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Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis

Engineering 2022年第3期8卷 174-182页

作者： Elaine Laihan Leung Huan-Ling Lai Run-ze Li Hu-Dan Pan ze-bo jiang Ying Li Fu-Gang Duan Jia-Hui Xu Yi-Zhong Zhang A-Xi Shi Chun-Li Wei Fang-Yuan Zhang Xiao-Jun Yao Liang Liu State Key Laboratory of Quality Research in Chinese Medicine&Macao Institute for Applied Research in Medicine and Health&Faculty of Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Pediatrics Pennsylvania State University College of MedicineHersheyPA 17033USA

Secondary amyloid A amyloidosis,a lethal complication,is induced when acute or chronic infection coexists with over-secretion of the serum amyloid A 1(SAA1)protein and deposition in key internal ***,using the whole-exome sequencing method,we identified a novel deleterious mutation SAA1.2 in rheumatoid arthritis(RA)***,the role of SAA1 in RA pathogenesis and its complications remains *** purpose of this study was to determine the pathogenetic roles of SAA1 protein isoforms in RA *** modified an experimental adenovirus infection protocol to introduce SAA1.2 gene alleles into the knee joints of mice and used SAA1.3 and SAA1.5 as *** tomography analysis was applied to determine changes in bone morphology and ***(IHC)analysis,flow cytometry,enzyme-linked immunosorbent assay(ELISA),and real-time polymerase chain reaction(RT-PCR)were used to investigate disease progression and cytokine alterations in the course of adenoviral SAA-induced knee joint inflammation and bone *** found that the arthritis-inducing effect of SAA1.2 transcription in the knee joints and mutant SAA1 protein secretion in blood resulted in the stimulation of immune responses,leading to CD8^(+)T cell and pro-inflammatory cytokine elevation,such as interleukin(IL)-6,IL-22,matrix metalloproteinase(MMP)-3,MMP-9,with subsequent synovial inflammation and bone *** findings indicate that SAA1 protein isoforms,particularly SAA1.2,play a significant role in the induction and progression of RA and may have potential value in the early diagnosis and severity prediction of RA.

关键词： Serum amyloid A 1 Rheumatoid arthritis Pathogenetic Intra-articular

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang Hua-Wei Zhang Xiao-Mei Song Yu-ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Using proteomic approach to discover the treatment mechanism of（Z）3,4,5,4’-trans-tetramethoxystilbene for inhibition of gefitinib-resistant non-small cell lung cancer

Using proteomic approach to discover the treatment mechanism...

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第21届全国色谱学术报告会及仪器展览会

作者： Xing-Xing Fan Xiao-Jun Yao So Wei Xu Vincent Kam-Wai Wong Jian-Xing He Jian Ding Min Huang Jun Huang Da-Kai Xiao ze-bo jiang Yan-Ling Zhou Richard Kin-Ting Kam Liang Liu Elaine Lai-Han Leung State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health Macau University of Science and Technology Guangzhou Institute of Respiratory Disease State Key Laboratory of Respiratory DiseaseThe 1st Affiliated Hospital of Guangzhou Medical College State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academic of Sciences Department Chemical Pathology Faculty of Medicinethe Chinese University of Hong Kong

Calcium is a second messenger which is required for regulation of many cellular processes. However,excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such,selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently,we have identified an effective analogue of resveratrol,（Z）3,4,5,4’-trans-tetramethoxystilbene（TMS） which selectively elevated the intracellular calcium level in gefitinib-resistant（G-R） non-small-cell lung cancer（NSCLC） cells. TMS exhibited significantly inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR was inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum（ER） stress and AMPK activation. Using i TRAQ proteomics analysis,we have further confirmed that mTOR pathway, which is the downstream of AMPK, was significantly suppressed by TMS. JNK, the cross-linker of ER stress and mTOR pathway was significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together,TMS showed promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients.

