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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Some Inequalities and Limit Theorems Under Sublinear Expectations

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 451-462页

作者： ze-Chun HU Yan-Zhi yang College of Mathematics Sichuan University Department of Mathematics Nanjigng University

In this note, we study inequality and limit theory under sublinear expectations. We mainly prove Doob＇s inequality for submartingale and Kolmogrov＇s inequality. By Kolmogrov＇s inequality, we obtain a special version of Kolmogrov＇s law of large numbers. Finally, we present a strong law of large numbers for independent and identically distributed random variables under one-order type moment condition.

关键词： sublinear expectation inequality the law of large numbers submartingale

Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan Pan Fu-yong Jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers):A case report

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World Journal of Clinical Cases 2022年第30期10卷 11146-11154页

作者： yong-Xun Zhao ze yang Li-Bin Ma Jia-Yao Dang Hui-Ying Wang The Seventh Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medical School The First Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND With the advancement of medical technology and improvement in living standards,the incidence of multiple primary cancers has gradually *** particular,tumors of the digestive system account for a large proportion of multiple primary *** diagnosis and treatment of chronic myeloid leukemia,particularly with synchronous gastric cancer,at the first consultation is relatively *** SUMMARY Herein,we present the case of a middle-aged man who was referred to the Department of Hematology owing to an elevated white blood cell *** the examination,he was diagnosed with chronic myeloid leukemia and was administered *** months after the initial diagnosis,he visited our hospital again for abdominal pain,and further examination revealed gastric *** discussion with a multidisciplinary team,S-1(Tegafur,Gimeracil,and Oteracil Potassium Capsules) combined with oxaliplatin—SOX regimen—was ***,the patient’s condition rapidly *** developed colonic obstruction and underwent an ostomy;however,he died less than 6 months after the initial *** Multiple primary cancers are influenced by environmental and genetic factors;a standardized multidisciplinary discussion plays a key role in treatment.

关键词： Multiple primary cancers Gastric cancer Leukemia Leukemia inhibitory factor Case report

Assessment of the Genetic Relationship and Diversity of Mango and Its Relatives by cpISSR Marker

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Agricultural Sciences in China 2007年第2期6卷 137-142页

作者： HE Xin-hua GUO yong-ze LI yang-rui OU Shi-jin Guangxi Crop Genetic Improvement and Biotechnology Laboratory Guangxi Academy of Agricultural Sciences Nanning 530007 P.R. China College of Agriculture Guangxi University Nanning 530004 P.R.China

Chloroplast inter-simple sequence repeat markers in mango were developed and used to analyze the genetic relationship and diversity of mango and its relatives. Thirty-six mango cultivars （Mangifera indica L.） and its relative species collected from the fruit germplasm collection in the Guangxi Academy of Agricultural Sciences, China, were examined by ISSR-PCR with chloroplast DNA （cpDNA）. Eight better primers for chloroplast DNA that provided reproducible, polymorphic DNA amplification patterns were screened from 50 ISSR primers and used for UPGMA analysis. According to the band patterns with 8 primers for chloroplast DNA, all cultivars tested were distinguished from each other and these showed ample genetic diversity; the average percentage of polymorphism was 77.2%. The 36 samples could be clustered into four groups by UPGMA analysis at the coefficient 0.74. The results indicated that the cplSSR marker was a new powerful tool for the identification of mango cultivars or its relative species, and their genetic relationship analysis and diversity evaluation.

关键词： Mangifera indica ISSR cpDNA genetic relationship genetic diversity

Redshift Dependence of the Low-energy Spectral Index of Gamma-Ray Bursts Revisited

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Research in Astronomy and Astrophysics 2023年第12期23卷 57-62页

作者： Xiao-Li Zhang yong-Feng Huang ze-Cheng Zou Department of Physics Nanjing UniversityNanjing 210023China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

A negative correlation was found to exist between the low-energy spectral index and the redshift of gamma-ray bursts(GRBs)by Amati et *** was later confirmed by Geng&Huang and Gruber et al.,but the correlation was also found to be quite dispersive when the sample size was significantly *** this study,we have established two even larger samples of GRBs to further examine the *** of our samples consists of316 GRBs detected by the Swift satellite,and the other one consists of 80 GRBs detected by the Fermi *** is found that there is no correlation between the two parameters for the Swift sample,but there does exist a weak negative correlation for the Fermi *** correlation becomes even more significant when the spectral index at the peak flux is *** is argued that the absence of the correlation in the Swift sample may be due to the fact that Swift has a very narrow energy response so that it could not measure the low-energy spectral index accurately *** studies based on even larger GRB samples are solicited.

