年龄性别相匹配的健康志愿者为对照进行MR扫描,获取高分辨常规MRI(T1WI、T2WI、FLAIR)图像及... 详细信息

目的:探讨多发性硬化(MS)早期常规MR扫描表现正常的胼胝体的磁共振弥散张量成像(DTI)的改变。方法:20例病程相对较短(平均2.3年)的MS患者和20个年龄性别相匹配的健康志愿者为对照进行MR扫描,获取高分辨常规MRI(T1WI、T2WI、FLAIR)图像及DTI图像,获得表现正常胼胝体(NACC)和额、枕部表现正常白质(NAWM)的部分各向异性指数(FA)值和平均扩散系数(MD)值。结果:早期MS患者的NACC与正常对照比较,其FA值显著下降(P<0.001)、MD值显著增加(P<0.001);早期MS患者额、枕部的NAWM和正常对照比较,其FA值(P=0.216)、MD值(P=0.673)差异均无统计学意义。NACC的平均MD值和反映脑实质中央性萎缩的Evans指数间存在相关性(r=0.648,P=0.043)。结论:定量磁共振弥散张量值(FA值和MD值)的变化表明MS疾病早期损害优先出现在胼胝体,胼胝体的结构特点可能是其在MS早期易受损害的重要原因。定量DTI可用于监控和评估早期MS患者NACC的改变和预后。

关键词：多发性硬化胼胝体磁共振成像

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功能磁共振成像在多发性硬化中的应用进展(英文)

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磁共振成像 2011年第4期2卷 252-259页

作者：周福庆 chi-shing zee 南昌大学第一附属医院放射科南昌330006 Department of Radiology Keck School of MedicineUniversity of Southern California

多发性硬化(MS)的一个重要的临床表现是认知障碍。有越来越多的证据显示,认知障碍的程度不仅与组织损坏程度有关,还同MS患者组织受损、组织修复及大脑皮层重组等因素间复杂的制约平衡关系密切相关。神经可塑性能够在大脑中散乱分布多个... 详细信息

多发性硬化(MS)的一个重要的临床表现是认知障碍。有越来越多的证据显示,认知障碍的程度不仅与组织损坏程度有关,还同MS患者组织受损、组织修复及大脑皮层重组等因素间复杂的制约平衡关系密切相关。神经可塑性能够在大脑中散乱分布多个病灶的情况下使得大脑维持正常运行,而功能磁共振成像(fMRI)及静息态fMRI能够为我们提供有关神经可塑性程度及性质的信息。MS患者除了临床表型之外,在对他们的视觉、认知及运动系统进行研究的过程中,还发现其大脑执行某项任务的区域发生了改变,或者使用了正常人脑在执行该任务时不会使用的区域。这些功能性改变与传统MRI中T2像可见病灶内及其周边的脑损伤范围及其严重程度,以及中枢神经系统(CNS)某些结构,包括脊髓及视神经的参与有关。脑功能异常不仅在急性复发之后,而且在病情稳定期也在随时间而不断变化。本文对任务fMRI及静息态fMRI在MS诊疗中的作用,fMRI技术的研究成果及其临床应用现状进行了总结,并对其未来发展方向进行展望。

关键词：多发性硬化功能磁共振成像认知障碍静息态中枢神经系统

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Importance of Modeling Heterogeneities and Correlation in Reservoir Properties in Unconventional Formations: Examples of Tight Gas Reservoirs

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Journal of Earth Science 2021年第4期32卷 809-817页

作者： Shengli Li Y.zee Ma Ernest Gomez School of Energy Resources China University of GeoscienceBeijing 100083China Information Solution SchlumbergerDenver CO 80202USA

We present lithofacies classifications for a tight gas sandstone reservoir by analyzing hierarchies of *** use principal component analysis(PCA)to overcome the two level of heterogeneities,which results in a better lithofacies classification than the traditional cutoff *** classical volumetric method is used for estimating oil/gas in-place resources in the petroleum industry since its inception is not accurate because it ignores the heterogeneities of and correlation between the petrophysical *** present the importance and methods of accounting for the heterogeneities of and correlation between petrophysical properties for more accurate hydrocarbon volumetric *** also demonstrate the impacts of modeling the heterogeneities and correlation in porosity and hydrocarbon saturation for hydrocarbon volumetric estimations with a tight sandstone gas ***,geoscientists have traditionally considered that small-scale heterogeneities only impact subsurface fluid flow,but not impact the hydrocarbon resource volumetric *** show the importance of modeling small-scale heterogeneities using fine cell size in reservoir modeling of unconventional resources for accurate resource assessment.

关键词： heterogeneity petrophysical property correlations Simpson’s paradox porosity gas saturation hydrocarbon volumetrics change of support problem

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