关键词： (Z)3,4,5,4’-trans-tetramethoxystilbene(TMS) non-small-cell lung cancer gefitinib resistance mTOR and autophagy

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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单宁酸改性互穿网络水凝胶促进断裂跟腱术后的组织重塑

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中国组织工程研究 2025年第4期29卷 721-729页

作者：张博张振江东北京大学第三医院运动医学科北京市100191

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿... 详细信息

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿网络水凝胶,表征水凝胶的微观形貌、力学性能、黏附性能、体外释药性能与生物相容性。②取30只SD大鼠,采用随机数字表法分为假手术组、手术组与水凝胶组,每组10只,后2组建立右后肢跟腱断裂模型,手术组采用改良Kessler法将断裂跟腱重新缝合,水凝胶组采用相同术式缝合断裂跟腱后将单宁酸改性互穿网络水凝胶贴片完全缠绕包裹于断端接合处。术后4周,对断裂跟腱进行影像学检查、组织学评价、生物力学测试及炎症因子水平检测。结果与结论:①扫描电镜下可见单宁酸改性互穿网络水凝胶呈多孔微观结构,孔径为3-10μm,并且水凝胶具备良好的体外释药性能、黏附强度与拉伸强度;CCK-8检测与活/死染色显示,该水凝胶对大鼠骨髓间充质干细胞增殖活性无明显影响,具备良好的生物相容性。②MRI成像显示,与手术组比较,水凝胶组大鼠跟腱呈均一低信号,跟腱前后径厚度减小,与周围组织分界更为明确,表现更接近假手术组。苏木精-伊红与Masson染色显示,手术组大鼠跟腱纤维排列松散混乱,细胞密度增加且排布杂乱,伴有明显炎性细胞浸润,部分区域出现腱内骨化;水凝胶组大鼠跟腱纤维排列有序,细胞密度降低且排布规整,炎性细胞浸润明显减少。手术组大鼠跟腱的拉伸强度低于假手术组(P<0.05),水凝胶组大鼠跟腱的拉伸强度高于手术组(P<0.05)。与假手术组比较,手术组大鼠跟腱中白细胞介素1β、白细胞介素6及肿瘤坏死因子α质量浓度及mRNA表达升高(P<0.05);与手术组比较,水凝胶组3种炎症因子水平及mRNA表达降低。③结果表明,单宁酸改性互穿网络水凝胶可显著抑制局部炎症反应、促进断裂跟腱组织重塑。

关键词：单宁酸水凝胶互穿网络跟腱断裂组织重塑组织再生

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bonding characteristics of the Al_2O_3-metal composite coating fabricated onto carbon steel by combustion synthesis

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International Journal of Minerals,Metallurgy and Materials 2014年第9期21卷 886-893页

作者： Xiao-feng Xue ze-hua Wang ze-hua Zhou Shao-qun jiang jiang-bo Cheng Chang-hao Wang Jia Shao College of Mechanics and Materials Hohai University

The fabrication of an alumina-metal composite coating onto a carbon steel substrate by using a self-propagating high-temperature synthesis technique was demonstrated. The effects of the type and thickness of the pre-coated layer on the binding structure and surface qual- ity of the coating were systematically investigated. The macrostructure, phase composition, and bonding interface between the coating and the substrate were investigated by scanning electronic microscopy （SEM）, X-ray diffraction （XRD）, and energy-dispersive X-ray spectrometry （EDS）. The diffraction patterns indicated that the coating essentially consisted of α-Al2O3, Fe（Cr）, and FeO-Al2O3. With an increase in the thickness of the pre-coated working layer, the coating became more smooth and compact. The transition layer played an important role in enhancing the binding between the coating and the substmte. When the pre-coated working layer was 10 mm and the pre-coated transition layer was 1 ram, a compact structure and metallurgical bonding with the substrate were obtained. Thermal shock test results indicated that the ceramic coating exhibited good thermal shock resistance when the sample was rapidly quenched from 800℃ to room temperature by plunging into water.

