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Multi-layer perceptron-based data-driven multiscale modelling of granular materials with a novel Frobenius norm-based internal variable

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2198-2218页

作者： Mengqi Wang Y.T.Feng Shaoheng Guan Tongming qu Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySwanseaWalesSA18EPUK Institute of Theoretical and Computational Physics Graz University of TechnologyGraz8010Austria Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyClearwater BayKowloonHong KongChina

One objective of developing machine learning(ML)-based material models is to integrate them with well-established numerical methods to solve boundary value problems(BVPs).In the family of ML models,recurrent neural networks(RNNs)have been extensively applied to capture history-dependent constitutive responses of granular materials,but these multiple-step-based neural networks are neither sufficiently efficient nor aligned with the standard finite element method(FEM).Single-step-based neural networks like the multi-layer perceptron(MLP)are an alternative to bypass the above issues but have to introduce some internal variables to encode complex loading *** this work,one novel Frobenius norm-based internal variable,together with the Fourier layer and residual architectureenhanced MLP model,is crafted to replicate the history-dependent constitutive features of representative volume element(RVE)for granular *** obtained ML models are then seamlessly embedded into the FEM to solve the BVP of a biaxial compression case and a rigid strip footing *** obtained solutions are comparable to results from the FEM-DEM multiscale modelling but achieve significantly improved *** results demonstrate the applicability of the proposed internal variable in enabling MLP to capture highly nonlinear constitutive responses of granular materials.

关键词： Granular materials History-dependence Multi-layer perceptron(MLP) Discrete element method FEM-DEM Machine learning

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Controlling secondary flow in high-lift low-pressure turbine using boundary-layer slot suction

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Chinese Journal of Aeronautics 2024年第3期37卷 21-33页

作者： Xiao qu Liunan LI Yingjie ZHANG Xingen LU Junqiang ZHU Yanfeng ZHANG School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100190China

The design of high-lift Low-Pressure Turbines(LPTs)causes the separation of the boundary layer on the suction side of the blade and leads to a strong secondary *** present study aims to minimize secondary losses through endwall slot suction and incoming wakes in a front-loaded high-lift LPT cascade with Zweifel of 1.58 under low Reynolds number of *** slotted schemes for the boundary layer of the endwall were designed(Plan A and Plan B),and the effects of suction mass flow on secondary flow were *** underlying physics of the endwall boundary layer of the suction and secondary flow under unsteady wakes was *** results show that slot suction at the endwall boundary layer can significantly suppress the secondary flow by removing low-momentum *** A and B significantly reduced the secondary kinetic energy by 44.2%and 36.9%,respectively,compared with the baseline cascade at the suction mass flow ratios of 1%.With an increase in the mass flow ratio of suction,the secondary flow was gradually reduced in both Plans A and *** is more beneficial to control the secondary flow to destroy the intersection of the pressure side and suction side of the horseshoe vortex before it develops into a passage *** unsteady wakes,the combined effects of incoming wakes and endwall boundary layer suction can further suppress the secondary flow at the suction mass flow ratios of 2%for Plan A,because the positive and negative vorticity inside upstream wakes accelerated the mixing of the main flow and secondary flow and thus increased the energy of secondary vortices.

关键词： Low-pressure turbine Secondary flow Flow control Boundary-layer suction Incoming wake

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An Effective Meshless Approach for Inverse Cauchy Problems in 2D and 3D Electroelastic Piezoelectric Structures

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2955-2972页

作者： Ziqiang Bai Wenzhen qu Guanghua Wu School of Automation Qingdao UniversityQingdao266071China School of Mathematics and Statistics Qingdao UniversityQingdao266071China Weifang University of Science and Technology Weifang262700China

In the past decade,notable progress has been achieved in the development of the generalized finite difference method(GFDM).The underlying principle of GFDM involves dividing the domain into multiple *** each sub-domain,explicit formulas for the necessary partial derivatives of the partial differential equations(PDEs)can be obtained through the application of Taylor series expansion and moving-least square approximation ***,the method generates a sparse coefficient matrix,exhibiting a banded structure,making it highly advantageous for large-scale engineering *** this study,we present the application of the GFDM to numerically solve inverse Cauchy problems in two-and three-dimensional piezoelectric *** our preliminary numerical experiments,we demonstrate that the proposed GFDMapproach shows great promise for accurately simulating coupled electroelastic equations in inverse problems,even with 3%errors added to the input data.