关键词： (stars:)gamma-ray burst general-methods statistical-catalogs

Short-and long-term outcomes following laparoscopic vs open surgery for pathological T4 colorectal cancer: 10 years of experience in a single center

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World Journal of Gastroenterology 2018年第1期24卷 76-86页

作者： Zi-Feng yang De-Qing Wu Jun-Jiang Wang ze-Jian Lv yong Li Department of General Surgery Guangdong General HospitalGuangdong Academy of Medical Sciences

AIM To evaluate the short-term and long-term outcomes following laparoscopic vs open surgery for pathological T4(pT 4) colorectal *** We retrospectively analyzed the short-and long-term outcomes of proven p T4 colorectal cancer patients who underwent complete resection by laparoscopic or open surgery from 2006 to 2015 at Guangdong General *** A total of 211 p T4 colorectal cancer patients were included in this analysis, including 101 cases in thelaparoscopy(LAP) group and 110 cases in the open surgery(OPEN) group [including 15(12.9%) cases of conversion to open surgery]. Clinical information(age, gender, body mass index, comorbidities, American Society of Anesthesiologists score, etc.) did not differ between the two groups. In terms of blood loss, postoperative complications and rate of recovery, the LAP group performed significantly more favorably(P ze the

关键词： pT4 colorectal cancer Laparoscopy Open surgery

Joint user association and resource partition for downlink-uplink decoupling in multi-tier HetNets

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Frontiers of Information Technology & Electronic Engineering 2017年第6期18卷 817-829页

作者： Zhi-yong FENG ze-bing FENG T.Aaron GULLIVER MOE Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications Department of Electrical and Computer Engineering University of Victoria

Traditional cellular networks require the downlink (DL) and uplink (UL) of mobile users (MUs) to be associated with a single base station (BS). However, the power gap between BSs and MUs in different transmission environments results in the BS with the strongest downlink differing from the BS with the strongest uplink. In addition, the significant increase in the number of wireless machine type communication (MTC) devices accessing cellular networks has created a DL/UL traffic imbalance with higher traffic volume on the uplink. In this paper,a joint user association and resource partition framework for downlink-uplink decoupling (DUDe) is developed for a tiered heterogeneous cellular network (HCN). Different from the traditional association rules such as maximal received power and range extension, a coalition game based scheme is proposed for the optimal user association with DUDe. The stability and convergence of this scheme are proven and shown to converge to a Nash equilibrium at a geometric rate. Moreover, the DL and UL optimal bandwidth partition for BSs is derived based on user association considering fairness. Extensive simulation results demonstrate the effectiveness of the proposed scheme,which enhances the sum rate compared with other user association strategies.

关键词： Downlink-uplink decoupling User association Resource partition Heterogeneous cellular network Coalition game

Structure Evolution Mechanism of Poly(acrylonitrile/itaconic acid/acrylamide) during Thermal Oxidative Stabilization Process

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Chinese Journal of Polymer Science 2017年第8期35卷 1020-1034页

作者： zhao-po zeng ze-chun shao 肖茹 yong-gen lu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering Donghua University Shanghai 201620 China

Polyacrylonitrile （PAN） polymers with different compositions were prepared by an efficient aqueous free-radical polymerization technique. Thermal properties of polyacrylonitrile homopolymer （PAN）, poly（acrylonitrile/itaconic acid） [P（AN/IA）] and poly（acrylonitrile/itaconic acid/acrylamide） [P（AN/IA/AM）] were studied by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and thermogravimetry in detail. It was found that AM had the ability to initiate and accelerate thermal oxidative stabilization process, which was confirmed by the lower initiation temperature and broader exothermic peak in P（AN/IA/AM） as compared with that in P（AN/IA） and PAN. The intensity of heat releasing during the thermal treatment was relaxed due to the presence of two separated exothermic peaks. Accompanied by DSC analysis and calculation of the apparent activation energy of cyclization reaction, two peaks were assigned to the ionic and free radical induction mechanisms, respectively. The higher rate constant in P（AN/IA/AM） indicated that the ionic mechanism actually had a kinetic advantage at promoting thermal stability over the free radical mechanism. This study clearly show that the synthesized P（AN/IA/AM） terpolymers possess larger room to adjust manufacture parameters to fabricate high performance of PAN-based carbon fibers.

关键词： PAN terpolymers Structural evolution Thermal oxidative stabilization Thermal analysis Kinetics