关键词： carbon steel combustion synthesis composite coatings phase composition morphology thermal shock resistance

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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Protecting User Privacy in a Multi-Path Information-Centric Network Using Multiple Random-Caches

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Journal of Computer Science & Technology 2017年第3期32卷 585-598页

作者： Wei-bo Chu Li-Fang Wang ze-Jun jiang Chin-Chen Chang School of Computer Science and Technology Northwestern Polytechnical University Xi'an 710072 China Department of Information Engineering and Computer Science Feng Chia University Taichung Taiwan 40724 China

In-network caching is a fundamental mechanism advocated by information-centric networks （ICNs） for efficient content delivery. However, this new mechanism also brings serious privacy risks due to cache snooping attacks. One effective solution to this problem is random-cache, where the cache in a router randomly mimics a cache hit or a cache miss for each content request/probe. In this paper, we investigate the effectiveness of using multiple random-caches to protect cache privacy in a multi-path ICN. We propose models for characterizing the privacy of multi-path ICNs with random-caches, and analyze two different attack scenarios： 1） prefix-based attacks and 2） suffix-based attacks. both homogeneous and heterogeneous caches are considered. Our analysis shows that in a multi-path ICN an adversary can potentially gain more privacy information by adopting prefix-based attacks. Furthermore, heterogeneous caches provide much better privacy protection than homogeneous ones under both attacks. The effect of different parameters on the privacy of multi-path random-caches is further investigated, and the comparison with its single-path counterpart is carried out based on numerical evaluations. The analysis and results in this paper provide insights in designing and evaluating multi-path ICNs when we take privacy into consideration.

关键词： information-centric network (ICN) user privacy cache snooping random-cache multi-path

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Chemical modification of barite for improving the performance of weighting materials for water-based drilling fluids

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Petroleum Science 2024年第1期21卷 551-566页

作者： Li-Li Yang ze-Yu Liu Shi-bo Wang Xian-bo He Guan-Cheng jiang Jie Zhang MOE Key Laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and ProspectingChina University of Petroleum(Beijing)Changping DistrictBeijing102249China MOE Key CNPC Drilling Research Institute Changping DistrictBeijing102206China

With increasing drilling depth and large dosage of weighting materials,drilling fluids with high solid content are characterized by poor stability,high viscosity,large water loss,and thick mud cake,easier leading to reservoir damage and wellbore *** this paper,micronized barite(MB)was modified(mMB)by grafting with hydrophilic polymer onto the surface through the free radical polymerization to displace conventional API barite *** suspension stability of water-based drilling fluids(WBDFs)weighted with API barite:mMB=2:1 in 600 g was significantly enhanced compared with that with API barite/WBDFs,exhibiting the static sag factor within 0.54 and the whole stability index of *** viscosity and yield point reached the minimum,with a reduction of more than 40%compared with API barite only at the same *** multi-stage filling and dense accumulation of weighting materials and clays,filtration loss was decreased,mud cake quality was improved,and simultaneously it had great reservoir protection performance,and the permeability recovery rate reached 87%.In addition,it also effectively improved the lubricity of *** sticking coefficient of mud cake was reduced by 53.4%,and the friction coefficient was ***,mMB can serve as a versatile additive to control the density,rheology,filtration,and stability of WBDFs weighted with API barite,thus regulating comprehensive performance and achieving reservoir protection *** work opened up a new path for the productive drilling of extremely deep and intricate wells by providing an efficient method for managing the performance of high-density WBDFs.

关键词： Drilling fluids Weighting materials Filtration control Reservoir protection Stability property

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Exosome-mediated crosstalk between microglia and neural stem cells in the repair of brain injury

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Neural Regeneration Research 2020年第6期15卷 1023-1024页

作者： bo-Ru Hou Cheng jiang ze-Ning wang Hai-Jun Ren Department of Neurosurgery Lanzhou University Second Hospital

Brain injury,especially that caused by stroke,is a leading cause of morbidity and mortality *** studies on the neuroprotective effects of neural stem cells(NSCs)after brain injury have shown that crosstalk among neural cells,including neuron–glial,glial–glial,NSC–neuronal and NSC–glial communication,plays a major role in post-injury ***,a better understanding of the factors involved in the interactions between NSCs and other neural cells should advance the development of therapeutic strategies for brain *** this article,we discuss the role of exosomes in the crosstalk between NSCs and microglia,focusing on key exosomal proteins and microRNAs in brain injury progression and repair.

关键词： protective neural mortality

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