关键词： Generalized finite difference method meshless method inverse Cauchy problems piezoelectric problems electroelastic analysis

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Determining Sets and Determining Numbers of Finite Groups

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Algebra Colloquium 2024年第1期31卷 111-128页

作者： Dengyin Wang Chi Zhang Haipeng qu School of Mathematics China University of Mining and Technology XuzhouJiangsu 221116China School of Mathematics and Computer Science Shanxi Normal University LinfenShanxi 041000China

A subset D of a group G is a determining set of G if every automorphism of G is uniquely determined by its action on D,and the determining number of G,a(G),is the cardinality of a smallest determining set.A group G is called a DEG-group if α(G)equals(G),the generating number of *** main results are as *** groups with determining number 0 or 1 are classified;finite simple groups and finite nilpotent groups are proved to be DEG-groups;for a given finite group H,there is a DEG-group G such that H is isomorphic to a normal subgroup of G and there is an injective mapping from the set of all finite groups to the set of finite DEG-groups;for any integer k≥2,there exists a group G such that α(G)=2 and(G)≥k.

关键词： determining number automorphisms nilpotent groups

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Polyoxometalates: metallodrug agents for combating amyloid aggregation

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National Science Review 2024年第7期11卷 279-291页

作者： Mengmeng Ma Zhenqi Liu Huisi Zhao Haochen Zhang Jinsong Ren Xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China

Alzheimer's disease(AD) is a devastating neurodegenerative disease that affects ～50 million people globally. The accumulation of amyloid-β(Aβ) plaques, a predominant pathological feature of AD, plays a crucial role in AD pathogenesis. In this respect, Aβ has been regarded as a highly promising therapeutic target for AD treatment. Polyoxometalates(POMs) are a novel class of metallodrugs being developed as modulators of Aβ aggregation, owing to their negative charge, polarity, and three-dimensional *** traditional discrete inorganic complexes, POMs contain tens to hundreds of metal atoms,showcasing remarkable tunability and diversity in nuclearities, sizes, and shapes. The easily adjustable and structurally variable nature of POMs allows for their favorable interactions with Aβ. This mini-review presents a balanced overview of recent progress in using POMs to mitigate amyloidosis. Clear correlations between anti-amyloid activities and structural features of POMs are also elaborated in detail. Finally, we discuss the current challenges and future prospects of POMs in combating AD.

关键词： amyloid inhibition metallodrug polyoxometalate amyloid-β Alzheimer's disease

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Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong Liu Yunbo Xie Bao-Peng Yang Huan-yue Wen Peng-Hui Yang Jin-E Lu Yan Liu Xi Chen Meng-Meng qu Yang Zhang Wei-Guo Hong Yong-Gang Li Junliang Fu Fu-Sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

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Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma:Based on muti-omics analysis and vitro assay

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Oncology Research 2024年第2期32卷 393-407页

作者： HONGYUAN LIANG YANQIU LI YONGGANG qu LINGYUN ZHANG Department of Radiology Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Clinical Medicine China Medical UniversityShenyangChina Department of Medical Oncology The First Hospital of China Medical UniversityShenyangChina

Advanced LUAD shows limited response to treatment including immune *** the development of sequencing omics,it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response *** GSE72094(n=386)and GSE31210(n=226)gene expression profile data in the GEO database,we identified genes associated with lung adenocarcinoma(LUAD)death using tools such as“edgeR”and“maftools”and visualized the characteristics of these genes using the“circlize”R *** constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression *** calculating the cell death index(CDI)of each individual,we divided LUAD patients into high and low CDI groups and examined the relationship between CDI and overall survival time by principal component analysis(PCA)and Kaplan-Meier *** also used the“ConsensusClusterPlus”tool for unsupervised clustering of LUAD subtypes based on model *** addition,we collected data on the expression of immunomodulatory genes and model genes for each cohort and performed tumor microenvironment *** also used the TIDE algorithm to predict immunotherapy responses in the CDI ***,we studied the effect of PRKCD on the proliferation and migration of LUAD cells through cell culture *** study utilized the TCGA-LUAD cohort(n=493)and identified 2,901 genes that are differentially expressed in patients with *** KEGG and GO enrichment analysis,these genes were found to be involved in a wide range of biological *** study also used univariate Cox regression models and LASSO regression analyses to identify 17 candidate genes that were best associated with mortality prognostic risk *** comparing the overall survival(OS)outcomes of patients with different CDI values,it was found that increased CDI levels were significantly associated with lower OS *** addition,the study used unsupervised cluster analysis to d

关键词： Lung adenocarcinoma Programmed cell death Iron-death Drug sensitivity Cancer therapy

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Analysis of Extended Fisher-Kolmogorov Equation in 2D Utilizing the Generalized Finite Difference Method with Supplementary Nodes

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 267-280页

作者： Bingrui Ju Wenxiang Sun Wenzhen qu Yan Gu Key Laboratory of Road Construction Technology and Equipment of MOE Chang’an UniversityXi’an710018China School of Mathematics and Statistics Qingdao UniversityQingdao266071China

In this study,we propose an efficient numerical framework to attain the solution of the extended Fisher-Kolmogorov(EFK)*** temporal derivative in the EFK equation is approximated by utilizing the Crank-Nicolson *** temporal discretization,the generalized finite difference method(GFDM)with supplementary nodes is utilized to address the nonlinear boundary value problems at each time *** supplementary nodes are distributed along the boundary to match the number of boundary *** incorporating supplementary nodes,the resulting nonlinear algebraic equations can effectively satisfy the governing equation and boundary conditions of the EFK *** demonstrate the efficacy of our approach,we present three numerical examples showcasing its performance in solving this nonlinear problem.

关键词： Generalized finite difference method nonlinear extended Fisher-Kolmogorov equation Crank-Nicolson scheme

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A demand forecasting model for urban air mobility in Chengdu,China

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Green Energy and Intelligent Transportation 2024年第3期3卷 11-23页

作者： Wenqiu qu Jie Huang Chenglong Li Xiaohan Liao State Key Laboratory of Resources and Environment Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100101China Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Civil Aviation Flight University of China Guanghan618307China The Research Center for UAV Applications and Regulation CASBeijing 100101China

The successful application of new technologies such as remotely piloted aircraft systems,distributed electric propulsion systems,and automatic control systems on electric vertical take-off and landing(eVTOL)aircraft has prompted Urban Air Mobility(UAM)to be mentioned *** is a newly raised transport mode of using eVTOL aircraft to transport people and cargo in urban areas,which is thought to share some of the traffic on the *** of the prerequisites for UAM to operate on a regular basis is that its demand can support the operating costs,so forecasting UAM demand is *** conduct UAM demand forecasting based on the four-step method,focusing on improving the third-step modal split,and propose a demand forecasting model based on the logit *** model combines a nested logit(NL)model with a multinomial logit(MNL)model to solve the problem of non-existent UAM sharing *** use Chengdu,China as an example,and focus on forecasting the UAM traffic demand in 2030 with the help of the four-step *** results show that UAM is suitable for shared operation during the early *** a fully shared operation,the UAM share rate increases by 0.73%for every kilometer increase in ***,UAM is more competitive than other modes for delivery distances exceeding 15 ***,using the distributions of the share rate and traffic flow pattern from the simulation,we propose the routes that can be prioritized for UAM operations in Chengdu.

关键词： Urban air mobility Four-step method Demand forecasting Logit model Share rate

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Navigating the Challenges of Emerging Contaminants to Protect Human and Ecological Health

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Engineering 2024年第6期37卷 1-2页

作者： Jiuhui qu Michael R.Hoffmann Gang Yu School of Environment Tsinghua UniversityBeijing 100084China Linde-Robinson Laboratories California Institute of TechnologyPasadenaCA 91125USA Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal UniversityZhuhai 519000China

Emerging contaminants are defined as chemicals that are not currently(or have only recently been)regulated and about which there are concerns regarding their impact on human or ecological *** contaminants are widely detected in air,water,soil,sediment,and biotic *** is against this backdrop of urgency that we have curated this special issue titled“Emerging Contaminants Control:Science and Technology,”with the goal of uniting the latest scientific insights and pioneering strategies to address this global *** special issue embarks on a comprehensive examination of the emerging contaminants dilemma,covering aspects such as risk assessment,remediation technologies,environmental surveying,and the broader implications for *** a collection of articles,we probe deep into the core of this issue,showcasing studies that range from appraising environmental risks to forging new methods for treatment and scrutinizing the occurrence of contaminants across different environmental settings.

关键词： Ecological surveying environmental

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